Navigation Links
Scientists discover a new player in innate immune response
Date:1/16/2008

All multicellular animals have an innate immune system: When bacteria, parasites or fungi invade the organism, small protein molecules are released that eliminate the attackers. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now discovered a new molecule that plays an important role in triggering the innate immune response of the fruit fly Drosophila, mice and even humans. Their work has just been published in the journal Nature Immunology.

The cells of the innate immune system recognize hostile invaders with the aid of receptors on their surface: The moment these receptors recognize a foreign structure, they send a message, via a complicated signaling pathway, into the cells interior. The cell then releases immunologically active proteins. The components of this signaling pathway have been conserved surprisingly well through evolution; the various signaling molecules are very similar from fly to man, both in structure and in function.

A group of scientists headed by Dr. Michael Boutros of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), collaborating with colleagues of the Centre National de la Recherche Scientifique (CNRS) in Strasbourg, made use of this fact: Using the Nobel-prize winning method of RNA interference (RNAi), they switched off individual molecules of the signaling pathway in Drosophila and have thus come across a new member: Akirin, meaning "making things clear" in Japanese. When they suppressed Akirin production in the immune cells of the flies, these were significantly more susceptible to bacterial infections. And when they knocked down the protein in all body cells, the fly larvae died in an early stage. Colleagues at Japan's Osaka University investigated the corresponding mouse Akirin: In mice, too, the protein fulfills the same function as in the fruit fly and in man.

"What is called the NF-B signaling pathway plays an important role in
'/>"/>

Contact: Stefanie Seltmann
s.seltmann@dkfz.de
49-622-142-2854
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists study the link between childrens nutrition and adult diseases
2. Scientists associate 6 new genetic variants with heart disease risk factor
3. CSHL scientists identify cells that promote formation of lethal lung metastases
4. Smithsonian scientists highlight environmental impacts of biofuels
5. Scientists find missing evolutionary link using tiny fungus crystal
6. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
7. Five young Hebrew University scientists win first competitive EU grants
8. Scientists find good news about methane bubbling up from the ocean floor
9. International scientists tackle obstacles to treating brain disorders
10. UC Irvine scientists find new way to sort stem cells
11. Top scientists meet for global conference on stem cell therapy for cardiovascular diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... PORT WASHINGTON, N.Y. , Oct. 15, 2014 ... in technology solutions for home and community-based care, ... the benefits of implementing Sandata,s Santrax® Electronic Visit ... Quality Care Services is a home health company ... Texas . ...
(Date:10/15/2014)... The German Gauß-Allianz has admitted Johannes Gutenberg University ... the Rhineland-Palatinate science hub continues to maintain a ... computing. , "The acceptance of Johannes Gutenberg ... Gauß-Allianz is a milestone in the national and ... support. The state of Rhineland-Palatinate can be proud ...
(Date:10/15/2014)... Conn. , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market releases ... MarketSite in Times Square on Monday October 13 th . ... CTO David Tunnel and angel investor Mr. Chad ... Pereira , CEO of NXT-ID thanked his investors and employees "for ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
... of the Walter and Eliza Hall Institute of Medical ... of the 2009 Pearl Meister Greengard Prize. ... the accomplishments of outstanding female scientists, at The Rockefeller ... prize was founded by Rockefeller Nobel laureate Paul Greengard ...
... highlands split and the Great Rift Valley formed, the ... different atmospheric circulation patterns than it does today, according ... central African nation. Neil J. Tabor, associate professor ... and an expert in sedimentology and isotope geochemistry, calculated ...
... over could benefit from new software* created at the National ... scientists has found a way to improve the efficiency of ... Alabama at Birmingham (UAB). Pneumonia is the world,s leading ... and poses a serious risk to elderly adults. The leading ...
Cached Biology News:Professor Suzanne Cory awarded 2009 Pearl Meister Greengard Prize 2Ethiopia's climate 27 million years ago had higher rainfall, warmer soil 2Scientists create NICE solution to pneumonia vaccine testing problems 2
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... P. Horovitz , Ph.D., from its board of directors effective ... in August 2003, and served as its chairman from June ... on the Nominating and Corporate Governance and Audit Committees of ... more than a decade of dedicated service to GenVec, and ...
(Date:10/20/2014)... 20, 2014 Earle Martin ... announced today that Ellen Teplitzky, an experienced attorney ... the pharmaceutical industry, has joined the firm as ... legal services practice. NDA Partners provides legal ... and testimony, to top law firms and their ...
(Date:10/19/2014)... 20, 2014 OCTOBER 20-22, ... (ABIM). ABIM will take place at ... about ABIM 2014 is now available at ... representing companies and organizations from all over ... information on the latest products and developments ...
(Date:10/19/2014)... 2014 The Asian Automatic patient billing ... analysis and forecast of revenue. The Automatic patient billing ... $463.9 million by 2018, at a developing CAGR of ... TOC of the Asian Automatic patient billing market, to ... also provides a glimpse of the segmentation of this ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... , , , ... be key regulators of lipid, glucose and overall energy metabolism. Bile acid ... energy expenditure in muscle and brown fat, thereby conferring resistance to weight ... Metabolism (Vol. 10, Issue 3, Sept. 2, 2009) elaborates on a ...
... , ST. LOUIS, Sept. 1 Express Scripts, ... following investor conferences in September: , , Thomas Weisel Partners ... Four Seasons Hotel in Boston, MA. , , Morgan Stanley ... Grand Hyatt Hotel in New York, NY. , , These ...
... PHILADELPHIA, Sept. 1 ERT (Nasdaq: ERES ), announced ... Keith Schneck, the Company,s Executive Vice President and CFO, are scheduled to ... on September 9, 2009 in New York City, New York. , ... Company,s corporate website at http://www.ert.com . The webcast may ...
Cached Biology Technology:Cell Metabolism Publishes Novel TGR5-Mediated Mechanism for the Treatment of Diabetes and Obesity 2Cell Metabolism Publishes Novel TGR5-Mediated Mechanism for the Treatment of Diabetes and Obesity 3Express Scripts to Present at Investor Conferences 2ERT to Present at Baird's 2009 Health Care Conference on September 9, 2009 2
... suspension array system, 100-240 V, uses xMAP ... to 100 proteins and peptides in one ... of up to 100 color-coded bead sets, ... a unique reactant (enzyme substrates, receptors, antigens, ...
... The high-throughput fluidics (HTF) system, 100-240 V, ... suspension array system that automates delivery of ... into the Bio-Plex array reader. The HTF ... nonpressurized bulk sheath container to constantly maintain ...
... PYREX Delong style shaker flasks have three ... agitation of solutions to improve oxygen or ... reciprocating shakers. The long neck reduces splashing ... Their uniform wall thickness provides the proper ...
... gradient system uses two Adept CE 4100 ... CE 4200 dual wavelength detector for added flexibility. ... by PowerStream data processing software and interface unit, ... The supplied analytical pumps may be substituted ...
Biology Products: