Navigation Links
Scientists discover small RNAs that regulate gene expression and protect the genome
Date:5/13/2008

gulators.

A New Class of RNA

Previously, researchers had recognized two classes of regulatory small RNA molecules in fruit flies, each with different protein partners. One class, called microRNAs, appears throughout the organism and acts to regulate the activity of many genes by joining with a special protein called Argonaute 1. A second class of RNA molecules, called piRNAs, occurs only in cells of the sex organs, and joins with different proteins, called Piwi proteins. Together, they act as a kind of immune system to suppress genetic interlopers called transposable elements, which were discovered at CSHL by Nobel laureate Barbara McClintock more than a half century ago, and which in certain cases can cause genomic havoc that underlies disease.

Dr. Hannon and his colleagues looked for RNA molecules that partner with a different protein, Argonaute 2, that belongs to the same family as Argonaute 1 and the Piwi proteins. Using advanced sequencing technology, they found that these small-RNA partners were distinct from either of the previously known classes of small RNAs. The new small-RNA class both modifies gene activity and suppresses transposable elements, thus serving as a defense mechanism.

These findings, the scientists write in a newly published paper in Nature, expands the known repertoire of small RNAs in fruit flies, and further blurs distinctions between the previously identified classes of small RNAs.

Pseudogenes: Not Just Junk

In related research, Hannon and his colleagues have published a paper announcing their discovery of a new source of regulatory RNA in mice. Many RNA sequences, such as microRNAs, are flagged as regulatory molecules because they physically fold on themselves. Special proteins recognize the resulting double-stranded RNA, and chemically slice it to release regulatory RNA snippets.

The CSHL team found that double-stranded structures also form from pseudogenes.
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Argonne scientists use lasers to align molecules
2. Too hot to handle! Scientists identify heat sensing regulator
3. Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
4. Scientists endure Arctic for last campaign prior to CryoSat-2 launch
5. Scientists discover why plague is so lethal
6. UF scientists discover compound that could lead to new blood pressure drugs
7. UIC scientists discover how some bacteria survive antibiotics
8. Scientists aim to boost world energy supplies -- with microbes!
9. Scientists determine drug target for the most potent botulinum neurotoxin
10. Scientists make chemical cousin of DNA for use as new nanotechnology building block
11. Scientists find stem cells for the first time in the pituitary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... – Accurate knowledge regarding Ebola is critical and pertinent ... of hazardous global outbreak and epidemic. The Journal, ... a special issue, Ebola Virus and Public Health, to ... knowledge in this critical societal moment. , On ... Ebola for Clinicians . The primer was prepared by ...
(Date:10/17/2014)... This news release is available in German . ... for only a very few drugs. When treating overdoses, doctors ... Treatment is especially difficult if there is a combination of ... is playing and accidentally swallows his grandmother,s pills? ETH professor ... Zurich wanted to find an answer to this question. "The ...
(Date:10/16/2014)... managers have a new synthesis of recent research findings ... forests in the two states. , The Ecology ... and Washington: A Synthesis of the Relevant Biophysical Science ... report published by the U.S. Forest Service,s Pacific Northwest ... from managers for a synthesis of the large body ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3New report synthesizes best available science on management of moist mixed-conifer forests 2
... Black-throated Blue Warbler journey from tropical Caribbean or South ... patch will they call home this year? And, how ... Ecologists studying biodiversity and conservationists preserving habitats have asked ... limited and imprecise means to answer them. Now a ...
... English whose first language is Chinese retrieve their native language ... June 2 issue of The Journal of Neuroscience . ... in adolescence or later recall the sounds of words from ... Jing Wu, PhD, and Guillaume Thierry, PhD, of Bangor University ...
... This press release is available in Spanish . ... longstanding mystery as to why a pathogen that threatens the ... It is because the fungus that causes the wheat ... to resistant varieties of wheat. ARS plant pathologist Yue ...
Cached Biology News:Lasers help researchers predict birds' preferred habitat 2Lasers help researchers predict birds' preferred habitat 3Second language learners recall native language when reading 2Uncovering the mystery of a major threat to wheat 2
(Date:10/22/2014)... Diego, CA (PRWEB) October 22, 2014 ... balances from Sartorius, A & D Weighing, Rice ... Sartorius CPA Semi-Micro Balance . The Sartorius CPA ... for an affordable high-quality, precise, and user-friendly laboratory ... manufacturing of laboratory equipment, their laboratory balances are ...
(Date:10/22/2014)... 2014 /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") ... for its Oral Amphotericin B program.  The company ... vitro work involving samples from HIV/AIDS patients ... complete pre clinical studies and regulatory filings to ... trial, utilizing approximately $700,000 of funding and technological ...
(Date:10/20/2014)... 2014 Mapp Biopharmaceutical,s valiant effort to ... to fight the Ebola outbreak will make the ... production of pharmaceuticals can be, according to Kalorama ... while some may be taken aback by the ... industry knowledge are well aware of the complex ...
(Date:10/20/2014)...  GenVec, Inc. (NASDAQ: GNVC ) today announced ... its board of directors effective on October 24, 2014.   Dr. ... as its chairman from June 2006 to November 2013.  During ... Governance and Audit Committees of the board.  ... dedicated service to GenVec, and its stockholders," said Wayne ...
Breaking Biology Technology:Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Zola P. Horovitz To Retire From GenVec Board 2
... The Albert and Mary Lasker Foundation , ... medical research, announced today the winners of the 2010 ... M. Friedman for basic medical research, Napoleone Ferrara ... for special achievement. The three awards—recognized as the most prestigious ...
... and Strengthens Supervisory Board With Joseph Feczko, Steven... -- AMSTERDAM, September 20, 2010 ... ... --> ... s = ,; var first_result; // Results are keyed by longUrl, so we need to grab the ...
... /PRNewswire-FirstCall/ - Neuro-Biotech Corporation (PINKSHEETS: MRES) (OTCQB: ... involved in the unique international niche of ... the opportunity to market 12 clinical "Neuro ... tests are without equal in being rapidly ...
Cached Biology Technology:2010 Lasker Awards Honor Trailblazers in Medical Research and Clinical Care 22010 Lasker Awards Honor Trailblazers in Medical Research and Clinical Care 32010 Lasker Awards Honor Trailblazers in Medical Research and Clinical Care 42010 Lasker Awards Honor Trailblazers in Medical Research and Clinical Care 52010 Lasker Awards Honor Trailblazers in Medical Research and Clinical Care 6AMT's EGM Passes All Resolutions and Strengthens Supervisory Board With Joseph Feczko, Steven Holtzman and Francois Meyer 2AMT's EGM Passes All Resolutions and Strengthens Supervisory Board With Joseph Feczko, Steven Holtzman and Francois Meyer 3AMT's EGM Passes All Resolutions and Strengthens Supervisory Board With Joseph Feczko, Steven Holtzman and Francois Meyer 4AMT's EGM Passes All Resolutions and Strengthens Supervisory Board With Joseph Feczko, Steven Holtzman and Francois Meyer 5AMT's EGM Passes All Resolutions and Strengthens Supervisory Board With Joseph Feczko, Steven Holtzman and Francois Meyer 6AMT's EGM Passes All Resolutions and Strengthens Supervisory Board With Joseph Feczko, Steven Holtzman and Francois Meyer 7AMT's EGM Passes All Resolutions and Strengthens Supervisory Board With Joseph Feczko, Steven Holtzman and Francois Meyer 8AMT's EGM Passes All Resolutions and Strengthens Supervisory Board With Joseph Feczko, Steven Holtzman and Francois Meyer 9AMT's EGM Passes All Resolutions and Strengthens Supervisory Board With Joseph Feczko, Steven Holtzman and Francois Meyer 10Neuro-Biotech's Solution for a Doctor near You: Early Detection for Alzheimer's and Chronic Fatigue Syndrome! 2
... The powerful solution for all plate washing ... format. ,The PW 384 provides an ... field of Drug Discovery (Assay development, Screening or ... speed ,The PW 384 has set ...
... Model 1575 immunowash microplate washer, 100-240 V, ... have flat-, U-, or V-bottom wells. This ... needle positions to an accuracy of 0.1 ... overflow washing. It can store up to ...
... a compact benchtop and stackable multi-function ... with a large display screen to ... Air circulation inside to evenly distribute ... be easily calibrated from the microprocessor ...
... compact benchtop and stackable multi-function incubator. ... a large display screen to accurately ... circulation inside to evenly distribute temperature ... easily calibrated from the microprocessor controller. ...
Biology Products: