Navigation Links
Researchers turn one form of neuron into another in the brain
Date:1/20/2013

e diseases.

"Neurodegenerative diseases typically effect a specific population of neurons, leaving many others untouched. For example, in ALS it is corticospinal motor neurons in the brain and motor neurons in the spinal cord, among the many neurons of the nervous system, that selectively die," Arlotta said. "What if one could take neurons that are spared in a given disease and turn them directly into the neurons that die off? In ALS, if you could generate even a small percentage of corticospinal motor neurons, it would likely be sufficient to recover basic functioning," she said.

The experiments that led to the new finding began five years ago, when "we wondered: in nature you never seen a neuron change identity; are we just not seeing it, or is this the reality? Can we take one type of neuron and turn it into another?" Arlotta and Rouaux asked themselves.

Over the course of the five years, the researchers analyzed "thousands and thousands of neurons, looking for many molecular markers as well as new connectivity that would indicate that reprogramming was occurring," Arlotta said. "We could have had this two years ago, but while this was a conceptually very simple set of experiments, it was technically difficult. The work was meant to test important dogmas on the irreversible nature of neurons in vivo. We had to prove, without a shadow of a doubt, that this was happening."

The work in Arlotta's lab is focused on the cerebral cortex, but "it opens the door to reprogramming in other areas of the central nervous system," she said.

Arlotta, an HSCI principal faculty member, is now working with colleague Takao Hensch, of Harvard's Department of Molecular and Cellular Biology, to explicate the physiology of the reprogrammed neurons, and learn how they communicate within pre-existing neuronal networks.

"My hope is that this will facilitate work in a new field of neurobiology that explores the boundaries and power of n
'/>"/>

Contact: Paola Arlotta
paola_arlotta@harvard.edu
Harvard University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... A ground breaking new book that brings together two ... to raise the profile of insect fossils through stunning ... David Penney and James E Jepson, details the incredible ... world, setting the scene for what these remarkable fossils ... and even the future of our planet. Like the ...
(Date:7/29/2014)... study from UC San Francisco is the first to ... overtime and accelerate cellular aging, these negative effects may ... sleeping well. , "The study participants who exercised, ... than the ones who didn,t maintain healthy lifestyles, even ... author Eli Puterman, PhD, assistant professor in the department ...
(Date:7/28/2014)... Pole in 1911, but new research shows that industrial ... data from 16 ice cores collected from widely spaced ... a group led by Joe McConnell of the Desert ... accurate and precise reconstruction to date of lead pollution ... an article published today in the online edition of ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2Healthy lifestyle may buffer against stress-related cell aging, study says 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3
... German . , In male songbirds of ... in spring, which leads to an increase in song activity ... little evidence so far about such a clear relationship between ... lower degree of seasonal changes of the environment. Researchers of ...
... found that microscopic particles containing proteins and nucleic acids ... premature babies from serious lung diseases and chronic lung ... earlier research suggesting that while transplanting a kind of ... reduce lung injury and prevent inflammation in a mouse ...
... Spring Harbor, N.Y. Cancer cells grow fast. That,s an ... through all the cell-cycle checkpoints and are continuously growing and ... need to speed up their metabolism. CSHL Professor ... target the cancer cell metabolic process and in the process ...
Cached Biology News:Testosterone regulates solo song of tropical birds 2Microscopic packets of stem cell factors could be key to preventing lung disease in babies 2Microscopic packets of stem cell factors could be key to preventing lung disease in babies 3Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells 2Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells 3
(Date:7/29/2014)... July 29, 2014 Human Longevity, Inc. (HLI), ... focused on extending the healthy, high performance human life ... , Ph.D., an expert in machine learning and machine ... to HLI from Google where he was Distinguished Research ... report directly to HLI Co-Founder and CEO, J. ...
(Date:7/29/2014)... , July 29, 2014  Pomerantz LLP is ... Inc. ("Impax" or the "Company") (NASDAQ: IPXL).  Such investors ... at rswilloughby@pomlaw.com or 888-476-6529, ext. 237. ... its officers and/or directors have violated Sections 10(b) and ... On July 29, 2014, Impax Laboratories, Inc. ...
(Date:7/29/2014)... PORTLAND, Oregon , July 29, 2014 ... titled, "Global surgical equipment market (types, applications and geography) ... Analysis, Research, Report, Opportunities, Segmentation and Forecast, 2013 - ... expected to reach $12.1 billion by 2020 registering a ... Due to the breakthrough achieved by the electro surgical ...
(Date:7/29/2014)... Philadelphia’s newest entrepreneurial incubation space is ready for business, and ... Center @3401 , a collaborative effort of Drexel University ... help attract and nurture start-up businesses in the region, officially ... , The Innovation Center @3401 (ic@3401), which is located at ... home of DreamIt Ventures and Point.io ...
Breaking Biology Technology:Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Impax Laboratories, Inc. - IPXL 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 3Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 2Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 3
... lab that studies learning technologies with the University of Wisconsin and ... evening at the World Futurist Society meeting . The futurists ... at the Academic Advanced Distributed Learning Co-Lab , Brown will ... looking to video games as a teaching tool. Read more. ...
... Wisconsin Governor Jim Doyle and former Governor Tommy Thompson ... advantages of electronic health records, however, Doyle and Thompson ... two-year state budget includes $10 million in grants and ... health records, a move that could help harness the ...
... First Dolly, now human embryos. , ,This weeks announcement out ... who cloned Dolly the sheep, has been granted a license ... to spark fresh hopes among disease sufferers, scientists and advocacy ... amyotrophic lateral sclerosis (ALS). , ,These diseases could be addressed ...
Cached Biology Technology:Tech Digest: Futurists on learning; Sonic Foundry; Accu Tech; Fiserv 2Electronic health records can save lives and improve medical care 2Electronic health records can save lives and improve medical care 3Human cloning plans get blessing from British government 2Human cloning plans get blessing from British government 3
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ...
... Maximize the value of your microarray data ... support you need from consultation to extensive ... date methods. Utilize our expertise in combination ... from your own microarray experiments., ,Normalization and ...
BD Falcon 850 cm Smooth-surface TufRol Roller Bottle, tissue-culture treated polystyrene, blow-molded one-piece design, with easy on/off non-vented cap. (2/sp, 20/ca) Packaging: 2 / pack, 20 /...
... of Flight Mass Analyzer for superior sensitivity, mass accuracy, and resolving ... m/z, * Precursor ion selection range: 150 - 4000 m/z, * ... with internal reference, * Dynamic range: 4 orders of magnitude ... ...
Biology Products: