Navigation Links
Researchers tune in to protein pairs
Date:1/27/2014

Rice University scientists have created a way to interpret interactions among pairs of task-oriented proteins that relay signals. The goal is to learn how the proteins avoid crosstalk and whether they can be tuned for better performance.

Each cell contains thousands of these two-component signaling proteins, which often act as sensors and trigger the cell to act.

The new research has significance for bioengineers who try to understand and modify signaling pathways to treat disease or carry out tasks. A paper on the research done at the Center for Theoretical Biological Physics (CTBP) at Rice's BioScience Research Collaborative appears online this month in the Proceedings of the National Academy of Sciences.

The research team led by Rice physicist Jos Onuchic and bioengineer Herbert Levine used the predictive power of their pioneering direct coupling analysis statistical method to compare the genomic roots of thousands of protein pairs collected from many different bacterial organisms. Their product is a new metric to judge how mutations affect the way the pairs work.

Two-component systems are usually disconnected proteins that transmit signals to trigger many types of actions within cells. In bacteria, for instance, the first component is a histidine kinase (HK) that senses conditions outside a cell and triggers the creation of a signal in a process called "autophosphorylation." The signal (that is, the phosphoryl group) generated on the kinase can then be passed to a response regulator (RR) protein, akin to a baton in a relay race. The regulator takes the baton and then generates a physiological response through the activation or repression of genes.

A central question for the researchers was how these kinases and regulators coevolve to recognize each other in a crowd, and why there's so little crosstalk leading to mismatched pairs.

"If we are going to figure out how cells are able to compute, we
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Ottawa researchers discover new combination therapy to kill cancer
2. Cleveland Clinic researchers discover process that turns good cholesterol bad
3. Researchers discover potential drug targets for early onset glaucoma
4. Researchers identify innate channel that protects against pain
5. Combustion continues to draw researchers to space station
6. Curtin researchers to hide our splashes from sharks
7. Researchers discover how heart arrhythmia occurs
8. Researchers collaborate to reduce effects of the aging eye
9. 1 step at a time, researchers learning how humans walk
10. Researchers discover that coevolution between humans and bacteria reduces gastric cancer risk
11. Researchers identify key components linking circadian rhythms and cell division cycles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... March 24, 2015   NexID Biometrics LLC, ... security-authentication needs, today announced the beginning of shipments of ... The company, based in Potsdam, ... three-day Connect:ID Expo, which began here today at the ... version 2.0 of its SDK boosts the accuracy rate ...
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... come out of research conducted on the edge of ... Olduvai Gorge in Tanzania since that produced by Louis ... a special issue of the prestigious Journal of ... of the Bernard Price Institute for Palaeontological Research, and ...
... on a unique vertebrate called the sea lamprey shows that ... development. These genes are paradoxically lost all throughout the developing ... or PGCs. The PGCs can be thought of as embryonic ... generation of lampreys. Based on computational analysis, a significant number ...
... rapidly create healthy clots and nearly double the survival ... research shows. "We knew an injection of these ... bleeding is stopped in time to increase survival following ... at Case Western Reserve University and leader of the ...
Cached Biology News:Dawn of humanity illuminated in special journal edition - 50 years after the Leakeys 2Research reveals unique solution to gene regulation 2Nanoparticles added to platelets double internal injury survival rate 2
(Date:3/27/2015)... March 27, 2015 WuXi PharmaTech (Cayman) ... R&D capability and technology platform company serving the ... today that an Investigational New Drug (IND) application ... rheumatoid arthritis has been accepted for review by ... In September 2012, MedImmune, the global ...
(Date:3/26/2015)... SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: SQD; ... including the appointment of auditors, its annual and special ... "Meeting") was adjourned, as previously disclosed on March 25, ... Toronto time). The date of the ... The Meeting will reconvene at the offices of the ...
(Date:3/26/2015)... BOSTON , March 26, 2015 /PRNewswire/ ... ), a global clinical research organization ... signed a definitive agreement to acquire all ... India ("QSI"), a leading provider of specialized ... refers to the collection, detection, assessment, monitoring, ...
(Date:3/25/2015)... pharmaceutical market is one of the most ... its absolute size, plus a growing economy and increasing ... Business Monitor International. The Russian market is set to ... market, with growth estimates around 10-15% annually reaching an ... About Green Cross Green Cross provides ...
Breaking Biology Technology:Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3SQI Diagnostics Inc. Announces Adjournment of Meeting 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4
... SAN DIEGO, March 25 ADVENTRX Pharmaceuticals, Inc. (NYSE ... for the fourth quarter and year ended December 31, ... we advanced a new business model focused on lower-risk ... our new lead programs, but given the difficult economic ...
... RICHMOND, Va., March 25 Insmed Inc. (Nasdaq: ... today announced that on Monday, March 23, 2009, NASDAQ issued ... a minimum $1 closing bid price and those rules requiring ... The suspension will remain in effect through Friday, July 17, ...
... - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ... enrolment in its U.K. clinical trial to evaluate ... in combination with gemcitabine (Gemzar(R)) in patients with ... The principal investigators are Dr. Johann de Bono ...
Cached Biology Technology:ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 2ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 3ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 4ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 5ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 6ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 7Insmed Announces That NASDAQ Further Extends Temporary Suspension of Minimum Bid Closing Price Rule 2Oncolytics Biotech(R) Inc. Completes Enrolment in Combination REOLYSIN(R)/Gemcitabine Trial 2Oncolytics Biotech(R) Inc. Completes Enrolment in Combination REOLYSIN(R)/Gemcitabine Trial 3
Request Info...
... 2 , Maintenance 112 days/each ... , Immunizations/Boost injections x5 /each ... /each , Production bleed (25 ml ... Bleed ~ 100 ml blood (~50 ml serum) x1 ...
FluoSpheres® biotin-labeled microspheres, 1.0 µm, yellow-green fluorescent (505/515) *1% solids*...
chk 1 kinase...
Biology Products: