Navigation Links
Scientists discover a new player in innate immune response
Date:1/16/2008

All multicellular animals have an innate immune system: When bacteria, parasites or fungi invade the organism, small protein molecules are released that eliminate the attackers. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now discovered a new molecule that plays an important role in triggering the innate immune response of the fruit fly Drosophila, mice and even humans. Their work has just been published in the journal Nature Immunology.

The cells of the innate immune system recognize hostile invaders with the aid of receptors on their surface: The moment these receptors recognize a foreign structure, they send a message, via a complicated signaling pathway, into the cells interior. The cell then releases immunologically active proteins. The components of this signaling pathway have been conserved surprisingly well through evolution; the various signaling molecules are very similar from fly to man, both in structure and in function.

A group of scientists headed by Dr. Michael Boutros of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), collaborating with colleagues of the Centre National de la Recherche Scientifique (CNRS) in Strasbourg, made use of this fact: Using the Nobel-prize winning method of RNA interference (RNAi), they switched off individual molecules of the signaling pathway in Drosophila and have thus come across a new member: Akirin, meaning "making things clear" in Japanese. When they suppressed Akirin production in the immune cells of the flies, these were significantly more susceptible to bacterial infections. And when they knocked down the protein in all body cells, the fly larvae died in an early stage. Colleagues at Japan's Osaka University investigated the corresponding mouse Akirin: In mice, too, the protein fulfills the same function as in the fruit fly and in man.

"What is called the NF-B signaling pathway plays an important role in
'/>"/>

Contact: Stefanie Seltmann
s.seltmann@dkfz.de
49-622-142-2854
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists study the link between childrens nutrition and adult diseases
2. Scientists associate 6 new genetic variants with heart disease risk factor
3. CSHL scientists identify cells that promote formation of lethal lung metastases
4. Smithsonian scientists highlight environmental impacts of biofuels
5. Scientists find missing evolutionary link using tiny fungus crystal
6. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
7. Five young Hebrew University scientists win first competitive EU grants
8. Scientists find good news about methane bubbling up from the ocean floor
9. International scientists tackle obstacles to treating brain disorders
10. UC Irvine scientists find new way to sort stem cells
11. Top scientists meet for global conference on stem cell therapy for cardiovascular diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2015)... YORK , July 21, 2015 ... systems, as seen in the recent U.S. Office ... a solution to the infosec conundrum, but developers ... is stored. To address this dilemma, Biometrics-as-a-Service provider ... its Biometric Tokenization SDK for third party integration. ...
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION ... new convenient and secure method to make payments.  ... payment methods, introduced with its groundbreaking voice-direct payment ...
(Date:7/9/2015)... , July 9, 2015  Unchained Labs just ... its acquisition of Avid Nano. Avid Nano designs, ... (DLS) systems.    Also today, Unchained ... and easiest to use protein sizing system. The ... a protein,s hydrodynamic size, size distribution, aggregation population ...
Breaking Biology News(10 mins):HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2
... who receives funding for basic research from the Air ... nanostructures that may some day be used in electronic, ... "Devices that are required in many of the ... in the sense that they are often exposed to ...
... -- Two neuroscientists at Cold Spring Harbor Laboratory (CSHL) ... nationwide named by the director of the National Institutes ... "transformative" research projects. Professor Partha Mitra, Ph.D., and ... selection -- announced by the NIH today -- in ...
... new university/industry network to pursue the development of biomaterials, ... increasing incidence of eye disease. The 20/20: NSERC ... as part of the Natural Sciences and Engineering Research ... Minister of State (Science and Technology) Gary Goodyear today ...
Cached Biology News:AFOSR's basic research may lead to revolutionary new devices 22 neuroscientists from Cold Spring Harbor Laboratory awarded 'transformative' NIH grants 22 neuroscientists from Cold Spring Harbor Laboratory awarded 'transformative' NIH grants 32 neuroscientists from Cold Spring Harbor Laboratory awarded 'transformative' NIH grants 4New research network at McMaster aims to build a better eye 2
(Date:7/28/2015)... Research and Markets ( http://www.researchandmarkets.com/research/z54c4k/biomedical ) ... Refrigerators and Freezers Market - Global Industry Analysis, ... 2022" report to their offering. ... has been segmented based on applications: hospitals, research ... The others segment includes applications of biomedical refrigerators ...
(Date:7/28/2015)... , July 28, 2015  Moerae Matrix Inc. ... 1 clinical trial with MMI-0100, a first-in-class inhibitor ... developed for pulmonary disorders characterized by inflammation and ... United Kingdom , is a double-blind, two-way ... the safety and tolerability of MMI-0100 when given ...
(Date:7/28/2015)... , July 28, 2015 ... company utilizing its proprietary plant-based rhCollagen technology for ... has been appointed Senior Director of Business Development, ... http://photos.prnewswire.com/prnh/20150728/246955 ) , Ms. ... marketing, regulatory and business strategy. Prior to joining ...
(Date:7/27/2015)... ... July 27, 2015 , ... ... the Biophotonics industry.The report provides a basic overview of the industry including definitions, ... the international markets including development trends, competitive landscape analysis, and key regions development ...
Breaking Biology Technology:Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 2Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 3Moerae Initiates Lipopolysaccharide (LPS) Challenge Study of Inhaled MMI-0100 for Pulmonary Disease Following Encouraging Safety and Tolerability Observed in Single Ascending Dose Phase 1 Study 2CollPlant Names Shomrat Shurtz Senior Director of Business Development 22015 Biophotonics Market Global Research 22015 Biophotonics Market Global Research 3
... Consulting US, a division of London-based Double Helix ... Stuchiner to the position of Vice President. ... strategic pricing, reimbursement and market access consultants with ... product commercialization services to firms in the pharmaceutical, ...
... Calif., March 30 TorreyPines Therapeutics, Inc. (Nasdaq: ... District Court of the Southern District of New York ... of Axonyx Inc. ("Axonyx") against Axonyx and several of ... in 2006. The plaintiffs alleged that the defendants made ...
... 30 BioMedical Enterprises, Inc. (BME), a rapidly growing ... orthopaedic memory metal implants, announced today that it has ... and Marketing. BME specializes in nitinol implants that ... together to promote bone union. The O ...
Cached Biology Technology:Double Helix Appoints Ann Stuchiner Vice President of US Consulting Division 2Stockholder Suits Related to TorreyPines Therapeutics, Inc. Dismissed 2BioMedical Enterprises, Inc. (BME) Announces the Appointment of Keith M. Peeples as Vice President, Sales and Marketing 2
... assay kit provides complete components including ... convenient detection of DNA fragmentation in ... incorporation of BrdU in the procedure ... digoxigenylated methods. Results can be analyzed ...
... LAS-3000 imaging system combines new CCD ... interface, providing significantly improved system sensitivity ... The system is especially dedicated to ... system for Western blotting applications.,Fuiji's LAS-3000 ...
... Life Science LAS-3000mini is a compact ... chemiluminescence applications, and the perfect standard ... 's LAS-3000 provides significantly improved system ... Glowell calibration standards validate that Fujis ...
... assays. The TUNEL-based assay kit provides complete ... for convenient detection of DNA fragmentation in ... offers an one-step labeling of apoptotic cells. ... hallmark of apoptosis in mammalian cells. MBLs ...
Biology Products: