Navigation Links
Salk scientists open new window into how cancers override cellular growth controls
Date:3/21/2012

LA JOLLA, CA----Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at the end of each chromosome.

Loss of telomeres forces cells out of the dividing game and into a growth arrest state called "senescence," but cancer cells evade this by employing an enzyme called telomerase to extend eroded telomeres.

If telomerase fails to activate, the tumor cells of about 10 percent of all human cancers have a back-up strategy to build serviceable telomeres and keep dividing. How that pathway, called ALT for alternative lengthening of telomeres, works is unclear, because researchers have had limited options to study it experimentally.

Now scientists at the at Salk Institute for Biological Studies have created roundworms that eke out an existence, and even manage to reproduce, relying solely on ALT to maintain telomeres. That study, published March 16 in EMBO Journal, provides a valuable tool to tinker with the ALT pathway and learn how to block it, with a goal of forcing tumor cells to senesce.

"These worms are the first multicellular organisms we can study in the laboratory that maintain their telomeres through the ALT pathway and not through telomerase," says Jan Karlseder, a professor in Salk's Molecular and Cell Biology Laboratory and the study's senior author. "Up to now we could only study ALT in cell lines derived from tumor cells. Now we can screen for compounds and genes that suppress or regulate ALT in a whole organism, which in worms is fairly easy to do."

The components of telomere-building pathways are prime targets for cancer researchers. "There is a huge interest in drugs that block telomerase, since 90 percent of cancers use it for telomere maintenance," says Daniel Lackner, a postdoctoral fellow in the Karlseder lab and one of the study's first authors. "But these drugs won't work for the 10
'/>"/>

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists discover new method of proton transfer
2. Brandeis scientists win prestigious prize for circadian rhythms research
3. American Society of Plant Biologists honors early career women scientists
4. Scientists produce eye structures from human blood-derived stem cells
5. Queens scientists seek vaccine for Pseudomonas infection
6. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
7. A*STAR scientists make groundbreaking discovery on stem cell regulation
8. Scripps Florida scientists awarded $3 million to develop new, more effective pain treatments
9. Scientists learn how insects remodel their bodies between life stages
10. UF scientists name new ancient camels from Panama Canal excavation
11. MU scientists study how to improve pesticide efficiency
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Salk scientists open new window into how cancers override cellular growth controls
(Date:8/6/2015)... Calif. , Aug. 6, 2015  Today, ... will visit Crossmatch ™ to learn firsthand ... and protect data. Crossmatch is a world leader ... technologies and expertise are helping federal agencies and ... and security.   "The vast majority ...
(Date:8/5/2015)... , Aug. 5, 2015 The biosensors market ... in applications, penetration into newer sectors, and development of ... global biosensors space has seen the entry of multiple ... so far. (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) ... Analysis of the Global Biosensors Market ( ...
(Date:7/31/2015)... julio de 2015 BGI llevará a cabo la ... 22 al 25 de octubre de 2015, en ... celebra su décimo aniversario este año. Desde su inauguración ... las reuniones anuales más influyentes del mundo en los ... conferencias científicas más dinámicas, entusiastas y amenas. ...
Breaking Biology News(10 mins):Rep. Honda to Visit Crossmatch in Redwood City 2Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3
... studied human brain samples to isolate a set of proteins ... shows an intriguing link between diseases and the evolution of ... of medical disability in the developed world according to the ... exceeds $300 billion. The brain is the most complex ...
... Federal Ministry of Education and Research (BMBF) will fund ... (FRM II) by German and international researchers to the ... years. The Helmholtz Research Centers Juelich, Berlin, and Geesthacht ... budgets. The basis for these grants is the cooperation ...
... It,s just a worm, a tiny soil-dwelling nematode worm ... biology as shown in a recent study authored by University ... on the circadian clock of the Caenorhabditis elegans ... Biology . "Circadian rhythms are important in all ...
Cached Biology News:The genetic basis of brain diseases 2The genetic basis of brain diseases 3German federal government bolsters neutron research in Garching 2German federal government bolsters neutron research in Garching 3Breakthrough in worm research has implications for human disease studies 2
(Date:8/27/2015)... MENLO PARK, Calif. , Aug. 27, 2015 /PRNewswire/ ... company in the emerging field of regenerative medicine, today ... two investor conferences in the month of September.  ... Officer, will present at Rodman & Renshaw,s 17th Annual ... 10:25am ET/7:25am PT at the St. Regis Hotel in ...
(Date:8/27/2015)... 27, 2015 HUYA Bioscience International (HUYA) today announced ... Japan Society of HTLV-1, held this week at the ... of the Society is to promote research on HTLV-1 ... medical technology and research related to these fields to ... "HUYA is proud to support this prestigious conference," said ...
(Date:8/27/2015)... (PRWEB) , ... August 27, 2015 , ... Inc. Magazine ... States, ranking iLab Solutions as number 1,361 in growth for the three years through ... the top 0.1% fastest-growing privately held organizations in the country. , “We are ...
(Date:8/27/2015)... TRIANGLE PARK, N.C. , Aug. 27, 2015 ... on the decision by FedEx, UPS and The ... of certain biological specimens classified as ,select agents, ... and long history of handling these sensitive shipments. ... knowledge of global transportation regulations, trained and certified ...
Breaking Biology Technology:Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... Calif., Oct. 14 GenVault Corporation today,announces that ... Senior Vice,President of Business Development. Mr. Sutherland will ... for partnering,and licensing the company,s products and technologies ... Mr. Sutherland has more than 25 years ...
... Systems, Inc., (OTC Bulletin Board: IMDS) a pioneer ... that its,distributor, Laszlo Meszaros of Kardia Hungary Kft., ... for Budapest, Hungary., (Logo: http://www.newscom.com/cgi-bin/prnh/20040412/IMDSLOGO ... at the new MeDoc HealthCare Center,(MDHC) located in ...
... chosen to enable patient care services in Australia through ... ... 110th Annual Convention --,Mirixa Corporation, the leader in pharmacy-based patient ... Australia, announced,today that they have signed a definitive technology licensing ...
Cached Biology Technology:Mark Sutherland Joins GenVault as Senior Vice President, Business Development 2Imaging Diagnostic Systems Sells Its CT Laser Mammography System to Budapest, Hungary 2Mirixa Announces Agreement With the Pharmacy Guild of Australia 2Mirixa Announces Agreement With the Pharmacy Guild of Australia 3
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed...
Protein 3D structure prediction, via threading. Easy to use....
... Standard Tray (3 per pack), 1. ... and blot processing.Automated staining of Coomassie ... and nucleic acid analysis.Prepares blots for ... detection.Programmable control of protocol, solution, volume, ...
DITHIOTHREITOL, 150UMOL, 1 EA. Dithiothreitol (DTT), 0.1 M Solution:, *0.1 M solution of DTT in high purity dH2O., *0.2 m filtered., *Storage: -20C. Category: SEQUENASE....
Biology Products: