Navigation Links
Scientists discover the mechanism of heart failure in fish exposed to oil spills
Date:2/14/2014

ith each heartbeat, countless cardiac muscle cells are synchronized so that their individual contractions add up to the coordinated pumping action of the heart. Near the end of each contraction cycle, positively charged potassium ions flow out of the muscle cell through ion channels in the cell membrane, priming the cell for the next cycle. This new research demonstrates that PAHs can block potassium ion channels in the heart cells of tunas. They can also disrupt calcium ion cycling within isolated muscle cells. Together, these effects are thought to underlie the slowed or irregular heartbeats observed in fish embryos exposed to crude oil.

"When we see these kinds of acute effects at the cardiac cell level," said Barbara Block, who led the team of Stanford University scientists working on this study, "it is not surprising that chronic exposure to oil from spills such as Deepwater Horizon can lead to long-term problems in fish hearts."

The study notes that, because the structure of ion channels is similar in the heart muscle cells of many species, related disruptions might occur in the hearts of other vertebrates.

To demonstrate the effect of PAHs on the cardiac cells of tuna, scientists had to measure the flow of electrical current across the membranes of individual cells. "That requires some very specialized skills and equipment," said John Incardona, another NOAA scientist and a coauthor of the study.

This experimental capacity was provided by the Tuna Research and Conservation Center, jointly operated by Stanford University and the Monterey Bay Aquarium. Scientists there measured the electrical properties of individual heart muscle cells using a "patch clamp" technique, which involves micron-scale glass electrodes.

The Stanford scientists provided expertise in tuna husbandry, cardiac physiology, single-cell electrophysiology, and optical imaging. NOAA's Ecotoxicology Program provided expertise in designing oil exposure studies, and in understa
'/>"/>

Contact: Rich Press
rich.press@noaa.gov
NOAA National Marine Fisheries Service
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists discover the mechanism of heart failure in fish exposed to oil spills
(Date:10/16/2014)... constantly wages war on the human body. Battles ... stalemate. In pancreatic cancer, this stalemate—known as tumor ... aggressively malignant, a phenomena that is poorly understood. ... the laboratory of Salvatore Torquato, a Professor of ... conditions surrounding tumor dormancy and the switch to ...
(Date:10/16/2014)... researchers have challenged conventional thinking on how the bowel ... mechanism for how bowel cancer starts. , The researchers ... and regenerating the ,crypts, that are a feature of ... involved in bowel cancer development, a controversial finding as ... , Using 3D imaging technologies, Dr Chin Wee Tan ...
(Date:10/16/2014)... 16, 2014) – Post-menopausal women experienced improvements in ... levels or genital bleeding, after 12 weeks of ... fermented soy germ-based nutritional supplement previously shown to ... new peer-reviewed pilot study reported in a poster ... scientific meeting. , "These data documented improved ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2Cryptic clues drive new theory of bowel cancer development 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2
... By manipulating highly specific gene-regulating molecules called microRNAs, scientists at ... in singling out and repressing stem-like cells in mouse breast ... to cancer. If certain forms of breast cancer do ... believe to be the case, then it is critical to ...
... induce cells to form parallel tube-like structures that could one ... found that they can control the cells, development by growing ... the work was posted this month in an online issue ... day be transplanted into tissues such as the kidneys, liver, ...
... events that are critical to a healthy life, giving ... to think. But thats if the neurotransmitters are getting ... cells, neurons or other cells. Now a ... transcription factor that controls a neurotransmitter in the nematode ...
Cached Biology News:CSHL scientists identify and repress breast cancer stem cells in mouse tissue 2CSHL scientists identify and repress breast cancer stem cells in mouse tissue 3MIT works toward engineered blood vessels 2Overexcited neurons not good for cell health 2Overexcited neurons not good for cell health 3
(Date:10/19/2014)... OCTOBER 20-22, 2014: The ... ABIM will take place at the Congress ... 2014 is now available at http://www.abim.ch ... and organizations from all over the globe ... the latest products and developments on the ...
(Date:10/19/2014)... 2014 The Asia-Pacific Bromine Market ... Asia-Pacific with analysis and forecast of revenue. , ... Bromine Market report, to get an idea of ... glimpse of the segmentation in the Asia-Pacific bromine ... figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine ...
(Date:10/19/2014)... October 19, 2014 The Asia-Pacific Speech ... market in Asia-Pacific with analysis and forecast of revenue. ... in 2014 to $208 million by 2019, at a ... to 2019. , Browse through the TOC of the ... of the in-depth analysis provided. It also provides a ...
(Date:10/19/2014)... October 19, 2014 The Asian Orthopedic braces ... in Asia with analysis and forecast of revenue. The Orthopedic ... grow to around $416.5 million by 2018, at a developing ... the TOC of the Asian Orthopedic braces and support systems ... This also provides a glimpse of the segmentation of orthopedic ...
Breaking Biology Technology:The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4
... Northwest,Biotherapeutics, Inc. (OTC Bulletin Board: NWBO; ... today that Lonza Group AG has,withdrawn all ... and other NWBT DCVax(R) products other than ... vaccine products infringed,certain gene expression technology patents ...
... offers substance abuse treatment for teens and adults, ... has announced the expansion of its treatment services to,include ... 12 - 17 as well,as adults, and the hospital ... health and dual diagnosis (substance abuse and,mental illness)., ...
... ALTO, Calif., Dec. 19 Alexza,Pharmaceuticals, Inc. (Nasdaq: ... Barron, MD, FACC to its Board of Directors. Dr. ... Officer at Genentech,where he leads the Development organization, which ... Barron joined Genentech in 1996 as a clinical scientist ...
Cached Biology Technology:Lonza Withdraws Majority of Claims in Patent Lawsuit Against Northwest Biotherapeutics 2Lonza Withdraws Majority of Claims in Patent Lawsuit Against Northwest Biotherapeutics 3Lonza Withdraws Majority of Claims in Patent Lawsuit Against Northwest Biotherapeutics 4Highlands Behavioral Health Hospital Unveils New Substance Abuse Detox Program 2Alexza Elects Dr. Hal V. Barron to Its Board of Directors 2Alexza Elects Dr. Hal V. Barron to Its Board of Directors 3
Human Xg Affinity Purified Polyclonal Ab Keywords: Xg glycoprotein, hereditary hemorrhagic telangiectasia Protein Family: ...
nuclear RNA export factor 1, mRNA...
Mycoplasma tested...
Human PDGF, CF...
Biology Products: