Navigation Links
Researchers identify key components linking circadian rhythms and cell division cycles
Date:1/14/2014

CINCINNATIResearchers at the University of Cincinnati (UC) have identified key molecular components linking circadian rhythms and cell division cycles in Neurospora crassa, providing insights that could lead to improved disease treatments and drug delivery.

The researchers in the UC College of Medicine Department of Molecular and Cellular Physiology, led by Christian Hong, PhD, published their findings Monday, Jan. 13, online ahead of print in PNAS (Proceedings of the National Academy of Sciences).

"Our work has large implications for the general understanding of the connection between the cell cycle and the circadian clock," says Hong, an assistant professor in the molecular and cellular physiology department who collaborated with an international team of researchers on the project.

The circadian rhythm, often referred to as the biological clock, is a cycle of biological activity based on a 24-hour period and generated by an internal clock synchronized to light-dark cycles and other external cues.

"Everything has a schedule, and we are interested in understanding these schedules at a molecular level," Hong says. "We also wanted to know the components that connect two different oscillators (the circadian clock and cell division, or mitosis)."

Using the filamentous (thread-like) fungi Neurospora crassa, the researchers investigated the coupling between the cell cycle and the circadian clock using mathematical modeling and experimentally validated model-driven predictions. They demonstrated a mechanism that is conserved (constant) in Neurospora as in mammals, which results in circadian clock-gated mitotic cycles.

"The cell divisions happened during a certain time of day," Hong says, "and they were molecularly regulated by the mechanisms of circadian rhythms."

The researchers showed that a conserved coupling between the circadian clock and the cell cy
'/>"/>

Contact: Keith Herrell
keith.herrell@uc.edu
513-558-4559
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Microbes swap for tiny goods in minuscule markets, researchers find
2. New discovery could stimulate plant growth and increase crop yields, researchers say
3. White House lauds ONR-funded researchers for early success
4. KIT researchers develop artificial bone marrow
5. Researchers pursuing arthritis protein
6. Researchers discover a tumor suppressor gene in a very aggressive lung cancer
7. Researchers unveil rich world of fish biofluorescence
8. Researchers propose alternative way to allocate science funding
9. New organization brings together top researchers to sequence the genomes of invertebrates
10. Plan to delist gray wolf endangers other threatened species, researchers find
11. Researchers say fructose does not impact emerging indicator for cardiovascular disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce ... been named the "Number One Best Tech Gift ... Modern ( http://www.rethinkmodern.com/ ) is a web magazine focused ... that have a unique function or design.  ...
(Date:3/3/2015)... Calif. , March 3, 2015 /PRNewswire/ ... leading provider of advanced cryogenic logistics solutions ... including immunotherapies, stem cells, cell lines, clinical ... reproductive medicine, today announced the expansion of ... Research Centers, ("Fred Hutch") Clinical Research ...
(Date:3/2/2015)... Lithuania , March 2, 2015   Neurotechnology ... technologies, today introduced the SentiGaze Software Development Kit ... to create applications that use off-the-shelf webcams to track ... user gazes at a monitor. Heatmaps can be used ... the effectiveness of online advertising. The SDK can also ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3
... group of nanoengineers, biologists and physicists have used innovative ... key player in DNA regulation, to reconcile a longstanding ... the mystery behind the origin of many diseases such ... discovery are highlighted in a paper in the ...
... CORVALLIS, Ore. Some people who are serious about ... one choice available to them that may yield a large ... by statisticians at Oregon State University concluded that in the ... an extra child is almost 20 times more important than ...
... of Hawai,i at Manoa researcher has published the first-ever assessment ... to the nation,s agriculture industry and the environment, should they ... article in the American Malacological Bulletin is authored ... Center for Conservation Research and Training (CCRT) and his team. ...
Cached Biology News:UC San Diego engineer provides insights to decades-old DNA squabble 2UC San Diego engineer provides insights to decades-old DNA squabble 3UC San Diego engineer provides insights to decades-old DNA squabble 4Family planning a major environmental impact 2
(Date:3/26/2015)... "In America," the popular news television program that airs ... by legendary film actor James Earl Jones, has announced that ... segment. , Botany is commonly described as the scientific ... a bit more complicated than that. Scientists and other professionals ... from the smallest bacteria known to man to the largest ...
(Date:3/25/2015)... 2015 Agnition announced today that it ... Farmer, airing for the first time at 7:30 a.m. ... Farmer will explore the extremely important role soil microbes ... a patented Microbial Catalystâ„¢ technology that enhances soil and ... segment will air again on April 28. , A ...
(Date:3/25/2015)... 25, 2015  S&P Capital IQ (MHFI) announced ... Report coverage on Abattis Bioceuticals Corp . ... is a specialty biotechnology company with capabilities through ... marketing proprietary ingredients, bio-similar compounds, patented equipment and ... North America . The company seeks to ...
(Date:3/25/2015)... UK (PRWEB) March 25, 2015 An ... natural ingredients in all forms of food nutrients, regulatory ... to a substantial rise in demand for natural astaxanthin ... have started to ramp up their capacities to satisfy ... both natural and synthetic source astaxanthin (used in nutraceuticals, ...
Breaking Biology Technology:Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 5Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2
... SAN DIEGO, July 24, 2008 NuVasive, Inc.,(Nasdaq: ... on developing products for,minimally disruptive surgical treatments for ... previously announced acquisition of the Osteocel,biologics business from ... $35,million in cash, plus additional milestone-based contingent payments ...
... Calif., July 24 Abaxis, Inc.,(Nasdaq: ABAX ), a ... results for the first,fiscal quarter ended June 30, 2008., ... up 7% over last year,s comparable quarter. -- Total ... 127 units or 19% over last ...
... physicians, pulmonary and critical care clinicians, ... overuse of antibiotics, DURHAM, N.C., July 24 ... of the American Thoracic Society and,Society of Hospital ... physicians, and researchers are unanimous in their view ...
Cached Biology Technology:NuVasive Completes Acquisition of Osteocel Biologics Business 2NuVasive Completes Acquisition of Osteocel Biologics Business 3NuVasive Completes Acquisition of Osteocel Biologics Business 4NuVasive Completes Acquisition of Osteocel Biologics Business 5Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 2Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 3Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 4Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 5Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 6Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 7Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 8U.S. Clinicians Indicate a Strong Need for New Tools to Combat Sepsis 2U.S. Clinicians Indicate a Strong Need for New Tools to Combat Sepsis 3
... the popular precision current source, designed ... neural transport tracers such as horseradish ... into neural tissue, is now available ... used to make small lesions, and ...
... with a shutter (controlled via a TTL signal ... Light Source produces a powerful, stable output from ... light source are available, providing a wavelength range ... provides peak-to-peak stability of less than 0.005% and ...
... Digital Clamp One can operate as a Voltage ... Conductance (Dynamic) Clamp in electrophysiology research applications. Performance ... conventional analog equipment. • ... recent advances in the capabilities of Digital Signal ...
... Agilent Technologies introduces an ... Series ICP-MS for Windows 2000 ... (OS). From September 2003, all ... be controlled by the new ...
Biology Products: