Navigation Links
Researchers identify gene linked to aggressive progression of liver cancer
Date:2/17/2009

RICHMOND, Va. (Feb. 17, 2009) Virginia Commonwealth University researchers have identified a gene that plays a key role in regulating liver cancer progression, a discovery that could one day lead to new targeted therapeutic strategies to fight the highly aggressive disease.

Hepatocellular carcinoma, HCC, or liver cancer, is the fifth most common cancer and the third leading cause of cancer deaths in the world. Treatment options for HCC include chemotherapy, chemoembolization, ablation and proton-beam therapy. Liver transplantation offers the best chance for a cure in patients with small tumors and significant associated liver disease.

In the study, published online in the February issue of the Journal of Clinical Investigation, researchers reported that the astrocyte elevated gene-1, AEG-1, plays a key role in regulating HCC in series of cellular models. By examining human liver tumor cells of patients with HCC, the team found that the expression of AEG-1 gradually increases as the tumor becomes more and more aggressive. Using microarray technology, they analyzed cDNA from the tumor cells and determined that AEG-1 modulates expression of genes relevant to the progression of HCC, including invasion, metastasis, resistance to chemotherapy, the formation of new blood vessels, and senescence. cDNAs are complementary DNAs that are generated from mRNAs to analyze gene expression profiles.

"AEG-1 also activates multiple intracellular signaling pathways that are known to be involved in HCC progression. So, strategies to inhibit AEG-1 that could lead to the shutdown of these pathways, either by small molecules or by siRNAs, might be an important therapeutic modality for HCC patients," said principal investigator Devanand Sarkar, Ph.D., MBBS, assistant professor in the Department of Human and Molecular Genetics in the VCU School of Medicine, and Harrison Endowed Scholar in Cancer Research at the VCU Massey Cancer Center.

siRN
'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Case Western Reserve researchers looking at light-induced toxins in air and water
2. McMaster researchers discover new mode of how diseases evolve
3. Researchers shed new light on connection between brain and loneliness
4. Texas researchers provide emissions data for livestock industry
5. Biodiversity itself begets a species cascade, researchers say
6. NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
7. While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
8. NSF-funded workshops help young researchers teach science
9. Researchers observe evolution chain reaction
10. Researchers examine role of climate change in disease spread
11. Mayo Clinic researchers suspect a novel gene is causing restless legs syndrome in a large family
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2015)... , Aug. 18, 2015  Navitas ... key contributor to the Submission Content Management ... IRISS, a non-profit forum. Dedicated to the Implementation ... a neutral platform for industry, vendors, health ... information and work towards a standard method ...
(Date:8/12/2015)... CORAL SPRINGS, Florida , August 12, 2015 /PRNewswire/ ... globally, the pace of mobile payment innovation and advanced ... continues to replace the way consumers rely on using ... forges ahead with reinventing the future for payment services ... Inc. (NASDAQ: NXTD ), :  Google, Inc. (NASDAQ: ...
(Date:8/10/2015)... Germany , August 10, 2015 /PRNewswire/ ... world leader in Eye Tracking Technology for more than ... Eye Tracking Platform for integration into all consumer display ... designs for seamless integration of eye tracking into consumer ... and augmented reality smart glasses. Omnivision,s leading sensor technology ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3
... March 31, 2010. An award-winning nature essay, written during ... John Burroughs Award for nature writing. The essay, "Mind ... professor emeritus at Indiana University, stresses the author,s connection ... contemplates the larger issue of how humans engage with ...
... the adult brain is well known. It is what is ... ventricles. This is where neural or brain stem cells reside, ... many years now, the subventricular zone has been suspected to ... the most deadly type of which is glioblastoma. ...
... toll on plants and animals alike. When cells are deprived ... water as a medium, chemicals and enzymes inside the cells ... fern" ( Polypodium polypodioides ), can survive extreme measures of ... content. How do the cells in these desiccation-tolerant plants remain ...
Cached Biology News:Nature essay made possible by Forest Service program, is Orion Magazine selection 2Brain tumors: Tissue stem cell turning into tumor stem cell 2Bringing dehydrated plants 'back to life' 2Bringing dehydrated plants 'back to life' 3
(Date:9/2/2015)... ... September 02, 2015 , ... ... will be attending Pharma Ed Resources upcoming educational seminar and training session ... leading speakers, this timely conference will provide Updates & Case Studies on the ...
(Date:9/2/2015)... , ... September 02, 2015 , ... ... manufacturing equipment, to creating professional commercial video content, to analysis of athletic performance. ... fascinating events that go by too quickly to process with the naked eye. ...
(Date:9/1/2015)... 2, 2015 Swecure, ... Forschung und Entwicklung neuartiger Therapien für Störungen ... und Reizdarm konzentriert, erhält vom US Patent ... neues Medikament patentiert wird. Das Medikament basiert ... Kindern verhindert und Entzündungen vorbeugt.   ...
(Date:9/1/2015)... , Sept. 1, 2015 The American Brain ... (LOI) for its Discovery Research Grant program. LOIs are ... 12:00 noon CDT. Discovery Grants are one-year, ... the potential to change current diagnostic or treatment paradigms ... specifically encourage novel research at its earliest stages, in ...
Breaking Biology Technology:Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 2Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 3Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 3Das Patent von Swecure zur Verhinderung von Allergien bei Kindern wird in den USA zugelassen 2American Brain Tumor Association Seeks Innovative Concepts For Discovery Research Grants 2
... National Institute of Standards and Technology (NIST) have ... to cracks and breakdown in bulk silicon crystalsa ... been thought not to exist. Their recently published* ... new silicon-based micro-electromechanical system (MEMS) devices that have ...
... Nov. 27 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. (NASDAQ: ... and,medical device company, is scheduled to participate in ... being held December 2 - 4 in Orlando, ... will give a 15-minute,formal presentation followed by a ...
... Nov. 27 Corium International, Inc.,a privately-held transdermal ... Gardner, M.D. and Daniel G. Welch to the ... Essex Woodlands Health,Ventures, is a Professor of Medicine ... of cell biology and pharmacology. In addition to,her ...
Cached Biology Technology:Job-related stress: NIST demonstrates fatigue effects in silicon 2Corium International, Inc. Announces Appointment of Phyllis Gardner, M.D. and Daniel G. Welch to Board 2Corium International, Inc. Announces Appointment of Phyllis Gardner, M.D. and Daniel G. Welch to Board 3
cystatin A (N-18)...
Human Cystatin A MAb (Clone 224705)...
...
... , Ultima II Series ,Developed ... II represents the finest, most enhanced ultra-low ... blood bank configurations, each Ultima II freezer ... with built-in voltage boost and surge suppressor, ...
Biology Products: