Navigation Links
Scientists find new targets that could increase effectiveness of breast cancer treatments
Date:6/5/2014

JUPITER, FL, June 5, 2014 Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments.

The study was published online ahead of print on June 5, 2014 by the journal Structure.

Approximately two out of three breast cancers are driven by receptors that bind the hormones estrogen and progesteronewhen the hormones bind to these receptors in cancer cells, they signal the cancer cells to grow. What makes the progesterone receptor therapeutically interesting is that it has two activation domainsAF1 and AF2. Normally, both are needed for full activation of the receptor.

"Using hydrogen-deuterium exchange technology, our study pinpoints just how AF2 communicates with AF1the first evidence of the long-range interaction between these two functional domains," said Patrick R. Griffin, a TSRI professor who led the study. "These findings support further research to look for promising small molecules that block that interaction."

The findings are especially important because in some mutations AF2 is deleted, yet the receptor still drives the cancer using its AF1 domain. Current drugs used for treating these cancers only target the AF2 domain, so with nothing to bind to, they do not work at all. While several studies have shown the importance of AF1, its binding domain is remarkably dynamic, frequently shifting shape and making it difficult to target with drugs.

In the new study, the scientists used an advanced technology known as hydrogen-deuterium exchange mass spectrometry (HDX) to measure the intricate interactions between the AF1 and AF2 domains of the progesterone receptor.

HDX mass spectrometry is a high-precision, high-sensitivity mapping technique that enabled the scientists to determine th
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists discover the basis of allergic reactions
2. MU scientists successfully transplant, grow stem cells in pigs
3. Scientists capture most detailed images yet of humans tiny cellular machines
4. NUS scientists demonstrate rare chemical phenomenon to harvest solar energy
5. Glow-in-the-dark tool lets scientists find diseased bats
6. Listening helps scientists track bats without exposing the animals to disease
7. Scientists control rapid re-wiring of brain circuits using patterned visual stimulation
8. Vines choke a forests ability to capture carbon, Smithsonian scientists report
9. Imaging scientists develop a better tool for tracking MS
10. Scientists map the worst times of day for people allergic to grass pollen
11. Scientists discover potential new target for cancer immunotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find new targets that could increase effectiveness of breast cancer treatments
(Date:3/11/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/3p32qm/access_control ) has ... by Product, Application & By Geography - Global Forecast ... , This report predicts that the access ... 2020, with an estimated CAGR of 10.6%. ... such as contact cards & readers, contactless cards & ...
(Date:3/10/2015)... 2015 Transforming How We Look ... Medicine in Human Space Flight" by Michael ... , Ph.D. was recently featured by Springer Science Media, highlighting ... Specifically, "Personalized Medicine in Human Space Flight" ... in 2013 and 2014 from Springer in the journal ...
(Date:3/5/2015)... 5, 2015 In Brazil , ... already using these solutions and 42 percent planning to invest ... approximately 25 percent of the companies will be investing in ... majority of companies in the region are currently opting for ... model will command significant attention in the coming years. This ...
Breaking Biology News(10 mins):Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4
... at an alarming rate compared with other species, according to ... The rate of extinctions increased noticeably after 1950, although ... of extinct species has grown by 25 percent since 1989. ... US Geological Survey, examines North American freshwater fish extinctions from ...
... 2012 Scientists already know that the tiny hairs on ... vertical surfaces. Now, University of Akron researchers are unfolding clues ... to create a synthetic adhesive that sticks when moist or ... the sole of a gecko toe, and the pad repels ...
... along the ground by alternately squeezing and stretching muscles ... each wave of contractions. Snails and sea cucumbers also ... our own gastrointestinal tracts operate by a similar action, ... the stomach. Now researchers at MIT, Harvard University ...
Cached Biology News:Gecko feet hold clues to creating bandages that stick when wet 2Soft autonomous robot inches along like an earthworm 2Soft autonomous robot inches along like an earthworm 3
(Date:3/26/2015)... SAN DIEGO , March 26, 2015  BioNano ... the appointment of  Terry Salyer as chief commercial ... building highly effective, worldwide sales teams in life sciences. ... Irys ® System, a genome-mapping platform to assemble ... and investigate structural variations. To date, 32 institutions located ...
(Date:3/26/2015)... March 26, 2015 PAREXEL International ... clinical research organization , announced today ... agreement to acquire all of the business ... leading provider of specialized pharmacovigilance services, based ... collection, detection, assessment, monitoring, and prevention of ...
(Date:3/26/2015)... Ale Gicqueau, Founder and President of Clinovo, ... at Align Technology, on “ Conducting Postmarket Registries - ... Global Conference and Exhibition on April 25th through April ... the poster presentation, Ale Gicqueau and Victor Chen will ... Registry, the requirements and resources to conduct the registry, ...
(Date:3/25/2015)... 2015 Agnition announced today that it ... Farmer, airing for the first time at 7:30 a.m. ... Farmer will explore the extremely important role soil microbes ... a patented Microbial Catalyst™ technology that enhances soil and ... segment will air again on April 28. , A ...
Breaking Biology Technology:BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2
... L.P., a subsidiary of Mylan Inc. (Nasdaq: ... market and distribute EMSAM(R) in the U.S. EMSAM, a ... which was approved by the U.S. Food and Drug ... depressive disorder. EMSAM previously was marketed and distributed by ...
... digital templating solution from Orthocrat. Using TraumaCad, UPMC Mercy,s ... within the UPMC enterprise. , ... ... today that UPMC Mercy, part of the UPMC global health ...
... 28 Cytopia Limited (ASX: CYT) announced that it will present ... CYT997, at the Annual Meeting of the American Society of Clinical ... clinical investigators for the program, will be presenting the poster in ... Therapeutics - Vascula ...
Cached Biology Technology:Dey L.P. to Market EMSAM(R) Skin Patch for Treatment of Major Depressive Disorder 2Orthocrat Announces Successful Implementation of TraumaCad at UPMC Mercy 2Orthocrat Announces Successful Implementation of TraumaCad at UPMC Mercy 3Oral VDA CYT997 - Phase I Clinical Trial Presentation at ASCO 2
Affinity Purified Rabbit Anti-mouse sRANKL Biotinylated Polyclonal Antibody...
Mouse anti-IkBa/MAD-3 Class: Antibody Product Group: Signalling molecules and phospho-specific Antibody...
Mouse monoclonal [002-49] to C1s ( Abpromise for all tested applications). entrezGeneID: 716 SwissProtID: P09871...
Goat polyclonal to HSPC150 ( Abpromise for all tested applications). entrezGeneID: 29089...
Biology Products: