Navigation Links
Researchers reveal HIV peptide's possible pathway into the cell
Date:1/17/2008

Troy, N.Y. - Two theoretical physicists at Rensselaer Polytechnic Institute have uncovered what they believe is the long-sought-after pathway that an HIV peptide takes to enter healthy cells. The theorists analyzed two years of biocomputation and simulation to uncover a surprisingly simple mechanism describing how this protein fragment penetrates the cell membrane. The discovery could help scientists treat other human illnesses by exploiting the same molecules that make HIV so deadly proficient.

The findings are detailed in the Dec. 26, 2007, issue of the Proceedings of the National Academy of Sciences (PNAS).

For the last decade, scientists have known that a positively charged, 11-amino-acid chain of HIV (HIV-1 Tat protein) can do the nearly unthinkable X cross through the cell membrane. Sometimes referred to as an "arrow protein," HIV-1 Tat pierces the cell membrane and carries a cargo though the cell membrane.

Its unique cell-puncturing ability has been the subject of hundreds of scientific articles investigating the type of materials that can piggyback on the peptide and also enter the cell. Researchers have proposed using the peptide to deliver genes for gene therapy and drugs that need to be delivered directly to a cell. But despite many potential medical applications, the actual mechanism that opens the holes in the cell remained undiscovered.

The Rensselaer researchers have discovered that the positively charged HIV peptide is drawn to negatively charged groups inside the cell membrane. When the HIV peptide cannot satisfy itself with the negative charges available on the cell membrane surface it is directly attached to, it reaches through the membrane to grab negatively charged groups in the molecules on the other side, opening a transient hole in the cell.

"What we saw in our computer calculations wasn't at all what we expected to see when we began," said co-lead author and Senior Constella
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. USC researchers identify mechanism that controls activation of stem cells during hair regeneration
2. Researchers put the bite on mosquitoes
3. Researchers find association between food insecurity and developmental risk in children
4. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
5. Japanese and German researchers meet to discuss climate change
6. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
7. Researchers uncover new piece to the puzzle of human height
8. Researchers create mathematical model of fruit fly eyes
9. Snoozing worms help Penn researchers explain the evolution of sleep
10. Researchers move 2 steps closer to understanding genetic underpinnings of autism
11. Rices West honored as one of Texas best researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers reveal HIV peptide's possible pathway into the cell
(Date:2/18/2015)...  Cepheid (NASDAQ: CPHD ) today announced that ... invited investors to participate via webcast. , Cowen and ... Tuesday, March 3, 2015 at 11.20 a.m. Eastern Time ... Wednesday, March 4, 2015 at 10.25 a.m. Eastern ... webcasts for these events, please visit Cepheid,s website at ...
(Date:2/12/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... for DISTRIBUTED METHOD AND SYSTEM TO IMPROVE ... further establishes NXT-ID,s position in the emerging "Internet of ... ability for multiple devices to collaborate with one another ...
(Date:2/9/2015)...  Lintec of America recently announced an exclusive license ... macrostructures, including sheets, yarns and ribbons, developed at the ... the vast industrial resources of the global Lintec Group, ... of America is forming the Nano-Science and Technology Center ... on scaling up the manufacturing and commercialization of nano ...
Breaking Biology News(10 mins):Cepheid to Webcast Upcoming Financial Presentations 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4
... Planck Institute for Human Cognitive and Brain Sciences and ... now developed a mathematical model which could significantly improve ... the future, this kind of algorithms which imitate brain ... them. Many people will have personal experience of ...
... cells for replication and production of virus progeny. Thus ... induces therapy resistance. New improved therapies attempt to targets ... The team led by Professor Dr. Ralf Bartenschlager, ... Hygiene Institute of Heidelberg University Hospital, has identified a ...
... at Carnegie Mellon University have developed an analytical technique ... complex disease syndromes such as diabetes, asthma and cancer, ... , Rather than searching one at a time for ... as in most conventional approaches, the Carnegie Mellon ...
Cached Biology News:Doing what the brain does -- how computers learn to listen 2Doing what the brain does -- how computers learn to listen 3New strategy for inhibiting virus replication 2Carnegie Mellon develops innovative method to detect genetic causes of complex diseases 2
(Date:2/26/2015)... Los Angeles, CA (PRWEB) February 26, 2015 ... organizing an online demonstration to support life extension technologies ... to 8pm UTC, Universal Coordinated Time, on March 21st ... around the world. , Eric Schulke, Founder of ... we must act with urgency. The Movement for Indefinite ...
(Date:2/26/2015)... BioEnterprise today announced that Northeast Ohio ... in growth funding during the past 13 years.  Funding ... – including the Ohio Third Frontier - and federal ... raised in the past five years. ... BioEnterprise Midwest Healthcare Growth Capital  Report.   ...
(Date:2/26/2015)... February 26, 2015 RURO, Inc., a ... FreezerPro® version 6.2 – the latest update to the ... is that of a quick and easy method to ... the latest version, RURO engineering has enhanced the system’s ... move large amounts of sample records. , "FreezerPro ...
(Date:2/26/2015)... Calif. , Feb. 26, 2015 ... Gold Partner status in Oracle PartnerNetwork. In attaining Gold ... its commitment to establish Oracle-related knowledge in delivering Ceres, ... challenges of joint customers. Originally developed for ... to rapidly zoom in and out of massive amounts ...
Breaking Biology Technology:Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 2More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 4RURO Releases FreezerPro® version 6.2 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 3Ceres Becomes Oracle PartnerNetwork Gold Level Partner 4
... Oct. 25 Cellectis (Alternext: ALCLS), the French genome ... and Application (CiRA) of Kyoto University, Kyoto, Japan, have ... to combine Cellectis, genome engineering technologies with CiRA,s induced ... characteristics of iPS cells for use as cellular tools. ...
... Oct. 22 Trius Therapeutics, Inc. (Nasdaq: TSRX ... at Trius Therapeutics, will present "Innovative Antibacterial Drugs by Design; ... event taking place on October 26, 2010 from 5:30-9:30 p.m. ... available at http://sdbn.org/october . About ...
... Bacterin International Holdings, Inc. (OTC Bulletin Board: ... for medical applications and revolutionary bone graft material, today ... M. Wickwire, a distinguished Washington, D.C. based attorney and ... & Carparelli, to its Board of Directors.  Effective immediately, ...
Cached Biology Technology:Cellectis and the Center for iPS Cells Research and Application Enter Collaboration 2Cellectis and the Center for iPS Cells Research and Application Enter Collaboration 3Bacterin International Reconstitutes Its Board of Directors and Appoints Experienced Legal and Financial Professionals 2Bacterin International Reconstitutes Its Board of Directors and Appoints Experienced Legal and Financial Professionals 3Bacterin International Reconstitutes Its Board of Directors and Appoints Experienced Legal and Financial Professionals 4
... utilize the membrane-permeant ester forms (CCF2-AM ... fluorescent beta-lactamase substrates, CCF2 and CCF4. ... cell, where cleavage by endogeneous cytoplasmic ... negatively charged forms, thereby trapping them ...
...
Homogenizing Solution, 18ml Proteinase K - [50ug/l] 75 l...
...
Biology Products: