Navigation Links
Scientists reveal quirky feature of Lyme disease bacteria
Date:3/21/2013

>"If Borrelia doesn't use iron, what does it use?" Culotta asked.

To find out, Culotta's lab joined forces with Mak Saito, a marine chemist at WHOI, who had developed techniques to explore how marine life uses metals. Saito was particularly intrigued because of the high incidence of Lyme Disease on Cape Cod, where WHOI is located, and because he specializes in metalloproteins, which contain iron, zinc, cobalt, and other elements often seen in vitamin supplements. The metals serve as linchpins, binding to enzymes. They help determine the enzymes' distinctive three-dimensional shapes and the specific chemical reactions they catalyze.

It's difficult to identify what metals are within proteins because typical analyses break apart proteins, often separating metal from protein. Saito used a liquid chromatography mass spectrometer to distinguish and measure separate individual Borrelia proteins according to their chemical properties and infinitesimal differences in their masses. Then he used an inductively coupled plasma mass spectrometer to detect and measure metals down to parts per trillion. Together, the combined analyses not only measured the amounts of metals and proteins, they showed that the metals are components of the proteins.

"The tools he has are fantastic," Culotta said. "Not too many people have this set of tools to detect metalloproteins."

The experiments revealed that instead of iron, Borrelia uses that element's next-door neighbor on the periodic chart, manganese, in certain Borrelia enzymes. These include an amino peptidase and an important antioxidant enzyme called superoxide dismutase.

Superoxide dismutase protects the pathogens against a second defense mechanism that the body throws against them. The body bombards pathogens with superoxide radicals, highly reactive molecules that cause damage within the pathogens. Superoxide dismutase is like an antioxidant that neutralizes the s
'/>"/>

Contact: Media Relations Office
media@whoi.edu
508-289-3340
Woods Hole Oceanographic Institution
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists create new tools for battling secondhand smoke
2. Academy scientists receive top honors for long-term research and training initiatives in Mongolia
3. Scientists discover reasons behind snakes shrinking heads
4. U of T scientists map genome that causes Dutch Elm Disease
5. Scientists discover novel chemical that controls cell behavior
6. 87 scientists elected to the American Academy of Microbiology
7. New book celebrates women scientists in the Americas
8. Stanford scientists calculate the carbon footprint of grid-scale battery technologies
9. Scientists discover distant relatives of gardeners friend
10. Monell scientists help identify a missing link in taste perception
11. UF scientists discover new crocodilian, hippo-like species from Panama
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists reveal quirky feature of Lyme disease bacteria
(Date:8/22/2014)... French . NAIROBI ... African soils looming as a major threat to food security ... over the last five years, 1.7 million African farmers in ... million hectares and helped them double or even triple crop ... Revolution in Africa (AGRA) focuses on intensive efforts initiated five ...
(Date:8/22/2014)... release is available in German . ... substances, in PCFs proteins are fixated in a way ... crystals. Next, the HZB and Fudan University researchers are ... as functional materials. Their findings are being published today ... 10.1038/ncomms5634). , Proteins are sensitive molecules. Everyone knows that ...
(Date:8/22/2014)... birds and the bees. But that old expression ... The fertilization process for flowering plants is particularly ... and female reproductive cells. New research from an ... and including Carnegie,s Wolf Frommer, David Ehrhardt, and ... process that guides flowering plant fertilization. It is ...
Breaking Biology News(10 mins):Effort to confront Africa's soil health crisis helps millions of farmers triple yields 2Effort to confront Africa's soil health crisis helps millions of farmers triple yields 3Effort to confront Africa's soil health crisis helps millions of farmers triple yields 4Proteins: New class of materials discovered 2Calcium and reproduction go together 2
... (Nov. 4, 2010) Columbia University Medical Center has ... in Cardiovascular Research, with the 2010 Lewis Katz Visiting ... renowned heart failure expert from University of Texas Southwestern ... winners of the 2010 Lewis Katz Cardiovascular Research Prize ...
... Nov. 4, 2010 BIO-key International, Inc. (OTC Bulletin ... biometric identification solutions, today announced plans to release third ...  In conjunction with the release, BIO-key has scheduled a ... Internet on Thursday, November 11, 2010 at 10:00 a.m. ...
... amount of water flowing in streams and rivers has ... that were assessed in a new nationwide USGS study. ... river ecosystems and loss of native species. ... to date of stream flow alteration," said Bill Werkheiser, ...
Cached Biology News:Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 2Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 3Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 4Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 5BIO-key® Announces Third Quarter 2010 Earnings Release and Conference Call Schedule 2Most river flows across the US are altered by land and water management 2
(Date:8/22/2014)... IN (PRWEB) August 22, 2014 The ... community and its members in Alaska that Alaska Governor ... Concurrent Resolution 15, further defining public use of Unmanned ... Systems Task Force. House Bill 255states that it is, ... to images captured by an unmanned aircraft system.” It ...
(Date:8/21/2014)... 21, 2014 DNA vaccine pioneer ... its development of JRC-LAMP-vax, an innovative and safe potential ... IC studies began this month in Hawaii, moving the ... , The Japanese red cedar releases pollen that causes ... Mountain Cedar pollen wreaks similar havoc in Colorado, New ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 His Majesty ... Opening , The Court of His Majesty Willem-Alexander, King ... attend the Grand Opening of POET-DSM Advanced Biofuels’ Project ... Sept. 3. , The King will take part in ... activity, scheduled for 11 a.m.-12:20 p.m. and tour the ...
(Date:8/21/2014)... 21, 2014 OTC Markets Group ... a biotechnology company, on its approval to list ... on OTCQX®, the best marketplace for established U.S. ... Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... execution of its growth strategy and achievement of ...
Breaking Biology Technology:State of Alaska Signs Unmanned Aircraft Systems Bill 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2
... CALGARY, Feb. 11 /PRNewswire-FirstCall/ - SemBioSys Genetics ... of therapeutic,proteins for metabolic and cardiovascular diseases, today ... of the Company, will be,presenting a corporate update ... on Wednesday, February 13, 2008 at the Waldorf ...
... Fla., Feb. 11 Further to Phlo,Corporation,s ("Phlo"") (OTC: ... Roll Out to Metropolitan New York City Account,Base," an ... distributor in Metropolitan New York City has sold and ... key account base,as part of such roll out. AQISS(TM) ...
... Feb. 11 Santaris Pharma, the,Danish biopharmaceutical company ... McCullagh, President and Chief Executive,Officer, will be presenting ... for,2008 at the Biotechnology Industry Organisation,s 10th Annual ... February 11th at 12:30 pm,US Eastern Standard Time ...
Cached Biology Technology:SemBioSys to present at the 10th Annual BIO CEO & Investor Conference 2Phlo Affiliate Reports Progress in New York City Metropolitan Area Roll-Out 2Santaris Pharma to Present at 10th Annual Biotechnology Industry Organisation CEO & Investor Conference - February 11th, 2008 2
MagSi uniform silica particles coated with a carboxyl group containing polymer, covalently attached to the bead surface....
MAb to Vasopressin Preservative: NaN3...
Mouse monoclonal [1C6/2] to Rad17 ( Abpromise for all tested applications). entrezGeneID: 5884 SwissProtID: Q9UPF5...
... glycoprotein. distributed in colon and rectum, ... lung and salivary gland tissues. ... and MUC2. Epitope: Tandem repeats ... MUC3 tandem repeat peptide Positive ...
Biology Products: