Navigation Links
Scripps Florida scientists uncover potential drug target to block cell death in Parkinson's disease
Date:1/10/2013

JUPITER, FL, January 10, 2013 Oxidative stress is a primary villain in a host of diseases that range from cancer and heart failure to Alzheimer's disease, Amyotrophic Lateral Sclerosis and Parkinson's disease. Now, scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that blocking the interaction of a critical enzyme may counteract the destruction of neurons associated with these neurodegenerative diseases, suggesting a potential new target for drug development.

These findings appear in the January 11, 2013 edition of The Journal of Biological Chemistry.

During periods of cellular stress, such as exposure to UV radiation, the number of highly reactive oxygen-containing molecules can increase in cells, resulting in serious damage. However, relatively little is known about the role played in this process by a number of stress-related enzymes.

In the new study, the TSRI team led by Professor Philip LoGrasso focused on an enzyme known as c-jun-N-terminal kinase (JNK). Under stress, JNK migrates to the mitochondria, the part of the cell that generates chemical energy and is involved in cell growth and death. That migration, coupled with JNK activation, is associated with a number of serious health issues, including mitochondrial dysfunction, which has long been known to contribute to neuronal death in Parkinson's disease.

The new study showed for the first time that the interaction of JNK with a protein known as Sab is responsible for the initial JNK localization to the mitochondria in neurons. The scientists also found blocking JNK mitochondrial signaling by inhibiting JNK interaction with Sab can protect against neuronal damage in both cell culture and in the brain.

In addition, by treating JNK with a peptide inhibitor derived from a mitochondrial membrane protein, the team was able to induce a two-fold level of protection of neurons in the substantia nigra pars compacta,
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps physicians call for change in cancer tissue handling
2. $1 million Kenan Trust Grant extends support of Scripps Florida education outreach
3. Scripps Research Institute scientists describe elusive replication machinery of flu viruses
4. Scripps Research Institute team identifies a potential cause of Parkinsons disease
5. Scripps Florida scientists design molecule that reverses some fragile X syndrome defects
6. Scripps Research Institute scientists show copper facilitates prion disease
7. Scripps Research scientists show potent new compound virtually eliminates HIV in cell culture
8. Scripps Research Institute wins $77 million to develop AIDS vaccine center
9. Scripps Florida scientists identify critical quality control for cell growth
10. Scripps Research Institute Scientists Develop Alternative to Gene Therapy
11. Scripps Research Institute announces five-year research collaboration with Bristol-Myers Squibb
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientists uncover potential drug target to block cell death in Parkinson's disease
(Date:8/27/2014)... century-old museum specimens hold clues to how global climate change ... kill trees and the news is not good. , ... and maple trees in warmer urban areas, which raises the ... says Dr. Elsa Youngsteadt, a research associate at NC State ... "More scale insects would be a problem, since scales can ...
(Date:8/26/2014)... Louis have developed algorithms to identify weak spots in ... The technology, which needs to be refined before it ... minor strains and tiny injuries in the body,s tissues ... available online Aug. 27 in the Journal of ... the nexus of the physical and life sciences. , ...
(Date:8/26/2014)... of harmful bacteria, biofilms make the treatment of ... biofilm pose a significant health risk due to ... biofilm-protected bacteria account for some 80 percent of ... to 1,000 times more resistant to antibiotics than ... have stumbled onto a magic bullet," said David ...
Breaking Biology News(10 mins):Museum specimens, modern cities show how an insect pest will respond to climate change 2New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3Breakthrough antibacterial approach could resolve serious skin infections 2Breakthrough antibacterial approach could resolve serious skin infections 3
... , Journal of Visualized Experiments , details the ... polymer, SurgiLux, was developed by scientists at the University ... from chitin, which is found in fungal cell walls ... allows SurgiLux to form low energy bonds between the ...
... Institute for Medical Research has been awarded a $1 ... which is administered by the National Institute for Occupational ... for Disease Control and Prevention (CDC), the National Institute ... comprehensively study the overall physical, mental and socioeconomic impact ...
... Manoel Manghi from Toulouse University in France and his colleagues ... to a double stranded molecule of DNA when it is ... be published in EPJ E . Instead of using ... settings, the authors focused on using a theoretical model to ...
Cached Biology News:New bio-adhesive polymer demonstrated in JoVE 2Feinstein Institute receives $1 million grant to study impact of World Trade Center attacks on responders 2
(Date:8/27/2014)... College, PA (PRWEB) August 27, 2014 ... Simulation Software with new features for the biomedical ... is an enhanced Biological Thermal Sensor, exclusive to the ... a specialty version of XFdtd, developed to calculate the ... export functionality has been added to all versions to ...
(Date:8/26/2014)... the thinnest-possible semiconductor, a new class of nanoscale ... , The University of Washington researchers have demonstrated ... be connected in an atomically seamless fashion known ... basis for next-generation flexible and transparent computing, better ... "Heterojunctions are fundamental elements of electronic and photonic ...
(Date:8/26/2014)... 26, 2014 An analysis by Replikins, Ltd. ... Mers CoV virus strains has revealed extensive ... 2012.  This conservation and sharing of specific Replikin gene ... Blocker-Vaccine™ candidate, as it did for the H5N1 influenza ... which have been found to be effective (1,2). ...
(Date:8/26/2014)... to the growing case for graphene being bumped ... in the high-tech world by the two-dimensional semiconductors ... researchers led by a scientist with the U.S. ... (Berkeley Lab) has reported the first experimental observation ... The recorded charge transfer time clocked in at ...
Breaking Biology Technology:Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 2Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 3Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2Competition for graphene 2
... today announced that Pat Basu, M.D., M.B.A. , ... as Chief Medical Officer. Dr. Basu has just completed ... a White House Fellow, America,s most prestigious and selective ... will play a critical role in advancing vRad,s efforts, ...
... Sequenom, Inc. (NASDAQ: SQNM ), a life ... the launch of its iPLEX ADME PGx panel developed ... distribution, metabolism, and excretion (ADME). This Research Use Only ... polymorphisms (SNP), insertions and deletions (INDELS) and copy number ...
... HILL, MA -- Boston College researchers have discovered two ... chemical vapor deposition, finding a disorderly tangle of tube ... nanoscopic tubes, according to a report in the latest ... using a thin layer of catalyst, Professor of Physics ...
Cached Biology Technology:vRad Adds White House Fellow, Dr. Pat Basu, to Its Leadership Teams 2Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 2Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 3Boston College Researchers discover 2 early stages of carbon nanotube growth 2
... can be induced prior to DNA purification ... stability of single-copy BACs with the high ... vectors. The kits provide the linearized vector ... screening system) necessary to create a 10X ...
...
... 3T3 cells were cultured in DMEM with 4 ... of growth. In order to keep the ... in acetone-methanol. The cells are arrayed on ... each wells surface specifically treated to enhance cellular ...
... Systems provide rapid, precise localization of ... frozen or paraffin-embedded tissue, cytospins and ... facilitate double or triple labeleing experiments, ... with primary antibodies of different animal ...
Biology Products: