Navigation Links
Researchers reveal HIV peptide's possible pathway into the cell
Date:1/17/2008

Troy, N.Y. - Two theoretical physicists at Rensselaer Polytechnic Institute have uncovered what they believe is the long-sought-after pathway that an HIV peptide takes to enter healthy cells. The theorists analyzed two years of biocomputation and simulation to uncover a surprisingly simple mechanism describing how this protein fragment penetrates the cell membrane. The discovery could help scientists treat other human illnesses by exploiting the same molecules that make HIV so deadly proficient.

The findings are detailed in the Dec. 26, 2007, issue of the Proceedings of the National Academy of Sciences (PNAS).

For the last decade, scientists have known that a positively charged, 11-amino-acid chain of HIV (HIV-1 Tat protein) can do the nearly unthinkable X cross through the cell membrane. Sometimes referred to as an "arrow protein," HIV-1 Tat pierces the cell membrane and carries a cargo though the cell membrane.

Its unique cell-puncturing ability has been the subject of hundreds of scientific articles investigating the type of materials that can piggyback on the peptide and also enter the cell. Researchers have proposed using the peptide to deliver genes for gene therapy and drugs that need to be delivered directly to a cell. But despite many potential medical applications, the actual mechanism that opens the holes in the cell remained undiscovered.

The Rensselaer researchers have discovered that the positively charged HIV peptide is drawn to negatively charged groups inside the cell membrane. When the HIV peptide cannot satisfy itself with the negative charges available on the cell membrane surface it is directly attached to, it reaches through the membrane to grab negatively charged groups in the molecules on the other side, opening a transient hole in the cell.

"What we saw in our computer calculations wasn't at all what we expected to see when we began," said co-lead author and Senior Constella
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. USC researchers identify mechanism that controls activation of stem cells during hair regeneration
2. Researchers put the bite on mosquitoes
3. Researchers find association between food insecurity and developmental risk in children
4. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
5. Japanese and German researchers meet to discuss climate change
6. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
7. Researchers uncover new piece to the puzzle of human height
8. Researchers create mathematical model of fruit fly eyes
9. Snoozing worms help Penn researchers explain the evolution of sleep
10. Researchers move 2 steps closer to understanding genetic underpinnings of autism
11. Rices West honored as one of Texas best researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers reveal HIV peptide's possible pathway into the cell
(Date:10/16/2014)... – Post-menopausal women experienced improvements in vaginal atrophy, ... genital bleeding, after 12 weeks of daily 10 ... germ-based nutritional supplement previously shown to help relieve ... pilot study reported in a poster at the ... , "These data documented improved vaginal epithelium, ...
(Date:10/15/2014)... book ,Models of Life, is a non-traditional biophysics textbook ... The book is a journey of discovery into biological ... life and biological regulation. It is about how our ... communication between the billions of cells in an organism. ... relationships between principles, which can be found on both ...
(Date:10/15/2014)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... growing mobile commerce market releases photos and video of the recent ... October 13 th . Gino Pereira , ... angel investor Mr. Chad A. Verdi rang the bell.  ... his investors and employees "for their work and dedication in bringing ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2New book about life as seen from physics 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
... time that several common species of seaweeds in both the ... chemical means. While competition between seaweed and ... of coral reefs worldwide, this chemical threat may provide a ... Seaweeds are normally kept in check by herbivorous fish, but ...
... hard winter for Monarch butterflies, according to Chip Taylor, director ... that low temperatures, storms and habitat destruction have all threatened ... a lot of time fretting over the status of the ... that will help me understand the past as a way ...
... from Rensselaer Polytechnic Institute will send an army of ... of preventing the formation and spread of biofilms, or ... the health of astronauts. The Micro-2 experiment, led ... Chemical and Biological Engineering at Rensselaer, is scheduled to ...
Cached Biology News:Researchers offer first proof that chemicals from seaweeds damage coral on contact 2Researchers offer first proof that chemicals from seaweeds damage coral on contact 3Researchers offer first proof that chemicals from seaweeds damage coral on contact 4As monarch butterflies journey north, gardeners can help protect species, researcher says 2Rensselaer researchers to send bacteria into orbit aboard space shuttle Atlantis 2
(Date:10/22/2014)... , Oct. 22, 2014  Actavis plc (NYSE: ... and Rhythm, a biopharmaceutical company, today announced that Actavis ... wholly owned subsidiary, Rhythm Health, Inc., which is developing ... of diabetic gastroparesis and other GI functional disorders. ... trial of relamorelin for the treatment of diabetic gastroparesis ...
(Date:10/22/2014)... Involution Studios , a healthcare software design ... Understanding Ebola . The goal of the ... follow informative tool for anyone wanting to know more ... , "As the news has spread in all directions ... not only a healthcare crisis with global impact, but ...
(Date:10/22/2014)... 2014 Physicians Choice Laboratory Services ... menu, which enables healthcare providers to individualize therapeutic ... evidence-based results, healthcare providers are better able to ... while minimizing risks for adverse drug reactions and ... the FDA [1] more than 2.2 million adverse ...
(Date:10/22/2014)... , Oct. 22, 2014 Nuvilex, Inc. ... approximately 400 million people worldwide are living with diabetes, ... people by 2030.  The global market for diabetes treatments ... approximately 330,000 people worldwide died from pancreatic cancer.  Pancreatic ... due to cancer in the United States ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2
... SAN DIEGO, Nov. 2 Cardium Therapeutics (NYSE Amex: ... 510(k) premarket notification with the U.S. Food and Drug ... product candidate. Excellagen XL is an ... customized collagen-based topical gel designed for use by physicians ...
... and LONDON, Nov. 2 A study from Thomson Reuters ... far outpacing research activity in the rest of the world. ... within the next decade. , The study, Global ... collaboration potential of China and its current place in world ...
... Pharmasset, Inc. (Nasdaq: VRUS ) today announced that it ... the Study of Liver Diseases (AASLD) on Monday, November 2, ... review Pharmasset,s progress on the programs that are the subject ... of this event via the internet, log on to the ...
Cached Biology Technology:Cardium Announces Plans to File FDA 510(k) Application for U.S. Marketing Clearance of ExcellagenXL(TM) Gel for Diabetic, Pressure and Venous Ulcers and Other Topical Wounds 2Cardium Announces Plans to File FDA 510(k) Application for U.S. Marketing Clearance of ExcellagenXL(TM) Gel for Diabetic, Pressure and Venous Ulcers and Other Topical Wounds 3Cardium Announces Plans to File FDA 510(k) Application for U.S. Marketing Clearance of ExcellagenXL(TM) Gel for Diabetic, Pressure and Venous Ulcers and Other Topical Wounds 4China's Research Output More Than Doubled Since 2004, Thomson Reuters Study Reveals 2Pharmasset to Webcast an Investor Event from the AASLD Meeting 2Pharmasset to Webcast an Investor Event from the AASLD Meeting 3Pharmasset to Webcast an Investor Event from the AASLD Meeting 4
Umbilical cord blood neutrophils, For immunohistochemistry (IHC)...
...
Adjustable tilt angle 0 to 20 Adjustable speed of 3-25 RPM Load capacity: 2.7 kg (6 lbs.) Ambient temperature range 4C to 65C Low voltage power is supplied by wall mount transformer...
... Clean spin filters allow for the rapid isolation ... your DNA gel slice in the spin filter, ... your DNA is recovered. There is no need ... buffers. Spin filters can also be used for ...
Biology Products: