Navigation Links
Salk scientists open new window into how cancers override cellular growth controls
Date:3/21/2012

LA JOLLA, CA----Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at the end of each chromosome.

Loss of telomeres forces cells out of the dividing game and into a growth arrest state called "senescence," but cancer cells evade this by employing an enzyme called telomerase to extend eroded telomeres.

If telomerase fails to activate, the tumor cells of about 10 percent of all human cancers have a back-up strategy to build serviceable telomeres and keep dividing. How that pathway, called ALT for alternative lengthening of telomeres, works is unclear, because researchers have had limited options to study it experimentally.

Now scientists at the at Salk Institute for Biological Studies have created roundworms that eke out an existence, and even manage to reproduce, relying solely on ALT to maintain telomeres. That study, published March 16 in EMBO Journal, provides a valuable tool to tinker with the ALT pathway and learn how to block it, with a goal of forcing tumor cells to senesce.

"These worms are the first multicellular organisms we can study in the laboratory that maintain their telomeres through the ALT pathway and not through telomerase," says Jan Karlseder, a professor in Salk's Molecular and Cell Biology Laboratory and the study's senior author. "Up to now we could only study ALT in cell lines derived from tumor cells. Now we can screen for compounds and genes that suppress or regulate ALT in a whole organism, which in worms is fairly easy to do."

The components of telomere-building pathways are prime targets for cancer researchers. "There is a huge interest in drugs that block telomerase, since 90 percent of cancers use it for telomere maintenance," says Daniel Lackner, a postdoctoral fellow in the Karlseder lab and one of the study's first authors. "But these drugs won't work for the 10
'/>"/>

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists discover new method of proton transfer
2. Brandeis scientists win prestigious prize for circadian rhythms research
3. American Society of Plant Biologists honors early career women scientists
4. Scientists produce eye structures from human blood-derived stem cells
5. Queens scientists seek vaccine for Pseudomonas infection
6. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
7. A*STAR scientists make groundbreaking discovery on stem cell regulation
8. Scripps Florida scientists awarded $3 million to develop new, more effective pain treatments
9. Scientists learn how insects remodel their bodies between life stages
10. UF scientists name new ancient camels from Panama Canal excavation
11. MU scientists study how to improve pesticide efficiency
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Salk scientists open new window into how cancers override cellular growth controls
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION ... new convenient and secure method to make payments.  ... payment methods, introduced with its groundbreaking voice-direct payment ...
(Date:7/9/2015)... Calif. , July 9, 2015 /PRNewswire/ ... leading developer of human interface solutions, today ... the industry,s first fully hardware encapsulated fingerprint ... secure authentication technology is literally off the ... and biometric matching within the fingerprint sensor ...
(Date:7/8/2015)... , July 8, 2015 The ... as this summer,s must have products such as wearables, smart ... as popularity for biometrics based devices continues to rapidly grow.  ... Inc. (NASDAQ: NXTD ), Google Inc. (NASDAQ: GOOG ... FIT ), GoPro, Inc. (NASDAQ: GPRO ) and ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6
... of the past decade such as the 2003 SARS ... deaths, and the 2009 H1N1 flu pandemic that killed about ... or bacteria could spread quickly across the globe, aided by ... complex network systems such as contagion patterns and information ...
... 16, 2012, Chikyu, operations in the second part of ... Drilling Project (JFAST), achieved another objective by installing temperature ... infers the fault slipped during the 2011 Tohoku Earthquake. ... scientific drilling vessel Chikyu to meet the challenge of ...
... Using recent advances in marine biomechanics, materials science, and ... and the California Institute of Technology (Caltech) have turned ... freely swimming "jellyfish." The finding serves as a ... muscular organs and simple life forms. It also suggests ...
Cached Biology News:New model of disease contagion ranks US airports in terms of their spreading influence 2New model of disease contagion ranks US airports in terms of their spreading influence 3Return to the Japan Trench 2Return to the Japan Trench 3Artificial jellyfish swims in a heartbeat 2Artificial jellyfish swims in a heartbeat 3Artificial jellyfish swims in a heartbeat 4
(Date:7/27/2015)... Wis. (PRWEB) , ... July 27, 2015 , ... ... and facility identification solutions, today announced a new video: 3 Ways to ... OSHA’s Hazard Communication Standard and the Globally Harmonized System (GHS) by effectively labeling ...
(Date:7/27/2015)... NEW YORK , July 27, 2015 /PRNewswire-USNewswire/ ... today announced the winners of its annual ... basic research by scientists who have been supported ... early career scientists to pursue innovative ideas in ... generate "proof" of concept for the early detection, ...
(Date:7/25/2015)... ... July 25, 2015 , ... Technology leader Anton Paar offers ... adjusts the surface temperature of the measuring prism. This is required to achieve ... and documentation are key requirements. It is likely that no refractometer manufacturers on ...
(Date:7/24/2015)... , July 24, 2015 Orexigen Therapeutics, Inc. ... results for the second quarter 2015 on Thursday, August ... will provide a business update and discuss the financial ... 8:00 a.m. Eastern Time (5:00 a.m. Pacific Time). ... by calling (800) 447-0521 (domestic) or (847) 413-3238 (international), ...
Breaking Biology Technology:Brady Releases “3 Roads to GHS Labels” Video 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 4Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 5Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 6It’s T-Time for Refractometers: On-site Temperature Check Now Available 2
... disease detection facility, developed by the University of Leicester, ... in Leicester Royal Infirmary,s A&E department. It is ... disease without the use of invasive probes, blood tests, ... three different types of cutting-edge technology in combination under ...
... Researchers at Duke University Medical Center, Beth Israel Deaconess Medical ... HIV vaccine design that uses an altered form of HIV,s ... showed that they could design HIV envelopes that could bind ... immune response in an animal model. Immature B cells are ...
... , Porphyrins are organic molecules that appear in the ... and have a metal atom ,at their center that ... ,in the field of molecular electronics lies in their ... explains the responsible of the work at the Nanomaterials ...
Cached Biology Technology:Leicester scientists deploy space-age technologies at science-fiction style 'sick bay' 2Leicester scientists deploy space-age technologies at science-fiction style 'sick bay' 3Leicester scientists deploy space-age technologies at science-fiction style 'sick bay' 4New HIV vaccine approach targets desirable immune cells 2New HIV vaccine approach targets desirable immune cells 3The quantum tunneling effect leads electron transport in porphyrins 2
... Loading Buffer contains a precipitant to ensure that ... tracking dye to allow the user to follow ... ReddyRun™: ABgene ® s proprietary mixture ... same buffer composition used in ReddyRun™ molecular weight ...
... number is a new ... easily match Cornings product ... availability yet, please order ... number (Z71,381-3) or contact ...
Excellent safety and durability., Remote control can be easily operated in your hand., Constant voltage control with 2 sets of terminals., Precise and durable circuit design. ...
Gel Loading Buffer contains a precipitant to ensure that the samples sink into the wells and a tracking dye to allow the user to follow the progress of electrophoresis....
Biology Products: