Navigation Links
Scientists film inner workings of the immune system
Date:12/3/2008

Forget what's number one at the box office this week. The most exciting new film features the intricate workings of the body, filmed by scientists using ground-breaking technology.

For the first time in Australia, scientists at Sydney's Centenary Institute have filmed an immune cell becoming infected by a parasite and followed the infection as it begins to spread throughout the body.

Professor Wolfgang Weninger, head of the Immune Imaging program at the Centenary Institute, says the discovery (published in PLoS Pathogens) was made possible using high powered multi-photon microscopy which allows real cells to be viewed in real time.

"Using multi-photon microscopy, we studied dendritic cells in the skin. Under normal conditions we found the cells in the epidermis (top layer) were static, whereas in the dermis (second layer) they were very active, moving around as though seeking out pathogens," explains Professor Weninger. "Once we established this, it was fascinating to introduce the Leishmania infection and watch as the parasite was picked up by the cells and the process by which it began to spread throughout the body."

Leishmaniasis affects up to 12 million people in parts of Africa, the Middle East and South America. The disease causes skin sores and can affect internal organs such as the spleen, liver and bone marrow. If left untreated, it can be fatal.

The ability to visually follow a pathogen on its journey through the immune cells provides critical insight for future vaccine design and has potential to improve current vaccinations.

"We now have a general idea of how pathogens are recognised by the immune system and which cells are involved," Professor Weninger says. "This means we can look at identifying the molecules responsible for the uptake of Leishmania infection and these molecules could become vaccine targets. Additionally, we can investigate the immune responses of other infections
'/>"/>

Contact: Erin Sharp
e.sharp@centenary.org.au
61-295-656-118
Research Australia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rooted plants move mysteriously down greenways, scientists say
2. Caltech scientists show function of helical band in heart
3. Argonne scientists discover possible mechanism for creating handedness in biological molecules
4. Scientists developing food allergy treatment
5. Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
6. CSHL scientists discover a new way in which epigenetic information is inherited
7. Caltech scientists develop barcode chip for cheap, fast blood tests
8. UNC scientists teach enzyme to make synthetic heparin in more varieties
9. Childrens Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
10. Scientists shed light on evolution of gene regulation
11. Scientists build roach motel for nasty bugs of the bacterial variety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market announces ... the Smart Wallet, at the 13 th annual ... global conference on the intersection of technology and the ... , founder and publisher of the Strategic News Service™, ...
(Date:10/15/2014)... rapidly and to an unexpected extent. The outbreak does ... the virus shows a new disease dynamic in regions, ... reason, the German National Academy of Sciences Leopoldina, acatech ... the Union of the German Academies of Sciences and ... today. , In the statement the academies call for ...
(Date:10/14/2014)... – Like discriminating thieves, prostate cancer tumors scavenge and ... body. But such avarice may be a fatal weakness. ... way to kill prostate cancer cells by delivering a ... destroys the diseased cells brimming with the mineral, leaving ... two drugs already commercially available for other uses, could ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5Prostate cancer's penchant for copper may be a fatal flaw 2
... new study led by the Wildlife Conservation Society and Zoological ... the Sahara, has suffered a catastrophic collapse of its wildlife ... representing 28 scientific organizations assessed 14 desert species and found ... confined to one percent or less of their historical range. ...
... and described a new species of wild eggplant, found in ... cowiei , recently detailed his findings in the journal ... "gender bending," and explained that the females actually pretend to ... doing is duping bees into visiting their flowers," Martine said. ...
... ALEXANDRIA, Va.December 3, 2013Nearly two-thirds (65%) of Americans ... shutdown in the months ahead as Congress continues ... a new national public opinion poll commissioned by ... sentiment is shared across party affiliations: Democrats (66%), ...
Cached Biology News:Study documents catastrophic collapse of Sahara's wildlife 2Unlikely collaboration leads to discovery of 'gender-bending' plant 2Unlikely collaboration leads to discovery of 'gender-bending' plant 3Majority of Americans believe another government shutdown likely in coming months 2Majority of Americans believe another government shutdown likely in coming months 3
(Date:10/22/2014)... , Oct. 22, 2014 Nuvilex, Inc. ... approximately 400 million people worldwide are living with diabetes, ... people by 2030.  The global market for diabetes treatments ... approximately 330,000 people worldwide died from pancreatic cancer.  Pancreatic ... due to cancer in the United States ...
(Date:10/20/2014)... , Oct. 20, 2014 Mapp Biopharmaceutical,s ... ZMapp™ antibody therapeutic to fight the Ebola outbreak ... and time-consuming the production of pharmaceuticals can be, ... publisher said that while some may be taken ... compound, those with industry knowledge are well aware ...
(Date:10/20/2014)... , October 20, 2014 , ... (GI) disorders and the delivery of care has revealed ... and worrying inequalities in the provision of healthcare services ... was commissioned by United European Gastroenterology (UEG), have been ... and public awareness of the burden of GI disorders ...
(Date:10/20/2014)... Rochelle, Virginia (PRWEB) October 20, 2014 ... of NDA Partners LLC, announced today that Ellen ... and legal support for the pharmaceutical industry, has ... and manager of its legal services practice. ... reports and expert witness and testimony, to top ...
Breaking Biology Technology:Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... /PRNewswire-FirstCall/ - Neptune Technologies &,Bioressources Inc. ("Neptune") (NASDAQ.NEPT ... 2009 first quarter ended August 31, 2008., ... 31, 2008 was,$2,366,000 compared to $2,085,000 for the ... of 13.5%., The Company substantially decreased its ...
... best "gecko foot" dry adhesive got a new competitor this ... the journal Science by a team of researchers from four ... ability of gecko lizards to scurry up walls and cling ... amazing ability to microscopic branched elastic hairs in their toes ...
... 2 in ranking; up six spots from last year, ... recognition as a leader in biotechnology not just for its,ground-breaking ... Monsanto, headquartered in St. Louis, Missouri, took second place ... a leading,industry publication. The company moved up six spots from ...
Cached Biology Technology:Neptune Technologies & Bioressources Inc. reports first quarter results 2Dry adhesive based on carbon nanotubes gets stronger, with directional gripping ability 2Dry adhesive based on carbon nanotubes gets stronger, with directional gripping ability 3Dry adhesive based on carbon nanotubes gets stronger, with directional gripping ability 4Monsanto Recognized as Top Biotechnology Employer by Science Magazine 2
... Ease of Use : GeneTraffic ... software tool for biological research. GeneTraffic provides ... to validate your data prior to analysis. ... Quickly define your projects using the MIAME ...
... rigid macroporous hydrophilic media. The rigid polymer ... pressures, while the macroporous beads enhance access ... reduces nonspecific binding. Macro-Prep High Q support ... very high flow rates and resolution. It ...
... siTrio siRNA --- a cocktail of 3 ... of interestis our most popular product. The ... 75% knockdown of your target gene when ... for transfection and confirmation of optimal transfection ...
... IDS 25-Hydroxy Vitamin D kit is ... determination of 25-hydroxyvitamin D (25-OH D) ... serum or plasma. Our patented DIRECT ... solvent precipitation and centrifugation and therefore ...
Biology Products: