Navigation Links
Scientists uncover previously unknown mechanism of memory formation
Date:1/30/2013

JUPITER, FL, January 30, 2013 It takes a lot to make a memory. New proteins have to be synthesized, neuron structures altered. While some of these memory-building mechanisms are known, many are not. Some recent studies have indicated that a unique group of molecules called microRNAs, known to control production of proteins in cells, may play a far more important role in memory formation than previously thought.

Now, a new study by scientists on the Florida campus of The Scripps Research Institute has for the first time confirmed a critical role for microRNAs in the development of memory in the part of the brain called the amygdala, which is involved in emotional memory. The new study found that a specific microRNAmiR-182was deeply involved in memory formation within this brain structure.

"No one had looked at the role of microRNAs in amygdala memory," said Courtney Miller, a TSRI assistant professor who led the study. "And it looks as though miR-182 may be promoting local protein synthesis, helping to support the synapse-specificity of memories."

In the new study, published in the Journal of Neuroscience, the scientists measured the levels of all known microRNAs following an animal model of learning. A microarray analysis, which enables rapid genetic testing on a large scale, showed that more than half of all known microRNAs are expressed in the amygdala. Seven of those microRNAs increased and 32 decreased when learning occurred.

The study found that, of the microRNAs expressed in the brain, miR-182 had one of the lowest levels and these decreased further with learning. Despite these very low levels, its overexpression prevented the formation of memory and led to a decrease in proteins that regulate neuronal plasticity (neurons' ability to adapt) through changes in structure.

These findings suggest that learning-induced suppression of miR-182 is a main supporting factor in the formation of long-term memory
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists uncover previously unknown mechanism of memory formation
(Date:3/26/2015)... 2015 The Granite Club, ... athletic club, today announced it has implemented a state-of-the-art ... movement for members and staff, while restricting access to ... we selected FST,s IMID Access system because it has ... members and staff, in addition to unparalleled security," said ...
(Date:3/24/2015)... DUBLIN , Mar. 24, 2015 Research and Markets ... "Face and Voice Biometrics - Global Strategic Business Report" report ... for Face and Voice Biometrics in US$ Thousands by the following ... analytics for the US, Canada , ... , Middle East & ...
(Date:3/24/2015)... Fla. , March 24, 2015   ... management solutions, today announced that its U.are.U ® ... accessory retailer Goorin Bros . to achieve ... biometrics-based solution secures access to the POS terminal, ... increased risk of data breaches. ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
... John Smol of Queen,s University in Kingston, Ontario, Canada, ... one of the five prestigious Premier,s Discovery Awards for 2009. ... of the Environmental Scientists of the Year by The Royal ... is series editor of the Springer book series Developments in ...
... Mass., June 2, 2009 -- New research shows some bees ... hind legs while flying. But this approach comes at a ... flight by roughly 30 percent, and cutting into the bees, ... Proceedings of the National Academy of Sciences . ...
... Ocean acidification, a direct result of increased CO2 emission, ... and may have a direct impact on our economy, ... Intensive fossil-fuel burning and deforestation over the last ... 40%, which has in turn fundamentally altered ocean chemistry ...
Cached Biology News:Springer Series editor John Smol receives two prestigious biology awards 2Trading energy for safety, bees extend legs to stay stable in wind 2Who will pick up the bill? 2
(Date:3/30/2015)... N.J. , March 30, 2015  Naldemedine, ... under development by Shionogi & Co., Ltd., met ... III study (COMPOSE I) for the treatment of ... non-cancer pain receiving opioid therapy. Study results showed ... statistically significantly improved the frequency of spontaneous bowel ...
(Date:3/29/2015)... 2015  Caris Life Sciences® today announced ... cell cervical cancer (SCCC) that shows multiplatform ... company,s panomic, comprehensive tumor profiling service, identified high ... explain sensitivities and resistance to common drug ... biomarkers may guide treatment strategies in rare, ...
(Date:3/27/2015)... 27, 2015 The consumption of compound ... the recession and high prices in 2008. However, the ... and keeps on gaining momentum now. , To date, ... more than 100,000 thousand tonnes. No considerable growth was ... global capacity rocketed during 2012-2013, registering 11% growth as ...
(Date:3/27/2015)... NEW YORK , March 27, 2015  Peter ... in Biomedical Science for his pioneering work on how ... the components of a regulatory mechanism that cells use ... proteins. Dr. Walter is a professor of biochemistry at ... the groundwork for treating a range of human diseases ...
Breaking Biology Technology:Shionogi & Co., Ltd. Announces That Naldemedine Meets Primary Endpoint In A Phase 3 Study For The Treatment Of Opioid-Induced Constipation 2Shionogi & Co., Ltd. Announces That Naldemedine Meets Primary Endpoint In A Phase 3 Study For The Treatment Of Opioid-Induced Constipation 3Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 2Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 3World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3
... DiObex, Inc., a privately held,biotechnology company focused on the ... CEO David Cory will deliver a,corporate presentation at the ... Medical Device Conference in New York,New York. The DiObex ... a.m. at the Grand Hyatt Hotel in the Broadway ...
... Echo Therapeutics,Inc. (OTC Bulletin Board: ECTE), a ... Patrick T. Mooney, M.D, Chairman,and Chief Executive Officer, ... February 7, 2008 at 3:50 pm Mountain Standard ... be held at the Four Seasons,Resort in Scottsdale, ...
... plc,(LSE:EHP) announced today that it had successfully completed ... its proprietary, minimally invasive,plucked human hair biomarker technology ... analysing gene expression change in,RNA extracted from the ... a single human,plucked hair. Changes in gene expression ...
Cached Biology Technology:Echo Therapeutics to Present at RedChip Small-Cap Investor Conference 2Epistem plc and AstraZeneca Complete Plucked Hair Biomarker Study for Oncology Drug Development 2Epistem plc and AstraZeneca Complete Plucked Hair Biomarker Study for Oncology Drug Development 3Epistem plc and AstraZeneca Complete Plucked Hair Biomarker Study for Oncology Drug Development 4
... Expand the computing power of your ValveBank ... sequences with a PC computer running Windows 98, ... load unlimited programs to disk, print out program ... memory in one simple step., EasyCode is used ...
Porcine Aortic Smooth Muscle Cells (PAOSMC) (>500,000 cells)...
Bovine Renal Artery Smooth Muscle Cells (BRASMC) (>500,000 cells)...
Porcine Aortic Endothelial Cells (PAOEC) (>500,000 cells)...
Biology Products: