Navigation Links
Saint Louis University researchers discover a way to detect new viruses
Date:6/17/2013

ST. LOUIS -- In research published in Biochemical and Biophysical Research Communications, Saint Louis University researchers describe a technology that can detect new, previously unknown viruses. The technique offers the potential to screen patients for viruses even when doctors have not identified a particular virus as the likely source of an infection.

In the new approach, scientists use blood serum as a biological source to categorize and discover viruses.

Taking advantage of the complete deciphering of the human genome, SLU researchers used a next-generation sequencing (NGS) approach called transcriptome subtraction. With this process, the research team subtracted the entire human genetic sequence from the genetic material in the blood they were examining. By studying what remained, they were able to identify viral genetic material in the blood.

"We have discovered a technology that allows us to detect new viruses," said Adrian Di Bisceglie, M.D., chairman of the department of internal medicine at Saint Louis University. "We isolate DNA and RNA, amplify the amount of genetic material present in the blood, do ultra-deep sequencing and use an algorithm to search for matches for every known piece of genetic code, both human and for microbes.

"Once we remove the known portions, we're ultimately left with new viruses."

When doctors suspect that a patient has a viral infection, it can be difficult to determine which virus is the culprit.

One way to test for the presence of a virus is to grow it in the lab from a biological sample, like tissue or blood, from the patient. However, that approach won't work if tissue isn't available, if there is no logical starting place for deciding which viruses to screen for (such as knowing that a patient was exposed to a particular virus), or in a "hit and run" viral infection, in which case there is a narrow time frame for tissue sampling.

Another o
'/>"/>

Contact: Carrie Bebermeyer
bebermcl@slu.edu
314-977-8015
Saint Louis University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
2. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
3. In a fight to the finish, Saint Louis University research aims knockout punch at hepatitis B
4. Saint Louis University, University of Toronto biologists help decode turtle genome
5. BP Deepwater Horizon oil spill exacerbated existing environmental problems in Louisiana marshes
6. SMU professor Louis Jacobs honored with prestigious award from Texas science teachers
7. Louisiana Tech University professor earns national honor from Society of American Foresters
8. University of Houston study shows BP oil spill hurt marshes, but recovery possible
9. University of Alberta led research may have discovered how memories are encoded in our brains
10. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
11. Marshall University study may lead to new treatments for prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... interim director of the University of Montana,s Wildlife Biology Program, ... Proceedings of the National Academy of Sciences on how ... ... Survey, the University of Washington, the Cary Institute of Ecosystem ... Northern Research Station examined 664 water samples collected every 10 ...
(Date:4/22/2014)... 22, 2014) Biotechnology scientists must be aware of ... and licensing guidelines, according to a new paper from ... in the current issue of the journal Regenerative ... 2013 U.S. Supreme Court ruling in the case Association ... occurring genes are unpatentable. The court case and rulings ...
(Date:4/22/2014)... London PETA International Science Consortium Ltd.,s nanotechnology expert ... strategy for nanomaterial hazard assessment" at the 7th ... 2014, in Antalya, Turkey. , Dr. Monita Sharma ... from the US National Academy of Sciences, " Toxicity ... Strategy ," which recommends use of non-animal methods involving ...
Breaking Biology News(10 mins):New research focuses on streamwater chemistry, landscape variation 2New patenting guidelines are needed for biotechnology 2New patenting guidelines are needed for biotechnology 3
... hit Rhode Island's Narragansett Bay during the summer of ... literally suffocates sea life. While some evidence of this ... Brown University ecologists went underwater and discovered a massive ... reefs located in the central bay, researchers found one ...
... environmental problem, especially on the Indian subcontinent. Researchers at ... genetic techniques to create "arsenic-eating" plants that could be ... however. The arsenic sequestered from soil remained largely in ... harvest for safe disposal. Now, the research team, led ...
... and breast cancers are leading causes of cancer death ... In a new scientific study, researchers present astonishing new ... the capacity to contribute to the process of early ... be published in the March 2006 issue of the ...
Cached Biology News:'Dead zone' summer killed billions of ocean state mussels 2Researchers discover way to transport environmental arsenic to plant leaves in new clean-up strategy 2Can dogs smell cancer? 2
(Date:1/15/2014)... 15, 2014 Cynvenio, a cancer diagnostics ... the genomic analysis of tumor cells in the bloodstream, ... web-based cancer decision support application powered by CollabRx, Inc. ... ClearID™ genomic test, Therapy Finder will provide breast cancer ...
(Date:1/15/2014)... RedBrick Health , a fast-growing leader in consumer ... EmblemHealth , the New York ... the RedBrick Compass health assessment, combined with the RedBrick ... members. EmblemHealth is among the first health plans in ...
(Date:1/15/2014)... A study has been launched to test whether technology ... help to tackle the problem of obesity.  This unique healthcare ... based in Stowmarket) and academics at University Campus Suffolk is ... which is inspired by equipment used to collect data about ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Two champions ... continued their sponsorship of an annual competition for middle ... and access to, innovative STEM study. The competition presents ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... hundreds of FDA inspectors; now it trains thousands of ... global team of FDA compliance experts, EduQuest is presenting ... training course for quality managers and regulatory specialists December ... (near I-95, Amtrak rail lines, and the Philadelphia airport). ...
... Inc. (OTC Bulletin Board: WDST ) a ... therapies to restore the health of damaged tissues and ... Randall McCoy and Chief Financial Officer, John Weber will ... 2010TIME: , 7:00 PM ESTLINK: , www.retailinvestorconferences.com ...
... ... ... ... by longUrl, so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
Cached Biology Technology:Former FDA Inspectors Train Medical Device, Pharmaceutical Companies How to Comply with Latest FDA Expectations for Validation and Part 11 2Regenicin to Present Live at RetailInvestorConferences.com on November 4th 2Hikma Expands its Global Injectables Business - Live Webcast 2Hikma Expands its Global Injectables Business - Live Webcast 3Hikma Expands its Global Injectables Business - Live Webcast 4Hikma Expands its Global Injectables Business - Live Webcast 5Hikma Expands its Global Injectables Business - Live Webcast 6Hikma Expands its Global Injectables Business - Live Webcast 7
...
Hamster serum...
... Labeling Kit with CyScribe GFX Purification ... and purification of Cy3- and Cy5-labeled ... complete cDNA labeling and purification.Flexible and ... performing labeling reactions with either Cy3- ...
Canine Serum...
Biology Products: