Navigation Links
Scientists discover an epigenetic cause of osteoarthritis
Date:7/6/2012

Bethesda, MDIn what could be a breakthrough in the practical application of epigenetic science, U.K. scientists used human tissue samples to discover that those with osteoarthritis have a signature epigenetic change (DNA methylation) responsible for switching on and off a gene that produces a destructive enzyme called MMP13. This enzyme is known to play a role in the destruction of joint cartilage, making MMP13 and the epigenetic changes that lead to its increased levels, prime targets for osteoarthritis drug development. In addition to offering a new epigenetic path toward a cure for osteoarthritis, this research also helps show how epigenetic changes play a role in diseases outside of cancer. This finding was recently published online in the FASEB Journal.

"As the population gets older, osteoarthritis presents increasing social and economic problems," said David A. Young, Ph.D., a researcher involved in the work from the Musculoskeletal Research Group at the Institute of Cellular Medicine at Newcastle University in Newcastle upon Tyne in the United Kingdom. "Our work provides a better understanding of the events that cause cartilage damage during osteoarthritis and provides hope that tailored drug development to prevent the progress of disease will improve the quality of life and mobility of many arthritis sufferers."

To make the discovery, Young and colleagues compared the extent to which DNA methylation was different in cartilage from patients suffering from osteoarthritis and healthy people of similar age. They found that at one small position, the gene for MMP13 had less DNA methylation in diseased patients. Then they confirmed that reduced methylation of this gene increases levels of the destructive enzyme MMP13.

"We've already seen how epigenetics has advanced our approach to cancer. Now we're seeing it with other diseases and even exercise." said Gerald Weissmann,
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. New York University scientists discover possible treatment to reduce scarring
2. Scientists discover new trigger for immense North Atlantic plankton bloom
3. Atmospheric scientists release first bottom-up estimates of Chinas CO2 emissions
4. Stanford scientists find molecule to starve lung cancer and improve ventilator recovery
5. Scripps Florida scientists identify critical quality control for cell growth
6. Gladstone scientists identify critical process in stem cell development
7. Wholly water -- students and scientists gather at NTU to discuss water problem
8. Cancer scientists link ‘oncometabolite’ to onset of acute myeloid leukemia
9. Rensselaer scientists unlock some key secrets of photosynthesis
10. Scripps Research Institute Scientists Develop Alternative to Gene Therapy
11. Scientists urge new approaches to plant research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Institute for Biologically Inspired Engineering at Harvard University ... be commercialized by a newly formed private company ... personalized medicine products. The announcement follows ... Technology Development (OTD) and the start-up Emulate Inc., ... human Organs-on-Chips platform. , "This is a ...
(Date:7/27/2014)... the asteroid strike that wiped them out if it ... scientists say. , A fresh study using up-to-date fossil ... build a new narrative of the prehistoric creatures, demise, ... in the few million years before a 10km-wide asteroid ... upheaval. This included extensive volcanic activity, changing sea levels ...
(Date:7/27/2014)... potential for global climate change to cut food supplies. ... the interactions between increasing temperature and air pollution ... , A new study involving researchers at MIT shows ... policymakers need to take both warming and air pollution ... looked in detail at global production of four leading ...
Breaking Biology News(10 mins):Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 2Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 3Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3
... Compared to European Americans, African Americans are four to five ... of African Americans with kidney failure have an increased risk ... a role in this skewed risk between races. Previous studies ... a role. The APOL1 gene creates a protein that is ...
... SAN FRANCISCO, Oct. 13, 2011 -- The tiny phytoplankton ... outsized role in drawing carbon from the atmosphere and sequestering ... as ocean water becomes warmer and more acidic, according to ... study published this week in the journal Global Change Biology, ...
... is a master builder. Using a bottom-up approach, nature ... materials, like diamonds, silicon and even table salt. In ... upon the type and arrangement of atoms within the ... University scientists has learned how to top nature by ...
Cached Biology News:Better ways to predict kidney disease risk for African Americans 2Better ways to predict kidney disease risk for African Americans 3Researchers explore plankton's shifting role in deep sea carbon storage 2Researchers explore plankton's shifting role in deep sea carbon storage 3Emulating -- and surpassing -- nature 2Emulating -- and surpassing -- nature 3
(Date:7/28/2014)... , July 28, 2014 /PRNewswire/ -   JOLT ... group of companies to join its growing portfolio of ... of Toronto,s JOLT accelerator, and ... on the roster. Since its launch ... have successfully raised  $7.5M of financing. Now at 23 ...
(Date:7/28/2014)... St Louis, MO (PRWEB) July 28, 2014 ... tools, software, and services that bring the power of ... for the inaugural Appistry Pipeline Challenge . ... Callum Bell, president of the National Center for Genome ... Children’s Mercy Hospitals and Clinics of Kansas City. Rounding ...
(Date:7/28/2014)... , July 28, 2014 Research and Markets ... Size Analysis Market 2014-2018" report to their offering. ... size analysis is a technique used to determine the size ... liquid. It is crucial to analyze the size of particles ... particle size analysis is performed to determine the behavior and ...
(Date:7/25/2014)... of bacteria live in each person,s digestive tract. Scientists ... and stave off harmful infections, but their role in ... shed light on the role of these bacteria, a ... Alm recently tracked fluctuations in the bacterial populations of ... described in the July 25 issue of the journal ...
Breaking Biology Technology:JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 2JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 3Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Global Particle Size Analysis Market 2014-2018 2Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3
... Thomson Reuters announced today the publication of a white ... in entering the Japanese generic drug market. , ... opportunities and strategies for success," notes that a combination ... aging population and wide-ranging government initiatives to reduce healthcare ...
... ROCKVILLE, Md., Oct. 1 Novavax, Inc. (Nasdaq: ... to the board,s corporate governance, compensation and finance committees, replacing ... member James Tananbaum who is retiring from the board. ... and immunology products companies and joined the Novavax board in ...
... BC, Oct. 1 /PRNewswire-FirstCall/ - avVaa World Health Care ... manufacturer and distributor of nationally branded therapeutic, natural skin ... launching their second test run of Neuroskin(R) Psoriasis Relief ... avVaa World Health Care Products will launch a two ...
Cached Biology Technology:Thomson Reuters Explores the Opportunities and Challenges of Entering the Japanese Generic Drug Market 2Thomson Reuters Explores the Opportunities and Challenges of Entering the Japanese Generic Drug Market 3Novavax Announces Board of Director Changes 2Novavax Announces Board of Director Changes 3avVaa World Health Care Products Inc. Announces Second DRTV Test Week 2avVaa World Health Care Products Inc. Announces Second DRTV Test Week 3
Human BMP 2 Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
...
... pAcGHLT-A,B,C Baculovirus ... Set,pAcGHLT-XylE Baculovirus ... Powder,Thrombin Dilution ... Cocktail,Insect Cell ...
...
Biology Products: