Navigation Links
Scientists discover how cigarette smoke causes cancer: Study points to new treatments, safer tobacco
Date:2/27/2008

Everyone has known for decades that that smoking can kill, but until now no one really understood how cigarette smoke causes healthy lung cells to become cancerous. In a new research report published in the March 2008 print issue of The FASEB Journal (http://www.fasebj.org), researchers from the University of California, Davis, show that hydrogen peroxide (or similar oxidants) in cigarette smoke is the culprit. This finding may help the tobacco industry develop safer cigarettes by eliminating such substances in the smoke, while giving medical researchers a new avenue to developing lung cancer treatments.

With the five-year survival rate for people with lung cancer at a dismally low 15.5 percent, we hope this study will provide better insight into the identification of new therapeutic targets, said Tzipora Goldkorn, senior author of the report.

In the research study, Goldkorn and colleagues describe how they exposed different sets of human lung airway cells (in the laboratory) to cigarette smoke and hydrogen peroxide. After exposure, these cells were then incubated for one to two days. Then they, along with unexposed airway cells, were assessed for signs of cancer development. The cells exposed to cigarettes smoke and the cells exposed to hydrogen peroxide showed the same molecular signatures of cancer development, while the unexposed cells did not.

Guns kill, bombs kill and cigarettes kill, said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal. While biologists cant do much about the first two, studies like this will help in the fight against tobacco-related death and disease. These experiments not only pin-point new molecular targets for cancer treatment, but also identify culprits in cigarette smoke that eventually will do the smoker in.

According to the U.S. Centers for Disease Control and Prevention, cigarette smoking is the single most preventable cause of premature death i
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Exeter scientists pour cold water on EU bird policy
2. Yale scientists create artificial cells that boost the immune response to cancer
3. Scientists unravel the genetic coding of the pea
4. Scientists discover giant fossil frog from hell
5. Advertisers, neuroscientists trace source of emotions in brain
6. Amazon corridors far too narrow, warn scientists
7. Dung happens and helps scientists
8. Priming scientists for successful media interviews
9. Scientists expand understanding of how river carbon impacts the Arctic Ocean
10. Fishermen and UCSB scientists explore ways to improve management of California spiny lobsters
11. Scientists rebuild ancient proteins to reveal primordial Earths temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... , April 21, 2015 ... government policies are boosting access control systems market in ... According to a recently published report by TechSci Research ... ", the access control systems market in ... billion by 2020.The access control systems market in the ...
(Date:4/14/2015)... April 14, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... the 2015 New York Design Awards under the category  ... York City Design Awards are part of a global ... 2,500 ratings from the marketplace, industry and judging panel. ...
(Date:4/8/2015)... , April 8, 2015  Infinisource, a ... and services, and Morpho, a leading supplier of ... to produce the market,s most advanced biometrically-enabled time ... iSolved NXG time clock is setting a bold, ... labor data for the small and mid-size employer. ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... JoVE, the Journal of Visualized Experiments will ... understand the genes that govern food-related behavior in honey ... one-step closer toward understanding and perhaps changing ... "Our technique has already helped to unravel [the] complex ...
... to clean up city parks, or scale back their driving ... for granted and ride free on the efforts of others. ... fund it. Or they run their lawn sprinklers during a ... consumption. A new report in Psychological Science in ...
... global water crisis that already has left almost 800 million ... many more in the years ahead -- are the topic ... Chemical & Engineering News . C&EN is the weekly newsmagazine ... Alex Scott, C&EN,s senior editor for Europe, points out ...
Cached Biology News:Honey bee gene targeting offers system to understand food-related behavior 2Trust in leaders, sense of belonging stir people to safeguard common goods, analysis shows 2Trust in leaders, sense of belonging stir people to safeguard common goods, analysis shows 3
(Date:4/24/2015)... DIEGO , April 24, 2015  Pfenex Inc. ... the development of biosimilar therapeutics including high value and ... its follow-on public offering of 6,000,000 shares of its ... $15.50 per share. Of the shares being offered, 2,610,000 ... shares are being offered by existing stockholders. Pfenex will ...
(Date:4/24/2015)... Seoul Semiconductor announced the expansion of ... the lighting market. In recent months, there ... in emerging markets such as Russia, South America, ... applications such as streetlight and area lighting, tunnel ... launched in 2005 the Acrich technology from Seoul ...
(Date:4/23/2015)... , April 23, 2015 /CNW/ - A new and ... award from North America,s ... Comparison won Silver in the "Sustainability, service" category ... The Brandcheck "Competitor Comparison" is a service that ... American and Global peers. This benchmarking process shows ...
(Date:4/23/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ), a ... the pharmaceutical, biotechnology and medical device industries, with operations ... the United States , today announced that it ... 2015 after the New York Stock Exchange closes on ... May 14, 2015 Shanghai time). The earnings release will ...
Breaking Biology Technology:Pfenex Inc. Announces Pricing Of Follow-on Offering 2Acrich Technology from Seoul Semiconductor Adopted in Installations Worldwide 2WuXi PharmaTech Schedules First-Quarter 2015 Earnings Release 2WuXi PharmaTech Schedules First-Quarter 2015 Earnings Release 3
... Watson , SmithKline Beecham ... , Due to recent technologies in ... of potential drug candidates, it has become vital that screening assays are ... for the adaptation of a variety of assays which can be automated. ...
... M.J. Price-Jones 1 , K.T. Hughes 1 and N.R.A. Jones 2 ... UK, 2 PerkinElmer Life Sciences, P.O.Box 10, FIN-20101, Turku, Finland) , ... INTRODUCTION , ... or luminescence detection of samples in microtitration plates, tubes or on filters. , ...
... Svenja Goth , PerkinElmer Life and ... Shelton, CT 06484-4794 USA , Didier Clnet Sanofi-Aventis ... Physical Characterization Laboratory , 13, quai Jules Guesde , ... Polymorphism , Separation of transitions ...
Cached Biology Technology:Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors 2Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors 3Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors 4Counting Cytostar-T scintillating microplates on the MicroBeta JET 2Counting Cytostar-T scintillating microplates on the MicroBeta JET 3Counting Cytostar-T scintillating microplates on the MicroBeta JET 4Counting Cytostar-T scintillating microplates on the MicroBeta JET 5Practical Applications of HyperDSC in a Pharmaceutical Laboratory 2Practical Applications of HyperDSC in a Pharmaceutical Laboratory 3Practical Applications of HyperDSC in a Pharmaceutical Laboratory 4Practical Applications of HyperDSC in a Pharmaceutical Laboratory 5
... flexible and easy to use ... control all members of the ... features a clear and easy-to-follow ... setup, user-friendly and highly sophisticated ...
Strip Removal Tool 25/Box...
The bench-top stand comfortably holds up to 6 Finnpipette Digital single- and multichannel pipettes. The crossbars are made of a grippy material to keep the pipettes firmly in place. Individual shelf...
... Analysis Note: Protein determined by Biuret Physical ... mM Tris-HCl, pH 7.6, 1 mM MgCl ... Preparation Unit Definition: One unit will ... minute at pH 9.8 at 37 C. ...
Biology Products: