Navigation Links
Scripps Research Institute Scientists Develop Alternative to Gene Therapy
Date:7/1/2012

LA JOLLA, CA July 1, 2012 Scientists at The Scripps Research Institute have discovered a surprisingly simple and safe method to disrupt specific genes within cells. The scientists highlighted the medical potential of the new technique by demonstrating its use as a safer alternative to an experimental gene therapy against HIV infection.

"We showed that we can modify the genomes of cells without the troubles that have long been linked to traditional gene therapy techniques," said the study's senior author Carlos F. Barbas III, who is the Janet and Keith Kellogg II Professor of Molecular Biology and Chemistry at The Scripps Research Institute.

The new technique, reported in Nature Methods on July 1, 2012, employs zinc finger nuclease (ZFN) proteins, which can bind and cut DNA at precisely defined locations in the genome. ZFNs are coming into widespread use in scientific experiments and potential disease treatments, but typically are delivered into cells using potentially risky gene therapy methods.

The Scripps Research scientists simply added ZFN proteins directly to cells in a lab dish and found that the proteins crossed into the cells and performed their gene-cutting functions with high efficiency and minimal collateral damage.

"This work removes a major bottleneck in the efficient use of ZFN proteins as a gene therapy tool in humans," said Michael K. Reddy, who oversees transcription mechanism grants at the National Institutes of Health's (NIH) National Institute of General Medical Sciences, which helped fund the work, along with an NIH Director's Pioneer Award. "The directness of Dr. Barbas's approach of 'simply' testing the notion that ZFNs could possess an intrinsic cell-penetrating ability is a testament to his highly creative nature and further validates his selection as a 2010 recipient of an NIH Director's Pioneer Award."

Questioning Assumptions

ZFNs, invented in the mid-1990s,
'/>"/>

Contact: Mika OnoScripps Research Institute scientists develop alternative to gene therapy
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Scripps Research Institute announces five-year research collaboration with Bristol-Myers Squibb
2. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
3. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
4. Plastic trash altering ocean habitats, Scripps study shows
5. Scripps Florida scientists identify neurotranmitters that lead to forgetting
6. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
7. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
8. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
9. Scripps Research Institute scientists develop antidote for cocaine overdose
10. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
11. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute Scientists Develop Alternative to Gene Therapy
(Date:3/24/2015)... BEACH GARDENS, Fla. , March 24, 2015 ... biometric identity management solutions, today announced that its ... premium clothing accessory retailer Goorin Bros . ... The Crossmatch biometrics-based solution secures access to the ... from the increased risk of data breaches. ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/18/2015)... -- As mobile payments become more prevalent amongst ... apps continue to be introduced into the market place at ... industry in focus today are:  NXT-ID, Inc. (NASDAQ: ... ), Apple Inc. (NASDAQ: AAPL ), Google Inc. ... FB ) NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
... , Jos Carlos Mendes Santos (a.k.a. Louro) is a handyman ... of the world with the highest biodiversity. Two years ago, ... the backyards of the off-the-grid house of amateur botanist and ... home to be grown on a window sill for closer ...
... N.C. -- The number of sea turtles accidentally caught and ... declined by an estimated 90 percent since 1990, according to ... and Conservation International. The report, published in the scientific ... measures that have been put into place over the last ...
... Important changes that will affect the publication of new ... International Botanical Congress are detailed in a paper that is ... total of sixteen leading academic journals. The paper, co-authored by ... Louis), presents the draft text of new articles to the ...
Cached Biology News:Amateur botanists in Brazil discover a genuflexing plant 2Amateur botanists in Brazil discover a genuflexing plant 3Accidental sea turtle deaths drop 90 percent in US fisheries 2Accidental sea turtle deaths drop 90 percent in US fisheries 3Revolutionary changes to the Botanical Code published in 16 journals and 5 languages 2
(Date:4/16/2015)... San Francisco, CA (PRWEB) April 16, 2015 ... is scheduled to report first quarter results on Thursday, ... the announcement, Cytokinetics’ senior management will host a conference ... and financial results and the company’s outlook for the ... and can be accessed from the homepage and in ...
(Date:4/16/2015)... , April 16, 2015  Schulman Associates IRB, ... technology, has signed a long-term lease on Laboratory Drive ... North Carolina . The location will house review ... to provide high quality reviews and customer service to ... represented Schulman in the deal, while Capital ...
(Date:4/16/2015)... N.C. (PRWEB) April 16, 2015 ... Carolina at Charlotte (UNC Charlotte) spin-out company, announced ... L. Cooper, Ph.D., M.D., as Chief Operating Officer ... years of experience in developing clinical diagnostic and ... and infectious disease. , Cooper’s extensive career transcends ...
(Date:4/16/2015)... , April 16, 2015 /PRNewswire/ - Portage Biotech ... Canadian Securities Exchange: PBT.U), is pleased to announce that ... Show on April 25, 2015 to be held in ... Gregory Bailey and Mr. James Mellon ... and an update on the key programs at its ...
Breaking Biology Technology:Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3Schulman IRB to Open Office in Research Triangle Park, N.C. 2OncoTAb Names Dr. David L. Cooper as COO 2Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4
... Technologies, Inc. has received a written notification from the ... to file financial reports for the quarter ending March 31, ... common stock from NASDAQ. , ,Representatives of Merge, which ... Listing Qualifications Panel to request that the panel grant Merge ...
... Milwaukee, Wis . - David Melbye hasn't been ... already has a significant information technology project under his ... Sewerage District , is wrapping up a major IT ... by the district's governing commission. While he's pleased with ...
... - Wisconsin Gov. Jim Doyle , noting that ... bipartisan legislation to overturn President Bush's ban on ... is delaying critical scientific research. , ,Doyle noted that ... to follow through on a commitment to schedule a vote ...
Cached Biology Technology:CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 2CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 3CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 4CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 5
... Convenient platform for tube handling and reagent dispensing ... tubes - 96 x 0.3ml U-bottom ... - Thermo-Fast® 96 Non-Skirted Plate - ... x 0.5ml Thermo-Tubes Multiple workstations can be securely stacked ...
... well Magnetic-Ring Stand is designed for paramagnetic ... microplates. The stand has a plastic base ... plate footprint. The use of 96 extremely ... easy magnetic separation. With this magnetic stand, ...
... • Enzyme concentration - 5 units/µL ,• ... higher yields ,• Leaves an 'A' overhang ... polymerase which exhibits very high activity in ... To ensure the quality of the enzyme, ...
Taq DNA Polymerase (T. aquaticus), 250 units. For PCR and other procedures requiring DNA polymerase activity at elevated temperatures. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzyme...
Biology Products: