Navigation Links
Researchers moving towards ending threat of West Nile virus
Date:7/3/2012

Mosquitoes are buzzing once again, and with that comes the threat of West Nile virus. Tom Hobman, a researcher with the Li Ka Shing Institute of Virology in the Faculty of Medicine & Dentistry, is making every effort to put an end to this potentially serious infection.

West Nile virus infections often result in flu-like symptoms that aren't life-threatening, and some in cases, infected people show no symptoms at all. But a significant percentage of patients develop serious neurological disease that includes inflammation in the brain, paralysis and seizures. In his latest research, published in the journal PLoS One, Hobman has discovered how the virus breaks through the normally rock-solid blood-brain barrier to the central nervous system. The virus breaks down two vital proteins that make up what is called the tight junction, a part of the blood-brain barrier.

"What we found in infected cells is there's less of two proteins called claudin and JAM (junctional adhesion molecule)," said Hobman. "The virus replication is causing degradation of two very important molecules that form these intra-cellular barriers. We can quantitate this and we've looked in at least three different cell types and we see the same thing happening."

Now Hobman and his graduate student Zaikun Xu would like to know how this is happening. Cells have built in pathways that regulate tight junctions, in part by controlling the levels of both JAM and claudin. Hobman hypothesizes that West Nile virus infection causes these pathways to go awry resulting in accelerated breakdown of claudin and JAM.

"Once we understand how West Nile virus affects the pathways that control the tight junctions of the blood-brain barrier, it may be possible to design drugs that prevent infection of the brain. I expect this will also be the case for related viruses that infect the central nervous system."

This builds on work his lab published last year showing that wh
'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-248-2048
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. NOAA researchers see dramatic decline of endangered white abalone
2. BESC researchers tap into genetic reservoir of heat-loving bacteria
3. Researchers and communities at risk join forces in volcano study
4. Penn researchers improve living tissues with 3-D printed vascular networks made from sugar
5. BUSM researchers identify role of FOXO1 gene in Parkinsons disease
6. How sweet it is: Tomato researchers discover link between ripening, color and taste
7. Researchers discover potential explanation for why a diet high in DHA improves memory
8. Rice researchers develop paintable battery
9. UMass Medical School researchers discover a new role for RNAi
10. Researchers develop new method for analyzing cell function
11. Maths formula leads researchers to source of pollution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... MADISON, Wis. , Jan. 15, 2015  BellBrook ... for drug discovery, announced the launch of a ... of the company,s Transcreener UDP Assay, a high ... enzymes. The new assay will allow for sensitive ...
(Date:1/22/2015)... (NASDAQ: NXTD and NXTDW) a biometric authentication company focused ... the Wocket™ smart wallet at CES 2015 in Las Vegas ... of the "11 Hot Products at CES" in a review published in ... by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
(Date:1/22/2015)... 21, 2015  Analyst Report Issued by Small Cap IR. In ... that planet-wide, transactions at merchants on the leading payment cards ... of credit, debit, and prepaid cards reached 6.54 billion.  Eight ... fraudulent card usage in 2012, and credit and debit card ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2
... pulp is wood. However, growing demand in the paper industry, ... sector to turn to other sources of raw materials, such ... This residue, obtained after crushing of the cane, is already ... (in South America and India for example, where it represents ...
... first biochemical marker linked to sleep loss, an enzyme in ... deprivation is prolonged. , Researchers hope to make amylase the ... and treatment of sleep disorders and may one day help ... a car or in other dangerous contexts. , ...
... Lee Dequeant, Ph.D., a Predoctoral Researcher at the Stowers ... Institute Investigator and an investigator with the Howard Hughes ... on a paper that identifies a network of cyclic ... spine formation in the embryo. , The ...
Cached Biology News:Developing uses for sugar-cane bagasse: Biotechnology applied to the paper industry 2Developing uses for sugar-cane bagasse: Biotechnology applied to the paper industry 3First biomarker for human sleepiness identified in fruit flies 2First biomarker for human sleepiness identified in fruit flies 3
(Date:3/6/2015)... According to a new market research report ... Xenograft, Suture Anchor, Interference Screws, Laparoscopic Instruments) by Application ... Global Forecast to 2019", published by MarketsandMarkets, the Soft ... in 2019 from $10.3 Billion in 2014, at a ... Browse 70 market data tables and 32 ...
(Date:3/6/2015)... , March 6, 2015   Senomyx , Inc. ... proprietary taste science technologies to discover, develop, and commercialize ... industries, announced today that John Poyhonen , the Company,s ... , Senior Vice President and Chief Financial Officer, will ... scheduled for Wednesday, March 11, at 2:00 p.m. Eastern ...
(Date:3/5/2015)... YORK , March 5, 2015  DuPont (NYSE: ... Morgan Aviation, Transportation and Industrials Conference held today in ... President Matthew L. Trerotola discussed strategy, progress ... Materials segments for DuPont.  Strengthening and growing the company,s ... the three areas of strategic priority for DuPont. ...
(Date:3/5/2015)... Altamonte Springs, FL (PRWEB) March 05, 2015 ... Jamie Damm for the position of Vice President of ... support managed care relationships for one of the nation’s ... Seattle, brings more than 15 years of specialty pharmacy ... Previously Damm worked with Raptor Pharmaceuticals, Vertex Pharmaceuticals, and ...
Breaking Biology Technology:Soft Tissue Repair Market worth $14.7 Billion in 2019 2Soft Tissue Repair Market worth $14.7 Billion in 2019 3Soft Tissue Repair Market worth $14.7 Billion in 2019 4SENOMYX TO WEBCAST CORPORATE PRESENTATION AT THE THE 27TH ANNUAL ROTH CONFERENCE 2DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 2DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 3DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 4BioPlus Specialty Pharmacy Announces Hiring of New Vice President of Managed Care: Jamie Damm 2
... Delivers Solid Financial Performance While Building for the Future, ... GENZ ) today reported strong sales and profit growth ... commercial and clinical,programs., Revenue increased 25 percent to ... quarter. The increase was driven by,growth across all areas ...
... TORONTO, July 23 /PRNewswire-FirstCall/ - Roche,(SWX: ROG) and ... two,companies have signed a definitive agreement for Roche ... price of approximately C$191 million. ARIUS is,the developer ... identifies and selects antibodies based on their functional,ability ...
... of,Directors of BD (Becton, Dickinson and Company) (NYSE: ... per common share. The dividend will be,payable on September ... 2008.,The indicated annual dividend rate is $1.14 per share., ... medical technology company that develops,manufactures and sells medical devices, ...
Cached Biology Technology:Genzyme Reports Strong Second-Quarter Growth 2Genzyme Reports Strong Second-Quarter Growth 3Genzyme Reports Strong Second-Quarter Growth 4Genzyme Reports Strong Second-Quarter Growth 5Genzyme Reports Strong Second-Quarter Growth 6Genzyme Reports Strong Second-Quarter Growth 7Genzyme Reports Strong Second-Quarter Growth 8Genzyme Reports Strong Second-Quarter Growth 9Genzyme Reports Strong Second-Quarter Growth 10Genzyme Reports Strong Second-Quarter Growth 11Genzyme Reports Strong Second-Quarter Growth 12Genzyme Reports Strong Second-Quarter Growth 13Genzyme Reports Strong Second-Quarter Growth 14Genzyme Reports Strong Second-Quarter Growth 15Genzyme Reports Strong Second-Quarter Growth 16Genzyme Reports Strong Second-Quarter Growth 17Roche starts acquisition process of ARIUS to gain access to new screening platform for antibody therapeutics 2Roche starts acquisition process of ARIUS to gain access to new screening platform for antibody therapeutics 3Roche starts acquisition process of ARIUS to gain access to new screening platform for antibody therapeutics 4
Leucine-rich repeat-containing G-protein coupled receptor 4...
WD-repeat protein 4...
Rabbit polyclonal to MDM2 (phospho S185) ( Abpromise for all tested applications). entrezGeneID: 4193 SwissProtID: Q00987...
... Cultured human omental preadipocytes ... but otherwise healthy donors. ... of diabetic cells. Please ... Support media also available. ...
Biology Products: