Navigation Links
Revolutionary project will obtain entire genome sequences in fight against Alzheimer's
Date:7/3/2012

Since 2004, UCLA's Laboratory of Neuro Imaging (LONI) has been responsible for receiving, organizing, archiving and disseminating the stream of data generated by the Alzheimer's Disease Neuroimaging Initiative (ADNI), an ambitious, worldwide effort by scientists to define the progression of Alzheimer's disease.

That stream of data will now turn into a flood, as LONI partners with an ambitious publicprivate effort to dig deeper into the causes of this devastating disease by obtaining the whole-genome sequencing of the more than 800 people enrolled in ADNI the largest cohort of individuals related to a single disease.

This work is expected to generate at least 165 terabytes of new genetic data, an amount roughly equivalent to the information contained in 165,000 entire copies of the Encyclopedia Britannica.

"This effort, involving almost 60 sites around the country, is the best chance we have for understanding this brutal disease," said LONI director Arthur Toga, a UCLA professor of neurology and one of the collaborators on the management of the sequencing efforts. "We collect vast amounts of imaging, cognitive and biosample data from hundreds of subjects with Alzheimer's disease, those at risk, and controls. One of the more unique aspects of this study is that all data are shared with any scientist, without embargo. We have already engaged many scientists around the world with this open access."

The new genome project is a significant extension of ADNI, which now enrolls people with Alzheimer's disease, mild cognitive impairment and normal cognition who have agreed to be studied in great detail over time. The goal is to identify and understand markers of the disease with the hope of improving early diagnosis and accelerating the discovery of new treatments.

All of the ADNI data continues to flow into UCLA's LONI, including detailed, long-term assessments of neuropsychological measures, standardized structura
'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mainz University coordinates new EU project on the origins of human settlement
2. Lab-engineered kidney project reaches early milestone
3. BGI and the Childrens Hospital of Philadelphia launch the 1,000 Rare Diseases Project
4. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
5. Reed Elsevier Environmental Challenge shortlists 2012 projects
6. BGI, GE Healthcare team up on pioneering stem cell science projects
7. Southampton researchers lead 2 international projects to help people out of poverty
8. UCSF artificial kidney project tapped for accelerated FDA program
9. University leads £6 million EU project to tackle obesity
10. EU project: Searching for exotics in the shrimp nets
11. Record-breaking grant: New research project to investigate the causes of mental disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Northwestern Medicine® scientists helps explain how bipolar disorder affects ... drug therapies to treat the mental illness. , ... same method recognized with the 2014 Nobel Prize ... tissue from mice with bipolar-like behaviors. In the synapses ... "nanodomain" structures with concentrated levels of ANK3 -- the ...
(Date:10/18/2014)... 2014 Psychological stress and stress-related psychiatric disorders are ... but the molecular mechanisms underlying this relation ... to the development of targeted preventive strategies ... devastating diseases. This work is presented at ... Berlin., Now an international group of researchers ...
(Date:10/17/2014)... University of Copenhagen have shown for the first time ... Cystic fibrosis patients, giving them the opportunity to get ... infections. , The study also discovered the bacterial growth ... was halted or slowed down by the immune cells. ... oxygen and helped "suffocate" the bacteria, forcing the bacteria ...
Breaking Biology News(10 mins):Bipolar disorder discovery at the nano level 2Researchers find why depression and aging linked to increased disease risk 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2
... a corporation has a public relations crisis, the news media ... to new research in the Journal of Consumer Research the ... and the situation. "A company can control what face ... the face shape of this person is not a trivial ...
... better at making product choices, according to a new ... who understand their emotional ability can make higher quality ... explain the authors, Blair Kidwell, David M. Hardesty, and ... know a lot about nutrition and know what foods ...
... PROVIDENCE, R.I. [Brown University] Imagine being paralyzed, unable to ... to five million Americans suffer from this debilitating situation. Or ... millions of Americans are affected by these infirmities. Now ... your hands or arms enough to tap out an e-mail ...
Cached Biology News:Brown to host conference on advances in neurotechnology 2Brown to host conference on advances in neurotechnology 3
(Date:10/25/2014)... and NEW YORK , ... (OTCQB: ACCPD), formerly Access Pharmaceuticals, Inc. (ACCP), a ... announced it has implemented a 1-for-50 reverse split ... of trading on Friday, October 24, 2014. PlasmaTech,s ... under new CUSIP number 72754H109 and temporary ticker ...
(Date:10/25/2014)... , October 24, 2014 ... http://www.researchandmarkets.com/research/t5t5pd/the_global_market ) has announced the addition of ... Graphene And Other 2-D Nanomaterials "  report ... http://photos.prnewswire.com/prnh/20130307/600769) , ,CNTs and graphene are the ... to man, with a performance-per-weight greater than ...
(Date:10/22/2014)... 21, 2014 The Americas Inorganic ... refrigerants market in Americas with analysis and forecast ... the Americas Inorganic Refrigerants Market report, to get ... also provides a glimpse of the segmentation in ... by various tables and figures. , ...
(Date:10/22/2014)... WriteResult, LLC – a premier ... working with a team of researchers from Yale University’s ... Farming Collaborative to provide electronic questionnaire data collection through ... which started in May, aims to evaluate the impact ... exposure to and participation in urban agriculture to impact ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 4The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3
... international scientific ... ... of antibody fragment therapeutics, today announced that it has,achieved high concentrations ... delivery via eye drops. These data were confirmed in,several independent preclinical ...
... from sunlight falling on only 9 percent of ... United States electricity needs if the energy could ... current-generation solar cell technologies are too expensive and ... of Northwestern University researchers has developed a new ...
... Monday, February 25, 2008 at ... ... Biopharmaceuticals,Inc. (Nasdaq: KERX ), a biopharmaceutical company focused on the,acquisition, ... of life-threatening,diseases, including diabetes and cancer (the "Company"), today announced,its results ...
Cached Biology Technology:ESBATech's Antibody Fragments Demonstrate Penetration into the Eye with Topical Delivery via Eye Drops 2ESBATech's Antibody Fragments Demonstrate Penetration into the Eye with Topical Delivery via Eye Drops 3Special coating greatly improves solar cell performance 2Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2007 Financial Results 2Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2007 Financial Results 3Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2007 Financial Results 4Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2007 Financial Results 5Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2007 Financial Results 6
... The T2-04 is an ultra-compact pump available ... (T2-04 TH) and ideal for use in portable ... 7 slpm, this pump works well in environments ... weight, and compact size are critical., Offers ...
XA7 B6...
Curcumin is an extract of turmeric root with antioxidant, anti-tumor promoter, and anti-inflammatory properties. Curcumin inhibits the induction of NOS in macrophages....
... The MEGAscript RNAi Kit ... of large mass amounts of ... in non-mammalian systems. The MEGAscript ... Ambions patented high-yield transcription technol-ogy ...
Biology Products: