Navigation Links
Scientists pinpoint molecular signals that make some women prone to miscarriage
Date:1/3/2013

The research, carried out at Imperial College London and the University of Warwick, suggests these signals could be targets for drugs that would help prevent miscarriage in women who are particularly vulnerable.

At the start of pregnancy, the fertilised embryo must embed itself in the lining of the uterus. The uterus is only receptive to embryos for a few days in each menstrual cycle, ensuring that embryos can only implant at the right stage of development. Currently scientists know only a few details about the biological processes that control when an embryo can be implanted.

In the latest study, published in the journal PLOS ONE, researchers studied chemical signals produced by human cells, taken from the lining of the uterus and grown in the lab. They identified a key role for a molecule called IL-33, which the cells secrete during the receptive phase and which influences the activity of nearby cells.

Normally, the effects of IL-33 and other chemical signals in the lining of the womb are short-lived, which helps to ensure that woman can only conceive during a narrow window. In cells from women who had suffered three or more miscarriages however, high levels of IL-33 continued to be secreted for 10 days, suggesting that the receptivity of the uterus was not being controlled properly in these women.

The study also looked at the effects of these molecular signals on fertility in mice. The researchers treated the uteruses of the mice with chemicals secreted by cells from the human womb lining. They found that chemicals produced by cells from women with repeated miscarriages extended the time during which mice could become pregnant, but also made miscarriages more likely. The researchers conclude that a prolonged window of fertility increases the risk of abnormal embryos implanting. In addition, it is associated with inflammation in the lining of the womb, which compromises the development of healthy embryos.

'/>"/>
Contact: Sam Wong
sam.wong@imperial.ac.uk
Imperial College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... Md. , April 2, 2015 At ... Salt Lake City , the American College ... of five new directors to its Board.  Members of ... the ACMG and for forming and advancing its policies ... medical genetics profession. "It,s an eventful time ...
(Date:4/2/2015)... 2015 Fingerprint Cards (FPC) has ... from the distributor World Peace Industrial Group (WPI), part ... although the major part of the shipments will take ... by smartphone manufacturers in China . ... the communicated revenue guidance of + 1 000 MSEK for ...
(Date:4/1/2015)... Medisafe ™, the leading global medication management platform with ... Android smartphones and tablets, announces today that ... allow patients to track and correlate their adherence directly ... be able to visualize in real-time how taking medication ... glucose levels and blood pressure. "Patients need ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2
... living on the Port Valdez seafloor to stabilize after ... at the University of Alaska Fairbanks. "The earthquake, ... tsunami waves that followed, impacted every marine community in ... professor at the UAF School of Fisheries and Ocean ...
... YORK (April 24, 2011) -- A team of scientists ... Weill Cornell Medical College has shed light on the ... the cell membranes of neurons that modulate the transfer ... The research, published today in the journal Nature, ...
... ,Chicago, IL Stephen Maturo, MD, of Boston, MA, ... Award for outstanding achievement in the field of pediatric ... (EMG) in Children with Vocal Fold Mobility: Results of ... 29 May 1, 2011, in Chicago, IL. The ...
Cached Biology News:Port Valdez invertebrates stabilized 26 years after quake 2Molecular movements of neural transporters unveiled 2Molecular movements of neural transporters unveiled 3Molecular movements of neural transporters unveiled 4Molecular movements of neural transporters unveiled 5Stephen Maturo, M.D., ear, nose and throat specialist, receives Charles Ferguson Award 2
(Date:4/16/2015)... , April 16, 2015 /PRNewswire/ - Portage Biotech ... Canadian Securities Exchange: PBT.U), is pleased to announce that ... Show on April 25, 2015 to be held in ... Gregory Bailey and Mr. James Mellon ... and an update on the key programs at its ...
(Date:4/16/2015)... 2015 A new infographic compiles useful ... research institutions to learn how Appleā€™s new framework can ... timing is ideal since Apple made Research Kit ... an open-source framework for developing medical research apps that ... for researchers to collect secure clinical data and communicate ...
(Date:4/16/2015)... 2015  EMD Serono today announced the US ... Germany , appointed Alise Reicin , ... Clinical Development.  Dr. Reicin brings extensive research and ... and Immunology. She is an accomplished pharmaceutical executive ... Vice President in various capacities across R&D at ...
(Date:4/16/2015)... April 16, 2015  Northwest Biotherapeutics, Inc. (NASDAQ: ... developing non-toxic DCVax® personalized immune therapies for cancer, ... the Loncar Cancer Immunotherapy Index (LCINDX), a professional ... the immunotherapy field within the biotechnology space.  ... top 25 companies" in the immunotherapy space, including ...
Breaking Biology Technology:Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4Infographic Illustrates Potential for Research Kit to Impact Clinical Research 2Infographic Illustrates Potential for Research Kit to Impact Clinical Research 3Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 3NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 2NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 3
... COLUMBIA, Md., Sept. 13 Martek Biosciences,Corporation (Nasdaq: ... presenting at the,upcoming UBS Global Life Sciences Conference ... September 24-27, 2007 at the Grand Hyatt in ... on Tuesday, September 25th at,3:00 p.m. Eastern Time. ...
... 13 Vet-Stem, Inc., the global leader,in regenerative ... to the Central Veterinary Research Laboratory (CVRL) of,Dubai ... the laboratory to,offer adipose- derived stem cell services ... ruler of Dubai and Prime Minister of the ...
... Together Thought Leaders,in Life Sciences and Clinical Diagnostics ... Netherlands, Sept. 13 Luminex,Corporation (Nasdaq: LMNX ... the agenda for Planet xMAP Europe 2007, the ... will be,held 2-3 October at the Berlage,s Exchange ...
Cached Biology Technology:Vet-Stem and Central Veterinary Research Labs of Dubai Sign Exclusive License 2Luminex Corporation Hosts the Fifth Annual Planet xMAP Europe 2007 Symposium 2Luminex Corporation Hosts the Fifth Annual Planet xMAP Europe 2007 Symposium 3
This modular benchtop laminar flow hood forces air through a 99.99% efficient HEPA filter to create a clean processing area. Options include a work bench, ionizaing bar, and air velocity gauge....
... Scientific ChromQuest Chromatography Data System (CDS) ... data acquisition, chromatography data processing and ... High Speed LC. The companys innovative ... maximize the benefits of Thermo Scientific ...
...
... optimised for SYBR Green I assays and contain ... with the exception of template and primers. The ... of active SYBR Green I dye and Thermo-Start ... that enables detection of low copy number targets., ...
Biology Products: