Navigation Links
Scientists reveal quirky feature of Lyme disease bacteria
Date:3/21/2013

Scientists have confirmed that the pathogen that causes Lyme Diseaseunlike any other known organismcan exist without iron, a metal that all other life needs to make proteins and enzymes. Instead of iron, the bacteria substitute manganese to make an essential enzyme, thus eluding immune system defenses that protect the body by starving pathogens of iron.

To cause disease, Borrelia burgdorferi requires unusually high levels of manganese, scientists at Johns Hopkins University (JHU), Woods Hole Oceanographic Institution (WHOI), and the University of Texas reported. Their study, published March 22, 2013, in the Journal of Biological Chemistry, may explain some mysteries about why Lyme Disease is slow-growing and hard to detect and treat. The findings also open the door to search for new therapies to thwart the bacterium by targeting manganese.

"When we become infected with pathogens, from tuberculosis to yeast infections, the body has natural immunological responses," said Valeria Culotta, a molecular biologist at the JHU Bloomberg School of Public Health. The liver produces hepcidin, a hormone that inhibits iron from being absorbed in the gut and also prevents it from getting into the bloodstream. "We become anemic, which is one reason we feel terrible, but it effectively starves pathogens of iron they need to grow and survive," she said.

Borrelia, with no need for iron,has evolved to evade that defense mechanism. In 2000, groundbreaking research on Borrelia's genome by James Posey and Frank Gherardini at the University of Georgia showed that the bacterium has no genes that code to make iron-containing proteins and typically do not accumulate any detectable iron.

Culotta's lab at JHU investigates what she called "metal-trafficking" in organismsthe biochemical mechanisms that cells and pathogens such as Borrelia use to acquire and manipulate metal ions for their biological purposes.

'/>"/>
Contact: Media Relations Office
media@whoi.edu
508-289-3340
Woods Hole Oceanographic Institution
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists create new tools for battling secondhand smoke
2. Academy scientists receive top honors for long-term research and training initiatives in Mongolia
3. Scientists discover reasons behind snakes shrinking heads
4. U of T scientists map genome that causes Dutch Elm Disease
5. Scientists discover novel chemical that controls cell behavior
6. 87 scientists elected to the American Academy of Microbiology
7. New book celebrates women scientists in the Americas
8. Stanford scientists calculate the carbon footprint of grid-scale battery technologies
9. Scientists discover distant relatives of gardeners friend
10. Monell scientists help identify a missing link in taste perception
11. UF scientists discover new crocodilian, hippo-like species from Panama
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists reveal quirky feature of Lyme disease bacteria
(Date:4/17/2014)... and fragmentation of forests in the Amazon help ... contributing to rapid and widespread forest loss during ... The findings show that forests in the Amazon ... coupled with forest fires lead to large-scale loss ... Balch, assistant professor of geography, Penn State. , ...
(Date:4/17/2014)... reporting in the Cell Press journal Current Biology ... with rather novel sex lives. The Brazilian insects, which ... Neotrogla , are the first example of an ... has been identified in several different animals, Neotrogla ... organ is also reversed," says Kazunori Yoshizawa from Hokkaido ...
(Date:4/17/2014)... are chock full of wild animals and plant life, ... fungi are churning away in the soil, decomposing organic ... the vital role these fungi play in ecological systems, ... team of scientists has generated a genetic map of ... The work was published this week in the ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3In sex-reversed cave insects, females have the penises 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3
... The U.S. Department of Energy,s (DOE) Argonne National Laboratory will ... 9:00 a.m. to 4:30 p.m. for a day of discovery and ... to the public. "The open house will be great fun ... love welcoming the community and having an opportunity to show off ...
... at high risk for breast or ovarian cancer are choosing ... cancer risk, according to a report in Cancer Epidemiology, ... for Cancer Research. "Women have their breasts or ovaries ... immediately after counseling or a genetic test result and can ...
... New Rochelle, NY, August 5, 2009A novel class of drugs ... can bind protein targets with a high strength and specificity ... broad range of common diseases, as described in a comprehensive ... , a peer-reviewed journal published by Mary Ann Liebert, Inc. ...
Cached Biology News:Argonne to showcase science and technology at community open house 2Women often opt to surgically remove their breasts, ovaries to reduce cancer risk 2Women often opt to surgically remove their breasts, ovaries to reduce cancer risk 3New DNA and RNA aptamers offer unique therapeutic advantages 2
(Date:1/15/2014)... January 15, 2014 More than 5 ... about 1 in 3 seniors will die with Alzheimer’s ... These jaw-dropping figures have shocked many Americans into looking ... help prevent these tragic age-related cognitive disorders. Jonathan Weisman, ...
(Date:1/15/2014)... 15, 2014 2013 was a banner ... State Technologies®. They saw continued independent research led by ... were awarded a $1 million grant from the Susanne ... and Behavior” a peer reviewed journal, Amy Grant highlighted ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 ... Almshouse Road, Warrington, Pa. , Details: The Hepatitis ... finding a cure for hepatitis B and improving the quality ... Crystal Ball on Friday, April 11 at Warrington Country Club ...
(Date:1/14/2014)... BURLINGAME, Calif. , Jan. 14, 2014 As pet owners ... no doubt many of them wrote: "Take better care of my ... and even designer clothes and top-brand carrying cases to take the ... Pet parents might also feel compelled to buy some pricey toys ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... of University of British Columbia researchers has developed a ... surface of high-temperature superconductors, a procedure considered impossible for ... Prof. Andrea Damascelli, the team deposited potassium atoms onto ... The approach allows the scientists to continuously manipulate the ...
... researchers have captured time-series snapshots of a solid ... Using femtosecond X-ray free electron laser (FEL) pulses, ... to observe condensed phase dynamics such as crack ... state or in biologically relevant environments. Other Livermore ...
... UC Riverside have made an accidental discovery in ... information in computers can be transported or stored. ... electrons possess that makes them behave like tiny ... of spin-based semiconductor technology such as ultrahigh-speed computers. ...
Cached Biology Technology:UBC physicists develop 'impossible' technique to study and develop superconductors 2A look into the nanoscale 2Discovery by UC Riverside physicists could enable development of faster computers 2Discovery by UC Riverside physicists could enable development of faster computers 3
... 301 Power Supply, 1. 300 V, ... or constant current modes.Single-unit increments in ... reproducibility.Suitable for submarine, mini vertical, and ... as semidry and mini tank blotting ...
B3-1...
Human CCL26/Eotaxin-3 MAb (Clone 115002)...
Normal sheep serum collected from healthy normal sheep...
Biology Products: