Navigation Links
Researchers moving towards ending threat of West Nile virus
Date:7/3/2012

Mosquitoes are buzzing once again, and with that comes the threat of West Nile virus. Tom Hobman, a researcher with the Li Ka Shing Institute of Virology in the Faculty of Medicine & Dentistry, is making every effort to put an end to this potentially serious infection.

West Nile virus infections often result in flu-like symptoms that aren't life-threatening, and some in cases, infected people show no symptoms at all. But a significant percentage of patients develop serious neurological disease that includes inflammation in the brain, paralysis and seizures. In his latest research, published in the journal PLoS One, Hobman has discovered how the virus breaks through the normally rock-solid blood-brain barrier to the central nervous system. The virus breaks down two vital proteins that make up what is called the tight junction, a part of the blood-brain barrier.

"What we found in infected cells is there's less of two proteins called claudin and JAM (junctional adhesion molecule)," said Hobman. "The virus replication is causing degradation of two very important molecules that form these intra-cellular barriers. We can quantitate this and we've looked in at least three different cell types and we see the same thing happening."

Now Hobman and his graduate student Zaikun Xu would like to know how this is happening. Cells have built in pathways that regulate tight junctions, in part by controlling the levels of both JAM and claudin. Hobman hypothesizes that West Nile virus infection causes these pathways to go awry resulting in accelerated breakdown of claudin and JAM.

"Once we understand how West Nile virus affects the pathways that control the tight junctions of the blood-brain barrier, it may be possible to design drugs that prevent infection of the brain. I expect this will also be the case for related viruses that infect the central nervous system."

This builds on work his lab published last year showing that wh
'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-248-2048
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. NOAA researchers see dramatic decline of endangered white abalone
2. BESC researchers tap into genetic reservoir of heat-loving bacteria
3. Researchers and communities at risk join forces in volcano study
4. Penn researchers improve living tissues with 3-D printed vascular networks made from sugar
5. BUSM researchers identify role of FOXO1 gene in Parkinsons disease
6. How sweet it is: Tomato researchers discover link between ripening, color and taste
7. Researchers discover potential explanation for why a diet high in DHA improves memory
8. Rice researchers develop paintable battery
9. UMass Medical School researchers discover a new role for RNAi
10. Researchers develop new method for analyzing cell function
11. Maths formula leads researchers to source of pollution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... by an international standards process, will be available soon ... invited review published in the OnlineFirst version of ... official journal of the American Society for Parenteral and ... the occurrence of misconnection that can be harmful and ... used to join medical devices, components, and accessories to ...
(Date:8/21/2014)... (ANU) team has successfully replicated one of the crucial ... powered by sunlight which could manufacture hydrogen as a ... It is an exciting prospect to use them to ... Dr Kastoori Hingorani, from the ARC Centre of Excellence ... Biology. , Hydrogen offers potential as a zero-carbon replacement ...
(Date:8/21/2014)... in severe abdominal pain, vomiting and systemic inflammation. Every ... with the disease resulting in 1000 deaths. There is ... fluid and nutritional support. , Dr Jason Bruce, ... research, said "The major causes of pancreatitis include bile ... combined with a high fat diet. In fact, the ...
Breaking Biology News(10 mins):New feeding tube connectors will improve patient safety 2Water and sunlight the formula for sustainable fuel 2Insulin offers new hope for the treatment of acute pancreatitis 2
... when exposed to cold air but not when diving ... the diving seal to conserve oxygen and minimize brain ... researchers presented the study at The American Physiological Society's ... Va., October 8-11. The researchers, Arnoldus Schytte Blix, Petter ...
... comforting thought unless the living thing in question is a ... developing drug resistance, outwitting immune systems, and evading cellular controls. ... perturbations such as mutations that affect the function of vital ... perform old tasks. Somehow the bad guys find ...
... A highly drug-resistant form of tuberculosis (TB) has been linked ... by researchers at Yale School of Medicine. , Published in ... the result of a five-year collaboration between a Yale and ... and TB care and treatment. , TB is the ...
Cached Biology News:Seals protect brain, conserve oxygen by turning off shivering response on icy dives 2Seals protect brain, conserve oxygen by turning off shivering response on icy dives 3Evolution and the workaround 2HIV/AIDS linked to extensively drug resistant TB 2
(Date:8/21/2014)... Sofia, Bulgaria (PRWEB) August 21, 2014 ... was released today by Ontotext . Now ... and semantic analysis of structured and unstructured data is ... of the cost of enterprise technology. Organizations that do ... approaches for data management can use S4 since there ...
(Date:8/21/2014)... 2014 On Wednesday of last week RENU ... Redox Signaling molecules, became available for purchase in Australia and ... way that RENU 28 works is, if you think about ... the rate of cellular renewal within your body. If you ... that rate of cellular renewal. What RENU 28 does is ...
(Date:8/20/2014)... often have it that American Indians largely were wiped ... influenza and tuberculosis brought to the New World by ... 20 million people lived in the Americas shortly before ... killed by European diseases., But new research led by ... Johannes Krause of the University of Tubingen in Germany ...
(Date:8/20/2014)... 2014 High performance computing (HPC) ... most complete climate and Earth system model to ... issues. , Eight national laboratories, including Lawrence ... Center for Atmospheric Research, four academic institutions and ... participating national laboratories include Argonne, Brookhaven, Lawrence Berkeley, ...
Breaking Biology Technology:Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4RENU 28 Skin Care Now Available in Australia and New Zealand 2Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3
... Vasogen Inc.,(NASDAQ: VSGN ; TSX:VAS), today announced that ... from the Listing Qualifications Department of The NASDAQ,Stock ... of its common,stock had fallen below $1.00 for ... in compliance with Marketplace Rule 4310(c)(4),(the "Rule"). In ...
... 25 Keryx Biopharmaceuticals,Inc. (Nasdaq: KERX ) announced ... Market ("Nasdaq") stating that the Company is not in,compliance ... on the Nasdaq Global Market pursuant to Marketplace Rule ... dated April 22,2008, is a standard communication when the ...
... April 25 ,Renovis, Inc. (Nasdaq: RNVS ), ... Services have joined ISS/Risk Metrics and Glass Lewis,& ... the merger,agreement with Evotec AG (Frankfurt Stock Exchange: ... May 1, 2008. In the proposed merger,each share ...
Cached Biology Technology:Vasogen Receives NASDAQ Notification Related to Minimum Bid Price 2Vasogen Receives NASDAQ Notification Related to Minimum Bid Price 3Keryx Biopharmaceuticals Receives Nasdaq Notification 2Keryx Biopharmaceuticals Receives Nasdaq Notification 3Proxy Governance and Egan-Jones Recommend Renovis Shareholders Vote For Merger With Evotec 2Proxy Governance and Egan-Jones Recommend Renovis Shareholders Vote For Merger With Evotec 3
Physical Form: powder Color: white Removes FLAG peptide from N-terminal and Met-N-terminal fusion proteins. Supplied with optimized enterokinase buffer....
This antibody detects ubiquitinated proteins on SDS-PAGE immunoblots. It does not detect free ubiquitin....
... and BR4i refrigerated multifunction centrifuges are equally capable ... a low sound level with a large range ... AUTO-LOCK rotor exchange system without tools ensures that ... seconds. Instant rotor exchange (5 sec.) ...
... Jouan B4i ventilated and BR4i refrigerated multifunction centrifuges ... speed operation at a low sound level with ... for biocontainment. Their AUTO-LOCK rotor exchange system without ... for use within seconds. Instant rotor ...
Biology Products: