Navigation Links
Researchers identify key components linking circadian rhythms and cell division cycles
Date:1/14/2014

CINCINNATIResearchers at the University of Cincinnati (UC) have identified key molecular components linking circadian rhythms and cell division cycles in Neurospora crassa, providing insights that could lead to improved disease treatments and drug delivery.

The researchers in the UC College of Medicine Department of Molecular and Cellular Physiology, led by Christian Hong, PhD, published their findings Monday, Jan. 13, online ahead of print in PNAS (Proceedings of the National Academy of Sciences).

"Our work has large implications for the general understanding of the connection between the cell cycle and the circadian clock," says Hong, an assistant professor in the molecular and cellular physiology department who collaborated with an international team of researchers on the project.

The circadian rhythm, often referred to as the biological clock, is a cycle of biological activity based on a 24-hour period and generated by an internal clock synchronized to light-dark cycles and other external cues.

"Everything has a schedule, and we are interested in understanding these schedules at a molecular level," Hong says. "We also wanted to know the components that connect two different oscillators (the circadian clock and cell division, or mitosis)."

Using the filamentous (thread-like) fungi Neurospora crassa, the researchers investigated the coupling between the cell cycle and the circadian clock using mathematical modeling and experimentally validated model-driven predictions. They demonstrated a mechanism that is conserved (constant) in Neurospora as in mammals, which results in circadian clock-gated mitotic cycles.

"The cell divisions happened during a certain time of day," Hong says, "and they were molecularly regulated by the mechanisms of circadian rhythms."

The researchers showed that a conserved coupling between the circadian clock and the cell cy
'/>"/>

Contact: Keith Herrell
keith.herrell@uc.edu
513-558-4559
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Microbes swap for tiny goods in minuscule markets, researchers find
2. New discovery could stimulate plant growth and increase crop yields, researchers say
3. White House lauds ONR-funded researchers for early success
4. KIT researchers develop artificial bone marrow
5. Researchers pursuing arthritis protein
6. Researchers discover a tumor suppressor gene in a very aggressive lung cancer
7. Researchers unveil rich world of fish biofluorescence
8. Researchers propose alternative way to allocate science funding
9. New organization brings together top researchers to sequence the genomes of invertebrates
10. Plan to delist gray wolf endangers other threatened species, researchers find
11. Researchers say fructose does not impact emerging indicator for cardiovascular disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) ... Market in the APAC Region 2015-2019"  report to ... emerging in this market is advances in technology. ... to upgrade biometric solutions to the latest standard ...
(Date:12/10/2014)... , Dec. 8, 2014 You,ve been here ... account but can,t remember your password, site key or the ... was your first grade teacher? Today, ... the app that will finally put an end to ... 1U TM . 1U leverages a user,s smartphone ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and ... the addition of the "Biometrics Market in ... http://photos.prnewswire.com/prnh/20130307/600769 ... projects such as rural banking and upgradation of ... trends witnessed in the market. Besides the aforementioned ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... paleoclimatology and ecology have paid homage to a king of ... him. The November issue of EARTH Magazine introduces ... thought to live alongside mammals during the Eocene. Find ... after and what gave it the evolutionary edge to successfully ...
... high-resolution X-ray imaging (termed microCT), 3D image segmentation, ... Carole Gee at the University of Bonn, Germany, ... material. Traditional techniques, such as thin-sectioning, require investigators ... to observe internal structures. Dr. Gee, however, has ...
... released today demonstrates how experiences impact genes that influence ... the annual meeting of the Society for Neuroscience and ... science and health, provide new insights into how experience ... addiction and memory formation. The studies focus ...
Cached Biology News:Visualizing the past: Nondestructive imaging of ancient fossils 2Nurture impacts nature: Experiences leave genetic mark on brain, behavior 2
(Date:12/19/2014)... 2014 LayerBio is an MIT spin-off ... care. The National Eye Institute (NEI) at the National ... I SBIR grant to develop a drug-eluting intraocular lens ... common cause of vision loss in people over age ... to Dr. Ken Mandell, LayerBio’s Founder and CEO, "There ...
(Date:12/19/2014)... December 19, 2014 In contrast to ... LEDs with various colors, Valoya uses proprietary LED technology ... offers best possible uniformity which is critical in low ... high spectral accuracy throughout its lifetime which is up ... tubes. , "The investment cost was clearly higher ...
(Date:12/19/2014)... 2014 Egenix, Inc. is pleased to announce that ... the Board, to succeed Donald Fresne ; Mr. Fresne ... as a member of the Board.  In recognition of the ... company over almost twenty years, the Board designated Mr. Fresne ... has established a Search Committee to find a suitable replacement ...
(Date:12/17/2014)... Based on the revenues gained from surgical imaging ... by four major players contributing to approximately 74% ... GE Healthcare (U.K.), Siemens AG (Germany), Philips (Netherlands), ... Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html , The leading ... its strong product portfolio, which includes its flagship ...
Breaking Biology Technology:LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... Most mechanical resonators damp (slow down) in a well-understood ... and his research group at the Catalan Institute of ... and carbon nanotubes exhibit nonlinear damping, opening up exciting ... In an article to be published in Nature ...
... TEI Biosciences Inc. was named a winner of ... Business Association of New England (SBANE) . TEI was ... winners in the for-profit category. Former winners of ... service and retail/distribution, and include Genzyme, Staples, iRobot, PictureTel, and ...
... ROCKVILLE, Md., May 13, 2011 Novavax, Inc. (Nasdaq: ... Frederick Driscoll, Chief Financial Officer of Novavax, will be presenting ... 16, 2011 at 10:30am at The Hard Rock Hotel, Hollywood, ... be accessed via the Company website at www.novavax.com ...
Cached Biology Technology:Exotic behavior when mechanical devices reach the nanoscale 2TEI Biosciences Wins SBANE 2011 New England Innovation Award 2
... Peptide microarrays containing peptidomimetics built on ... on-chip synthesis platform. These microarrays are ... Custom Peptide Microarray Service. ... is completely customer specified. Thousands of ...
... are custom designed to meet your needs. ... 8,455 features per array (2 arrays/1" x ... array (1 array/slide). Features ... - This extended length delivers higher sensitivity ...
... Chemicon Select Tissue Arrays are intended ... individual tissues were fixed in neutral buffered ... identification and diagnosis was performed by certified ... their paraffin blocks and relocated into a ...
... Chemicon Select Tissue Arrays are intended for ... tissues were fixed in neutral buffered formalin ... and diagnosis was performed by certified pathologists. ... paraffin blocks and relocated into a new ...
Biology Products: