Navigation Links
Safer, cheaper building blocks for future anti-HIV and cancer drugs
Date:7/3/2014

A team of researchers from KU Leuven, in Belgium, has developed an economical, reliable and heavy metal-free chemical reaction that yields fully functional 1,2,3-triazoles. Triazoles are chemical compounds that can be used as building blocks for more complex chemical compounds, including pharmaceutical drugs.

Leveraging the compound's surprisingly stable structure, drug developers have successfully used 1,2,3-triazoles as building blocks in various anti-HIV, anti-cancer and anti-bacterial drugs. But efforts to synthesize the compound have been hampered by one serious hurdle: they depend on harmful heavy metals to work, and this severely limits their biological applications.

In new experiments reported in the journal Angewandte Chemie, Dr. Joice Thomas, Prof. Dr. Wim Dehaen and their team at KU Leuven's Molecular Design and Synthesis lab confirm for the first time that 1,2,3-triazoles can be synthesized through a metal-free, three-component reaction using readily available ingredients.

"We were able to develop a reaction that provided a good yield, high regioselectivity and easy access to diversely functionalized 1,2,3-triazoles," says corresponding author Prof. Dr. Wim Dehaen. "In other words, the reaction produces plenty of the compounds we're looking for, does so reliably without unwanted or unexpected outcomes, and does this in a way that makes it easy for us to isolate the compound. This makes our method highly desirable."

"Moving forward, we will focus on expanding the chemistry developed here to other new reactions while also exploring their possible applications in pharmaceutical as well as supra-molecular sciences," says lead author Dr. Joice Thomas.


'/>"/>

Contact: Wim Dehaen
wim.dehaen@chem.kuleuven.be
32-163-27439
KU Leuven
Source:Eurekalert

Page: 1

Related biology news :

1. New class of nanoparticle brings cheaper, lighter solar cells outdoors
2. Shifting evolution into reverse promises cheaper, greener way to make new drugs
3. Now it will become cheaper to make second-generation biofuel for our cars
4. A quicker, cheaper way to detect staph in the body
5. Iron-based process promises greener, cheaper and safer drug and perfume production
6. New method to diagnose sepsis is faster, cheaper
7. Novel LEDs pave the way to cheaper displays
8. Team uses forest waste to develop cheaper, greener supercapacitors
9. A route for steeper, cheaper, and deeper roots
10. Breakthrough could lead to cheaper, more sustainable chemical production
11. Waste cooking oil makes bioplastics cheaper
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Queen in Lewis Carroll,s Through the Looking Glass, ... University of Singapore improved a 35-year-old ecology model ... to millions of years. , The new model, ... the "Red Queen Effect," an evolutionary hypothesis introduced ... suggests that organisms must constantly increase their fitness ...
(Date:7/30/2014)... A deep-sea octopus protected and tended her eggs until ... published July 30, 2014 in the open-access journal ... Aquarium Research Institute and colleagues. , Octopuses typically have ... females protect and take care of their fertilized eggs ... eggs for 1 to 3 months, but little is ...
(Date:7/30/2014)... Chemical Society (ACS) announced today that David L. Kaplan, ... Biomaterials Science & Engineering as editor-in-chief. With the ... new journal will feature high-quality research in the rapidly ... naturally derived materials that interact with living or biological ... reflects the tremendous growth in the field of biomaterials ...
Breaking Biology News(10 mins):Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3Deep-sea octopus has longest-known egg-brooding period 2ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor 2
... is also available in Chinese on EurekAlert! ... A new laser-beam steering system that aims and focuses bursts ... has been demonstrated by collaborating researchers from Duke University and ... Applied Physics Letters , published by the American Institute of ...
... the RMS Titanic, which is contributing to its deterioration. ... the exterior of ships and underwater metal structures such ... findings in the latest issue of the International ... 8 December, isolated the micro-organisms from a ,rusticle, collected ...
... book, Illinois Birds: A Century of Change, literally took 100 ... Illinois was conducted from 1906-1909. It was repeated from 1956-1958 ... When the 100-year anniversary of that first survey was approaching, ... seized the window of opportunity to do it again and ...
Cached Biology News:Tiny laser light show illuminates quantum computing 2New microscopic life aboard the RMS Titanic 2New book on 100 years of Illinois birds 2New book on 100 years of Illinois birds 3New book on 100 years of Illinois birds 4
(Date:7/30/2014)... , July 30, 2014 Regulus Therapeutics ... company leading the discovery and development of innovative medicines ... results and highlights for the quarter ended June 30, ... financial markets close. Regulus will host ... 2014, at 5:00 pm Eastern Daylight Time to discuss ...
(Date:7/30/2014)... N.Y. and PARIS , ... and Sanofi (EURONEXT: SAN and NYSE: SNY) today announced ... and Drug Administration (FDA) rare pediatric disease priority review ... submission for alirocumab.  The priority review voucher entitles the ... provides for an expedited 6-month review from the filing ...
(Date:7/30/2014)... 2014 W. R. Grace & ... the REVELERIS® Prep purification system , a ... and other researchers to perform both flash and ... , With the REVELERIS® Prep purification system, researchers ... modes with a simple touch of the screen, ...
(Date:7/30/2014)... , July 30, 2014  Decision Resources ... and medical directors in the United ... of biosimilar market penetration will be the level ... (MCOs) and the expected lower cost to patients. ... biosimilars that meet their pricing expectations in order ...
Breaking Biology Technology:Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 2Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6Grace Launches New REVELERIS® Prep Purification System 2Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 2Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 3
... March 17 The following was issued,today by the ... president & CEO, Greater Baltimore Committee, 140 company ... WHAT:, The third annual Greater Baltimore Region Bioscience ... 8:00 a.m. / Breakfast & Registration, 8:45 - ...
... 17 Mercury Therapeutics,Inc. (MTI), a company ... targeted drugs, announces that it has retained ... on its strategic and partnering,opportunities, with the ... This appointment follows a significant amount ...
... ST. LOUIS, March 17 (Nasdaq: SIAL ) ... holding its 2008 Annual,Business Review on Wednesday, March 19, ... at 2909 Laclede, St. Louis, Mo. 63103, The ... by 12:30 p.m. CDT,and will also be webcast over ...
Cached Biology Technology:Greater Baltimore Committee to Announce Winners of Third Baltimore Region Bioscience Awards at Ceremonies on March 18 2Mercury Therapeutics, Inc: Marquant Appointed to Advise on Strategic and Partnering Opportunities 2Mercury Therapeutics, Inc: Marquant Appointed to Advise on Strategic and Partnering Opportunities 3
...
... Rabbit Antibody to CRF ... with the ovine CRF sequence ... Cells and fibres are found ... of rat brain in colchicine ...
...
Alexa Fluor 647 anti-mouse Qa-2...
Biology Products: