Navigation Links
Researchers make living model of brain tumor
Date:2/16/2012

ry vessels, which congregated around the tumor and created the blood vessel architecture. The advantage of a 3-D model rather than Petri-dish-type analyses is that the endothelial cells attach to the tumor, rather than being separated from the substrate. This means the researchers can study their formation and growth, as well as the action of anti-therapeutic agents, just as they would in a living organism.

"You want to see nanoparticles that diffuse through the endothelial cells, which is lost in 2-D because you just have diffusion into media," Ho said.

Other 3-D tissue models have been "forced cell arrangements," Ho said. The 3-D glioma model, in contrast, allowed the glioma and the endothelial cells to assemble naturally, just as they would in real life. "It more clearly mimics what would actually happen," Ho explained.

The group then attached tumstatin, part of a naturally occurring protein found in collagen, to iron-oxide nanoparticles and dosed the mold. True to form, the nanoparticles were gobbled up by the endothelial cells. In a series of in vitro experiments, the team reported the tumstatin iron-oxide nanoparticles decreased vasculature growth 2.7 times more than under normal conditions over eight days. "The growth is pretty much flat," Ho said. "There's no new growth of endothelial cells." The next step is to test the tumstatin nanoparticles' performance in the 3-D environment.

"This model has significant potential to help in the testing and optimization of the design of therapeutic/diagnostic nanocarriers and determine their therapeutic capabilities," the researchers write.


'/>"/>
Contact: Richard Lewis
Richard_Lewis@brown.edu
401-863-3766
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers make living model of brain tumor
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, ... and authentication solutions, today announced enhanced functionality of ... authentication solution.  The enhancements build on the ... the DigitalPersona Altus platform and provide expanded ... In today,s environment of increasing ...
(Date:6/17/2015)... Germany , June 17, 2015 ... Standard: QIA) today launched new Investigator ® STR assay ... the United States . The new genetic ... key genomic markers (short tandem repeats or STRs) for DNA ... evaluate the quality of DNA in each sample, a novel ...
(Date:6/16/2015)... 16, 2015  With the increasing number and severity ... top concern. The recent compromise of Federal employee ... strong authentication within government agencies. HYPR Corp. ... password (OTP) authenticator, has been submitted for testing and ... 3 validation for tamper proofing. The ...
Breaking Biology News(10 mins):Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3
... 24, 2010 The National Science Foundation this week ... American Society for Biochemistry and Molecular Biology to establish ... nation. The initiative aims to improve undergraduate-level teaching ... and skills for the discipline and by developing appropriate ...
... MADISON, WI, June, 2010 The approach the ... gas emissions from agricultural anaerobic lagoons that treat manure ... to 65%, according to scientists from the University of ... feeding operations prior to application to crops as a ...
... the earth,s atmospheric composition are likely to alter plant ... reach levels double those of the preindustrial era by ... food for a rapidly growing population. University ... carbon dioxide, elevated ozone and higher atmospheric temperatures on ...
Cached Biology News:NSF grant will develop new online hub for biochemistry, molecular biology educators 2Scientists question EPA estimates of greenhouse gas emissions 2Climate change complicates plant diseases of the future 2Climate change complicates plant diseases of the future 3
(Date:6/30/2015)... WA (PRWEB) , ... June 30, 2015 , ... ... a hydrophilic filter that does not sacrifice selectivity to achieve faster flow rates ... combines extremely fine pores with significant open space to allow easy liquid flow ...
(Date:6/30/2015)... June 30, 2015  Custom Computer Specialists, Inc. ("Custom"), ... they are silver sponsors of the Primary Care Development ... Custom is lending their support of PCDC,s mission to ... Since its founding in 1993, PCDC has been ... area.  PCDC has financed over 100 completed primary care ...
(Date:6/30/2015)... ... June 30, 2015 , ... Cannavoices , Inc., ... unprecedented digital video and broadcast initiative. Produced by filmmakers, the multi-platform initiative aims ... legal medical cannabis stories ever assembled. , Cannavoices profiles Advocates, Patients, Entrepreneurs, ...
(Date:6/29/2015)... 2015 BioNano Genomics, Inc., the leader in ... announced today that a collaboration led by the Icahn ... creation of the first comprehensive analysis of a diploid ... for sequencing and genome mapping. This study, published today ... of the contiguous diploid human genome assembly obtained without ...
Breaking Biology Technology:New Nanofiber Membrane Provides Fast, Efficient Filtration 2Custom Computer Specialists Announces Sponsorship Of The Primary Care Development Corporation's Corporate Circle 2Cannavoices Launches a Legal Medical Cannabis Documentary Initiative 2Cannavoices Launches a Legal Medical Cannabis Documentary Initiative 3BioNano Mapping Technology Achieves Most Contiguous Clone-free Human Genome Assembly to Date 2BioNano Mapping Technology Achieves Most Contiguous Clone-free Human Genome Assembly to Date 3
... by the British Heart Foundation (BHF), has tested a new ... patient,s risk of having a heart attack (1). ... Research Excellence, in collaboration with the University of Cambridge are ... CT scanning to image the disease processes directly in the ...
... age of high-speed computing, the photon is king. However, producing ... time-consuming process, until now. Thanks to the work by ... The Edward S. Rogers Sr. Department of Electrical & Computer ... the production of special class of photons faster and easier. ...
... ALBANY, N.Y., April 30, 2012   AMRI ... an approach that further focuses its research and ... the life sciences and other industries. AMRI SMARTSOURCING™ ... customers to reach more successful outcomes. SMARTSOURCING™ is ...
Cached Biology Technology: Scientists develop new technique that could improve heart attack prediction 2Research breakthrough takes supercomputing out of the lab 2AMRI Launches SMARTSOURCING™ For Contract Manufacturing and Research Services 2
BBS/Glycerol/Casein Block and Diluent - 10X Concentrate, 1 L...
Ms anti-Cyclophilin D...
From micro to giga sizes, from single prep to high-throughput, Invitrogen's range of plasmid purification kits offers superior performance to match the demands of your downstream application....
... Upright Freezer Inventory Storage Racks ... configurations available to fit all makes ... refrigerators. Made of high quality ... 3" high fiberboard, stainless steel or ...
Biology Products: