Navigation Links
Scientists discover a new player in innate immune response
Date:1/16/2008

All multicellular animals have an innate immune system: When bacteria, parasites or fungi invade the organism, small protein molecules are released that eliminate the attackers. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now discovered a new molecule that plays an important role in triggering the innate immune response of the fruit fly Drosophila, mice and even humans. Their work has just been published in the journal Nature Immunology.

The cells of the innate immune system recognize hostile invaders with the aid of receptors on their surface: The moment these receptors recognize a foreign structure, they send a message, via a complicated signaling pathway, into the cells interior. The cell then releases immunologically active proteins. The components of this signaling pathway have been conserved surprisingly well through evolution; the various signaling molecules are very similar from fly to man, both in structure and in function.

A group of scientists headed by Dr. Michael Boutros of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), collaborating with colleagues of the Centre National de la Recherche Scientifique (CNRS) in Strasbourg, made use of this fact: Using the Nobel-prize winning method of RNA interference (RNAi), they switched off individual molecules of the signaling pathway in Drosophila and have thus come across a new member: Akirin, meaning "making things clear" in Japanese. When they suppressed Akirin production in the immune cells of the flies, these were significantly more susceptible to bacterial infections. And when they knocked down the protein in all body cells, the fly larvae died in an early stage. Colleagues at Japan's Osaka University investigated the corresponding mouse Akirin: In mice, too, the protein fulfills the same function as in the fruit fly and in man.

"What is called the NF-B signaling pathway plays an important role in
'/>"/>

Contact: Stefanie Seltmann
s.seltmann@dkfz.de
49-622-142-2854
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists study the link between childrens nutrition and adult diseases
2. Scientists associate 6 new genetic variants with heart disease risk factor
3. CSHL scientists identify cells that promote formation of lethal lung metastases
4. Smithsonian scientists highlight environmental impacts of biofuels
5. Scientists find missing evolutionary link using tiny fungus crystal
6. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
7. Five young Hebrew University scientists win first competitive EU grants
8. Scientists find good news about methane bubbling up from the ocean floor
9. International scientists tackle obstacles to treating brain disorders
10. UC Irvine scientists find new way to sort stem cells
11. Top scientists meet for global conference on stem cell therapy for cardiovascular diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... fragmentation of forests in the Amazon help create ... to rapid and widespread forest loss during drought ... findings show that forests in the Amazon could ... with forest fires lead to large-scale loss of ... assistant professor of geography, Penn State. , "We ...
(Date:4/17/2014)... in the Cell Press journal Current Biology ... rather novel sex lives. The Brazilian insects, which represent ... Neotrogla , are the first example of an animal ... been identified in several different animals, Neotrogla ... is also reversed," says Kazunori Yoshizawa from Hokkaido University ...
(Date:4/17/2014)... animals and plant life, but there,s an invisible machine ... the soil, decomposing organic matter and releasing carbon into ... play in ecological systems, their identities have only now ... a genetic map of more than 10,000 species of ... week in the Proceedings of the National Academy ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3In sex-reversed cave insects, females have the penises 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3
... found that the allergenicity of peanut products could be ... North Carolina A&T University report their findings today at ... Microbiology. , "Due to the wide use of peanuts ... soups there is a need to inactivate peanut allergens ...
... Researchers from the University of Pittsburgh report the first ... treatment of congenital muscular dystrophy (CMD) in mice, demonstrating ... on gene therapy ever being feasible for children with ... in this week's online edition of the Proceedings of ...
... analyze DNA from giant, extinct lemurs, according to a Yale ... the National Academy of Sciences. , Radiocarbon dating of the ... that each of the individuals analyzed died well over 1,000 ... professor in the Department of Ecology and Evolutionary Biology. , ...
Cached Biology News:No small feat: First ever gene therapy success for muscular dystrophy achieved 2No small feat: First ever gene therapy success for muscular dystrophy achieved 3Ancient DNA confirms single origin of Malagasy primates 2
(Date:1/14/2014)... leading provider of strategic communications services to corporations and organizations preparing ... the United States and Europe , ... returning to the firm,s Washington, D.C. office. ... two years of service as Associate Commissioner for the Office of ...
(Date:1/14/2014)... EquitiesIQ, a leading informational research provider, has ... an emerging biomedical company acquiring, developing, manufacturing, and marketing ... Free report download: http://equitiesiq.com/reports/alliqua/ , In late ... and Board, which launched the company’s new strategy to ...
(Date:1/14/2014)... DIEGO and BETHESDA, Md. ... are joining together with two institutes from the National ... reliable tools for bringing safer, more effective treatments to ... the National Center for Advancing Translational Sciences (NCATS) and ...
(Date:1/14/2014)... Canada (PRWEB) January 14, 2014 In ... its motives and methods in product development and promotion ... the industry. This mistrust, fueled by concerns about the ... fed by reports of spectacular fines to the world’s ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... 10% of all sales ... to be donated to ALSF, ... Tastykake snack line, today announced the re-issue,of Alex,s Lemon Krimpets(R) and ... nation,s leading organizations in the,fight against childhood cancer. Named for Alexandra ...
... 4, 2008 Scientists in fields,as diverse as ... the Olympus FluoroPoint(TM) single molecule fluorescence,detection system for ... laboratories around the world, the system, with its ... use, is now,available for the first time to ...
... Professionals and Addressing the ... Issues Facing Clinical Labs Worldwide, ABBOTT PARK, Ill., April ... support of an initiative to,raise international awareness of the role ... contribution to improve,patient outcomes. Through a program called Labs Are ...
Cached Biology Technology:Tasty Baking Company Continues Partnership With Alex's Lemonade Stand Foundation To Fight Childhood Cancer 2Olympus FluoroPoint(TM) System Provides High-Sensitivity Single Molecule and Protein Interaction Analysis for Screening and Research 2Olympus FluoroPoint(TM) System Provides High-Sensitivity Single Molecule and Protein Interaction Analysis for Screening and Research 3International Federation of Clinical Chemistry Forms Partnership With the Labs Are Vital(TM) Initiative 2International Federation of Clinical Chemistry Forms Partnership With the Labs Are Vital(TM) Initiative 3
MarrowMAX Bone Marrow Medium...
... recognizes murine IRF7 protein, and ... related IRF proteins. Reactivity of ... protein was confirmed by western ... cells transfected with IRF7. Reactivity ...
Rabbit anti-phospho-EGFr (Tyr992) - Concentrate...
Contains L-glutamine...
Biology Products: