Navigation Links
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
Date:2/24/2009

ing diabetes and obesity. Despite the propensity for obesity from their original genes, the new mice lost weight while eating up to 30 percent more food than other mice.

In the earlier study, the mice ate a regular diet. In this new study, the researchers fed PKC beta-deficient and normal mice either a diet in which 60 percent of calories were derived from fat the high-fat diet or a standard diet in which 15 percent of calories came from fat. In the typical American diet, about 40 percent of calories are derived from fat.

The normal mice on the high-fat diet showed weight gain within three weeks, a trend that continued throughout the 12-week study. The PKC beta-deficient mice on the same diet gained less weight even while appearing to be extra hungry and eating more calories than the normal mice meaning their lower body weight was not the result of eating less.

Of animals eating the high-fat diet, the fat tissue and livers in the normal mice were larger than those in the PKC beta-deficient mice, as well. The livers of the normal mice were on average about 50 percent larger than the livers in mice lacking the gene. And the white fat tissue the tissue in which PKC beta was expressed as a result of the high-fat diet was almost three times as heavy in the normal mice as in the PKC beta-deficient mice.

The protein-deficient mice were able to clear insulin to regulate blood sugar more rapidly than normal mice after eating the high-fat diet, meaning avoiding obesity also allowed them to avoid development of insulin resistance associated with diabetes, said Mehta, also an investigator in Ohio State's Davis Heart and Lung Research Institute.

"Obesity leads to liver damage and to diabetes. So if we can take care of obesity associated with a high-fat diet, we can also take care of most of the related disorders," Mehta said.

A separate component of the current study further showed that mice engineered to be obese als
'/>"/>

Contact: Kamal Mehta
Mehta.80@osu.edu
614-688-8451
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers generate functional neurons from somatic cells
2. UNH researchers studying spiny dogfish, Gulf of Maines mini shark
3. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
4. Case Western Reserve researchers develop wireless activation of brain circuits
5. Caltech and UCSD researchers shed light on how proteins find their shapes
6. Researchers call for nitrogen and phosphorus reductions to combat eutrophication in aquatic systems
7. Researchers explore new driver of transplant rejection: Platelets
8. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
9. Researchers isolate protein domain linked to tumor progression
10. CSHL researchers identify gene that helps plant cells keep communication channels open
11. Researchers identify gene linked to aggressive progression of liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... German . ... to a striking pattern of blue stripes alternating with golden ... cells, and yellow cells emerge during growth in the skin ... mosaic to compose the characteristic colour pattern. ,While ... interact to form proper stripes, the embryonic origin of the ...
(Date:8/28/2014)... Minn. A Mayo Clinic researcher and his collaborators ... up and enhance the process of re-engineering cells for ... uses network biology methods to aid stem cell engineering. ... engineering are described in two back-to-back papers in the ... a broad range of uses for all types of ...
(Date:8/28/2014)... groups and clinicians is critical to the development ... of Georgia research. , A qualitative study of ... that role models for successful breastfeeding help positively ... "Mothers who received that support are more likely ... Alex Anderson, an associate professor in the College ...
Breaking Biology News(10 mins):How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3New tool aids stem cell engineering for medical research 2Breastfeeding study shows need for effective peer counseling programs 2
... life sciences journal F1000Research is that ... the article. Openly sharing data is an important step in ... published research, as well as enabling data reuse. ... the data in the journal,s articles to be assessed and ...
... balanced interplay of four molecules that trigger and govern ... an important basic science discovery, it helps explain why ... genes cannot fight infection effectively, and develop rare and ... of a number of different types of cells that ...
... poison-dart frog, a red male isn,t much brighter than a green ... the green and red variants of the same species of frog ... Ecology and Sociobiology , led by Beatriz Willink of the Universidad ... The bright colors of poison-dart frogs serve not only ...
Cached Biology News:F1000Research launch data plotting tool 2Molecular interplay explains many immunodeficiencies 2Green poison-dart frog varies mating call to suit situation 2
(Date:8/28/2014)... research platform uses a laser to measure ... stress and heating, an approach likely to ... and batteries., This new technique, called nanomechanical ... and the surface stress of microscale structures ... the merits of surface-stress influence on mechanical ...
(Date:8/28/2014)... 2014  Next month, executives from clinical trial marketing firm ... beginning with Patient-Centered Clinical Trials 2014 , to be ... , September 4-5. Patient recruitment experts Bonnie A. ... will share insights on the benefits of employing an ... – from media to mobile apps – can be used ...
(Date:8/28/2014)... Fla. Exciting new work by a Florida State ... system that can take your temperature, emit white light, ... And, the molecule looks like a butterfly. , Biwu ... Biomedical Engineering in the FAMU-FSU College of Engineering, created ... but has continued to discover that his creation has ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 PrimeSource ... construction materials, selected SoundConnect to support ... cloud based audio and web conferencing platform GlobalMeet ... support PrimeSource’s employees’ needs. SoundConnect delivers award ... , PrimeSource Building Products will be utilizing ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2
... launched interactive, personalized services for Milwaukee drivers through ... announced Thursday. Traffic.com will provide area commuters with ... roadway traffic conditions including congestion levels, incidents, travel ... news release. , ,Data for the site will ...
... actors from two hemispheres came together outside Madison Friday ... Kazusa DNA Research Institute signed off on ... three-year agreement will involve exchanges between the Kazusa Institute, ... genome, and Promega with its technology for expressing and ...
... Systems, Inc. on Monday announced a 20.3 percent increase in ... quarter of production and shipment of its MRI monitor to ... year-end numbers, the company said fourth-quarter net sales for fiscal ... $6,667,617 for the same period of fiscal year 2004. , ...
Cached Biology Technology:Promega, Japanese lab announce partnership 2
MOUSE ANTI SIMIAN VIRUS 5 Immunogen: Simian virus 5...
... Serum • Beagle serum is collected from ... year of age Available Anticoagulants: ... N-06: K2EDTA N-08: Potassium ... Alsevers N-05: ACD N-07: ...
MOUSE ANTI BOVINE TROPONIN I...
Normal donkey serum collected from healthy normal donkeys....
Biology Products: