Navigation Links
Scientists pinpoint molecular signals that make some women prone to miscarriage
Date:1/3/2013

The research, carried out at Imperial College London and the University of Warwick, suggests these signals could be targets for drugs that would help prevent miscarriage in women who are particularly vulnerable.

At the start of pregnancy, the fertilised embryo must embed itself in the lining of the uterus. The uterus is only receptive to embryos for a few days in each menstrual cycle, ensuring that embryos can only implant at the right stage of development. Currently scientists know only a few details about the biological processes that control when an embryo can be implanted.

In the latest study, published in the journal PLOS ONE, researchers studied chemical signals produced by human cells, taken from the lining of the uterus and grown in the lab. They identified a key role for a molecule called IL-33, which the cells secrete during the receptive phase and which influences the activity of nearby cells.

Normally, the effects of IL-33 and other chemical signals in the lining of the womb are short-lived, which helps to ensure that woman can only conceive during a narrow window. In cells from women who had suffered three or more miscarriages however, high levels of IL-33 continued to be secreted for 10 days, suggesting that the receptivity of the uterus was not being controlled properly in these women.

The study also looked at the effects of these molecular signals on fertility in mice. The researchers treated the uteruses of the mice with chemicals secreted by cells from the human womb lining. They found that chemicals produced by cells from women with repeated miscarriages extended the time during which mice could become pregnant, but also made miscarriages more likely. The researchers conclude that a prolonged window of fertility increases the risk of abnormal embryos implanting. In addition, it is associated with inflammation in the lining of the womb, which compromises the development of healthy embryos.

'/>"/>
Contact: Sam Wong
sam.wong@imperial.ac.uk
Imperial College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... 4, 2014   Neurotechnology , a provider ... the latest version of its fingerprint matching algorithm ... MINEX evaluation organized by NIST. The MINEX ... the INCITS 378 fingerprint standard template format. MINEX ... tenders in the United States ...
(Date:11/3/2014)... ANGELES , Nov. 3, 2014  NeuroSigma ... -based life sciences company focused on commercialization ... system for the treatment of neurological and ... of Industrial Property has issued a Notice of ... patent application is co-owned by NeuroSigma and the ...
(Date:11/2/2014)... support of a bold quest to rid the world ... today announced an award of US$156 million to PATH ... building new vaccines that will interrupt the cycle of ... zero" agenda. Such vaccines would ensure that parasite reintroduction ... "immunological bed net." , This approach to developing ...
Breaking Biology News(10 mins):Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 4
... provide a look at the ash and gas clouds being ... NOAA,s GOES-13 satellite to provide a week long look at ... westerly winds carry the debris (ash and smoke) far to ... down the ash before it can go far in the ...
... 2012 Scientists at The Scripps Research Institute have ... the market to treat neuropathic pain and epilepsy, helps ... treatments, gabapentin targets stress systems in the brain that ... 12-week trial of 50 treatment-seeking cannabis users, those who ...
... /PRNewswire-iReach/  -- Global Information Inc. is announces limited time ... important Boston healthcare conferences: Next-Gen Kinase ... rapidly maturing kinase inhibitors field will gather to explore ... Next-Gen Kinase Inhibitors Conference in Cambridge, MA. ...
Cached Biology News:NASA's new satellite movie of 1 week's ash activity from Mexico's Popocatepetl Volcano 2Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit 2Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit 3Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27 2Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27 3
(Date:11/18/2014)... New Brunswick, NJ (PRWEB) November 18, 2014 ... of Data Quality and Transparency Reporting solutions, announced ... has gone live using its Consummate Providerâ„¢ solution ... Consummate Providerâ„¢ is a Global, SaaS based, Data ... Science organizations and their third party Providers improve ...
(Date:11/18/2014)... Ft. Lauderdale, FL (PRWEB) November 18, 2014 ... 12) have announced the launch of PAWSitively Curing ... Awareness Month. This new 501(c) (3) non-profit organization is ... Every dollar donated goes directly to the University ... proud to partner with PAWSitively Curing Cancer as the ...
(Date:11/18/2014)... Philadelphia, PA (PRWEB) November 18, 2014 ... healthcare planning and design expertise to the nation's hospitals ... is best served by those dedicating their careers to ... As a respected contributor in her respective field, Laura ... engineering expertise at the 2014 Winter Simulation Conference. ...
(Date:11/18/2014)... , Nov. 18, 2014  Asterias Biotherapeutics, ... in the emerging field of regenerative medicine, today ... (oligodendrocyte progenitor cells) for complete cervical spinal cord ... ten "Top Advanced Therapies Projects to Watch" by ... to receive this significant industry honor, which represents ...
Breaking Biology Technology:Alanda Software Completes Successful Implementation of Global Data Quality & Vendor Management Solution for Top Tier Global Biopharmaceutical Company 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 3Array Healthcare Simulation Expert Slated to Speak at Winter Simulation Conference 2Asterias Biotherapeutics Named as a "Top Advanced Therapies Projects to Watch" and Will Present at the Therapeutic Area Partnerships Conference 2Asterias Biotherapeutics Named as a "Top Advanced Therapies Projects to Watch" and Will Present at the Therapeutic Area Partnerships Conference 3
... NEW YORK, Jan. 27, 2011 The Alzheimer,s ... has awarded a grant of $195,000 to ALS ... toxic proteins implicated in Alzheimer,s disease. ... will identify and develop small-molecule brain-penetrant inducers of ...
... SAN CARLOS, Calif. and HOPKINTON, Mass., Jan. 27, ... Sciences, Inc. (Nasdaq: CALP ) today ... automated methods for next generation sequencing sample preparation ... to enable researchers to leverage NuGEN,s Ovation® and ...
... technique for rapidly prototyping nanoscale devices and structures that ... away when done. Hard-tip, soft-spring lithography (HSL) rolls ... high resolution -- and the best of polymer pen ... HSL could be used in the areas of electronics ...
Cached Biology Technology:Alzheimer's Drug Discovery Foundation Funds ALS Biopharma to Develop Small Molecules for Alzheimer's Disease 2NuGEN and Caliper Partner to Eliminate Next-Gen Sequencing Sample Preparation Bottlenecks 2NuGEN and Caliper Partner to Eliminate Next-Gen Sequencing Sample Preparation Bottlenecks 3Making a point 2Making a point 3