Navigation Links
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
Date:2/24/2009

o had about 500 percent more of the gene in their fat cells than did normal mice. Mehta and colleagues have assembled a team that includes an endocrinologist, bariatric surgeon and molecular biologist to examine human fat tissue from obese and lean patients to see if levels of PKC beta are elevated in obese humans, as well.

"It is very likely that this gene may be involved in a predisposition to obesity," he said.

Knowing the gene is responsive in the fat cells is important to figuring out how to suppress its action. Future research will involve deleting the gene from fat cells in mice to see if these new mice have the same lean body type as mice that are completely deficient of PKC beta throughout their entire genome.

"We are generating more mouse models to vary expression of this gene and study the consequences of that on obesity and related disorders," Mehta said.

So far, mouse models lacking the protein have not shown any damaging side effects related to the suppression of the gene, Mehta said. He speculates that PKC beta could be a so-called "thrifty" gene left over from humans' days as hunter-gatherers, when the body needed to retain fat for survival.


'/>"/>

Contact: Kamal Mehta
Mehta.80@osu.edu
614-688-8451
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers generate functional neurons from somatic cells
2. UNH researchers studying spiny dogfish, Gulf of Maines mini shark
3. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
4. Case Western Reserve researchers develop wireless activation of brain circuits
5. Caltech and UCSD researchers shed light on how proteins find their shapes
6. Researchers call for nitrogen and phosphorus reductions to combat eutrophication in aquatic systems
7. Researchers explore new driver of transplant rejection: Platelets
8. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
9. Researchers isolate protein domain linked to tumor progression
10. CSHL researchers identify gene that helps plant cells keep communication channels open
11. Researchers identify gene linked to aggressive progression of liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2015)... -- Acuity Market Intelligence,s latest research "The Global Biometrics ... Privacy" forecasts that between 2014 and 2020 nearly ... to smart mobile devices by 2.2 billion mobile ... to generate more than $67.9 billion in total ...    "Biometrics is at the center ...
(Date:7/9/2015)... , July 9, 2015  Unchained Labs ... announcing its acquisition of Avid Nano. Avid Nano ... scattering (DLS) systems.    Also today, ... fastest and easiest to use protein sizing system. ... measures a protein,s hydrodynamic size, size distribution, aggregation ...
(Date:7/8/2015)... The consumer products industry for innovative ... products such as wearables, smart wallets & other smart technology ... devices continues to rapidly grow.  Biometrics & Wearable Device Companies ... Google Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... (NASDAQ: GPRO ) and Baidu Inc. (NASDAQ: BIDU ...
Breaking Biology News(10 mins):Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6
... Fables have long cast scorpions as bad-natured killers of hapless ... State University scientists, however, see them in a different light. ... effects of scorpion venom with the hopes of finding new ... published in the current issue of the Journal of ...
... CORVALLIS, Ore. - They can be both a blessing and a ... species are found from mountain tops to smoking volcanic vents on the ... to support much of the plant and animal life on Earth. ... And to a large extent, no one cared. Such has been the ...
... 27, 2011 Americans may not be getting enough calcium ... the May 2011 issue of the Journal of the ... focusing on calcium intake in the US population because both ... and compared to accompanying patterns in energy intake. "Calcium ...
Cached Biology News:Research outlines mysterious evolution of nematodes -- one of Earth’s first animals 2Research outlines mysterious evolution of nematodes -- one of Earth’s first animals 3Americans still may not be getting enough calcium 2Americans still may not be getting enough calcium 3
(Date:7/30/2015)... 2015   Senomyx , Inc. (NASDAQ: SNMX ... to discover, develop, and commercialize novel flavor ingredients for ... financial results for the second quarter 2015. ... remain on track to achieve our commercial and financial ... of the Company. "Since our last quarterly earnings report, ...
(Date:7/30/2015)... ... July 30, 2015 , ... As part of its 2015 growth plan and as a ... technical service business units, Whitehouse Laboratories is pleased to announce that it has begun ... Container Center of Excellence and will be strictly dedicated to basic USP 51, USP 61, ...
(Date:7/29/2015)... US-Australian drug discovery company, Novogen Limited (ASX: NRT; NASDAQ: ... progressing its ground-breaking technology platforms to Phase 1 clinical ... Company delivers the best value for shareholders. ... the Company currently had an extensive program of activities ... academic partnerships and initiatives, and he was working with ...
(Date:7/29/2015)... ... 29, 2015 , ... G-CON Manufacturing, Inc., the leading prefabricated ... generation cell therapy POD® design. The 2nd generation portfolio not only delivers design ... POD® design. , “G-CON first offered our miniPOD CT product line to ...
Breaking Biology Technology:SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3
... 2011 /PRNewswire/ -- bioTheranostics, a bioMerieux company ... disease management, announced today study results published in the ... related to the clinical validity and the clinical ... to aid in the determination of the origin of ...
... an early-stage cancer drug discovery and development company, has ... financing.  Led by The Column Group and joined by ... funds supplement a recently awarded $11 million grant from ... Peloton officials said the company will focus ...
... 26, 2011 The Raymond and Ruth ... Pennsylvania announces the launching of a first-of-its-kind ... orphan diseases. The Center will bring together, without ... treating orphan diseases: establishing dedicated research support facilities, ...
Cached Biology Technology:New Study Reports CancerTYPE ID Expands Tumor Type Coverage and Demonstrates Clinical Utility 2New Study Reports CancerTYPE ID Expands Tumor Type Coverage and Demonstrates Clinical Utility 3Peloton Therapeutics Completes $18 Million Series A Financing 2Peloton Therapeutics Completes $18 Million Series A Financing 3Penn Receives $10 Million to Create Center for Orphan Disease Research and Therapy 2
...
... For use in Refrigerated Vapor Trap ... Vacuum Source (UVS) Models UVS400, UVS400A and ... polymer suitable for use for temperatures ranging ... has excellent thermal stability and does not ...
... 10X Automation Buffer is a concentrated formulation ... autostainers employing capillary action technology, as well ... in collaboration with David Brigati M.D., Department ... OK. This buffer is recommended for all ...
... The new MALDI O-TOF creates a ... on an orthogonal platform that has been ... the University of Manitoba. , As the ... orthogonal design and collisional cooling, the prOTOF ...
Biology Products: