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Scientists find new targets that could increase effectiveness of breast cancer treatments
Date:6/5/2014

e specific regions of the receptor that are altered upon interaction. This information was used to infer structural changes that result from the interaction and to probe the conformational flexibility of intact multidomain proteins.

In addition to exploring potential new drugs for breast cancer, the researchers also hope to investigate the implications for prostate cancer, another hormone-driven disease.

"Many features of the androgen receptor are similar to progesterone receptor, as they belong to the same subfamily of steroid receptors," said Devrishi Goswami, the first author of the study and a member of the Griffin laboratory. "It could work the very same way. So these new insights may also help in finding new approaches to treating hormone-therapy-resistant prostate cancer."


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Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

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