Navigation Links
SUMO wrestling cells reveal new protective mechanism target for stroke
Date:5/17/2013

Scientists investigating the interaction of a group of proteins in the brain responsible for protecting nerve cells from damage have identified a new target that could increase cell survival.

The discovery, made by researchers from the University's School of Biochemistry and published in the EMBO journal with additional comment in Nature Reviews, could eventually lead to new therapies for stroke and other brain diseases.

The research builds on earlier work by the team which identified a protein, known as SUMO, responsible for controlling the chemical processes which reduce or enhance protection mechanisms for nerve cells in the brain. The team's latest work has now identified the key role that SUMO plays in promoting cell survival.

During cell stress a protein response triggers a protective mechanism that allows cell adaptation and survival. This process, known as SUMOylation, involves the attachment of a small protein called Small Ubiquitin-related Modifier (SUMO) to target proteins. This pathway is essential for survival of all plant and animal cells because it regulates how proteins interact with each other and can protect nerve cells against damage.

The findings have shown that SUMOylation of a protein called dynamin-related protein 1 (Drp1) is particularly important because it controls the release of chemical signals from mitochondria that instruct the cell to die in a process called apoptosis.

SUMOylation of Drp1 reduces mitochondrial release of these 'death' signals and helps nerve cells survive toxic insults associated with stroke. In the future, finding effective methods to enhance SUMOylation of Drp1 may also be beneficial for cell survival in other diseases including heart attacks and Alzheimer's disease.

The European Research Council-funded study, entitled 'SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia' published in the EMBO Journ
'/>"/>

Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-011-792-88086
University of Bristol
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Stem cells can repair a damaged cornea
3. Scientists produce eye structures from human blood-derived stem cells
4. Study demonstrates cells can acquire new functions through transcriptional regulatory network
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Researchers print live cells with a standard inkjet printer
7. Nanopills release drugs directly from the inside of cells
8. Protein jailbreak helps breast cancer cells live
9. Newly found protein helps cells build tissues
10. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
11. Housekeeping mechanism for brain stem cells discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... book that brings together two of the major disciplines ... of insect fossils through stunning photographs and unique illustrations. ... E Jepson, details the incredible preservation and diversity of ... for what these remarkable fossils can tell us about ... of our planet. Like the mosquito in Jurassic Park, ...
(Date:7/28/2014)... of two additional coral communities showing signs of damage from ... the 2010 spill in the Gulf of Mexico. The discovery ... of biology at Penn State University. A paper describing this ... the Gulf of Mexico will be published during the last ... the journal Proceedings of the National Academy of Sciences ...
(Date:7/28/2014)... professor John Essigmann and colleagues from the University of Washington ... if they could induce the virus to mutate uncontrollably, they ... a strategy that our immune system uses against many viruses. ... HIV to mutate at an enhanced rate, as expected. But ... small clinical trial reported in 2011. In a new study, ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Forced mutations doom HIV 2Forced mutations doom HIV 3Forced mutations doom HIV 4
... Researchers at the Virginia Bioinformatics Institute at Virginia Tech and ... at 454 Life Sciences of Branford, Conn., have sequenced the ... is a naturally occurring strain of B. abortus ... John Buck in 1923. It has been used for more ...
... eastern spinner dolphins in the eastern tropical Pacific Ocean ... death in the tuna purse-seine fishery between 1960 and ... "These estimates are encouraging because they are consistent ... stocks are recovering, now that reported fishery mortality has ...
... the strange properties of quantum mechanics to the macroscopic ... series of recent developments. The exciting progress was made ... recently at a high level conference organised by the ... Frderung der wissenschaftlichen Forschung in sterreich (FWF) and the ...
Cached Biology News:Brucella abortus S19 genome sequenced; points toward virulence genes 2NOAA study shows eastern tropical pacific ocean dolphin populations improving 2Europe gets together to harness quantum physics 2Europe gets together to harness quantum physics 3Europe gets together to harness quantum physics 4
(Date:7/29/2014)... 29, 2014 July 29, 2014 ... in the biotechnology industry, announced that it has ... Inc. to explore financing opportunities that build shareholder ... breakthrough vaccine platform with the potential to transform ... exclusively licensed the well-established LAMP platform from Johns ...
(Date:7/29/2014)... 2014  Sigma-Aldrich Corporation (NASDAQ: SIAL ) ... its investment in Green Chemistry and donated more than ... year, the Company announced Monday in its new ... World? The report comes in a ... a responsible corporate citizen, including recognition for the second ...
(Date:7/29/2014)... SILVER SPRING, Md., July 29, 2014  United ... today announced its financial results for the ... "Our continued growth shows that our medicines ... from pulmonary arterial hypertension (PAH)," said Martine ... Executive Officer. "The commercial launch this quarter ...
(Date:7/29/2014)... July 29, 2014 Eppendorf Centrifuge ... product selection. Eppendorf 5427 R is geared towards high-end ... – it is targeted towards work requiring high sample ... R as it compliments their extensive 16, 48, and ... of microcentrifuge tubes, PCR tubes, PCR strip tubes, and ...
Breaking Biology Technology:Immunomic Therapeutics Engages Newport Coast Securities, Inc. 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 3Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 3United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 2United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 3United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 4United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 5United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 6United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 7United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 8United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 9United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 10United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 11United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 12United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 13International Pipette Distributor, Pipette.com Announces the Addition of the Eppendorf Centrifuge 5427 R to Their Product Portfolio 2
... XR(TM) rosacea-specific study also slated for presentation at American ... NAPA, Calif., March 5 Senetek PLC (OTC ... the development of technologies that target the science of ... launching at the American Academy of Dermatology,s 67th Annual ...
... AMSTERDAM, March 5 ,Agendia, a world leader in ... Albert A. (Al) Luderer to its Supervisory Board. ... more than 30 years of experience in in ... he,is the Chief Executive Officer and President of ...
... Fla., March 5 NeoGenomics, Inc. (NASD OTC Bulletin Board: NGNM), ... for the fourth quarter and full-year ended December 31, 2008. ... Revenue of $5.9 million, an increase ... 17.2% sequential increase in revenues in Q4 08 vs. Q3 08 ...
Cached Biology Technology:Pyratine XR(TM) Launches at 67th AAD Meeting, Offering Hope to 14 Million Rosacea Sufferers 2Pyratine XR(TM) Launches at 67th AAD Meeting, Offering Hope to 14 Million Rosacea Sufferers 3Agendia Appoints Seasoned Diagnostics Executive Albert A. Luderer to Supervisory Board 2NeoGenomics Announces Fourth Quarter and Full Year 2008 Financial Results 2NeoGenomics Announces Fourth Quarter and Full Year 2008 Financial Results 3NeoGenomics Announces Fourth Quarter and Full Year 2008 Financial Results 4NeoGenomics Announces Fourth Quarter and Full Year 2008 Financial Results 5NeoGenomics Announces Fourth Quarter and Full Year 2008 Financial Results 6NeoGenomics Announces Fourth Quarter and Full Year 2008 Financial Results 7NeoGenomics Announces Fourth Quarter and Full Year 2008 Financial Results 8
Request Info...
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
... custom siRNA service provides the premium quality ... research. Custom siRNAs can be readily ordered ... target sequence, or by providing the sense ... Ambion's Silencer Validated and ...
Biology Products: