Navigation Links
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
Date:2/24/2009

COLUMBUS, Ohio Scientists have determined that a specific gene plays a role in the weight-gain response to a high-fat diet.

The finding in an animal study suggests that blocking this gene could one day be a therapeutic strategy to reduce diet-related obesity and associated disorders, such as diabetes and liver damage, in humans.

The researchers found that a diet rich in fat induced production of this gene, called protein kinase C beta (PKC beta), in the fat cells of mice. These mice rapidly gained weight while eating a high-fat diet for 12 weeks.

On the other hand, mice genetically engineered to lack PKC beta gained relatively little weight and showed minimal health effects after eating the same high-fat diet.

In comparing the effects of the high-fat diet and a regular diet, the scientists found that mice fed the high-fat diet produced more PKC beta in their fat tissue than did mice eating a regular diet.

"So we now know this gene is induced by a high-fat diet in fat cells, and a deficiency of this gene leads to resistance to fat-induced obesity and related insulin resistance and liver damage," said Kamal Mehta, senior author of the study and a professor of molecular and cellular biochemistry in Ohio State University's College of Medicine.

"It could be that the high-fat diet is a signal to the body to store more fat. And when that gene is not there, then the fat storage cannot occur."

Though the complete mechanism remains unknown, the research to date suggests that rather than storing fat, mice lacking the gene burn fat more rapidly than they would if the PKC beta were present, Mehta said.

The research is available online in the journal Hepatology and is scheduled for later print publication.

Mehta and colleagues previously had created the hybrid mouse model by cross-breeding mice deficient in PKC beta with the C57 black mouse, a common animal used in research for study
'/>"/>

Contact: Kamal Mehta
Mehta.80@osu.edu
614-688-8451
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers generate functional neurons from somatic cells
2. UNH researchers studying spiny dogfish, Gulf of Maines mini shark
3. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
4. Case Western Reserve researchers develop wireless activation of brain circuits
5. Caltech and UCSD researchers shed light on how proteins find their shapes
6. Researchers call for nitrogen and phosphorus reductions to combat eutrophication in aquatic systems
7. Researchers explore new driver of transplant rejection: Platelets
8. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
9. Researchers isolate protein domain linked to tumor progression
10. CSHL researchers identify gene that helps plant cells keep communication channels open
11. Researchers identify gene linked to aggressive progression of liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014  HITLAB SM announced today its completion of ... adherence to current U.S. Food and Drug Administration (FDA) ... device and smart phone application trials utilizing the highest ... "HITLAB is determined to improve global healthcare access, quality, ...
(Date:12/17/2014)... Dec. 16, 2014  Automation is fundamentally transforming the travel ... international borders. Over the past decade, ePassports, biometric readers, ... self process through border control via eGates and Automated ... airports, seaports, and land borders across the globe. ...
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in India 2015-2019" ... major trend emerging in this market is the adoption ... than one characteristic of an individual for verification and ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... often behave differently than temperate soils when being farmed. ... cultivated. With food shortages looming and soil quality declining ... and sub-tropical farming more productive and sustainable. New research ... a winter cover crop is most effective in retaining ...
... Georgia researchers have developed a new technology that ... from readily available non-food crops, such as Bermudagrass, ... "Producing ethanol from renewable biomass sources such as ... in large quantities," said Joy Peterson, professor of ...
... the U.S. will be overweight or obese by 2030, with ... $956.9 billion, according to researchers at the Johns Hopkins Bloomberg ... Quality and the University of Pennsylvania School of Medicine. Their ... Obesity . "National survey data show that the ...
Cached Biology News:New UGA biomass technology dramatically increases ethanol yield from grasses and yard waste 2New UGA biomass technology dramatically increases ethanol yield from grasses and yard waste 3Study suggests 86 percent of Americans could be overweight or obese by 2030 2
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was ... Pre-Conference seminar on probiotics in San Diego, CA. , ... conference for health care professionals. This year’s pre-conference seminar was ... in health. Dr. Leyer spoke about the emerging topics and ...
(Date:1/22/2015)... , Nueva Jersey , 22 de enero de ... Biomedical Research abre hoy su llamada a nominaciones para ... investigación científica ha hecho, o tiene el potencial para ... humana. Las nominaciones se aceptarán hasta el 15 de ...
(Date:1/22/2015)... PRINCETON, N.J. , Jan. 22, 2015  Derma ... tissue regeneration company focused on advanced wound care, ... from placental tissues, have been added to the ... announcement increases the opportunity for the AMNIOEXCEL® and ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... Biomedical Research Program Awards Peer-Reviewed Grant, SARASOTA, Fla., ... was awarded the Florida Department of Health and James ... for its advanced cancer research in using B-amyloid protein ... in the amount of $100,000 was awarded to Roskamp,s,Investigator ...
... Barr Pharmaceuticals,Inc. (NYSE: BRL ) today ... a challenge of the patents listed by TAP,Pharmaceuticals ... Disintegrating Tablets (lansoprazole), 15mg and,30mg., Barr filed ... IV certification for a generic Prevacid SoluTab product ...
... Va., June 10 Diffusion Pharmaceuticals,LLC, a clinical-stage ... life-threatening unmet medical needs, today announced,the addition of ... (Photo: http://www.newscom.com/cgi-bin/prnh/20080610/NETU101 ), Mr. ... Virginia National Bank in,Charlottesville, Virginia. He also is ...
Cached Biology Technology:Roskamp Institute Wins Grant for Lung Cancer Research 2Barr Confirms Patent Challenge of Prevacid(R) SoluTab(TM) Delayed-Release Orally Disintegrating Tablets, 15mg and 30mg 2Barr Confirms Patent Challenge of Prevacid(R) SoluTab(TM) Delayed-Release Orally Disintegrating Tablets, 15mg and 30mg 3Diffusion Pharmaceuticals Announces Addition of Mark T. Giles to its Board of Directors 2
Human SPARC-like 1 Biotinylated Affinity Purified PAb...
Request Info...
Any form, any size, any number of mutageneses. ExonBio provides the best service with double sequecing to make sure the success of the mutagenesis....
Request Info...
Biology Products: