Navigation Links
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
Date:2/24/2009

ing diabetes and obesity. Despite the propensity for obesity from their original genes, the new mice lost weight while eating up to 30 percent more food than other mice.

In the earlier study, the mice ate a regular diet. In this new study, the researchers fed PKC beta-deficient and normal mice either a diet in which 60 percent of calories were derived from fat the high-fat diet or a standard diet in which 15 percent of calories came from fat. In the typical American diet, about 40 percent of calories are derived from fat.

The normal mice on the high-fat diet showed weight gain within three weeks, a trend that continued throughout the 12-week study. The PKC beta-deficient mice on the same diet gained less weight even while appearing to be extra hungry and eating more calories than the normal mice meaning their lower body weight was not the result of eating less.

Of animals eating the high-fat diet, the fat tissue and livers in the normal mice were larger than those in the PKC beta-deficient mice, as well. The livers of the normal mice were on average about 50 percent larger than the livers in mice lacking the gene. And the white fat tissue the tissue in which PKC beta was expressed as a result of the high-fat diet was almost three times as heavy in the normal mice as in the PKC beta-deficient mice.

The protein-deficient mice were able to clear insulin to regulate blood sugar more rapidly than normal mice after eating the high-fat diet, meaning avoiding obesity also allowed them to avoid development of insulin resistance associated with diabetes, said Mehta, also an investigator in Ohio State's Davis Heart and Lung Research Institute.

"Obesity leads to liver damage and to diabetes. So if we can take care of obesity associated with a high-fat diet, we can also take care of most of the related disorders," Mehta said.

A separate component of the current study further showed that mice engineered to be obese als
'/>"/>

Contact: Kamal Mehta
Mehta.80@osu.edu
614-688-8451
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers generate functional neurons from somatic cells
2. UNH researchers studying spiny dogfish, Gulf of Maines mini shark
3. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
4. Case Western Reserve researchers develop wireless activation of brain circuits
5. Caltech and UCSD researchers shed light on how proteins find their shapes
6. Researchers call for nitrogen and phosphorus reductions to combat eutrophication in aquatic systems
7. Researchers explore new driver of transplant rejection: Platelets
8. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
9. Researchers isolate protein domain linked to tumor progression
10. CSHL researchers identify gene that helps plant cells keep communication channels open
11. Researchers identify gene linked to aggressive progression of liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... of bacterial culprits that may drive inflammatory bowel diseases ... patients, own intestinal immune responses as a guide. , ... Cell . , Trillions of bacteria exist within ... in the development and progression of IBD. Yet it,s ... affect a person,s susceptibility to IBD and its potential ...
(Date:8/28/2014)... Minn. A Mayo Clinic researcher and his collaborators ... up and enhance the process of re-engineering cells for ... uses network biology methods to aid stem cell engineering. ... engineering are described in two back-to-back papers in the ... a broad range of uses for all types of ...
(Date:8/28/2014)... -- Privacy Advocate and Senior Staff Attorney at the Electronic ... lineup of biometric and mobile commerce experts set to ... in Tampa, Florida on September ... Steven Rahman, Director, Technology and Strategy at Samsung, and Philippe ... of this year,s event is Mobility at the Crossroads ...
Breaking Biology News(10 mins):Yale study identifies possible bacterial drivers of IBD 2New tool aids stem cell engineering for medical research 2Biometrics UnPlugged Welcomes the Electronic Frontier Foundation's Jennifer Lynch to the Mobility at the Crossroads of Commerce and Privacy Summit 2
... X syndrome (FXS) is the most common hereditary form ... from attention deficit and/or hyperactivity disorder (ADHD), which complicates ... medication such as Ritalin is often successfully used to ... it is effective in children with mental retardation, it ...
... choose the nesting location of their first breeding season has ... a new University of Maryland/National Zoo study of the ... in their first year may help determine where they breed ... significantly affect the population as climate change makes their winter ...
... January 2001, the world held its breath when the tanker ... and began breaking up in the heart of one of ... the Galapagos Islands. At risk were vast numbers of ... Charles Darwin that contributed to his landmark theory of evolution ...
Cached Biology News:Effective ADHD treatment found for children with fragile X syndrome 2Early environment may be key to determining bird migration location 2Early environment may be key to determining bird migration location 3First wind turbines on Galapagos Islands will halve diesel imports, reduce risk of future oil spills 2First wind turbines on Galapagos Islands will halve diesel imports, reduce risk of future oil spills 3First wind turbines on Galapagos Islands will halve diesel imports, reduce risk of future oil spills 4
(Date:8/28/2014)... (PRWEB) August 28, 2014 Best Sanitizers, ... for the food processing industry, is asking industry professionals ... side comparison of the E2 soap they’re currently using ... Foam Soap . Hand hygiene is critical to ... food processing environment. Six key criteria are identified to ...
(Date:8/28/2014)... Aug. 28, 2014 ... market research report is available ... Whole Exome Sequencing Market by ... Target Enrichment), by Services (Sequencing), ... by Application (Cancer, Monogenic disorders) ...
(Date:8/28/2014)... , Aug. 28, 2014  Armetheon, Inc. ... developing novel mid- to late-stage cardiovascular drug candidates, ... in its first round of financing. The Series ... and Hercules Bioventures with participation from investors that ... pharmaceutical executive, Dr. Larry Hsu , the ...
(Date:8/28/2014)... August 28, 2014 PrimeSource Building ... materials, selected SoundConnect to support their ... based audio and web conferencing platform GlobalMeet powered ... PrimeSource’s employees’ needs. SoundConnect delivers award winning ... PrimeSource Building Products will be utilizing GlobalMeet ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3PrimeSource Chooses SoundConnect as Collaboration Provider 2
... chief becomes marketer Rockwell reports dividend ... patent-strategy conference RoleFlow Software Targets Human Resources Efficiency ... ,The Wisconsin Alumni Association has created a Web site to ... . The site uses MonsterTrak , a service of ...
... What does it mean to the biotech community to have ... be thoroughly addressed at the Wisconsin Life Sciences and ... Spawns Novel Therapies. The conference will be held November 16 ... showcase about 20 companies, 11 from Wisconsin, will strut ...
... to those risk-addicted Californians: Saddled with a debt running into ... their credit cards and pinch pennies. They borrow even more ... happened last week when California voters overwhelmingly approved Proposition 71, ... in bonds to pay for human embryonic stem cell research. ...
Cached Biology Technology:Tech Digest: whats moving in the Midwest (11/3/04) 2Life-sciences conference to feature novel research with clinical potential 2California stem cell initiative should wake up Washington and Madison 2California stem cell initiative should wake up Washington and Madison 3
Kinase Buffer can be used to assay protein kinase activity...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
...
Biology Products: