Navigation Links
Scientists uncover previously unknown mechanism of memory formation
Date:1/30/2013

JUPITER, FL, January 30, 2013 It takes a lot to make a memory. New proteins have to be synthesized, neuron structures altered. While some of these memory-building mechanisms are known, many are not. Some recent studies have indicated that a unique group of molecules called microRNAs, known to control production of proteins in cells, may play a far more important role in memory formation than previously thought.

Now, a new study by scientists on the Florida campus of The Scripps Research Institute has for the first time confirmed a critical role for microRNAs in the development of memory in the part of the brain called the amygdala, which is involved in emotional memory. The new study found that a specific microRNAmiR-182was deeply involved in memory formation within this brain structure.

"No one had looked at the role of microRNAs in amygdala memory," said Courtney Miller, a TSRI assistant professor who led the study. "And it looks as though miR-182 may be promoting local protein synthesis, helping to support the synapse-specificity of memories."

In the new study, published in the Journal of Neuroscience, the scientists measured the levels of all known microRNAs following an animal model of learning. A microarray analysis, which enables rapid genetic testing on a large scale, showed that more than half of all known microRNAs are expressed in the amygdala. Seven of those microRNAs increased and 32 decreased when learning occurred.

The study found that, of the microRNAs expressed in the brain, miR-182 had one of the lowest levels and these decreased further with learning. Despite these very low levels, its overexpression prevented the formation of memory and led to a decrease in proteins that regulate neuronal plasticity (neurons' ability to adapt) through changes in structure.

These findings suggest that learning-induced suppression of miR-182 is a main supporting factor in the formation of long-term memory
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists uncover previously unknown mechanism of memory formation
(Date:8/12/2015)... CORAL SPRINGS, Florida , August 12, 2015 /PRNewswire/ ... globally, the pace of mobile payment innovation and advanced ... continues to replace the way consumers rely on using ... forges ahead with reinventing the future for payment services ... Inc. (NASDAQ: NXTD ), :  Google, Inc. (NASDAQ: ...
(Date:8/12/2015)... , Aug. 12, 2015  Synaptics Inc. ... human interface solutions, today announced that four of ... Match-in-Sensor solution, have officially been named FIDO Certified™ ... part of the certification, Synaptics, Natural ID™ fingerprint ... Universal Authentication Framework (UAF) standard and are interoperable ...
(Date:8/10/2015)... Germany , August 10, 2015 ... in Eye Tracking Technology for more than two decades, ... Platform for integration into all consumer display formats. The ... seamless integration of eye tracking into consumer tablets, laptops, ... reality smart glasses. Omnivision,s leading sensor technology contributes to ...
Breaking Biology News(10 mins):Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3
... issue of The American Naturalist, Tom E. X. Miller, ... the University of Nebraska, Lincoln) examined herbivore dynamics, specifically ... , Plant-insect ecologists typically attribute the differences to ... plant tissues. However, the researchers found that cactus-feeding insects ...
... role in longevity, with longer-lived rodents showing significantly lower ... new study has found. , The study further strengthens ... shorter its life, and vice versa, said Mario Pinto, ... regulate metabolic rate. , "Thyroid hormones are key ...
... international Census of Marine Life (CoML), a team of ... explore coral reef biodiversity in the largest fully protected ... National Monument. Led by the National Oceanic and ... funding from NOAA's Coral Reef Conservation Program and the ...
Cached Biology News:Longer-lived rodents have lower levels of thyroid hormone 2First Biodiversity Census of coral reef ecosystems in the NW Hawaiian Islands 2First Biodiversity Census of coral reef ecosystems in the NW Hawaiian Islands 3
(Date:9/1/2015)... NJ (PRWEB) , ... September 01, 2015 , ... ... that highlights the opportunities for advanced analytics utilizing data lakes in the healthcare ... industries, Healthcare has seen an explosion of data over the last few years as ...
(Date:9/1/2015)... ... September 01, 2015 , ... A ... discovered by researchers at the Keck Graduate Institute and its collaborators. The discovery ... The findings were published online on August 27 by Scientific Reports, an open ...
(Date:9/1/2015)... Shire plc (LSE: SHP, NASDAQ: ... to its Board of Directors as a Non-Executive Director. Sara ... Risk Committee of the Shire Board. Both appointments will be ... served as Chairman, President and Chief Executive Officer of Dun ... 12-year tenure at D&B, she helped drive the transformation of ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... of its properties such as low carbon footprints and compostability. These properties can ... petroleum based plastics. On the basis of applications, the market for biodegradable plastics ...
Breaking Biology Technology:New White Paper Explores Data Lake Opportunities in the Healthcare Industry 2Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 2Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 3Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 4Shire Appoints Sara Mathew to Board of Directors 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5
... The Philadelphia area-based probiotics firm Kibow Biotech will be ... present at the BIO 2009 Company Forum, ... Tuesday, May 19. BIO is the world,s largest biotechnology ... more than 1,200 member companies and institutions worldwide. BIO ...
... announced that Chief Executive Officer, Mitchell H. Gold, M.D., ... Of The Year (R) 2009 Award in the ... the awards program recognizes entrepreneurs who demonstrate extraordinary success ... commitment to their businesses and communities. Mitchell Gold ...
... PAREXEL Consulting will present insights into achieving regulatory approval ... 18-21, 2009 at the Georgia World Congress Center in ... PAREXEL International (Nasdaq: PRXL ) and leading ... PAREXEL Consulting experts will be on site at the ...
Cached Biology Technology:Kibow Biotech, Inc. to Present at BIO 2009 International Convention: Innovations to Heal, Fuel, and Feed the World 2Kibow Biotech, Inc. to Present at BIO 2009 International Convention: Innovations to Heal, Fuel, and Feed the World 3Kibow Biotech, Inc. to Present at BIO 2009 International Convention: Innovations to Heal, Fuel, and Feed the World 4Dendreon Corporation CEO Mitchell H. Gold, M.D. Named Ernst & Young Entrepreneur of the Year(R) 2009 Award Finalist in the Pacific Northwest 2PAREXEL Consulting Experts To Present Insights Into Achieving Regulatory Approval at the 2009 BIO International Convention 2PAREXEL Consulting Experts To Present Insights Into Achieving Regulatory Approval at the 2009 BIO International Convention 3PAREXEL Consulting Experts To Present Insights Into Achieving Regulatory Approval at the 2009 BIO International Convention 4
... Timp-4 has been reported in heart ... fibroblasts in cell culture conditions. ... TPA stimulates production of TIMP-4 in ... protein levels produced often require concentration ...
Goat polyclonal to HSPC150 ( Abpromise for all tested applications). entrezGeneID: 29089...
Anti-MMP-13 Collagenase-3, amino terminal end of active enzyme; rabbit host...
...
Biology Products: