Navigation Links
Scripps Research Institute team identifies a potential cause of Parkinson's disease
Date:11/19/2012

LA JOLLA, CA November 19, 2012 Deciphering what causes the brain cell degeneration of Parkinson's disease has remained a perplexing challenge for scientists. But a team led by scientists from The Scripps Research Institute (TSRI) has pinpointed a key factor controlling damage to brain cells in a mouse model of Parkinson's disease. The discovery could lead to new targets for Parkinson's that may be useful in preventing the actual condition.

The team, led by TSRI neuroscientist Bruno Conti, describes the work in a paper published online ahead of print on November 19, 2012 by the Journal of Immunology.

Parkinson's disease plagues about one percent of people over 60 years old, as well as some younger patients. The disease is characterized by the loss of dopamine-producing neurons primarily in the substantia nigra pars compacta, a region of the brain regulating movements and coordination.

Among the known causes of Parkinson's disease are several genes and some toxins. However, the majority of Parkinson's disease cases remain of unknown origin, leading researchers to believe the disease may result from a combination of genetics and environmental factors.

Neuroinflammation and its mediators have recently been proposed to contribute to neuronal loss in Parkinson's, but how these factors could preferentially damage dopaminergic neurons has remained unclear until now.

Making Connections

Conti and his team were looking for biological pathways that could connect the immune system's inflammatory response to the damage seen in dopaminergic neurons. After searching human genomics databases, the team's attention was caught by a gene encoding a protein known as interleukin-13 receptor alpha 1 chain (IL-13Ra1), as it is located in the PARK12 locus, which has been linked to Parkinson's.

IL-13rα1 is a receptor chain mediating the action of interleukin 13 (IL-13) and interleukin 4 (IL-4), two
'/>"/>

Contact: Jann Coury
jcoury@scripps.edu
858-784-8245
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
4. Scripps Research Institute scientists develop antidote for cocaine overdose
5. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
6. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
7. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
8. Scripps Florida scientists identify neurotranmitters that lead to forgetting
9. Plastic trash altering ocean habitats, Scripps study shows
10. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
11. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute team identifies a potential cause of Parkinson's disease
(Date:4/23/2014)... in their mid-thirties and forties, face a devastating ... two decades. "Mutant" protein clusters, long blamed for ... the primary focus of therapies in development by ... Prof. Gerardo Lederkremer and Dr. Julia Leitman of ... Immunology, in collaboration with Prof. Ulrich Hartl of ...
(Date:4/23/2014)... Toronto Scarborough research shows that male black widow spiders ... a rare example of mate preference by male spiders. ... Emily MacLeod and Maydianne Andrade, a professor in UTSC,s ... studies and the wild that males overwhelmingly chose to ... black widows can tell whether a potential mate is ...
(Date:4/23/2014)... source of a unique rhythmic sound, recorded for decades ... the Antarctic minke whale ( Balaenoptera bonaerensis ). First ... who thought it sounded like a duck, the bio-duck ... Southern Ocean, but its source has remained a mystery, ... of researchers deployed acoustic tags on two Antarctic minke ...
Breaking Biology News(10 mins):On the defensive 2On the defensive 3Picky male black widow spiders prefer well-fed virgins 2Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3
... have uncovered a dramatic new twist in the battle against ... itself immune to a key component of the only effective ... team of TB researchers at Leicester announced a new advance ... They isolated the molecular weapons of the bacterium and are ...
... spring arrives across the country, tourists returning to beaches will ... algae that make water unfit for swimming and pose risks ... realize is that the small streams running through their neighborhoods ... feeds the algae blooms. A new study published in ...
... RIDGE, Tenn., March 12, 2008 -- Noted green energy ... this years Global Venture Challenge, a business competition and ... Ridge National Laboratory. The focus of this years ... bioenergy, energy efficiency and power generation sectors. Sridhar, ...
Cached Biology News:Scientists discover how TB 'develops invincibility' against only available treatment 2From the backyard to the ocean: New study shows streams act as key nitrogen filters 2
(Date:1/14/2014)... 2014 iLab Solutions, the leader in core ... Director of Product Strategy. In this role, Michelle will work ... to guide in the development of iLab products. Her main ... possible benefit to the scientific community by offering the most ...
(Date:1/14/2014)...  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology company ... addressing major unmet medical needs using RNA-targeted technologies, ... Allowance from the United States Patent and Trademark ... for the treatment of fibrosis. The patent covers ...
(Date:1/14/2014)... 14, 2014   Kinaxis ®, provider of RapidResponse ®, ... and operations planning ( S&OP ) service, is proud to ... which will be held at the Hilton San Diego Bayfront, ... customer Elisabeth Kaszas , Director of Supply Chain at ...
(Date:1/14/2014)... CA (PRWEB) January 14, 2014 Kerr Corporation, ... 10-minute video and additional how-to information about dual arch impressions ... Restorations with Dual Arch Impressions,” the blog entry serves up ... technique and houses a step-by-step demonstration by Dr. David Little ...
Breaking Biology Technology:iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... hair-like blood vessels in the back of our eyes, researchers ... those that bring blood to the heart respond to air ... otherwise healthy people exposed to high levels of air pollution ... of heart disease. Previous studies linked pollution to heart ...
... An international team of researchers has succeeded in creating ... for the first time, allowing them to examine the ... the University of Leeds, the US Department of Energy,s ... Facilities Council,s Rutherford Appleton Laboratory say the breakthrough will ...
... Mass. -- Researchers at Tufts University School of Engineering have ... and two variations, using E. coli as the ... 24, 2010, issue of Chemistry and Biology, offers ... new drugs that will combat the growing incidence of antibiotic ...
Cached Biology Technology:Photos of tiny blood vessels in the eye link air pollution to heart disease 2Scientists create highly ordered artificial spin ice using nanotechnology 2Scientists create highly ordered artificial spin ice using nanotechnology 3Erythromycin A produced in E. coli for first time 2
Procollagen type I C-terminal propeptide (human, PICP)...
... in Early Drug Development with Imaging Mass ... drug compound localization data in early drug ... mass spectrometry service maps unlabeled ... so you can localize drugs and metabolites ...
... LC Sciences provides a unique new ... DNA synthesis serving diverse needs in genomics, ... applications. OligoMix is a MIXTURE of a ... sequences delivered in a single microtube. OligoMix ...
... is an automated, high-resolution protein analysis ... ProteomeLab family of products, the PA ... automated protein characterization solutions including molecular ... carbohydrate profiling and mechanisms to study ...
Biology Products: