Navigation Links
Researchers identify how to switch off cancer cell genes
Date:11/12/2007

Los Angeles, Nov. 12, 2007-- A new study led by researchers at the University of Southern California (USC) identifies how genes are silenced in cancer cells through distinct changes in the density of nucleosomes within the cells.

The findings, published in the Nov. 13 issue of the journal Cancer Cell, will enable researchers to explore new therapies to switch the genes back on and may lead to novel treatments for human cancers, says study lead author Peter A. Jones, Ph.D., D.Sc., director of the USC/Norris Comprehensive Cancer Center and Distinguished Professor at the Keck School of Medicine of USC.

"The study shows for the first time exactly how genes get shut down in cancer cells," Jones says. "It identifies what the target looks like so that new therapies can be designed to turn them back on."

The study showed that silencing of transcription start sites in some cancer cells involves distinct changes in nucleosomal occupancy'or the density of nucleosomes'in the cell. Researchers found that three nucleosomes, almost completely absent from the start site in normal cells, are present in the methylated and silenced promoter, suggesting that epigenetic silencing may be accomplished by the stable placement of nucleosomes into previously vacant positions.

DNA cytosine methylation'the addition of a group of specific chemicals to a stretch of DNA that can lock or silence a gene'may ultimately lead to silencing by enabling the stable presence of nucleosomes at the start sites of cancer-related genes, the study suggests.

"We believe these findings will contribute to the development of cancer therapies," Jones says. "We were surprised to find how rigid the inactive structure is, and how rapidly it can be dissolved by drug treatment."


'/>"/>

Contact: Meghan Lewit
lewit@usc.edu
323-442-2830
University of Southern California
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), ... published by MarketsandMarkets, the market is expected to be worth USD 18.98 billion ... Continue Reading ... ...      (Logo: ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... ... NDA Partners Chairman Carl Peck, MD , announced today that Richard Kenley, ... Pharmaceutical Development Business Unit of Cardinal Health, has joined the firm as an Expert ... Chief Operating Officer at Anaborex, Senior VP and General Manager of the San Diego ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... device compliance and commercialization, has just released version 9.0 of the Cognition Cockpit ... latest version of Cockpit,” says David Cronin, CEO of Cognition. “We’re thrilled to ...
(Date:5/18/2017)... ... May 17, 2017 , ... HOLLOWAY AMERICA, ... including food and dairy, munitions, and pharmaceutical/biotech, recently introduced The Revolution Lift™, a ... use. The improvement in technology comes on the heels of HOLLOWAY’s release of ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... example, are more likely to develop Alzheimer’s disease, while men are at greater ... for this gender-specific neuronal bias is the aim of a research program at ...
Breaking Biology Technology: