Navigation Links
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
Date:2/24/2009

o had about 500 percent more of the gene in their fat cells than did normal mice. Mehta and colleagues have assembled a team that includes an endocrinologist, bariatric surgeon and molecular biologist to examine human fat tissue from obese and lean patients to see if levels of PKC beta are elevated in obese humans, as well.

"It is very likely that this gene may be involved in a predisposition to obesity," he said.

Knowing the gene is responsive in the fat cells is important to figuring out how to suppress its action. Future research will involve deleting the gene from fat cells in mice to see if these new mice have the same lean body type as mice that are completely deficient of PKC beta throughout their entire genome.

"We are generating more mouse models to vary expression of this gene and study the consequences of that on obesity and related disorders," Mehta said.

So far, mouse models lacking the protein have not shown any damaging side effects related to the suppression of the gene, Mehta said. He speculates that PKC beta could be a so-called "thrifty" gene left over from humans' days as hunter-gatherers, when the body needed to retain fat for survival.


'/>"/>

Contact: Kamal Mehta
Mehta.80@osu.edu
614-688-8451
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers generate functional neurons from somatic cells
2. UNH researchers studying spiny dogfish, Gulf of Maines mini shark
3. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
4. Case Western Reserve researchers develop wireless activation of brain circuits
5. Caltech and UCSD researchers shed light on how proteins find their shapes
6. Researchers call for nitrogen and phosphorus reductions to combat eutrophication in aquatic systems
7. Researchers explore new driver of transplant rejection: Platelets
8. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
9. Researchers isolate protein domain linked to tumor progression
10. CSHL researchers identify gene that helps plant cells keep communication channels open
11. Researchers identify gene linked to aggressive progression of liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/143028 for MINIATURE, ... ENERGY TRANSFER  NXT-ID introduces a new ... This patent surrounds the use of miniature antenna ...
(Date:4/1/2015)... 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces the second ... is underway to early access pre-order customers. ... at retail outlets including Walmart, Target, AT&T, Dunkin, Donuts, ... was accepted at all outlets and very easy to ...
(Date:3/26/2015)... The Granite Club, ... club, today announced it has implemented a state-of-the-art access ... for members and staff, while restricting access to authorized ... selected FST,s IMID Access system because it has the ... and staff, in addition to unparalleled security," said ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... 45,000 corneal transplant eye surgeries are performed in the ... effort to standardize this complex procedure, two video articles ... JoVE, the Journal of Visualized Experiments . These ... and the United States. By utilizing the JoVE,s ...
... as ,green phones, for communication with other bugs. A ... insects are also able to leave ,voicemail, messages in ... effects on soil fungi. Researchers from the Netherlands Institute ... unique messaging service in the ragwort plant. The influential ...
... non-protein-coding RNAs start off as long strands of ... a special kind of machinery, the "Microprocessor" complex, to ... miRNAs bind to messenger RNA (mRNAs) molecules, inhibiting their ... hundreds of different proteins. But the Microprocessor complex ...
Cached Biology News:Pre-surgical steps for eye surgery are standardized through JoVE's video publication 2Voicemail discovered in nature 2Living microprocessor tunes in to feedback 2
(Date:5/5/2015)... Plymouth, Mich. (PRWEB) May 05, 2015 ... expanding publishing services to develop custom course materials for ... with annual enrollments as low as 200 students. ... to a broader range of higher education instructors,” said ... around the country, we can do our part to ...
(Date:5/5/2015)... IN (PRWEB) May 05, 2015 The ... the state of Indiana, led by Indiana Gov. Mike ... Day. The AMA Foundation will host a Family Fest ... celebration. All proceeds will benefit the Wounded Warrior Project. ... the Academy of Model Aeronautics—the country’s foremost organization for ...
(Date:5/5/2015)... DIEGO , May 5, 2015  A group ... formation of the Coma Research Institute, a non-profit organization ... patients and families suffering from disorders of consciousness.  ... - http://photos.prnewswire.com/prnh/20150504/213779LOGO   ... disorder of consciousness, in which no voluntary actions can ...
(Date:5/5/2015)... May 05, 2015 Research and Markets ... of the "Clinical Laboratory, Molecular Diagnostics and ... to 2019 - Europe Version" report to ... in the area of molecular diagnostics and pharmacogenics ... evolving world market that is moving out of ...
Breaking Biology Technology:Hayden-McNeil Expands Publishing Program to Service Lower Enrollment Courses 2State of Indiana proclaims August 15 as Model Aviation Day 2Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 2Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 3Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 4Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 5European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2
... ... QCam imaging driver for QImaging cameras. This interface provides support for Microsoft,s 64-bit ... faster analysis. , ... (PRWEB) January 20, 2010 -- QImaging, a leading developer and manufacturer of high-performance, ...
... Bacteria that produce compounds to reduce inflammation and strengthen host ... Such probiotic microbes could be the most successful treatment for ... the February issue of the Journal of Medical Microbiology ... causes severe watery and bloody diarrhoea and abdominal pain. It ...
... , , BRISBANE, Calif. , Jan. ... that it plans to offer, subject to market and other conditions, ... The company expects to grant the underwriters a 30-day option to ... connection with the offering. All of the shares in the offering ...
Cached Biology Technology:QImaging Introduces 64-Bit QCam Driver 2Promising probiotic treatment for inflammatory bowel disease 2InterMune Announces Proposed Public Offering of Common Stock 2InterMune Announces Proposed Public Offering of Common Stock 3
... Ideal for cell culture scale-up, these ... 10 7 - 10 9 range ... bottles or spinner flasks. • High mechanical ... leak tested prior to shipping • Certified ...
BD BioCoat Laminin 150 mm Culture Dishes...
...
The BD CBA Human Apoptosis Kit can be used to quantitatively measure,cleaved PARP, Bcl-2, and active Caspase-3 protein levels in a single sample. The,Kit performance has been optimized for analysis o...
Biology Products: