Navigation Links
Scripps Research Institute scientists achieve most detailed picture ever of key part of hepatitis C
Date:11/28/2013

LA JOLLA, CANovember 28, 2013Scientists at The Scripps Research Institute (TSRI) have determined the most detailed picture yet of a crucial part of the hepatitis C virus, which the virus uses to infect liver cells. The new data reveal unexpected structural features of this protein and should greatly speed efforts to make an effective hepatitis C vaccine.

The findings, which appear in the November 29, 2013 issue of the journal Science, focus on a protein known as E2 envelope glycoprotein.

"We're excited by this development," said Ian A. Wilson, the Hansen Professor of Structural Biology at TSRI and a senior author of the new research with TSRI Assistant Professors Mansun Law and Andrew B. Ward. "It has been very hard to get a high resolution structure of E2 and it took years of painstaking work to finally accomplish that."

Any successful hepatitis C vaccine is likely to target the E2 protein. Scientists already have isolated rare antibodies from patients that can bind E2 in ways that neutralize a broad range of viral strains.

"It took our team six years to crack this very difficult scientific problem, but we didn't give up," said Law. "Now that we can visualize the structural details of these binding sites, we can design vaccine molecules that mimic them."

A Silent Killer

There has long been an urgent need for an effective vaccine against hepatitis C virus. Once confined to isolated geographical regions, the virus spread globally during the 20th century, chiefly via blood transfusions, unsterilized medical instruments and re-used hypodermic needles. Although hospitals have screened blood products for hepatitis C virus (HCV) since the early 1990s, as many as 200 million people currently are thought to harbor the virus. These include more than 3 million people in the United States, where the virus is responsible for more deaths each year than HIV.

HCV was able to spread so widely because
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scripps oceanography researchers engineer breakthrough for biofuel production
2. NIH awards Scripps Translational Science Institute $29 million grant
3. James Cameron to be publicly honored with Scripps Nierenberg Prize
4. Scripps Research announces research & license agreement with Janssen Pharmaceuticals
5. John Moores gives $2 million to Scripps Research to develop river blindness field test
6. Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
7. Vibrant mix of marine life found at extreme ocean depths, Scripps analysis reveals
8. Scripps Florida scientist awarded prestigious Javits Neuroscience Investigator Award
9. Scripps Research Institute study shows how brain cells shape temperature preferences
10. Scripps Florida scientists uncover potential drug target to block cell death in Parkinsons disease
11. Scripps physicians call for change in cancer tissue handling
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute scientists achieve most detailed picture ever of key part of hepatitis C
(Date:2/5/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market, announces it ... Conference on January 29 th at 10:30 a.m. ... of NXT-ID will present and host a live Q&A ... and its full suite of biometric technologies. Investors can ...
(Date:1/22/2015)... S.A. ("Company") (BM&FBOVESPA: VLID3 ON), is pleased to inform its ... of Washington,s Department of Licensing, in the United ... system for driver,s licenses and identification cards to its subsidiary, ... will start in January 2015, with enrollment and card production ...
(Date:1/22/2015)... N.C. , Jan. 16, 2015  A man-made form ... memory and other mental capabilities in adults with mild ... pilot study led by researchers at Wake Forest Baptist ... adults diagnosed with amnesic mild cognitive impairment (MCI) or ...
Breaking Biology News(10 mins):CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3Valid USA Signs Contract For Washington Driver's License Issuance 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3
... the extraction of water for irrigation and overfishing all threaten ... sensitive to changes in its environment and, according to the ... the year 2040 and will have completely disappeared from Iberian ... Global warming is threatening the existence of many fish species, ...
... -- What if you could shut down several emergency ... hacking a pacemaker and reprogramming it to cause a ... an espionage film, they are also some of the ... working to prevent. Eugene Vasserman, assistant professor; John ...
... The Scripps Research Institute have designed a compound that shows ... closely linked to fragile X syndrome, a genetic condition that ... only known single-gene cause of autism. The study, published ... Biology September 4, 2012, focuses on tremor ataxia syndrome, ...
Cached Biology News:Trout will become extinct in the Iberian Peninsula in less than 100 years 2Trout will become extinct in the Iberian Peninsula in less than 100 years 3Internal relations 2Internal relations 3Internal relations 4Scripps Florida scientists design molecule that reverses some fragile X syndrome defects 2
(Date:2/27/2015)... The fully automated supercritical fluidic chromatography-based ... analyze up to 48 samples utilizing automatic extraction ... targets by mass spectrometry. , The Nexera ... requirements of a wide range of applications, including ... search for disease biomarkers, additives in forming polymers, ...
(Date:2/27/2015)... Brighton, Illinois (PRWEB) February 27, 2015 ... Matt Sims, General Manager of State Line Farms, received ... Award recognizes a producer, under the age of 35, ... , "It is an honor to win the Tomorrow's ... to discovering who won the Top Producer Award and ...
(Date:2/27/2015)... , Feb. 27, 2015   PureTech , ... inventing and commercializing disruptive products and technologies in the ... Viehbacher , former CEO and Member of the Board ... "It,s has been a pleasure to ... excited that we will be working together more closely ...
(Date:2/26/2015)... 2015  23andMe, the leading personal genetics company, today ... Privacy Officer and Corporate Counsel. Black brings a strong ... well as health care regulations. As a member of ... for reviewing, updating and enhancing the company,s privacy and ... She joined the company January 5, 2015 and reports ...
Breaking Biology Technology:Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 2Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 3Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 423andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2
... University of Wisconsin-Madison Lidar (Light Detection and Ranging) group was ... Land Elevation Satellite) laser device. Lidars Arctic HSRL ... because it operates on the same wavelength as the ICESat. ... climate and changing polar ice sheets in the Arctic. ...
... business is turning around a sick company before all of ... into bankruptcy. Realizing the painful reality of how bad things ... senior executives to deal with truthfully. They grasp at straws ... close that big outstanding proposal, and things will be back ...
... at a double-digit pace in 2003, but there are indications ... year, according to global HR outsourcing and consulting firm Hewitt ... percent average increase for employers, which is lower than 2003's ... absorb the majority of next year's increase, but many are ...
Cached Biology Technology:UW-Madison Laser Device to Study Polar Ice Caps 2Turning Around a Sick Company 2Health Care Costs Continue Double-Digit Pace, But May Start Moderating in 2004 2Health Care Costs Continue Double-Digit Pace, But May Start Moderating in 2004 3
albumin from bovine serum (BSA), tetramethylrhodamine conjugate...
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed...
... Blot Processing mini Tray (3 per ... gel staining and blot processing.Automated staining ... for proteins and nucleic acid analysis.Prepares ... and chromogenic detection.Programmable control of protocol, ...
75 x 25 mm; sterile, recommended for immunohistochemistry of cell lines growing in suspension, Poly-D-Lysine coated, glass slides with polystyrene vessel, lid and safety removal tool...
Biology Products: