Navigation Links
Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses
Date:2/22/2009

February 22, 2009--Researchers at the Dana-Farber Cancer Institute (Dana-Farber), Burnham Institute for Medical Research (Burnham) and the Centers for Disease Control and Prevention (CDC) have reported the identification of human monoclonal antibodies (mAb) that neutralize an unprecedented range of influenza A viruses, including avian influenza A (H5N1) virus, previous pandemic influenza viruses, and some seasonal influenza viruses. These antibodies have the potential for use in combination with other treatments to prevent or treat certain types of avian and seasonal flu. The study will be published online on February 22 in Nature Structural and Molecular Biology.

The antibodies identified by the team of scientists neutralize a broad range of influenza A subtypes because they bind to the highly conserved stem region of H5 type hemaglutinin (HA). Binding to the stem prevents a conformational change in the protein that is necessary for viral entry into the host cell, thereby preventing further infection of host cells and the rise of escape mutants.

"The head portion of hemaglutinin is highly mutable, leading to the rise of forms of the virus that can evade neutralizing antibodies," said Robert Liddington, Ph.D., professor and director, Infectious and Inflammatory Disease Center at Burnham and one of the investigators on the study. "However, the stem region of hemaglutinin is highly conserved because it undergoes a dramatic conformational change to allow entry of viral RNA into the host cell. It's very difficult to get a mutation that doesn't destroy that function, which explains why we aren't seeing escape mutants and why these antibodies neutralize such a variety of strains of influenza."

While more costly to produce than existing influenza drugs, therapeutic antibodies can be readily manufactured and stockpiled. In the event of a pandemic, the antibodies could be used in combination with antiviral therapies to contain the outbr
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2015)... , May 20, 2015 NXT-ID, Inc. ... that its wholly owned subsidiary, 3D-ID LLC, a company ... Team Battelle for the biometrics technology portion of the ... Contract from the Department of the Army. ... products developed for government, law enforcement and security agencies. ...
(Date:5/14/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ... Sensors Market in Smart Mobile Devices " report ... 2014 was a watershed year for fingerprint sensors in ... Pay,. Apple gave fingerprint sensors a raison d,etre in ... sensors are a must-have feature in flagship smartphones. ...
(Date:5/10/2015)... Fingerprint Cards (FPC) has received an order for ... World Peace Industrial Group (WPI), part of WPG Holdings. WPI ... . Deliveries are planned to take place during Q3 2015 ... China . The order value of 235 ... 1 000 MSEK for 2015.   Jörgen Lantto, acting ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2
... from blood poisoning? To answer this question, the doctor draws ... for testing. This takes up valuable time, which could cost ... to analyze blood there and then and have the results ... developed by scientists at the Fraunhofer Institute for Physical Measurement ...
... collaborated in the development of a disinfection system that may ... cleaned as well as stop bed bug outbreaks in hotels ... hospital deaths are preventable with better cleaning methods," says Dick ... Staff. "It has been reported that more than 100,000 people ...
... A new study examining the complex and dynamic interactions ... Bay, South Africa, offers new insights on the physical ... marine environment. University of Miami (UM) Rosenstiel School ... Hammerschlag, and a colleague from the University of British ...
Cached Biology News:Recognizing blood poisoning quickly 2New disinfection technique could revolutionize hospital room cleaning 2
(Date:5/21/2015)... 2015 Research and Markets ( ... "2015 Global Survey on Flow Cytometry Adoption ... The primary goal of this research is to ... reagents. Key information the survey seeks to collect ... cytometers, predominantly used applications for flow cytometers, respondents, ...
(Date:5/20/2015)... , May 20, 2015 Research and Markets ... of the "Top Technologies in HW_Technical Insights" ... of this report evaluated technology trends in the Health ... that are likely to have an impact in the ... analysis of the top 10 health and wellness technologies ...
(Date:5/20/2015)... , May 20, 2015  Health eCareers, the ... healthcare organizations with job seekers looking for the ... a new mobile and online tool dedicated exclusively ... industry. SHIFT enables employers to quickly ... travel nursing, per diem and other temporary positions, ...
(Date:5/20/2015)... , May 20, 2015  Resolution Bioscience announced ... ctDx ALK TM , a blood-based liquid biopsy ... cell lung carcinoma (NSCLC), the most common form of ... test to guide patients to personalized therapies and direct ... The Department of Health, the CLIA authority ...
Breaking Biology Technology:Global Survey on Flow Cytometry Adoption Trends 2015 2Top Technologies in the Health and Wellness Industry 2015 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3Resolution Bioscience Receives CLIA Certification for its Diagnostic Laboratory and Launches CLIA-Certified Liquid Biopsy for Lung Cancer 2
... 4 Genomic Health,Inc. (Nasdaq: GHDX ) ... and Chief Executive Officer, will present at the ... 11, 2007 at 3:00 p.m.,Pacific Time. To ... the,presentation, visit the Investor Relations section of Genomic ...
... service to provide patients & physicians with immediate, personalized ... ... PARK, N.C., Oct. 4 Today hundreds of,millions of Americans ... access to the most current information about the risk,profile of ...
... 4 Millennium,Pharmaceuticals, Inc. (Nasdaq: MLNM ) ... Ph.D., to its Board of Directors. Dr. Leiden, ... venture capital firm,has a distinguished career of more ... pharmaceutical sectors. Prior to joining Clarus, Dr. Leiden,served ...
Cached Biology Technology:Genomic Health to Present at BIO InvestorForum 2007 2iGuard Transforms Drug Safety Alert and Update Process 2iGuard Transforms Drug Safety Alert and Update Process 3iGuard Transforms Drug Safety Alert and Update Process 4Life Sciences Leader Joins Millennium Board of Directors 2Life Sciences Leader Joins Millennium Board of Directors 3
MOUSE ANTI HUMAN MOC31:AZIDE FREE...
... the ultimate in utility and flexibility press-to-seal ... the needs of the researcher. They are ... or as sheet material that can be ... isolators are autoclavable and non-cytotoxic and can ...
... Lacks the mycobacteria found in Complete Freund's ... reason, Incomplete, Freund's Adjuvant is ... be used to produce water-in-oil emulsions of immunogens. ... and long-lasting antibody responses which can be attributed ...
2,4-Dinitrophenyl hapten is conjugated to Keyhole Limpet (KLH) protein through lysine....
Biology Products: