Navigation Links
Researchers unlock the potential for exploring kidney regeneration
Date:2/1/2011

Boston, MA - It is estimated that up to 10 percent of the U.S. population may have some form of renal disease, with 450,000 patients with end stage renal disease (ESRD) requiring hemodialysis. Researchers at Brigham and Women's Hospital, Massachusetts General Hospital and the University of Pittsburgh have identified a cell in zebrafish that can be transplanted from one fish to another to regenerate nephrons, providing the potential to improve kidney function. These findings are published in the February 3 edition of Nature.

Currently, the five-year survival rate for patients on dialysis is 33 percent, worse than the survival rate for many forms of cancer. This epidemic of renal failure is projected to grow as obesity, poor nutrition and lack of exercise increase the incidence of diabetes and hypertension. There is also evidence that intra-uterine growth retardation and low birth weight/prematurity reduce the number of nephrons in each kidney thereby increasing the risk of hypertension and renal failure when these premature infants become adults. The cost of treating end stage renal disease is currently 32 billion dollars annually and is likely to double in the next decade.

One of the reasons renal failure is so common, is that humans are unable to generate any new nephrons, the basic filtration unit of the kidney, after the 36th week of gestation. In contrast, many non-mammalian vertebrates continue to generate nephrons throughout their lives and can generate new nephrons following renal injury. Understanding how non-mammalian vertebrates like zebrafish, carry out this remarkable regenerative process and why mammals have lost this ability is a fundamental biologic question. We believe that answering this question might provide new ways to repair damaged human kidneys and dramatically extend and improve the lives of hundreds of thousands of patients with chronic renal failure.

In a collaborative effort including two gro
'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers bust bat rabies stereotype
2. Salk researchers discover that stem cell marker regulates synapse formation
3. Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
4. Researchers identify biomarkers of poor outcomes in preemies
5. Researchers register new species using DNA-based description
6. Nearly 10 million euros ($13.6 million) in ERC grants for 6 Technische Universitaet Muenchen researchers
7. Climate change threatens many tree species, say Hebrew U. researchers
8. Researchers find smoking gun of worlds biggest extinction
9. 2 bacterial enzymes confer resistanceto common herbicide, say MU researchers
10. Go figure: Math model may help researchers with stem cell, cancer therapies
11. Researchers discover giant crayfish species right under their noses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... A leading U.S. Ebola researcher from the University of Texas ... a blend of three monoclonal antibodies can completely protect monkeys ... days after infection, at a time when the disease is ... written an editorial for Nature discussing advances in ... Marburg virus are among the most deadly of pathogens, with ...
(Date:8/29/2014)... in German . ... is considered the oldest form of communication. Acting as ... example, the sexual attraction between males and females. Fish ... coordinate reproductive behavior in males and females. Scientists at ... Algarve in Faro, Portugal, and at the Max Planck ...
(Date:8/29/2014)... of the Tibetan plateau -- the largest topographic anomaly ... both its profound effect on climate and its reflection ... GSA Bulletin , Katharine Huntington and colleagues employ a ... modern and fossil snail shells to investigate the uplift ... , Views range widely on the timing of surface ...
Breaking Biology News(10 mins):Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... to life-threatening bleeding episodes is misdiagnosed in 15 per ... international research project led by a Queen,s professor. ... decision," says Maha Othman, a professor in the Department ... research project on the rare platelet type of von ...
... caching of whitebark pine seeds by the Clark,s nutcracker in ... regenerate populations of the imperiled conifer in most of its ... in the February issue of Science Findings , a ... Stationsuggests, for the first time, that the success of whitebark ...
... The Society for Neuroscience (SfN) has been ... create and maintain BrainFacts.org , a unique nonprofit ... and promise of brain research. With joint founding partners ... will launch the Web site in late spring 2012 ...
Cached Biology News:Conservation of whitebark pine may hinge on preservation of ponderosa 2Conservation of whitebark pine may hinge on preservation of ponderosa 3Society for Neuroscience awarded $1.53 million to create BrainFacts.org 2Society for Neuroscience awarded $1.53 million to create BrainFacts.org 3
(Date:8/31/2014)... 2014 Wockhardt Limited today announces a major ... research when two of its drugs, WCK 771 and ... (QIDP) status from U.S. Food & Drug Administration (FDA). ... pathogens which have a high degree of unmet need ... Disease Control (a top U.S. government health and safety ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 This ... current state of the Epoxy Hardener industry ... basic overview of the industry, including definitions, applications ... Chinese domestic market analysis are provided with a ... of the market. A comparison between the international ...
(Date:8/29/2014)... are based on electrons, but one of the most ... i.e. circuits based on light (photons) instead of electrons. ... a stream of single photons and control their direction. ... attempts to achieve this control, but now scientists at ... steady stream of photons emitted one at a time ...
(Date:8/29/2014)... Pittsburgh, PA (PRWEB) August 29, 2014 ... Chairman, Hub MacDonald, and colleague Koichiro Matsuda, Horiba Scientific, ... JASIS on September 5, 2014. JASIS , Asia’s ... September 3-5, 2014, in Makuhari Messe, Japan. , ... New Tools for Bioanalysis from Single Molecules to Single ...
Breaking Biology Technology:U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3Breakthrough in light sources for new quantum technology 2Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2
... Inc. (NYSE: TMO ) announced that it will ... at the Westin St. Francis,Hotel in San Francisco, Calif. ... 4:00 p.m. (PST)., Marijn E. Dekkers, president and ... overview of the company and discuss its,expectations for future ...
... Pafuramidine on Clinical Hold ... Schedule Zensana(TM) ... N.J., Dec. 28 Par,Pharmaceutical Companies, Inc. (NYSE: ... the,development status of its three, in-licensed, proprietary pipeline,products: ...
... from Faux Science, NORTH KINGSTOWN, R.I., Dec. ... Pain Society, Dominion Diagnostics sponsored an extensive,educational program ... Test, Which Patient and Discriminating Real Science from ... FCP, DAAPM. Dr.,Barkin is an Associate Professor, Faculty ...
Cached Biology Technology:Thermo Fisher Scientific to Present at the 26th Annual JPMorgan Healthcare Conference 2Strativa Pharmaceuticals, the Proprietary Products Division of Par Pharmaceutical, Provides an Update on Development Status of Pafuramidine and Other in-Licensed Products 2Strativa Pharmaceuticals, the Proprietary Products Division of Par Pharmaceutical, Provides an Update on Development Status of Pafuramidine and Other in-Licensed Products 3Strativa Pharmaceuticals, the Proprietary Products Division of Par Pharmaceutical, Provides an Update on Development Status of Pafuramidine and Other in-Licensed Products 4Strativa Pharmaceuticals, the Proprietary Products Division of Par Pharmaceutical, Provides an Update on Development Status of Pafuramidine and Other in-Licensed Products 5Arizona Pain Society and Dr. Robert Barkin, Rush University Medical Center, Present Program on Comprehensive Urine Drug Testing Sponsored by Dominion Diagnostics 2
Identify and characterize Phosphoinositide (PI(4,5)P2) binding...
... unit with motorized heated lid and skirted inner ... for microarrays and chips. The four screw-down points ... force of the motorized lid is set with ... results. This interchangeable Moto Alpha unit functions on ...
... factor 15 (KLF15) KLF15 is a ... abundantly expressed in the liver, kidneys, heart, ... Specificity: Polyclonal antibody produced in rabbits ... a region of human KLF15 with an ...
... Affi-Prep protein A media yield highly ... prior to analysis of other immunoglobulin ... antigen purification. Protein A binds to ... IgG from mammalian species. This ready-to-use, ...
Biology Products: