Navigation Links
Researchers seeking to identify Alzheimer's risk focus on specific blood biomarker
Date:9/9/2008

NEW YORK A simple blood test to detect whether a person might develop Alzheimer's disease is within sight and could eventually help scientists in their quest toward reversing the disease's onset in those likely to develop the debilitating neurological condition.

Building on a study that started 20 years ago with an elderly population in Northern Manhattan at risk or in various stages of developing Alzheimer's disease, the Columbia research group has yielded ground-breaking findings that could change the way the disease is treated or someday prevent it. These findings suggest that by looking at the blood doctors may be able to detect a person's predisposition to developing the dementia-inducing disease that robs a person of their memory and ability carry out tasks essential to life.

Results presented online in the Proceedings of the National Academy of Sciences during the week of Sept. 8, 2008 suggest that individuals with elevated levels of a certain peptide in the blood plasma, Amyloid Beta 42 (A42), are at increased risk of developing Alzheimer's disease and that the decline of A42 in the bloodstream may reflect the compartmentalization or "traffic jam" of A42 in the brain, which occurs in the brain's of people with Alzheimer's.

"To date, A42 levels have measured most reliably in the cerebrospinal fluid, which is more difficult to collect than blood," said Nicole Schupf, Ph.D., Dr.P.H., associate professor of clinical epidemiology at Columbia University Medical Center and lead author of the paper. "Blood draws can be done with relative ease and greater frequency than spinal taps, which is typically the way cerebrospinal fluid is collected."

In this study, researchers found that plasma levels of A42 appear to increase before the onset of Alzheimer's disease and decline shortly after the onset of dementia. Researchers surmise that A42 may become trapped in the brain, which could account for the decrease in levels post-dementia.

The principal investigator on the Northern Manhattan study, Richard Mayeux, M.D., M.S., professor of neurology, psychiatry, and epidemiology, and co-director of the Taub Institute of Research on Alzheimer's Disease and the Aging Brain at CUMC, likens the finding to something similar that is seen in heart attack patients, who typically have elevated lipid levels in their bloodstream prior to a heart attack, but post-heart attack lipid levels may decrease.

Using more specific antibodies developed by the Ravetch Laboratory at Rockefeller University, the researchers were able to hone in on the most detrimental form of amyloid compound, the protofibrillar form of A, according to Dr. Mayeux, who is the senior author of this paper.

While the cognitive impairments of Alzheimer's can be monitored throughout the disease course, clinicians have had no reliable way to monitor the pathologic progression of the disease. Being able to reliably measure A levels in the blood could provide clinicians with a tool that forecasts the onset of Alzheimer's much earlier. Earlier detection would of course be an important step in combating the disease, researchers said.


'/>"/>

Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert  

Related biology news :

1. ISU researchers help map first plant-parasitic nematode genome sequence
2. Collaboration between researchers yields more comprehensive portrait of brain cancer
3. Tel Aviv University researchers create new stem cell screening tool
4. Hopkins researchers piece together gene network linked to schizophrenia
5. TGen and Washington University researchers discover new approach to treating endometrial cancer
6. Researchers devise means to create blood by identifying earliest stem cells
7. Researchers discover atomic bomb effect results in adult-onset thyroid cancer
8. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
9. Indiana U researchers launch social networking and research management tool for scientists
10. UC Davis researchers define characteristics, treatment options for XXYY syndrome
11. Munich researchers discover key allergy gene
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers seeking to identify Alzheimer's risk focus on specific blood biomarker
(Date:3/9/2017)... , March 9, 2017 4Dx has publicly ... Lung Imaging Workshop at the University of Pennsylvania. Founder ... to deliver the latest data to world leaders in ... brings together leaders at the forefront of the industry ... imaging. "The quality of the imaging ...
(Date:3/6/2017)... , March 6, 2017 ... sales technology, today announced Predictive Sales Coach TM ... infusing actionable sales intelligence into Salesforce. This unique ... enable their sales organizations with deep knowledge of ... allow for intelligent engagement. Predictive Sales Coach extends ...
(Date:3/2/2017)... 2017 Australian stem cell and regenerative medicine ... signed an agreement with the Monash Lung Biology Network, ... Institute and Department of Pharmacology at Monash University, ... study to support the use of Cymerus™ mesenchymal stem ... Asthma is a chronic, long term lung condition ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... NEWARK, Del. , March 29, 2017 ... medicine company, and W. L. Gore & ... announced a collaborative research agreement whereby the two companies ... delivery device technologies that provide protection from immune rejection. ... has been developing innovative stem cell-derived cell replacement therapies ...
(Date:3/29/2017)... -  GeneNews Limited (TSX:GEN) ("GeneNews" or the "Company") announced ... stratification test for breast cancer, via its Virginia ... incorporates a blood-based biomarker test with a sophisticated algorithm to ... cancer.   ... BreastSentry measures the fasting plasma levels of two biomarkers ...
(Date:3/29/2017)... 2017 The Global Microfluidic Chips Market by ... specialized and comprehensive study on the existing state of the global ... Europe and Asia-Pacific , ... and Africa . ... Browse 172 Tables and Figures, 13 Major ...
(Date:3/28/2017)... Hong Kong (PRWEB) , ... March 28, 2017 ... ... has selected NetDimensions Learning to replace paper-based processes and enhance training plan management ... “We are very pleased to partner with the SHL Group to help improve ...
Breaking Biology Technology: