Navigation Links
Scientists discover small RNAs that regulate gene expression and protect the genome
Date:5/13/2008

RNA is best known as a working copy of the DNA sequence of genes. In this role, its a carrier of the genes instructions to the cell, which manufactures proteins according to information in the RNA molecule.

But molecular biologists have increasingly realized that many RNA snippets -- so-called small RNAs -- also directly influence which genes make proteins, and in some cases, how much protein. Theyve also found that some small RNAs play a unique role in protecting the integrity of genetic material.

Scientists at Cold Spring Harbor Laboratory (CSHL) have played a central role in these discoveries since the beginning of the decade. In recent weeks they have published additional findings adding to our knowledge of small RNAs, identifying a brand new class and clarifying how a known class acts to regulate gene activity.

It turns out that there are more types of small RNA molecules than anyone initially suspected, said Gregory J. Hannon, Ph.D., CSHL professor and pioneer in small RNA research. And we are finding that each type that we discover acts in more ways than had previously been appreciated.

Advanced Sequencing

RNA molecules consist of sequences of chemical units, or bases, that are copies of the DNA sequence. Each specific sequence can recognize related sequences in other RNA or DNA molecules. To regulate cellular activities, small RNA snippets, each containing 20 to 30 bases, join with special protein helpers to eliminate or modify target molecules. But of the billions of bases in a cells DNA, what determines which RNA snippets are chosen for this role"

Dr. Hannon and his collaborators are harnessing highly efficient new machines that determine the sequence of bases in millions of small RNA molecules simultaneously. They then scan the known genome to find matching sequences, as well as the sequences nearby. This original context is crucial to understanding why some snippets are chosen as re
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Argonne scientists use lasers to align molecules
2. Too hot to handle! Scientists identify heat sensing regulator
3. Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
4. Scientists endure Arctic for last campaign prior to CryoSat-2 launch
5. Scientists discover why plague is so lethal
6. UF scientists discover compound that could lead to new blood pressure drugs
7. UIC scientists discover how some bacteria survive antibiotics
8. Scientists aim to boost world energy supplies -- with microbes!
9. Scientists determine drug target for the most potent botulinum neurotoxin
10. Scientists make chemical cousin of DNA for use as new nanotechnology building block
11. Scientists find stem cells for the first time in the pituitary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... Scientists from the Florida campus of The Scripps ... plays a critical but previously unknown role in learning ... a novel role for a protein known as RGS7, ... eLife , a publisher supported by the Howard Hughes ... Trust. , "This is a critical building block that ...
(Date:4/22/2014)... Massachusetts Amherst and the Instituto Nacional de Pesquisas da ... discovered a new genus and species of electric knifefish ... Amazonia State of Brazil. , Professor Cristina Cox Fernandes ... Alves-Gomes of INPA, describe the new bluntnose knifefish in ... the Natural Sciences of Philadelphia . , Their ...
(Date:4/22/2014)... same crystal structure as a mineral first found in ... efficiency charts faster than almost anything researchers have seen ... way of using sunlight to generate electricity may be ... Department,s National Renewable Energy Laboratory (NREL) are analyzing the ... and broad spectrum of expertise to uncover the secrets ...
Breaking Biology News(10 mins):Scientists identify critical new protein complex involved in learning and memory 2New electric fish genus and species discovered in Brazil's Rio Negro 2NREL unlocking secrets of new solar material 2NREL unlocking secrets of new solar material 3NREL unlocking secrets of new solar material 4NREL unlocking secrets of new solar material 5NREL unlocking secrets of new solar material 6
... brain that controls insulin responses has been shown to ... evidence that the disease can be treated in its ... Rhode Island Hospital and Brown Medical School. , ... prevent several components of neurodegeneration and preserve learning and ...
... known that animals use song as a way of attracting ... unusual way of scaring off predators ?by singing to them. ... that wild gibbons in Thailand have developed a unique song ... survival, the gibbons appear to use the song not just ...
... 21 September, 2006 - Elsevier is delighted to ... the journal Vaccine: HPV Vaccines and Screening in ... provides a comprehensive and invaluable update for paediatricians, ... major donor institutions worldwide. , With the arrival ...
Cached Biology News:Insulin receptor stops progression of Alzheimer's disease 2Insulin receptor stops progression of Alzheimer's disease 3Singing for survival 2Singing for survival 3
(Date:1/15/2014)... Village, Calif. (PRWEB) January 15, 2014 ... treatment and management through the genomic analysis of tumor ... offer Therapy Finder™, a web-based cancer decision support application ... reporting option with Cynvenio’s ClearID™ genomic test, Therapy Finder ...
(Date:1/15/2014)... Houston, TX (PRWEB) January 15, 2014 ... Alzheimer’s disease, and about 1 in 3 seniors will ... ( source ). These jaw-dropping figures have shocked many ... function and, hopefully, help prevent these tragic age-related cognitive ...
(Date:1/15/2014)... CA (PRWEB) January 15, 2014 ... research solutions, today announced that Lupin Limited, one of ... Freeslate’s CM Protégé PharmD System for high ... Mumbai, India, is focused on a wide range of ...
(Date:1/14/2014)... 2014 Histogen, Inc., a regenerative medicine ... grown under simulated embryonic conditions, today announced that they ... Medical, Inc. for physician-dispensed aesthetic products containing Histogen’s proprietary ... agreement is an amendment to the existing license between ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... NORTH HOLLYWOOD, Calif., June 17 IPC The,Hospitalist Company, ... group practice, today reaffirmed its guidance for full year ... to $245 million and full year,2008 earnings per adjusted ... quarter related to the Company,s IPO) to be in ...
... Lifesciences,Corporation (NYSE: EW ), a world leader ... is scheduled to participate in the,18th Annual Wachovia ... Nantucket, Massachusetts on Tuesday, June 24, 2008., ... chief,financial officer & treasurer, is scheduled to speak ...
... Assured Biomarker ... Pharmaceutical Industry, PHILADELPHIA and LONDON, June 17 ... information for,businesses and professionals, announced today the launch ... new solution will be the first to provide ...
Cached Biology Technology:IPC The Hospitalist Company, Inc. Reaffirms Guidance for 2008 2IPC The Hospitalist Company, Inc. Reaffirms Guidance for 2008 3IPC The Hospitalist Company, Inc. Reaffirms Guidance for 2008 4Edwards Lifesciences to Present at the 18th Annual Wachovia Nantucket Equity Conference 2Thomson Reuters Launches New Biomarkers Solution 2
Immunochemistry 1 & 2...
...
Hucal Agx Antigen Expression Service Specificity: Hucal Agx ...
MHC. Sections include: the isolation and functional properties of antigen-presenting cells analysis of MHC class II endocytosis and peptide turnover analysis of signalling via MHC class II molecu...
Biology Products: