Navigation Links
Scripps Research Institute scientists achieve most detailed picture ever of key part of hepatitis C
Date:11/28/2013

LA JOLLA, CANovember 28, 2013Scientists at The Scripps Research Institute (TSRI) have determined the most detailed picture yet of a crucial part of the hepatitis C virus, which the virus uses to infect liver cells. The new data reveal unexpected structural features of this protein and should greatly speed efforts to make an effective hepatitis C vaccine.

The findings, which appear in the November 29, 2013 issue of the journal Science, focus on a protein known as E2 envelope glycoprotein.

"We're excited by this development," said Ian A. Wilson, the Hansen Professor of Structural Biology at TSRI and a senior author of the new research with TSRI Assistant Professors Mansun Law and Andrew B. Ward. "It has been very hard to get a high resolution structure of E2 and it took years of painstaking work to finally accomplish that."

Any successful hepatitis C vaccine is likely to target the E2 protein. Scientists already have isolated rare antibodies from patients that can bind E2 in ways that neutralize a broad range of viral strains.

"It took our team six years to crack this very difficult scientific problem, but we didn't give up," said Law. "Now that we can visualize the structural details of these binding sites, we can design vaccine molecules that mimic them."

A Silent Killer

There has long been an urgent need for an effective vaccine against hepatitis C virus. Once confined to isolated geographical regions, the virus spread globally during the 20th century, chiefly via blood transfusions, unsterilized medical instruments and re-used hypodermic needles. Although hospitals have screened blood products for hepatitis C virus (HCV) since the early 1990s, as many as 200 million people currently are thought to harbor the virus. These include more than 3 million people in the United States, where the virus is responsible for more deaths each year than HIV.

HCV was able to spread so widely because
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scripps oceanography researchers engineer breakthrough for biofuel production
2. NIH awards Scripps Translational Science Institute $29 million grant
3. James Cameron to be publicly honored with Scripps Nierenberg Prize
4. Scripps Research announces research & license agreement with Janssen Pharmaceuticals
5. John Moores gives $2 million to Scripps Research to develop river blindness field test
6. Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
7. Vibrant mix of marine life found at extreme ocean depths, Scripps analysis reveals
8. Scripps Florida scientist awarded prestigious Javits Neuroscience Investigator Award
9. Scripps Research Institute study shows how brain cells shape temperature preferences
10. Scripps Florida scientists uncover potential drug target to block cell death in Parkinsons disease
11. Scripps physicians call for change in cancer tissue handling
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute scientists achieve most detailed picture ever of key part of hepatitis C
(Date:8/27/2014)... is entering what is described by the Volunteer Wildfire ... The Eastern Cape provincial government warned residents in certain ... winds and veld fires. A high veld fire ... along the coast in the Great Kei and Mnquma ... and during thunderstorms. The thunderstorms bring lightning strikes ...
(Date:8/27/2014)... to pay a premium for fruits, vegetables and other ... label claims is another matter. Now scientists studying conventional ... make sure farms are labelling their produce appropriately. Their ... and Food Chemistry , could help prevent organic food ... Safety Authority and the Wuerzburg University note that the ...
(Date:8/27/2014)... have shown that excessive iron is closely ... Previous studies from Chunyan Guo and co-workers ... shown that baicalin prevented iron accumulation after ... 1 expression, and increased ferroportin 1 expression ... disease rats. However, the relationship between iron ...
Breaking Biology News(10 mins):
... 2010, a Cathay Pacific Airways plane was arriving in Hong ... was forced to make a hard landinginjuring dozens. The potential ... diesel fuel is increasing as biodiesel becomes more popular and ... store and transport the two types of fuels. ...
... , This news release is available in ... of things -- be it the grains of sand on a beach, ... use a part of the brain that is organized topographically, researchers have ... "numerosity" assessment are laid out in a shape that allows those most ...
... A team of researchers led by Charles D. Nichols, ... Center New Orleans, has successfully translated a new technology ... flies. This powerful genetic tool Designer Receptors ... selectively, rapidly, reversibly, and dose-dependently remotely control behaviors and ...
Cached Biology News:University of Tennessee professor and student develop device to detect biodiesel contamination 2Finally mapped: The brain region that distinguishes bits from bounty 2Finally mapped: The brain region that distinguishes bits from bounty 3LSUHSC researchers develop new system to better study behavior, cell function 2
(Date:8/27/2014)... Aug. 27, 2014 Research and Markets ... Isotope Ratio Mass Spectrometer Industry Report 2014" report ... Isotope Ratio Mass Spectrometer Industry Report 2014 is a ... the global isotope ratio mass spectrometer industry. ... including definitions, classifications, applications and industry chain structure. The ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 BIOEQUA, an ... through the use of a handheld spray, has made ... United States. , The brand began with an ... researchers were surprised to learn that the application of ... extremely small and delivered directly to skin's basal layer. ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 WriteResult, LLC ... – has once again shown superiority when it comes ... by completing the ePRO portion of their most recent ... The Japan-based pharma chose WriteResult’s digital writing platform to ... – the first to complete drew data from a ...
(Date:8/26/2014)... Bellingham, WA (PRWEB) August 26, 2014 ... visions for next-generation wearable technology, and inspiration for ... highlights at this year’s brighter, busier SPIE ... California, Convention Center. More than 4,400 international scientists, ... conferences, courses, an exhibition, and industry sessions sponsored ...
Breaking Biology Technology:Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4
... Seeks to Develop New Prescription Adult Cough Products Using ... Lipocine,s Proprietary Lip,ral(TM) Technologies, CHESTER, N.J. ... Inc. (Nasdaq: ARxT ) and Lipocine Inc., a,privately- ... technologies to address key unmet drug delivery and,therapeutics needs, ...
... Over 20 new speakers will,grace the faculty ... Analysis" conference in two weeks in New Jersey. ... Business Analysis, and Market,Forecasting executives; 200 from the ... attend the meeting. Competition has never been fiercer ...
... be Used to Accurately Measure Cardiac Output ... Cardiopulmonary Exercise Testing (CPX), WASHINGTON, September 19 Cheetah ... output monitoring, announced at HFSA the results of the study,"Markers ... The study, led by Dr. Jon Myers of Stanford ...
Cached Biology Technology:Adams Respiratory Therapeutics and Lipocine Enter into License and Collaboration Agreement 2Adams Respiratory Therapeutics and Lipocine Enter into License and Collaboration Agreement 3New Competitive Intelligence Speakers Spark Interest in Pharmaceutical Conference on October 1-2 in NJ 2Cheetah Medical's NICOM Non-Invasive Cardiac Output Monitor Featured in a Presentation at the Heart Failure Society of America (HFSA) Annual Meeting 2Cheetah Medical's NICOM Non-Invasive Cardiac Output Monitor Featured in a Presentation at the Heart Failure Society of America (HFSA) Annual Meeting 3
... fragment based screening project: , ... 96 shape-diverse mixtures of 4 (5 uL each) , ... , Individual compounds are dissolved in DMSO ... mM. Supplied in 5 96-well trays. Dilute library ...
... interferons are cytopathic effect inhibition assays, also ... The neutralization assay measures the antibody's ability ... cytokine. Sample types include; tissue culture supernatents; ... assays, one unit is defined as the ...
... G bind specifically to Fc regions of ... G conjugates are commonly used as affinity ... subtypes from serum, hybridoma ascites fluids, tissue ... reagents are also commonly used to capture ...
... SYS203 is a complete, flexible system ... small samples, as is frequently required ... designed around Instechs miniature Clark-style polarographic ... inch in diameter (3.2 mm), it ...
Biology Products: