Navigation Links
Scripps Research Institute scientists show copper facilitates prion disease
Date:8/10/2012

LA JOLLA, CA, August 9, 2012 Many of us are familiar with prion disease from its most startling and unusual incarnationsthe outbreaks of "mad cow" disease (bovine spongiform encephalopathy) that created a crisis in the global beef industry. Or the strange story of Kuru, a fatal illness affecting a tribe in Papua New Guinea known for its cannibalism. Both are forms of prion disease, caused by the abnormal folding of a protein and resulting in progressive neurodegeneration and death.

While exactly how the protein malfunctions has been shrouded in mystery, scientists at The Scripps Research Institute now report in the journal Proceedings of the National Academy of Sciences (PNAS) that reducing copper in the body delays the onset of disease. Mice lacking a copper-transport gene lived significantly longer when infected with a prion disease than did normal mice.

"This conclusively shows that copper plays a role in the misfolding of the protein, but is not essential to that misfolding," said Scripps Research Professor Michael Oldstone, who led the new study.

"We've known for many years that prion proteins bind copper," said Scripps Research graduate student Owen Siggs, first author of the paper with former Oldstone lab member Justin Cruite. "But what scientists couldn't agree on was whether this was a good thing or a bad thing during prion disease. By creating a mutation in mice that lowers the amount of circulating copper by 60 percent, we've shown that reducing copper can delay the onset of prion disease."

Zombie Proteins

Unlike most infections, which are caused by bacteria, viruses, or parasites, prion disease stems from the dysfunction of a naturally occurring protein.

"We all contain a normal prion protein, and when that's converted to an abnormal prion protein, you get a chronic nervous system disease," said Oldstone. "That occurs genetically (spontaneously in some people) or is acquired by pass
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
4. Scripps Research Institute scientists develop antidote for cocaine overdose
5. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
6. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
7. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
8. Scripps Florida scientists identify neurotranmitters that lead to forgetting
9. Plastic trash altering ocean habitats, Scripps study shows
10. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
11. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute scientists show copper facilitates prion disease
(Date:4/22/2014)... 2014) Biotechnology scientists must be aware of the ... licensing guidelines, according to a new paper from Rice ... the current issue of the journal Regenerative Medicine ... U.S. Supreme Court ruling in the case Association for ... genes are unpatentable. The court case and rulings garnered ...
(Date:4/22/2014)... of Massachusetts Amherst and the Instituto Nacional de Pesquisas ... have discovered a new genus and species of electric ... the Amazonia State of Brazil. , Professor Cristina Cox ... Antnio Alves-Gomes of INPA, describe the new bluntnose knifefish ... of the Natural Sciences of Philadelphia . , ...
(Date:4/22/2014)... of Kentucky has discovered new methods to build heat ... research, led by Peixuan Guo, professor and William ... of Pharmacy and Markey Cancer Center, is reported in ... Material To Build Robust Structures with Defined Shape and ... Jasinski. , The article, which will appear in a ...
Breaking Biology News(10 mins):New patenting guidelines are needed for biotechnology 2New patenting guidelines are needed for biotechnology 3New electric fish genus and species discovered in Brazil's Rio Negro 2RNA shows potential as boiling-resistant anionic polymer material for nanoarchitectures 2
... SANTA CRUZ, CA--Observations at submarine springs found along the ... preview of the possible fate of coral reef ecosystems ... pH (a measure of acidity) in the water around ... result from the widespread acidification of surface waters that ...
... Electronic infrastructures open new horizons for collaboration and acceleration ... such as scratchpads.eu , yield opportunities, ... newly collected data coming from different sources and working ... journal ZooKeys presenting the results ...
... FAIRFAX, Va.Researchers have published the largest single patient ... following patients with retrievable inferior vena cava (IVC) ... to the lungs. This study, which is important ... supports existing guidelines developed by the Society of ...
Cached Biology News:Submarine springs offer preview of ocean acidification effects on coral reefs 2Submarine springs offer preview of ocean acidification effects on coral reefs 3Electronic infrastructures accelerate biodiversity discoveries 2IVC filters: Society of Interventional Radiology leads in patient care, safety, research 2IVC filters: Society of Interventional Radiology leads in patient care, safety, research 3
(Date:1/14/2014)... 2014 As pet owners drew up their lists of New ... "Take better care of my furry companion." Nowadays there are pet ... carrying cases to take the little canine or feline darlings along ... to buy some pricey toys at the pet store. But anyone ...
(Date:1/14/2014)... and BETHESDA, Md. , Jan. ... together with two institutes from the National Institutes of ... for bringing safer, more effective treatments to patients on ... Center for Advancing Translational Sciences (NCATS) and the National ...
(Date:1/14/2014)... WESTBOROUGH, Mass. , Jan. 14, 2014  RXi ... on discovering, developing and commercializing innovative therapies addressing ... announced that it received the Notice of Allowance ... on its unique self-delivering RNAi compounds (sd-rxRNA®), for ...
(Date:1/14/2014)... Washington, USA, and Cardiff, UK (PRWEB) January 13, 2014 ... photonics technology development leader with more than 20 years ... society for optics and photonics . Hainsey will serve ... are delighted to have Dr. Hainsey join SPIE as ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... International, Inc. (OTCQX: DATA), a technology and services company ... industry, today announced the award of a Phase III ... A CRO specializing in dermatology, Symbio will be utilizing ... EDC. In an effort to meet the timelines ...
... Reportlinker.com announces that a new market research ... World Bioplastics Industry , ... to increase more than fourfold by 2013 ... plastic resins that are biodegradable or derived from ...
... The positive mix lift expected as farmers choose to ... MON ) to reconfirm its commitment to double its ... Hugh Grant will tell investors today. Speaking at the ... launches for its Genuity(TM) SmartStax(TM) corn and Genuity(TM) Roundup ...
Cached Biology Technology:DATATRAK Signs New Client for Rescue Study 2DATATRAK Signs New Client for Rescue Study 3DATATRAK Signs New Client for Rescue Study 4Reportlinker Adds World Bioplastics Industry 2Reportlinker Adds World Bioplastics Industry 3Reportlinker Adds World Bioplastics Industry 4Reportlinker Adds World Bioplastics Industry 5Reportlinker Adds World Bioplastics Industry 6Reportlinker Adds World Bioplastics Industry 7Reportlinker Adds World Bioplastics Industry 8Reportlinker Adds World Bioplastics Industry 9Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 2Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 3Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 4Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 5Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 6Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 7Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 8
Request Info...
...
Candida (IgG) -Ab EIA Sample Size: 5 l...
Automated centrifuge for the processing of microplates and tubes; can be integrated into automated process using inexpensive robotics due to its unique sample handling platform....
Biology Products: