Navigation Links
Researchers reveal HIV peptide's possible pathway into the cell
Date:1/17/2008

tion Professor of Biocomputation and Bioinformatics Angel Garcia. "The mechanism for entrance in the cell was clear in one simulation, but in some instances simulations show one result and you never see that result again. Then we started doing other simulations and it kept happening again and again."

Garcia and his collaborator, postdoctoral researcher Henry Herce, initially set out to uncover how the peptide interacts with a lipid bilayer that is used to model the cell membrane. A highly efficient biological system, the cell membrane is composed of a lipid bilayer (made up of two monolayers) designed to protect the cell by preventing the influx of material. Each lipid in the bilayer has a polar, or charged, end and a non-polar end. A monolayer of lipids faces the exterior of the cell, with the polar end facing the outside of the cell. Another monolayer is under the first layer, forming the bilayer. The polar end of the lower layer faces the interior of the cell, forming a middle section containing the uncharged halves of both monolayers.

Because charged particles seek each other in order to neutralize themselves and achieve a more stable state, the surface of the polar cell membrane and the positively charged HIV peptide are drawn to one another. But the interior of the bilayer is not charged and forms a strong barrier against the entrance of any charged material.

As was expected, in their simulations the researchers observed that the positive charges in the peptide quickly attached to the surface of the cell membrane and sought out and reacted with negatively charged phosphates from the charged portion of the lipid bilayer to satisfy their need for neutrality. "Then the peptide entered the forbidden territory of the cell," Garcia said. The positively charged peptide entered the membrane. "This is when this mechanism starts to challenge conventional wisdom," he said.

The researchers' model systems show the peptides grabbing for
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. USC researchers identify mechanism that controls activation of stem cells during hair regeneration
2. Researchers put the bite on mosquitoes
3. Researchers find association between food insecurity and developmental risk in children
4. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
5. Japanese and German researchers meet to discuss climate change
6. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
7. Researchers uncover new piece to the puzzle of human height
8. Researchers create mathematical model of fruit fly eyes
9. Snoozing worms help Penn researchers explain the evolution of sleep
10. Researchers move 2 steps closer to understanding genetic underpinnings of autism
11. Rices West honored as one of Texas best researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers reveal HIV peptide's possible pathway into the cell
(Date:9/2/2014)... researchers at the University of Warwick in the UK ... in the Journal Early Human Development , has ... hospital after birth and the use of mechanical ventilation ... children. , Mathematic abilities are crucial for lifelong academic ... preterm children. Earlier studies of children who are born ...
(Date:9/2/2014)... is considered the most ideal source of nutrition ... critical role in the evolution and civilizations of ... contains a large number of bacterial species, including ... as no surprise to scientists and physicians. , ... to be the result of co-evolutionary and co-adaptive ...
(Date:9/2/2014)... 2, 2014) In the battle between our immune ... ally in bacteria-killing viruses known as phages. In a ... Partners In Health, Haiti,s National Public Health Laboratory, and ... give up their virulence in order to survive. Importantly, ... found that cholera,s mutational escape from phage predation occurs ...
Breaking Biology News(10 mins):Mechanical ventilation a key indicator for pre-term children's math problems 2Are human breast milk microbiome 'neutral'? 2Are human breast milk microbiome 'neutral'? 3War between bacteria and phages benefits humans 2War between bacteria and phages benefits humans 3
... Society has announced the winners of its second ... Society,s 57th Annual Meeting at the Pennsylvania Convention ... Society,s Committee for Professional Opportunities for Women (CPOW), ... number of women biophysicists and encourage their participation ...
... male jaguar and an adult male ocelot have been photographed ... monitoring cameras. The images were collected as part of the ... Arizona. Both animals appear to be in good health. ... from wildlife cameras set up as part of the research ...
... LA JOLLA, CA January 8, 2013 - Chemists at The ... one of the most fundamental tasks in molecular biology. Their new ... that these cells may be easily located and/or selected out from ... in a recent issue of the chemistry journal Angewandte Chemie ...
Cached Biology News:Biophysical Society announces winners of 2013 CPOW travel awards 2Wildlife monitoring cameras click jaguar and ocelot photos 2Wildlife monitoring cameras click jaguar and ocelot photos 3Chemists devise inexpensive, benchtop method for marking and selecting cells 2Chemists devise inexpensive, benchtop method for marking and selecting cells 3
(Date:8/31/2014)... Texas (PRWEB) August 31, 2014 ... the current state of the Epoxy Hardener ... a basic overview of the industry, including definitions, ... and Chinese domestic market analysis are provided with ... landscape of the market. A comparison between the ...
(Date:8/29/2014)... August 29, 2014 The global ... billion in 2019. It is expected to grow ... 2019, and was valued at $1.8 billion in ... Transparency Market Research. , For more information regarding ... . , The research report, titled “Companion Diagnostics ...
(Date:8/29/2014)... Hills, NY (PRWEB) August 29, 2014 ... Burnt Hills Veterinary Hospital are seeking candidates to participate ... dogs with osteoarthritis. The ultimate goal of this ... donor stem cells into one or two arthritically affected ... treated joints. , Candidates for the current investigational ...
(Date:8/29/2014)... San Antonio, TX (PRWEB) August 29, 2014 ... 9001:2008 and ISO 13485:2003 certified, GAMP® 5 compliant ... been awarded an international Phase II clinical trial ... non-Hodgkin’s lymphoma. , Throughout this trial, Intrinsic Imaging ... but not limited to, protocol and charter development, ...
Breaking Biology Technology:Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2
... HALIFAX, May 23 /PRNewswire/ - ImmunoVaccine Technologies Inc. ... for being,recognized as one of Pennsylvania,s Best 50 ... of Immunotope Inc., received the honors,from Pennsylvania Governor ... in the biotech industry. Her clinical work in,antigen ...
... EXTON, Pa., May 23 BioTrends Research ... Nephrology," providing insight,into the referral patterns and ... from the perspective of Nephrologists,Cardiologists, Endocrinologists, and ... offers a comprehensive view, based on,qualitative interviews ...
... and PHILADELPHIA, Pennsylvania, May 23, Shire Limited ("Shire") (LSE: ... an,application has been made to the UK Listing Authority ... of 5 pence each in the,capital of Shire to ... on the,London Stock Exchange. Dealings will commence today at ...
Cached Biology Technology:ImmunoVaccine Technologies Congratulates Dr. Ramila Philip as One of PA's Best 50 Women in Business 2Nephrologists and Non-Nephrologists Alike Report Increased Attention on Chronic Kidney Disease 2Application for Listing of Shire Limited Ordinary Shares 2Application for Listing of Shire Limited Ordinary Shares 3