Navigation Links
Scientists chart gene expression in the brain across lifespan
Date:10/28/2011

The "switching on" or expression of specific genes in the human genome is what makes each human tissue and each human being unique. A new study by researchers at the Johns Hopkins Bloomberg School of Public Health, the Lieber Institute for Brain Development, and the National Institute of Mental Health found that many gene expression changes that occur during fetal development are reversed immediately after birth. Reversals of fetal expression changes are also seen again much later in life during normal aging of the brain. Additionally, the team observed the reversal of fetal expression changes in Alzheimer's disease findings reported in other studies. The research team also found that gene expression change is fastest in human brain tissue during fetal development, slows down through childhood and adolescence, stabilizes in adulthood, and then speeds up again after age 50, with distinct redirection of expression changes prior to birth and in early adulthood. Their findings are published in the Oct. 27, 2011, edition of Nature. All of the data are available to the public as a web-based resource at: http://www.libd.org/braincloud.

Using a number of genomic analysis technologies, the research team conducted genome-wide genetic (DNA) and gene expression (RNA) analyses of brain tissue samples from the prefrontal cortex. Tissue represented the various stages of the human lifespan.

"We think that these coordinated changes in gene expression connecting fetal development with aging and neurodegeneration are central to how the genome constructs the human brain and how the brain ages," said Carlo Colantuoni, PhD, one of the lead authors of the study and a former research associate with the Department of Biostatistics at the Johns Hopkins Bloomberg School of Public Health. Colantuoni recently joined the Lieber Institute for Brain Development on the Johns Hopkins Medical Campus.

The research also
'/>"/>

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... Utah , Dec. 4, 2014  Tute Genomics, ... raised $2.3 million in Series A1 funding led by ... investors also participated in the investment round. ... the healthcare community adopts next-generation sequencing and seeks new ... said Reid Robison , MD MBA, and CEO ...
(Date:11/21/2014)... -- Earlier this year Donald Spector , Chairman of ... the most prolific inventors in the world, got a ... to third party agencies. Spector envisioned this technology even ... earliest known patents in this area. Now major technology ... care, elder care and hospital applications. This technology has ...
(Date:11/18/2014)... 17, 2014   News Highlights: ... to develop The Partners Data Lake, an agile ... Data Lake will allow researcher and clinicians to ... and the lives of patients , The ... activities across the Partners system, breaking down physical ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... solar cells are expected to be highly efficient, thinner, more ... cells of today. This could pave the way for them ... globally. Nanyang Technological University (NTU) today announced that it ... set up a new research centre that will pioneer the ...
... co-authored by Columbia Engineering professor Kartik Chandran and recently ... , shows that reducing nitrogen pollution generated by wastewater ... well as the expected benefits for the environment. ... U.S. who worked on the study, along with James ...
... BELLINZONA (Switzerland) July 28, 2011 A paper ... , describes a novel, proprietary monoclonal antibody (FI6) discovered ... for Research in Biomedicine ("IRB") and the UK Medical ... that targets all 16 hemagglutinin subtypes of influenza A ...
Cached Biology News:NTU unveils new center to develop solar cells and clean energy systems of tomorrow 2NTU unveils new center to develop solar cells and clean energy systems of tomorrow 3New study outlines economic and environmental benefits to reducing nitrogen pollution 2New study outlines economic and environmental benefits to reducing nitrogen pollution 3Humabs discovers the first antibody to neutralize both group 1 and group 2 influenza A viruses 2
(Date:12/19/2014)... YORK , Dec. 18, 2014 Relmada ... therapies for the treatment of chronic pain, announced the ... today. "This was a transformational year in ... promising future for our company," said Sergio Traversa ... year, we have executed on key financial, human resource ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 Based ... the overall surgical imaging market is dominated by ... the surgical imaging market. These players include GE ... Ziehm Imaging (Germany). , Full Report Copy ... of GE Healthcare can be attributed to its ...
(Date:12/17/2014)... 17, 2014 Achim Noack has been ... Stoller Group. In this position, Noack will assist Jerry ... matters, develop marketing strategy and supervise global marketing management ... “Achim has tremendous knowledge and experience in the crop ... “His experience and innovative thinking will be a great ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 Once more, ... provide a larger packaged waste water treatment plant to ... Abdullah Economic City (KAEC). Two years ago Bioshaft successfully ... Gate Development, serving two residential towers with an occupancy ... over a quarter million gallons per day and was ...
Breaking Biology Technology:Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2
... - Rich media developer Sonic Foundry, Inc. ... that has enabled it to access what CEO Rimas Buinevicius ... this process in motion with a registered direct filing ... that seeks to establish a three-year timeframe in which the ...
... Most school districts still are not teaching skills needed for ... are behind in understanding that we are way beyond the ... teaching the classical three Rs. I am not talking about ... and routine. All of these add up to regimentation, which ...
... - Global Renewable LLC, a Whitewater, Wis. partnership that includes ... build and operate a $195 million ethanol plant in the ... approvals, the Sharon Ethanol Plant annually would produce between 105 ... estimated 55 new full-time jobs and more than 200 temporary ...
Cached Biology Technology:Sonic Foundry explores capital options 2Rote education fails the Information Age 2Rote education fails the Information Age 3Rote education fails the Information Age 4
Goat polyclonal to Haptoglobin ( Abpromise for all tested applications). Antigen: Affinity purified human haptoglobin. Entrez GeneID: 3240 Swiss Protein ID: P00738...
Rabbit polyclonal to Somatostatin 28 ( Abpromise for all tested applications). entrezGeneID: 6750 SwissProtID: P61278...
... 96 well Magnetic-Ring Stand is designed for ... U-bottom microplates. The stand has a plastic ... microtiter plate footprint. The use of 96 ... and easy magnetic separation. With this magnetic ...
... polymerase from Thermus aquaticus expressed in E. ... tube of 250 units enzyme/tube and Buffer ... is the same enzyme as AmpliTaq DNA ... proprietary separation process to ensure that contaminating ...
Biology Products: