Navigation Links
Researchers unlock the potential for exploring kidney regeneration
Date:2/1/2011

Boston, MA - It is estimated that up to 10 percent of the U.S. population may have some form of renal disease, with 450,000 patients with end stage renal disease (ESRD) requiring hemodialysis. Researchers at Brigham and Women's Hospital, Massachusetts General Hospital and the University of Pittsburgh have identified a cell in zebrafish that can be transplanted from one fish to another to regenerate nephrons, providing the potential to improve kidney function. These findings are published in the February 3 edition of Nature.

Currently, the five-year survival rate for patients on dialysis is 33 percent, worse than the survival rate for many forms of cancer. This epidemic of renal failure is projected to grow as obesity, poor nutrition and lack of exercise increase the incidence of diabetes and hypertension. There is also evidence that intra-uterine growth retardation and low birth weight/prematurity reduce the number of nephrons in each kidney thereby increasing the risk of hypertension and renal failure when these premature infants become adults. The cost of treating end stage renal disease is currently 32 billion dollars annually and is likely to double in the next decade.

One of the reasons renal failure is so common, is that humans are unable to generate any new nephrons, the basic filtration unit of the kidney, after the 36th week of gestation. In contrast, many non-mammalian vertebrates continue to generate nephrons throughout their lives and can generate new nephrons following renal injury. Understanding how non-mammalian vertebrates like zebrafish, carry out this remarkable regenerative process and why mammals have lost this ability is a fundamental biologic question. We believe that answering this question might provide new ways to repair damaged human kidneys and dramatically extend and improve the lives of hundreds of thousands of patients with chronic renal failure.

In a collaborative effort including two gro
'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers bust bat rabies stereotype
2. Salk researchers discover that stem cell marker regulates synapse formation
3. Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
4. Researchers identify biomarkers of poor outcomes in preemies
5. Researchers register new species using DNA-based description
6. Nearly 10 million euros ($13.6 million) in ERC grants for 6 Technische Universitaet Muenchen researchers
7. Climate change threatens many tree species, say Hebrew U. researchers
8. Researchers find smoking gun of worlds biggest extinction
9. 2 bacterial enzymes confer resistanceto common herbicide, say MU researchers
10. Go figure: Math model may help researchers with stem cell, cancer therapies
11. Researchers discover giant crayfish species right under their noses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... 2,000 patients referred for evaluation of suspected genetic ... for 25 percent, including detection of a number ... to disease, according to a study appearing in ... to coincide with the American Society of Human ... exons or coding regions of thousands of genes ...
(Date:10/17/2014)... German . Why ... order to reproduce? And why are there two sexes anyway? ... issue of the research journal Molecular Human Reproduction ... from Bielefeld University Bielefeld has compiled this special issue on ... female to copulate with several males in quick succession – ...
(Date:10/16/2014)... constantly wages war on the human body. Battles ... stalemate. In pancreatic cancer, this stalemate—known as tumor ... aggressively malignant, a phenomena that is poorly understood. ... the laboratory of Salvatore Torquato, a Professor of ... conditions surrounding tumor dormancy and the switch to ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Sperm wars 2Modeling tumor dormancy 2
... was launched today by the Chinese National Space Administration ... Centre, Sichuan, atop a Long March 3A rocket. ... to land robotic explorers on the Moon before 2020. ... first is to make three-dimensional images of many lunar ...
... and Ludwigshafen, Germany-October 24, 2007-Harvard University,s Office of ... agreement to jointly establish the BASF Advanced Research ... of Engineering and Applied Sciences (SEAS) the initiative ... and schools throughout the University. Set up ...
... Researchers at the University of Minnesotas Stem Cell Institute ... used to study how human embryonic stem cells differentiate. ... Experimental Biology and Medicine. Researchers know very little ... fully understand these cells self renewal capacity and pluripotency, ...
Cached Biology News:Chang'e-1 -- new mission to Moon lifts off 2BASF and Harvard University announce extensive research collaboration 2
(Date:10/22/2014)... Involution Studios , a healthcare ... new infographic, Understanding Ebola . The goal ... easy to follow informative tool for anyone wanting to ... and prevention. , "As the news has spread in ... outbreak represents not only a healthcare crisis with global ...
(Date:10/22/2014)... 22, 2014 Currently offering a ... & D Weighing, Rice Lake, and Ohaus, Pipette.com ... . The Sartorius CPA Semi-Micro Balance is ideal ... precise, and user-friendly laboratory balance. , Sartorius is ... their laboratory balances are well known for their ...
(Date:10/22/2014)... 22, 2014 Physicians Choice Laboratory ... pharmacogenetics menu, which enables healthcare providers to individualize ... PCLS’s evidence-based results, healthcare providers are better able ... therapy, while minimizing risks for adverse drug reactions ... to the FDA [1] more than 2.2 million ...
(Date:10/22/2014)...   Synthetic Biologics, Inc. (NYSE MKT: SYN), ... infections and diseases, announced today that the U.S. Patent ... for a composition of matter patent application that covers ... SYN-004. This is Synthetic Biologics, first allowed patent application ... to the Company,s extensive C. difficile patent ...
Breaking Biology Technology:Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4
... Wis . - Nearly half of the nation's top 25 ... Endpoint Exchange, LLC , a business unit of ... Ilsley Corp. , ,Twelve of the nation's largest banks ... instead of having to physically convey them, a capability that ...
... money from the Minority Business Development Fund , the ... minority-owned technology businesses in Madison. , , Gov. Jim Doyle ... will receive loans to help them expand and create jobs. ... capital to develop and market a private, anonymous software transaction ...
... Wis. - Following a devastating legal rebuke, the ... the company he founded to pursue other business interests. ... the Verona-based provider of uninterruptible power supply services, resigned ... president Charley Eaton was appointed president of JT Packard. ...
Cached Biology Technology: