Navigation Links
Scientists discover small RNAs that regulate gene expression and protect the genome
Date:5/13/2008

RNA is best known as a working copy of the DNA sequence of genes. In this role, its a carrier of the genes instructions to the cell, which manufactures proteins according to information in the RNA molecule.

But molecular biologists have increasingly realized that many RNA snippets -- so-called small RNAs -- also directly influence which genes make proteins, and in some cases, how much protein. Theyve also found that some small RNAs play a unique role in protecting the integrity of genetic material.

Scientists at Cold Spring Harbor Laboratory (CSHL) have played a central role in these discoveries since the beginning of the decade. In recent weeks they have published additional findings adding to our knowledge of small RNAs, identifying a brand new class and clarifying how a known class acts to regulate gene activity.

It turns out that there are more types of small RNA molecules than anyone initially suspected, said Gregory J. Hannon, Ph.D., CSHL professor and pioneer in small RNA research. And we are finding that each type that we discover acts in more ways than had previously been appreciated.

Advanced Sequencing

RNA molecules consist of sequences of chemical units, or bases, that are copies of the DNA sequence. Each specific sequence can recognize related sequences in other RNA or DNA molecules. To regulate cellular activities, small RNA snippets, each containing 20 to 30 bases, join with special protein helpers to eliminate or modify target molecules. But of the billions of bases in a cells DNA, what determines which RNA snippets are chosen for this role"

Dr. Hannon and his collaborators are harnessing highly efficient new machines that determine the sequence of bases in millions of small RNA molecules simultaneously. They then scan the known genome to find matching sequences, as well as the sequences nearby. This original context is crucial to understanding why some snippets are chosen as re
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Argonne scientists use lasers to align molecules
2. Too hot to handle! Scientists identify heat sensing regulator
3. Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
4. Scientists endure Arctic for last campaign prior to CryoSat-2 launch
5. Scientists discover why plague is so lethal
6. UF scientists discover compound that could lead to new blood pressure drugs
7. UIC scientists discover how some bacteria survive antibiotics
8. Scientists aim to boost world energy supplies -- with microbes!
9. Scientists determine drug target for the most potent botulinum neurotoxin
10. Scientists make chemical cousin of DNA for use as new nanotechnology building block
11. Scientists find stem cells for the first time in the pituitary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... tube connectors, designed by an international standards process, will ... According to an invited review published in the OnlineFirst ... NCP ), the official journal of the American Society ... will greatly reduce the occurrence of misconnection that can ... connectors, which are used to join medical devices, components, ...
(Date:8/21/2014)... from North Carolina State University have developed a novel ... model has applications for creating new materials as well ... "Our new technique allows us to model much larger ... much more quickly," says Nan Li, lead author of ... in NC State,s Department of Materials Science and Engineering. ...
(Date:8/20/2014)... a study of 158 pregnant teenagers in Rochester, NY, ... intentional consumption of ice, cornstarch, vacuum dust, baby powder ... Cornell study. , Moreover, such teens had significantly lower ... eat nonfood substances. , Pregnant teens, regardless of pica, ... lead to iron deficiency and anemia. Low iron in ...
Breaking Biology News(10 mins):New feeding tube connectors will improve patient safety 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2Pica in pregnant teens linked to low iron 2
... WASHINGTON, D.C. (March 7, 2011) -- All our daily activities, ... on signals carried along the body,s vast network of neurons. ... small molecules within nerve cells -- receptors, ion channels, and ... recently, the study of these molecules in real time has ...
... gene that causes Hajdu-Cheney syndrome, a disorder of the ... The study, published in Nature Genetics today, ... highlights the gene as a potential target for treating ... reported cases of Hajdu-Cheney syndrome (HCS), of which severe ...
... separates from Greenland, is the calving due to typical ... called the Scalable, Efficient, and Accurate Community Ice Sheet ... Ridge National Laboratory, aims to use state-of-the-art simulation to ... climate. ORNL computational Earth scientist Kate Evans leads ...
Cached Biology News:Gene responsible for severe osteoporosis disorder discovered 2
(Date:8/21/2014)... 2014  Four-dimensional (4-D) printing develops materials that ... stimuli such as changes in temperature. This advanced ... in multiple industries.  In the near future, 4-D ... objects ranging from human organs to parts used ... Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... Wednesday of last week RENU 28, the world's first and ... for purchase in Australia and New Zealand, and the response ... is, if you think about the definition of aging, it's ... within your body. If you think about the definition of ... What RENU 28 does is it works with these tiny ...
(Date:8/20/2014)... Aug. 20, 2014 Neurotrope, Inc. (OTCQB: ... conference call to provide an update on Company ... daylight timeDial-in numbers:(888) 505-4369 (U.S. and Canada) or ... cast: www.neurotropebioscience.com , under "Investor Relations"The teleconference replay ... through September 2, 2014 at (888) 203-1112 (U.S. ...
(Date:8/20/2014)... August 20, 2014 Not long ago, ... studies should be performed late in the development cycle ... But current regulatory trends suggest that, like many things ... rise. In recent years, multiple drug sponsors have been ... address specific questions during phase I/II. It’s not only ...
Breaking Biology Technology:Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4RENU 28 Skin Care Now Available in Australia and New Zealand 2Neurotrope To Host Conference Call 2Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2
... LA JOLLA, Calif., Jan. 13 Burnham ... an assay development and license agreement with ... L.L.C. (J&JPRD). The agreement is Burnham,s ... company.Under this multi-year agreement, Burnham will provide ...
... - GeneNews Limited (TSX: GEN), a company focused ... detection of diseases and personalized health management, today ... 7,473,528 entitled "Method for the detection of Chagas ... protects the Company,s discovery of a blood biomarker-based ...
... Datafarm, Inc. a leading provider of Electronic Document Publishing Solutions and ... announce the appointment of Mr. Daniel F. Orfe to Vice President, ... will oversee Datafarm,s Regulatory Services Group. , ... Marlborough, ...
Cached Biology Technology:Burnham Announces Assay Development and License Agreement with Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 2GeneNews granted U.S. patent for Chagas disease based on Sentinel Principle(TM) platform 2Datafarm, Inc., Announces the Appointment of Daniel F. Orfe to Vice President, Global Regulatory Submission Services 2Datafarm, Inc., Announces the Appointment of Daniel F. Orfe to Vice President, Global Regulatory Submission Services 3Datafarm, Inc., Announces the Appointment of Daniel F. Orfe to Vice President, Global Regulatory Submission Services 4
... Rabbit Reticulocyte Lysate contains the cellular components ... acids, initiation, elongation and termination factors) but ... Untreated Lysate is used primarily for the ... abundant source of endogenous globin mRNA. Untreated ...
... All MagCellect Ferrofluid products perform ... with R&D Systems MagCellect Magnet. ... this neodymium iron boron permanent ... x 75 mm test tubes ...
... The ScriptCap™ 2'-O-Methyltransferase converts Cap 0 (or ... The Cap 1 structure has been shown ... up to 50%. This improvement is seen ... ScriptCap™ m7G Capping System as well as ...
Request Info...
Biology Products: