Navigation Links
Researchers identify key components linking circadian rhythms and cell division cycles
Date:1/14/2014

CINCINNATIResearchers at the University of Cincinnati (UC) have identified key molecular components linking circadian rhythms and cell division cycles in Neurospora crassa, providing insights that could lead to improved disease treatments and drug delivery.

The researchers in the UC College of Medicine Department of Molecular and Cellular Physiology, led by Christian Hong, PhD, published their findings Monday, Jan. 13, online ahead of print in PNAS (Proceedings of the National Academy of Sciences).

"Our work has large implications for the general understanding of the connection between the cell cycle and the circadian clock," says Hong, an assistant professor in the molecular and cellular physiology department who collaborated with an international team of researchers on the project.

The circadian rhythm, often referred to as the biological clock, is a cycle of biological activity based on a 24-hour period and generated by an internal clock synchronized to light-dark cycles and other external cues.

"Everything has a schedule, and we are interested in understanding these schedules at a molecular level," Hong says. "We also wanted to know the components that connect two different oscillators (the circadian clock and cell division, or mitosis)."

Using the filamentous (thread-like) fungi Neurospora crassa, the researchers investigated the coupling between the cell cycle and the circadian clock using mathematical modeling and experimentally validated model-driven predictions. They demonstrated a mechanism that is conserved (constant) in Neurospora as in mammals, which results in circadian clock-gated mitotic cycles.

"The cell divisions happened during a certain time of day," Hong says, "and they were molecularly regulated by the mechanisms of circadian rhythms."

The researchers showed that a conserved coupling between the circadian clock and the cell cycle exists via serine/threonine protein kinase-29 (STK-29), the Neurospora homolog (possessing similar DNA sequence) of mammalian WEE1 kinase.

Additionally, the researchers conducted phase-shift experiments in which they transferred Neurospora to constant darkness, then administered a 90-minute pulse of white fluorescent light at indicated time points in order to induce phase-shift.

"We were able to show that when we phase-shift the circadian clock, we also observe phase-shifting of the cell cycle components," Hong says. By building on experimentally validated mathematical models from Neurospora, researchers will be able to make predictions in other Neurospora strains and mammalian cells.

As Hong puts it, "This discovery will serve as a stepping stone for further investigations to uncover conserved principles of coupled mechanisms between the cell cycle and circadian rhythms."


'/>"/>
Contact: Keith Herrell
keith.herrell@uc.edu
513-558-4559
University of Cincinnati Academic Health Center
Source:Eurekalert

Related biology news :

1. Microbes swap for tiny goods in minuscule markets, researchers find
2. New discovery could stimulate plant growth and increase crop yields, researchers say
3. White House lauds ONR-funded researchers for early success
4. KIT researchers develop artificial bone marrow
5. Researchers pursuing arthritis protein
6. Researchers discover a tumor suppressor gene in a very aggressive lung cancer
7. Researchers unveil rich world of fish biofluorescence
8. Researchers propose alternative way to allocate science funding
9. New organization brings together top researchers to sequence the genomes of invertebrates
10. Plan to delist gray wolf endangers other threatened species, researchers find
11. Researchers say fructose does not impact emerging indicator for cardiovascular disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access ... 15.1% over the next decade to reach approximately $1,580 million by ... and forecasts for all the given segments on global as well ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... Tunnell ... part in sessions at the ISPE Annual Meeting and Expo , to be ... Diego Marina. The event’s theme is “Driving innovation to advance patient therapies.” , The ...
(Date:8/16/2017)... ... , ... While art and science are often thought of as two completely ... A Mesh Is Also a Snare, a group exhibition presented by the Philadelphia-based ... Gallery (EKG) on August 17 and run through September 30. An opening reception will ...
(Date:8/16/2017)...  This year,s edition of the Inc. 5000 features a now-familiar name: ... has made the list for the third year in a row. Now ... companies based on a set of quantitative metrics. In addition, BioPoint was ... in the Bay State . ... Inc. 5000 ...
(Date:8/15/2017)... ... , ... Kapstone Medical is proud to announce that it has ... and inventors develop and safeguard their latest innovations. The company has grown from ... of clients in the United States and around the world. , Company Founder ...
Breaking Biology Technology: