Navigation Links
Scientists discover a new player in innate immune response
Date:1/16/2008

All multicellular animals have an innate immune system: When bacteria, parasites or fungi invade the organism, small protein molecules are released that eliminate the attackers. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now discovered a new molecule that plays an important role in triggering the innate immune response of the fruit fly Drosophila, mice and even humans. Their work has just been published in the journal Nature Immunology.

The cells of the innate immune system recognize hostile invaders with the aid of receptors on their surface: The moment these receptors recognize a foreign structure, they send a message, via a complicated signaling pathway, into the cells interior. The cell then releases immunologically active proteins. The components of this signaling pathway have been conserved surprisingly well through evolution; the various signaling molecules are very similar from fly to man, both in structure and in function.

A group of scientists headed by Dr. Michael Boutros of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), collaborating with colleagues of the Centre National de la Recherche Scientifique (CNRS) in Strasbourg, made use of this fact: Using the Nobel-prize winning method of RNA interference (RNAi), they switched off individual molecules of the signaling pathway in Drosophila and have thus come across a new member: Akirin, meaning "making things clear" in Japanese. When they suppressed Akirin production in the immune cells of the flies, these were significantly more susceptible to bacterial infections. And when they knocked down the protein in all body cells, the fly larvae died in an early stage. Colleagues at Japan's Osaka University investigated the corresponding mouse Akirin: In mice, too, the protein fulfills the same function as in the fruit fly and in man.

"What is called the NF-B signaling pathway plays an important role in
'/>"/>

Contact: Stefanie Seltmann
s.seltmann@dkfz.de
49-622-142-2854
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists study the link between childrens nutrition and adult diseases
2. Scientists associate 6 new genetic variants with heart disease risk factor
3. CSHL scientists identify cells that promote formation of lethal lung metastases
4. Smithsonian scientists highlight environmental impacts of biofuels
5. Scientists find missing evolutionary link using tiny fungus crystal
6. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
7. Five young Hebrew University scientists win first competitive EU grants
8. Scientists find good news about methane bubbling up from the ocean floor
9. International scientists tackle obstacles to treating brain disorders
10. UC Irvine scientists find new way to sort stem cells
11. Top scientists meet for global conference on stem cell therapy for cardiovascular diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... 2015  HYPR Corp. today announced it has ... Alliance tm , an industry consortium transforming online ... share technology and collaborate to deliver open specifications ... secure and private, and easier to use. ... protects sensitive user information and eliminates the dependency ...
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
(Date:4/8/2015)... , April 8, 2015  Infinisource, a ... and services, and Morpho, a leading supplier of ... to produce the market,s most advanced biometrically-enabled time ... iSolved NXG time clock is setting a bold, ... labor data for the small and mid-size employer. ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... as a folk remedy, but now scientists from Britain and ... as a treatment for herpes. The team,s findings, published in ... between two teams to established scientific evidence for traditional medicines. ... across mainland Europe and Asia. From the Middle Ages onwards ...
... OAK RIDGE, Tenn, Feb. 22, 2011 -- A theoretical ... National Laboratory is bringing supercomputer simulations and experimental results ... ORNL,s Jeremy Smith collaborated on devising a method -- ... experiments and computer simulations to strengthen analyses of molecules ...
... Conservation Society (WCS) working in conjunction with the Turtle ... from around the world some of which currently ... hunting for both food and the pet trade along ... in the next decade unless drastic conservation measures are ...
Cached Biology News:Old folk remedy revived: How tansy may be a treatment for herpes 2'Fingerprints' match molecular simulations with reality 2Shellshock: New report lists 25 most endangered turtle species 2
(Date:5/4/2015)... May 4, 2015   St. Jude Children,s ... better computer tool for finding genetic alterations that ... were difficult to identify with whole-genome sequencing. The ... Nature Methods . The tool is ... Segmentation by Regression Tree in Next Generation Sequencing. ...
(Date:5/4/2015)... May 4, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) ... on Form 20-F for the fiscal year ended December ... ("SEC"). The annual report on Form 20-F contains information ... in the area of cancer immune checkpoints. This project ... high specificity and binding in targeting certain identified immune ...
(Date:5/4/2015)... , May 4, 2015 /PRNewswire/ - Fluorinov ... to announce the appointment of Dr. Roger J ... experience guiding biotech companies in matters including corporate ... leadership team and adds significant regulatory expertise as ... Dr. Garceau brings 30 years of pharmaceutical development ...
(Date:5/4/2015)... 4, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ... independent team of researchers from South ... (TB4) plays an important role in accelerating the ... an experimental mouse model, by promoting blood vessel ... dermal tissue.  The research found that the underlying ...
Breaking Biology Technology:Scientists dramatically improve method for finding common genetic alterations in tumors 2Scientists dramatically improve method for finding common genetic alterations in tumors 3Scientists dramatically improve method for finding common genetic alterations in tumors 4Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 2Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 3Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 2Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 3
... on Business Expected -, HOUSTON, Sept. 15 ... on an initial assessment, its corporate,headquarters in Houston, ... Hurricane,Ike., However, the facility could remain without ... currently operating out of its disaster recovery,facility., ...
... Medical Corporation,(OTC Bulletin Board: CONX), a worldwide developer ... conference call on Thursday, September,25, 2008, at 4:00 ... operating,performance for its fiscal year ended June 30, ... and marketing activities., Corgenix invites all those ...
... an emerging biotech,company focused on developing novel ... demonstrating that its enzyme,replacement therapy (ERT) for ... been severely weakened by the disease. Earlier ... ENB-0040, significantly,increases survival and prevents bone hypomineralization ...
Cached Biology Technology:Cyberonics Provides Update on Business Operations Following Hurricane Ike 2Cyberonics Provides Update on Business Operations Following Hurricane Ike 3Enobia Pharma Presents PreClinical Data Showing ENB-0040 Significantly Improved Survival and Healed Skeletal Manifestations of Severe Hypophosphatasia in Mice 2Enobia Pharma Presents PreClinical Data Showing ENB-0040 Significantly Improved Survival and Healed Skeletal Manifestations of Severe Hypophosphatasia in Mice 3
Mouse monoclonal [4i144] to HLA Class II DQ1 7 ( Abpromise for all tested applications). Antigen: Full length protein (Human): HLA Class 2 Antigen DQ1,7....
ASCIZ...
Goat polyclonal to CHMP5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-NKDGVLVDEFGLPQ, corresponding to C terminal amino acids 202-215 of Human CHMP5 Entrez GeneID: ...
...
Biology Products: