Navigation Links
Scientists discover how cigarette smoke causes cancer: Study points to new treatments, safer tobacco
Date:2/27/2008

Everyone has known for decades that that smoking can kill, but until now no one really understood how cigarette smoke causes healthy lung cells to become cancerous. In a new research report published in the March 2008 print issue of The FASEB Journal (http://www.fasebj.org), researchers from the University of California, Davis, show that hydrogen peroxide (or similar oxidants) in cigarette smoke is the culprit. This finding may help the tobacco industry develop safer cigarettes by eliminating such substances in the smoke, while giving medical researchers a new avenue to developing lung cancer treatments.

With the five-year survival rate for people with lung cancer at a dismally low 15.5 percent, we hope this study will provide better insight into the identification of new therapeutic targets, said Tzipora Goldkorn, senior author of the report.

In the research study, Goldkorn and colleagues describe how they exposed different sets of human lung airway cells (in the laboratory) to cigarette smoke and hydrogen peroxide. After exposure, these cells were then incubated for one to two days. Then they, along with unexposed airway cells, were assessed for signs of cancer development. The cells exposed to cigarettes smoke and the cells exposed to hydrogen peroxide showed the same molecular signatures of cancer development, while the unexposed cells did not.

Guns kill, bombs kill and cigarettes kill, said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal. While biologists cant do much about the first two, studies like this will help in the fight against tobacco-related death and disease. These experiments not only pin-point new molecular targets for cancer treatment, but also identify culprits in cigarette smoke that eventually will do the smoker in.

According to the U.S. Centers for Disease Control and Prevention, cigarette smoking is the single most preventable cause of premature death i
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Exeter scientists pour cold water on EU bird policy
2. Yale scientists create artificial cells that boost the immune response to cancer
3. Scientists unravel the genetic coding of the pea
4. Scientists discover giant fossil frog from hell
5. Advertisers, neuroscientists trace source of emotions in brain
6. Amazon corridors far too narrow, warn scientists
7. Dung happens and helps scientists
8. Priming scientists for successful media interviews
9. Scientists expand understanding of how river carbon impacts the Arctic Ocean
10. Fishermen and UCSB scientists explore ways to improve management of California spiny lobsters
11. Scientists rebuild ancient proteins to reveal primordial Earths temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... over the last decade in Taiyuan, China, have substantially ... a greater than 50% reduction in costs associated with ... according to researchers at the Columbia Center for Children,s ... Health, the Shanxi Medical University, the Center of Diseases ... University School of Public Health. , The study is ...
(Date:9/2/2014)... take stress in stride; others are done in by ... molecular mechanisms of this so-called stress gap in mice ... could lead researchers to better understand the development of ... people, each animal has unique experiences as it goes ... experiences can alter the expression of genes, and as ...
(Date:9/1/2014)... held that corals whose calcium-carbonate skeletons form ... organisms that rely entirely on ocean currents to ... But now scientists at MIT and the Weizmann ... that they are far from passive, engineering their ... greatly enhance their ability to exchange nutrients and ...
Breaking Biology News(10 mins):Clean air halves health costs in Chinese city 2Discovery hints at why stress is more devastating for some 2Discovery hints at why stress is more devastating for some 3Nature's tiny engineers 2Nature's tiny engineers 3
... A genetic variant of a receptor in the ... whether the neurotransmitter dopamine is released in the brain ... researchers at the National Institute on Alcohol Abuse and ... Dopamine is involved in transmitting the euphoria and ...
... first time successfully imaged the internal tissues of a ... technique borrowed from biomedical science. The findings are published ... worms are important for the functioning of marine ecosystems, ... understand their physiology, ecology and evolution," explained John Dinley ...
... imbalances at the heart of childhood brain tumors known as ... active in some tumors and is now the focus of ... research, published in the May 17 online edition of the ... between the defects underlying these tumors in children and adults, ...
Cached Biology News:Receptor variant influences dopamine response to alcohol 2Scientists use biomedical technique to image marine worm 2Push to understand basis of childhood brain tumors leads to a new treatment target 2Push to understand basis of childhood brain tumors leads to a new treatment target 3
(Date:9/2/2014)... 2, 2014  Spherix Incorporated (SPEX) -- an intellectual property development ... property, today announced that the United States Patent & ... in the month of August that are part of ... The issued patents are: , U.S.RE45,065 ... 19, 2014; and , U.S.RE45,095 issued August 26, ...
(Date:9/1/2014)... 1, 2014 Reportlinker.com announces that a ... catalogue: India Solid Waste Management Vehicles ... http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html In ... governing bodies responsible for complete handling and regulation ... average, around 135,000 MT solid waste is generated ...
(Date:8/31/2014)... 2014 Wockhardt Limited today announces a major ... research when two of its drugs, WCK 771 and ... (QIDP) status from U.S. Food & Drug Administration (FDA). ... pathogens which have a high degree of unmet need ... Disease Control (a top U.S. government health and safety ...
(Date:8/31/2014)... 31, 2014 This is a ... of the Epoxy Hardener industry in Global ... of the industry, including definitions, applications and industry ... market analysis are provided with a focus on ... market. A comparison between the international and Chinese ...
Breaking Biology Technology:United States Patent & Trademark Office Issues Three New Standard Essential Patents to Spherix 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3
... , , , , , , ... The time increment, which can be programmed as desired with every temperature , ... temperature for each cycle. , , With ... successive extension of the , elongation. , ...
... for Detecting Listeria monocytogenes , , ... Andrea Tanzer and Christian Rohrer , Andrea Tanzer, Institute ... Christian Rohrer, Eppendorf AG, Germany, , , ... Bacterial enteritides, which are triggered by contaminated foodstuffs, , ...
... , , , , ... Dietmar Kahle, PhD , Peter Scheinert, PhD, Bernhard-Nocht-Institute ... Hamburg , former address: University of Kiel, Institute ... , Barbara Behrens, PhD, and Dietmar Kahle, PhD, Eppendorf-Netheler-Hinz ...
Cached Biology Technology:Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 2Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 3Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 4Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 5Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 6Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 7Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 2Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 3Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 4Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 5Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 6Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 7Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 8Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 9Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 10
The FliTrx Panning Kit is designed to simplify panning for protein-protein interactions with the FliTrx Random Peptide Display Library or the pFliTrx Peptide Display Vector....
... The GeneSwitch Cell Lines stably express ... Each cell line is functionally tested ... with the expression control vector pGene/V5-His/lacZ ... after treatment with mifepristone (Figure 1). ...
... Modules Highly efficient ... cloning into advanced λ ... For flexibility ... Systems, the modules of ...
... Re-Blot Western Blot Recycling Kit is ... Western blots that have been developed ... other isotopes. It is not recommended ... 4-chloronapthol, etc.), as it is not ...
Biology Products: