Navigation Links
Scripps Research Institute scientists show copper facilitates prion disease
Date:8/10/2012

LA JOLLA, CA, August 9, 2012 Many of us are familiar with prion disease from its most startling and unusual incarnationsthe outbreaks of "mad cow" disease (bovine spongiform encephalopathy) that created a crisis in the global beef industry. Or the strange story of Kuru, a fatal illness affecting a tribe in Papua New Guinea known for its cannibalism. Both are forms of prion disease, caused by the abnormal folding of a protein and resulting in progressive neurodegeneration and death.

While exactly how the protein malfunctions has been shrouded in mystery, scientists at The Scripps Research Institute now report in the journal Proceedings of the National Academy of Sciences (PNAS) that reducing copper in the body delays the onset of disease. Mice lacking a copper-transport gene lived significantly longer when infected with a prion disease than did normal mice.

"This conclusively shows that copper plays a role in the misfolding of the protein, but is not essential to that misfolding," said Scripps Research Professor Michael Oldstone, who led the new study.

"We've known for many years that prion proteins bind copper," said Scripps Research graduate student Owen Siggs, first author of the paper with former Oldstone lab member Justin Cruite. "But what scientists couldn't agree on was whether this was a good thing or a bad thing during prion disease. By creating a mutation in mice that lowers the amount of circulating copper by 60 percent, we've shown that reducing copper can delay the onset of prion disease."

Zombie Proteins

Unlike most infections, which are caused by bacteria, viruses, or parasites, prion disease stems from the dysfunction of a naturally occurring protein.

"We all contain a normal prion protein, and when that's converted to an abnormal prion protein, you get a chronic nervous system disease," said Oldstone. "That occurs genetically (spontaneously in some people) or is acquired by pass
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
4. Scripps Research Institute scientists develop antidote for cocaine overdose
5. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
6. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
7. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
8. Scripps Florida scientists identify neurotranmitters that lead to forgetting
9. Plastic trash altering ocean habitats, Scripps study shows
10. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
11. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute scientists show copper facilitates prion disease
(Date:10/31/2014)... Geologists are letting the air out of a nagging mystery ... have long speculated as to why animal species didn,t flourish ... to prosper at the end of the Proterozoic period, about ... stretch before that, when most researchers think there also was ... so great then, after all. , In a study published ...
(Date:10/31/2014)... uncovered key steps involved in programmed cell death, offering ... cancers and neurodegenerative diseases. , The research teams ... to discover the three-dimensional structure of a key cell ... in how it causes cell death. Their studies were ... Proceedings of the National Academy of Sciences ...
(Date:10/30/2014)... soil subsidence and reduce greenhouse gas emissions, according ... by Dartmouth College researchers and their colleagues. , ... to continually measure the fluctuations of both carbon ... in the journal by Global Change ... organic soils has resulted in vast soil subsidence ...
Breaking Biology News(10 mins):Lack of oxygen delayed the rise of animals on Earth 2A matter of life and death: Cell death proteins key to fighting disease 2Dartmouth study finds restoring wetlands can lessen soil sinkage, greenhouse gas emissions 2
... A deadly, rare type of soft-tissue cancer may be completely ... growth, UT Southwestern Medical Center researchers report. In the ... found that inhibiting the action of a protein called BRD4 ... malignant peripheral nerve sheath tumors (MPNSTs). "This study identifies ...
... international group of investigators has discovered new genes, pathways ... to rheumatoid arthritis (RA). The findings are published online ... association study (GWAS) meta-analysis in more than 100,000 people ... sites of genetic variation involved in risk for RA. ...
... of Excellence for Coral Reef Studies has been awarded $A28m ... Centre will be reorganised into three new research programs - ... Responding to a Changing World. , Centre Director, Professor Terry ... provide understanding of coral reefs and their interaction with ...
Cached Biology News:UTSW study identifies potential therapeutic target for incurable, rare type of soft-tissue cancer 2Researchers complete a milestone in defining the genetic basis of rheumatoid arthritis 2
(Date:10/31/2014)... FAIRFIELD, Connecticut (PRWEB) October 31, 2014 ... remains sanitary is an uphill battle in many corners ... for a rural farming community in northwestern Bolivia where ... is where a group from Fairfield University’s School of ... at the Unidad Academica Campesina (UAC), “the united college ...
(Date:10/31/2014)... October 30, 2014 Two separate ... were hosted by Charm Sciences at its Andover, ... week in the US, the participants discussed international ... hygiene management, and process verification, and received hands-on ... This was the first visit to the United ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 This ... Global and China Biocides industry. The report provides ... and industry chain structure as well as industry ... including China’s domestic market as well as Global ... analysis. The report on the Chinese biocides ...
(Date:10/31/2014)... 2014 ENVIRON , an ... today that Dr. Harvey Clewell III has rejoined ... work closely with senior professionals in ENVIRON’s Health ... serve at The Hamner Institutes for Health Sciences ... where he is Director, Center for Human Health ...
Breaking Biology Technology:Fairfield University School of Engineering project reduces illness in rural community 2Fairfield University School of Engineering project reduces illness in rural community 3Charm Sciences Hosts Executives from Latin America for Dairy Safety Executive Seminar 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 3Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3
... a world-wide leader in custom genomic and molecular ... position itself as the Next-Generation Sequencing Provider of ... attributed to the company,s ability to respond quickly ... genomics technologies. Building on this success, SeqWright announced ...
... that a new market research report is available in ... 1011 http://www.reportlinker.com/p0358381/Industrial-Biotechnology-China-News-1011.html ... not past." Owing to the monetary easing policy adopted ... affect almost all industries in China, including corn products. ...
... can be used to control the electrical properties ... devices and highly sensitive sensors. This year,s ... into graphene, recognising its potential for many applications ... technology. The UK,s National Physical Laboratory, along with ...
Cached Biology Technology:SeqWright Continues Expansion of Next-Generation Sequencing Capabilities 2Reportlinker Adds Industrial Biotechnology China News 1011 2New research shows how light can control electrical properties of graphene 2
... A full-featured high-performance ICP-MS system designed for ... interface, Omega II off-axis ion lens, true ... 7500a can handle the widest range of ... the 7500a now includes as standard Agilents ...
... Identical to the DH-2000, except that it ... 190-1700 nm wavelength range and comes with a ... up to 5 Hz) The DH-2000 ... spectrum of deuterium and tungsten halogen light sources ...
One controller two vessel system suitable for early stage of fermentation, and small scale, Application : cultivation of microorganisms and human or animal cells...
... handy dispensers save space and organize ... other garb. They are the perfect ... used in labs, processing and manufacturing. ... and the particles they attract. Many ...
Biology Products: