Navigation Links
Scientists film inner workings of the immune system
Date:12/3/2008

Forget what's number one at the box office this week. The most exciting new film features the intricate workings of the body, filmed by scientists using ground-breaking technology.

For the first time in Australia, scientists at Sydney's Centenary Institute have filmed an immune cell becoming infected by a parasite and followed the infection as it begins to spread throughout the body.

Professor Wolfgang Weninger, head of the Immune Imaging program at the Centenary Institute, says the discovery (published in PLoS Pathogens) was made possible using high powered multi-photon microscopy which allows real cells to be viewed in real time.

"Using multi-photon microscopy, we studied dendritic cells in the skin. Under normal conditions we found the cells in the epidermis (top layer) were static, whereas in the dermis (second layer) they were very active, moving around as though seeking out pathogens," explains Professor Weninger. "Once we established this, it was fascinating to introduce the Leishmania infection and watch as the parasite was picked up by the cells and the process by which it began to spread throughout the body."

Leishmaniasis affects up to 12 million people in parts of Africa, the Middle East and South America. The disease causes skin sores and can affect internal organs such as the spleen, liver and bone marrow. If left untreated, it can be fatal.

The ability to visually follow a pathogen on its journey through the immune cells provides critical insight for future vaccine design and has potential to improve current vaccinations.

"We now have a general idea of how pathogens are recognised by the immune system and which cells are involved," Professor Weninger says. "This means we can look at identifying the molecules responsible for the uptake of Leishmania infection and these molecules could become vaccine targets. Additionally, we can investigate the immune responses of other infections
'/>"/>

Contact: Erin Sharp
e.sharp@centenary.org.au
61-295-656-118
Research Australia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rooted plants move mysteriously down greenways, scientists say
2. Caltech scientists show function of helical band in heart
3. Argonne scientists discover possible mechanism for creating handedness in biological molecules
4. Scientists developing food allergy treatment
5. Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
6. CSHL scientists discover a new way in which epigenetic information is inherited
7. Caltech scientists develop barcode chip for cheap, fast blood tests
8. UNC scientists teach enzyme to make synthetic heparin in more varieties
9. Childrens Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
10. Scientists shed light on evolution of gene regulation
11. Scientists build roach motel for nasty bugs of the bacterial variety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... are anything but sustainable: environmental damage to soil ... increasingly evident. Despite their disadvantages, however, monocultures remain ... the sole possibility of achieving higher yields in ... an ecology professor at the University of Zurich, ... forestry. After all, a new study carried out ...
(Date:10/15/2014)... N.Y. , Oct. 15, 2014 ... solutions for home and community-based care, today announced ... of implementing Sandata,s Santrax® Electronic Visit Verification™ Solution ... Services is a home health company founded in ... Texas . The study ...
(Date:10/15/2014)... The Ebola virus is spreading rapidly and to an ... experienced in the past and the virus shows a ... been recorded before. For this reason, the German National ... of Science and Engineering, and the Union of the ... statement on the Ebola epidemic today. , In the ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Sandata Announces Case Study with Quality Care Services, Inc. 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
... researchers have found that years after experiencing childhood ... than expected in their elderly counterparts, but rather ... commensurate with normal aging. , "Other researchers have ... later in life, but we've actually found it ...
... of a nation-wide study published in the latest issue ... Physicians in AIDS Care (JIAPAC), HIV positive patients and ... and how it's treated. , The study uncovered differences ... of treatment, the various goals of treatment, and even ...
... of poultry flocks could make the spread of deadly ... at the Universities of Edinburgh and Warwick have found. ... are effective on individual birds, the disease is likely ... been protected. The study, published in Nature journal, is ...
Cached Biology News:Survivors of childhood polio do well decades later as they age 2Bird flu study highlights need to vaccinate flocks effectively 2
(Date:10/25/2014)... The Workgroup for Electronic Data ... on the use of health IT to create ... of four new co-chairs to the organization’s Security ... ,     Peter Dumont, Senior Director – Privacy ... Deloitte Consulting LLP ,     Deidre Rodriguez, Director ...
(Date:10/25/2014)... 2014 Berkshire Corporation, the world ... announce the release of the ValuSeal® IonX™ cleanroom ... contamination containment in critical processing applications. , Recommended ... cleanroom environments, ValuSeal® IonX™ is a laser sealed ... that continues Berkshire’s innovative focus on meeting new ...
(Date:10/25/2014)... 2014 Research and Markets has ... Product , Research Area & by End User - ... In this report, the global epigenetics ... areas, and end users. The product segments of the ... & consumables, kits, and reagents. The subsegments of the ...
(Date:10/22/2014)... October 21, 2014 The Americas ... inorganic refrigerants market in Americas with analysis and ... of the Americas Inorganic Refrigerants Market report, to ... This also provides a glimpse of the segmentation ... supported by various tables and figures. , ...
Breaking Biology Technology:WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2Ions Are Bygones, Berkshire Announces the Release of New Innovative Cleanroom Wipers 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 3The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3
... a currently available yet underused vaccine against typhoid fever is ... vaccinees. The study, conducted by the International Vaccine ... and Enteric Diseases (NICED) in Kolkata, India, was published in ... of Medicine (NEJM). The IVI, based in Seoul, Korea, ...
... , , RICHMOND, Calif., July 22 ... that the company will release its second quarter 2009 financial results ... release will be followed by a conference call at 5:00 p.m. ... webcast. During the conference call, the company will review the financial ...
... , , , , ... a development-stage company focused on novel biopolymer implant therapies to treat ... the corporation to CardioPolymers, Inc. , , ... "The name change, which is effective immediately, better reflects our focus ...
Cached Biology Technology:Vi typhoid vaccine proves highly effective in young children 2Vi typhoid vaccine proves highly effective in young children 3Sangamo BioSciences Announces Second Quarter 2009 Conference Call and Webcast 2Sangamo BioSciences Announces Second Quarter 2009 Conference Call and Webcast 3Symphony Medical Changes Name to CardioPolymers, Inc. 2
...
... This modular benchtop fume hood ... allowing safe indoor release of ... most organic contaminants. Configurations are ... flow; options include final HEPA ...
...
... The Staccato Series of systems provide ... drug discovery , genomics, proteomics and drug ... three base configurations; Mini Workstation Series, Application ... Sciclone ELISA Station is a remarkably compact ...
Biology Products: