Navigation Links
Researchers identify key components linking circadian rhythms and cell division cycles
Date:1/14/2014

CINCINNATIResearchers at the University of Cincinnati (UC) have identified key molecular components linking circadian rhythms and cell division cycles in Neurospora crassa, providing insights that could lead to improved disease treatments and drug delivery.

The researchers in the UC College of Medicine Department of Molecular and Cellular Physiology, led by Christian Hong, PhD, published their findings Monday, Jan. 13, online ahead of print in PNAS (Proceedings of the National Academy of Sciences).

"Our work has large implications for the general understanding of the connection between the cell cycle and the circadian clock," says Hong, an assistant professor in the molecular and cellular physiology department who collaborated with an international team of researchers on the project.

The circadian rhythm, often referred to as the biological clock, is a cycle of biological activity based on a 24-hour period and generated by an internal clock synchronized to light-dark cycles and other external cues.

"Everything has a schedule, and we are interested in understanding these schedules at a molecular level," Hong says. "We also wanted to know the components that connect two different oscillators (the circadian clock and cell division, or mitosis)."

Using the filamentous (thread-like) fungi Neurospora crassa, the researchers investigated the coupling between the cell cycle and the circadian clock using mathematical modeling and experimentally validated model-driven predictions. They demonstrated a mechanism that is conserved (constant) in Neurospora as in mammals, which results in circadian clock-gated mitotic cycles.

"The cell divisions happened during a certain time of day," Hong says, "and they were molecularly regulated by the mechanisms of circadian rhythms."

The researchers showed that a conserved coupling between the circadian clock and the cell cy
'/>"/>

Contact: Keith Herrell
keith.herrell@uc.edu
513-558-4559
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Microbes swap for tiny goods in minuscule markets, researchers find
2. New discovery could stimulate plant growth and increase crop yields, researchers say
3. White House lauds ONR-funded researchers for early success
4. KIT researchers develop artificial bone marrow
5. Researchers pursuing arthritis protein
6. Researchers discover a tumor suppressor gene in a very aggressive lung cancer
7. Researchers unveil rich world of fish biofluorescence
8. Researchers propose alternative way to allocate science funding
9. New organization brings together top researchers to sequence the genomes of invertebrates
10. Plan to delist gray wolf endangers other threatened species, researchers find
11. Researchers say fructose does not impact emerging indicator for cardiovascular disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) has ... - NEC" report to their offering. ... to supply a range of IT security management and ... on the development of a Big Data and cloud ... Asia-Pacific region is a core ...
(Date:4/6/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM FOR ... introduces a new revolutionary method and system to ... of miniature antenna modules for multiple purposes including ...
(Date:4/2/2015)... -- According to preliminary estimates Fingerprint Cards, ... than 125 MSEK. This exceeds the guidance provided by ... for Q1 2015 would be in line with the ... The operating result for the first quarter is estimated ... will as previously communicated be published on May 21. ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Revises Revenues for Q1 2015 2
... (January 9, 2013) -- A new study by NYU School ... gut bacterium Helicobacter pylori ( H. pylori ) isn,t ... and may even protect against stroke and some cancers. The findings, ... period of some 12 years, are published online, January 9, in ...
... its Education Committee travel award to attend the Biophysical ... in Philadelphia, February 2-26, 2013. The recipients of this ... fellows, are selected based on scientific merit. Each ... will receives a travel grant, and will be ...
... of overweight and obese Americans has increased, the amount ... decreased -- especially for patients with high blood pressure ... Medicine researchers. More than 145 million adult Americans ... the National Ambulatory Medical Care Survey for the years ...
Cached Biology News:Disappearing bacterium may protect against stroke 2Disappearing bacterium may protect against stroke 3Biophysical Society announces winners of 2013 Education Committee travel awards 2Biophysical Society announces winners of 2013 Education Committee travel awards 3Biophysical Society announces winners of 2013 Education Committee travel awards 4Biophysical Society announces winners of 2013 Education Committee travel awards 5Biophysical Society announces winners of 2013 Education Committee travel awards 6Weight counseling decreases despite rise in obesity 2Weight counseling decreases despite rise in obesity 3
(Date:4/16/2015)... 2015 Regis Technologies looks forward to ... Cancer Research (AACR) annual meeting. Regis will exhibit at ... Saturday, April 18, in Philadelphia and running through April ... of the oldest and largest organization focused on cancer ... and partners with survivors to promote awareness and research ...
(Date:4/16/2015)... -- In recognition of World Hemophilia Day, Biogen  (NASDAQ: ... more than 15 prominent landmarks red throughout the ... Zakim Bridge and Prudential Tower, Chicago,s ... and Denver,s Coors Field . ... and coincide with hemophilia community events in a dozen locations ...
(Date:4/16/2015)... April 16, 2015 ... pharmaceutical investment and R&D group, and Lancet, ... research, development and commercialization of new medicines ... the intention to stimulate the innovative development ...      (Logo: http://photos.prnewswire.com/prnh/20150416/739742-a) ,     (Logo: http://photos.prnewswire.com/prnh/20150416/739742-b) , ...
(Date:4/16/2015)... SAN DIEGO , April 16, 2015 ... company dedicated to improving cancer surgeries, announced today that ... lead fluorescent cancer illuminator, AVB-620, in women with primary, ... trial, the company also welcomed the addition of ... affairs. The open label, dose escalation study ...
Breaking Biology Technology:Regis Technologies Joins American Association for Cancer Research Annual Meeting 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4Lancet and ChemRar High Tech Center Have Announced a Partnership in the Development and Production of Novel Drugs in Russia 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 3
... Accurate Measurement of Women,s Ovarian ... ... will be the first IVF center in the southeast to offer,the Repromedix ... woman,s egg supply by combining multiple factors,including the measurement of ovary-related hormones ...
... suit claims company insiders knowingly misrepresented the ... ... Hagens Berman Sobol Shapiro filed a,proposed class-action lawsuit on behalf ... executives,knowingly misrepresented the company and chief executive officer Gary A.,Reys, ...
... Eli Lilly and Company,strongly objects to implications in a ... suppressed results of negative clinical,trials., The story, based ... of,Medicine (NEJM), cited Prozac and Lilly as high-profile examples ... Not only was,the Times, story inaccurate when it comes ...
Cached Biology Technology:Georgia Reproductive Specialists is First in Southeast to Offer Pioneering Test of Women's Biological Clock 2Georgia Reproductive Specialists is First in Southeast to Offer Pioneering Test of Women's Biological Clock 3Hagens Berman Sobol Shapiro: Lawsuit Filed Against CellCyte Genetics Corporation 2Hagens Berman Sobol Shapiro: Lawsuit Filed Against CellCyte Genetics Corporation 3In response to a New England Journal of Medicine article published yesterday and subsequent media coverage, Eli Lilly and Company issued the following statement: 2In response to a New England Journal of Medicine article published yesterday and subsequent media coverage, Eli Lilly and Company issued the following statement: 3In response to a New England Journal of Medicine article published yesterday and subsequent media coverage, Eli Lilly and Company issued the following statement: 4
Topoisomerase II...
BD BioCoat Fibronectin 150 mm Culture Dishes...
... General description: Dish uses include large-scale ... Compatible with PBA Flexys TM automated ... number is a new product number, created ... showing no availability yet, please order under ...
BD BioCoat Collagen IV 150 mm Culture Dishes...
Biology Products: