Navigation Links
Scientists discover a new player in innate immune response
Date:1/16/2008

All multicellular animals have an innate immune system: When bacteria, parasites or fungi invade the organism, small protein molecules are released that eliminate the attackers. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now discovered a new molecule that plays an important role in triggering the innate immune response of the fruit fly Drosophila, mice and even humans. Their work has just been published in the journal Nature Immunology.

The cells of the innate immune system recognize hostile invaders with the aid of receptors on their surface: The moment these receptors recognize a foreign structure, they send a message, via a complicated signaling pathway, into the cells interior. The cell then releases immunologically active proteins. The components of this signaling pathway have been conserved surprisingly well through evolution; the various signaling molecules are very similar from fly to man, both in structure and in function.

A group of scientists headed by Dr. Michael Boutros of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), collaborating with colleagues of the Centre National de la Recherche Scientifique (CNRS) in Strasbourg, made use of this fact: Using the Nobel-prize winning method of RNA interference (RNAi), they switched off individual molecules of the signaling pathway in Drosophila and have thus come across a new member: Akirin, meaning "making things clear" in Japanese. When they suppressed Akirin production in the immune cells of the flies, these were significantly more susceptible to bacterial infections. And when they knocked down the protein in all body cells, the fly larvae died in an early stage. Colleagues at Japan's Osaka University investigated the corresponding mouse Akirin: In mice, too, the protein fulfills the same function as in the fruit fly and in man.

"What is called the NF-B signaling pathway plays an important role in
'/>"/>

Contact: Stefanie Seltmann
s.seltmann@dkfz.de
49-622-142-2854
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists study the link between childrens nutrition and adult diseases
2. Scientists associate 6 new genetic variants with heart disease risk factor
3. CSHL scientists identify cells that promote formation of lethal lung metastases
4. Smithsonian scientists highlight environmental impacts of biofuels
5. Scientists find missing evolutionary link using tiny fungus crystal
6. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
7. Five young Hebrew University scientists win first competitive EU grants
8. Scientists find good news about methane bubbling up from the ocean floor
9. International scientists tackle obstacles to treating brain disorders
10. UC Irvine scientists find new way to sort stem cells
11. Top scientists meet for global conference on stem cell therapy for cardiovascular diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... 2015 Synaptics, Inc. (Nasdaq: SYNA ), ... that members of the executive management team will present ... Technology Leadership Forum on Tuesday, August 11, 2015 at ... at the Sonnenalp Resort in Vail, CO. ... forward-looking information. An audio webcast of the event will ...
(Date:7/31/2015)... SHENZHEN, China , 31 de julio de 2015 ... sobre Genómica (ICG-10,  www.icg-10.org ) del 22 al 25 ... . La conferencia celebra su décimo ... se ha convertido en una de las reuniones anuales ... ,ómicas, y es una de las conferencias científicas más ...
(Date:7/31/2015)... , Chine, 31 juillet 2015 La ... www.icg-10.org ) sera organisée par le BGI du ... Shenzhen en Chine. La ... son inauguration en 2006, l,ICG est devenue l,une ... le domaine des « omiques » et c,est aussi la ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3
... cell scientists have a new theory for how stem ... development. A cell,s fate, the researchers found, is determined ... best known for its role in,inflammation and pain. The ... could potentially,make liver and pancreas cells easier to generate ...
... news release is available in German . ... of amino acids and are vital for all cell processes. Proteases ... they cut other proteins at given positions and thereby execute important ... length or breaking proteins apart they, for example, activate or deactivate ...
... Professor of Entomology at North Carolina State University (NCSU), ... lecture at Entomology 2014, the 62nd Annual Meeting of ... in Portland, Oregon, November 16-19, 2014. The topic ... L. Rabb, a professor of entomology at NCSU and ...
Cached Biology News:Harvard scientists find cell fate switch that decides liver, or pancreas? 2Two new weapons in the battle against bacteria 2NCSU entomologist Fred Gould to present 2014 Founders' Memorial Lecture 2
(Date:9/1/2015)... Sept. 1, 2015 The American Brain Tumor ... for its Discovery Research Grant program. LOIs are due ... noon CDT. Discovery Grants are one-year, $50,000 ... potential to change current diagnostic or treatment paradigms for ... encourage novel research at its earliest stages, in the ...
(Date:9/1/2015)... 2015 Prostate cancer is the second ... men. One in seven men will be diagnosed ... are diagnosed annually. That said, not every diagnosis ... new technique, MRI Fusion Biopsy, to more accurately ... only the affected areas and monitoring areas ...
(Date:9/1/2015)... ... ... In her thought provoking debut novel ‘ Ebola Vaccine Wars ’ (eBookIt.com; ... an Ebola pandemic that is on the cusp of wiping out humanity. Venice introduces ... counterterrorism, and who continues to appear in this series of books by Venice. ...
(Date:9/1/2015)... Poway, CA (PRWEB) , ... September 01, 2015 ... ... Equine Cervical Facet joint disease. , Equine cervical facet joint problems can ... joints gradually enlarge, and can cause impingement of nerve roots or of the ...
Breaking Biology Technology:American Brain Tumor Association Seeks Innovative Concepts For Discovery Research Grants 2September Is Prostate Cancer Awareness Month 2September Is Prostate Cancer Awareness Month 3September Is Prostate Cancer Awareness Month 4Alexi Venice’s Debut Novel Takes on the Human Testing of a Vaccine for Ebola and Revenge by an Anti-Big Pharma Terrorist Group in ‘Ebola Vaccine Wars' 2Alexi Venice’s Debut Novel Takes on the Human Testing of a Vaccine for Ebola and Revenge by an Anti-Big Pharma Terrorist Group in ‘Ebola Vaccine Wars' 3VetStem Biopharma Announces New Clinical Research Program for Equine Cervical Facet Joint Disease 2VetStem Biopharma Announces New Clinical Research Program for Equine Cervical Facet Joint Disease 3
... 2011 SARcode Corporation has named Todd Creech as ... effective February 1, 2011. Creech has been fulfilling both ...   (Photo: http://photos.prnewswire.com/prnh/20110214/FL47222LOGO ) ... experience in finance and leadership roles and has demonstrated ...
... 2011 Aperion Biologics, Inc. announced the enrollment and ... trial of its Z-Lig™ Anterior Cruciate Ligament Reconstruction (ACLR) ... knee.  The primary objective of the multicenter study is ... of Z-Lig in the reconstruction of patients, knees with ...
... 11, 2011 Genesis Biopharma, Inc. (OTC ... developing targeted cancer therapies, today announced that Anthony J. ...  Mr. Cataldo succeeds Robert Brooke, who now serves as ... Company named Michael Handelman as Chief Financial Officer, Treasurer ...
Cached Biology Technology:Todd A. Creech Named Chief Financial Officer and Vice President of Business Development for SARcode Corporation 2Todd A. Creech Named Chief Financial Officer and Vice President of Business Development for SARcode Corporation 3Aperion Biologics Initiates Clinical Trial of Z-Lig™ Device for Anterior Cruciate Ligament Reconstruction 2Genesis Biopharma Announces Management and Board Changes 2Genesis Biopharma Announces Management and Board Changes 3
XBP-1 (F-4)...
Mouse monoclonal [AE3] to Cytokeratin 1 - 8, prediluted ( Abpromise for all tested applications). Antigen: Tissue / cell preparation - Human epidermal cells. Entrez GeneID: 140807 Swiss P...
pETDuet-1 is designed for the coexpression of two target genes....
...
Biology Products: