Navigation Links
Researchers reveal HIV peptide's possible pathway into the cell
Date:1/17/2008

Troy, N.Y. - Two theoretical physicists at Rensselaer Polytechnic Institute have uncovered what they believe is the long-sought-after pathway that an HIV peptide takes to enter healthy cells. The theorists analyzed two years of biocomputation and simulation to uncover a surprisingly simple mechanism describing how this protein fragment penetrates the cell membrane. The discovery could help scientists treat other human illnesses by exploiting the same molecules that make HIV so deadly proficient.

The findings are detailed in the Dec. 26, 2007, issue of the Proceedings of the National Academy of Sciences (PNAS).

For the last decade, scientists have known that a positively charged, 11-amino-acid chain of HIV (HIV-1 Tat protein) can do the nearly unthinkable X cross through the cell membrane. Sometimes referred to as an "arrow protein," HIV-1 Tat pierces the cell membrane and carries a cargo though the cell membrane.

Its unique cell-puncturing ability has been the subject of hundreds of scientific articles investigating the type of materials that can piggyback on the peptide and also enter the cell. Researchers have proposed using the peptide to deliver genes for gene therapy and drugs that need to be delivered directly to a cell. But despite many potential medical applications, the actual mechanism that opens the holes in the cell remained undiscovered.

The Rensselaer researchers have discovered that the positively charged HIV peptide is drawn to negatively charged groups inside the cell membrane. When the HIV peptide cannot satisfy itself with the negative charges available on the cell membrane surface it is directly attached to, it reaches through the membrane to grab negatively charged groups in the molecules on the other side, opening a transient hole in the cell.

"What we saw in our computer calculations wasn't at all what we expected to see when we began," said co-lead author and Senior Constella
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. USC researchers identify mechanism that controls activation of stem cells during hair regeneration
2. Researchers put the bite on mosquitoes
3. Researchers find association between food insecurity and developmental risk in children
4. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
5. Japanese and German researchers meet to discuss climate change
6. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
7. Researchers uncover new piece to the puzzle of human height
8. Researchers create mathematical model of fruit fly eyes
9. Snoozing worms help Penn researchers explain the evolution of sleep
10. Researchers move 2 steps closer to understanding genetic underpinnings of autism
11. Rices West honored as one of Texas best researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers reveal HIV peptide's possible pathway into the cell
(Date:9/30/2014)... environment on Earth, but when the climate changes and ... limit. The amount of time needed to adjust to ... cope in the future, reveals a new study from ... scientific journal Proceedings of the Royal Society B ... levels of greenhouse gases in the atmosphere. The greenhouse ...
(Date:9/30/2014)... DURHAM, N.C. -- Pollution in urban and farm runoff ... a new study finds. , The study, published ... shows that nitrogen in the runoff ends up in ... tumors on the animals, eyes, flippers and internal organs. ... and the National Oceanic and Atmospheric Administration (NOAA) conducted ...
(Date:9/30/2014)... of Ludwig-Maximilians-Universitaet (LMU) in Munich report that a ... more sensitive to chemotherapeutic drugs. They have also ... new target for anti-tumor agents. , Researchers ... Stephan Sieber of the Technische Universitt Mnchen have ... potential new weapon in the fight against malignant ...
Breaking Biology News(10 mins):Shape up quickly -- applies to fish, too! 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Cancer therapy: Driving cancer cells to suicide 2
... Advancement of Science (AAAS) meeting in Washington, D.C., February ... from solar and renewable energy solutions to the latest ... president, will deliver the President,s Address at the opening ... Friday, February 18 ...
... affordable, high throughput DNA sequencing, coupled with improved bioinformatics ... the field of molecular plant breeding. Multidisciplinary breeding programs ... investigate genome-wide variations in DNA sequences and link them ... many genes, such as hybrid vigor. Furthermore, there has ...
... a method based on geographic positioning systems that allowed ... in a way similar to how geographers characterize mountain ... that reflects how "rugged" the surface of the tooth ... the shearing molars in insect eaters and omnivores to ...
Cached Biology News:Tip sheet: Caltech researchers presenting at AAAS 2Tip sheet: Caltech researchers presenting at AAAS 3UMass Amherst biologists use GPS to 'map' bats teeth to explore evolutionary adaptations to diet 2
(Date:9/30/2014)... Lyme Research Alliance (LRA), the ... at universities, today announced the awarding of seven grants ... and cure for Lyme and other tick-borne diseases. ... in its history—over 20 grant proposals—a 100 percent increase ... to receive so many solid applications from talented scientists ...
(Date:9/30/2014)... Windsor, CT (PRWEB) September 30, 2014 ... distributor of scientific research products, recently opened an ... its comprehensive cell culture product lines developed and ... through its online store include Biological Industries’ Nutristem® ... (hMSC) and human embryonic stem cell (hESC) culture. ...
(Date:9/30/2014)... 2014 UFP Technologies, a producer ... has recently introduced a custom insulated shipping container ... The new insulated shipper solves the issue of ... UFP Technologies’ BioShell is a universal storage container ... handling and shipping. The insulated shipper keeps frozen ...
(Date:9/30/2014)... Toronto, Ontario, Canada (PRWEB) September 30, 2014 ... requirements based on 500 square feet. per employee, which included ... different world back then.” says Jeff Howell, partner at ... tenant advisory firm in Toronto. “By the year 2000, ... We are now seeing that number come down to 175 ...
Breaking Biology Technology:Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3
... Telephone Corp. is opening a liason office with one ... campus. Hiroki Tanaka, vice president and general manager of ... seeking out opportunities for the company to expand further ... relationship during governor Jim Doyle's trade mission to Japan ...
... card American businesses have left to play if they ... and chief information officers must take the lead in ... Peters. , ,Peters spoke on Wednesday of the merits ... Wisconsin business executives during the Wisconsin Innovates Conference in ...
... Wis. Neurognostics Inc. said it has partnered ... combined functional magnetic resonance imaging software product. , ,"Both ... practice," said Doug Tucker, CEO of Neurognostics , ... collaborate on our efforts to develop clinically useful fMRI ...
Cached Biology Technology:Peters: Innovation the only edge that remains for American business 2
... EZ-Spread Plating Beads Sterile plating in ... glass rods and potentially hazardous ethanol flaming, ... choices of ready-to-use sterile packaging: dispenser bottle for ... plating, Fastest and easiest way to ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... a regulated environment, Pipette Tracker Pro ... that automates gravimetric pipette calibration and ... meets todays regulatory compliance requirements. Pipette ... that includes a full security implementation, ...
... the yolk protein Vtg in plasma from juvenile ... biomarker for endocrine disrupting chemicals (EDCs) with estrogenic ... an accepted screening test for the estrogenic effects ... EIA kit is a double-antibody immunometric (sandwich) EIA ...
Biology Products: