Navigation Links
Scientists engineer strain of MERS coronavirus for use in a vaccine
Date:9/9/2013

Scientists have developed a strain of the Middle East respiratory syndrome coronavirus (MERS-CoV) that could be used as a vaccine against the disease, according to a study to be published in mBio, the online open-access journal of the American Society for Microbiology. The mutant MERS virus, rMERS-CoV-ΔE, has a mutation in its envelope protein that makes it capable of infecting a cell and replicating its genetic material, but deprives it of the ability to spread to other tissues and cause disease. The authors say once additional safe guards are engineered into the virus, it could be used as the basis of a safe and effective live-attenuated vaccine against MERS.

"Our achievement was a combination of synthetic biology and genetic engineering," says co-author Luis Enjuanes of The Autonomous University of Madrid (Universidad Autnoma de Madrid).

"The injected vaccine will only replicate in a reduced number of cells and produce enough antigen to immunize the host," he says, and it cannot infect other people, even those in close contact with a vaccinated person.

Since MERS was first identified in June 2012, the World Health Organization has been notified of 108 cases of infection, including 50 deaths. Although the total number of cases is still relatively small, the case fatality rate and the spread of the virus to countries beyond the Middle East is alarming to public health officials. If the virus evolves the ability to transmit easily from person to person, a much more widespread epidemic is possible. Diagnostic assays and antiviral therapies for MERS have been described, but reliable vaccines have not yet been developed.

Enjuanes and his team applied what they had learned from 30 years of research on the molecular biology of coronaviruses to synthesize an infectious cDNA clone of the MERS-CoV genome based on a published sequence. They inserted the viral cDNA chromosome into a bacterial artificial chromosome, and m
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... vanished from tropical islands because of human impact, ... fossils can be used to restore lost biodiversity. ... found in fossil bones, which contain evidence for ... study available online and in the September issue ... island ecosystems provide vital clues for saving endangered ...
(Date:9/22/2014)... crop by-products such as straw could be made quicker ... the UK and France. , Researchers funded by ... discovered variant straw plants whose cell walls are more ... not significantly smaller or weaker than regular plants. ... food security as biofuels from non-food crops become easier ...
(Date:9/22/2014)... Brain & Behavior Research Foundation today ... Investigator Grants valued at more than $12.7 ... promising young scientists. Recipients of the $30,000+/year, ... seek to identify causes, improve treatments and ... affect one in four people, including anxiety, ...
Breaking Biology News(10 mins):Answer to restoring lost island biodiversity found in fossils 2Plant variants point the way to improved biofuel production 2Brain & Behavior Research Foundation awards 200 NARSAD Young Investigator grants 2
... from UC San Diego are collaborating with scientists ... to map patterns of biodiversity and land use ... combined with climate models, will project how climate ... policy for setting aside conservation easements. Wildlife, ...
... the biggest challenges facing humanity is to halt the destruction ... task that must be urgently addressed and in which we ... is our duty to do all we can for the ... researchers Harold Mooney and Peter Raven, regarded as the architects ...
... In a recent paper published in Nature Geoscience (*), ... Centre for Geosciences, Potsdam and her Danish colleague Nils ... that motions in the fluid in the Earths core ... effects the magnetic field of our Planet. ...
Cached Biology News:Biodiversity maps developed by UCSD scientists will help guide conservation measures in East Africa 2Biodiversity maps developed by UCSD scientists will help guide conservation measures in East Africa 3BBVA Foundation Awards for Biodiversity Conservation 2BBVA Foundation Awards for Biodiversity Conservation 3BBVA Foundation Awards for Biodiversity Conservation 4
(Date:9/23/2014)... MN (PRWEB) September 23, 2014 ... NimbeLink, a developer of cellular modems , ... finalist in the Startup category for the 2014 ... be held at the Minneapolis Convention Center on ... companies and individuals who have shown superior technology ...
(Date:9/22/2014)... Pearl's Premium Ultra Low Maintenance Lawn ... grass seed this week with the release of their ... with the fact that it is time to plant ... , As of the date 6/4/13, Pearl's Premium ... industry experts and the media including: The National ...
(Date:9/22/2014)... LEGO-like components developed by researchers at the USC ... to build a 3-D microfluidic system quickly and ... hand. , Microfluidic systems are used in ... precisely manipulate small volumes of fluids for use ... pathogen detection, clinical diagnostic testing, and synthetic chemistry. ...
(Date:9/22/2014)... generated a new star-shaped molecule made up of interlocking rings, ... , Known as a ,Star of David, molecule, ... quarter of a century and the team,s findings are published ... of two molecular triangles, entwined about each other three times ... each triangle is 114 atoms in length around the perimeter. ...
Breaking Biology Technology:NimbeLink Named Finalist for 15th Annual Tekne Awards 2NimbeLink Named Finalist for 15th Annual Tekne Awards 3Pearl's Premium Ultra Low Maintenance Lawn Seed Announces A Major Breakthrough In Drought Tolerant Grass Seed 2Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 2Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 3Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 4Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 5
... gave about $400,000 worth of software to Lad ... and their families. Rob Busch, enterprise sales manager for ... the non-profit's Synergy School in Milwaukee for the formal ... upgrade Lad Lakes network and software infrastructure, including the ...
... NimbleGen Systems Inc. closed its latest, $8.2 ... to $50 million, the company said. , ,The company makes ... have thousands of individual genetic samples on them arranged in ... of DNA and do comparisons. , , Cargill Ventures ...
... in the next ten years, according to a proposal that ... the Senate for a vote this month. State Senator Joe ... Wisconsin that would be regulated similarly to airports. , ,Leibhams ... regulate private space travel in the area, receive any potential ...
Cached Biology Technology:Space port could open in Sheboygan in next 10 years 2Space port could open in Sheboygan in next 10 years 3
... The Thermo Sequenase Dye Primer Manual ... used with fluorescent dye-labeled primers and high-resolution ... step followed by standard slab gel electrophoresis ... fluorescently tagged sequencing products. The kit ...
Rabbit polyclonal to Esa1 ( Abpromise for all tested applications)....
... records analyzes and reports the data from any ... the a chart recorder. The final data is ... The end-point selection is automatic for Systolic, Mean, ... computed. The user is always in the position ...
... EIA Principle: Glutathion-S-transferases (GST) ... are involved in the detoxification processes. ... subgroups: Alpha, Mu, Pi, Teta and ... physiochemical, immunological, enzymatic and s Sample ...
Biology Products: