Navigation Links
Researchers identify biomarkers of poor outcomes in preemies
Date:1/27/2011

Researchers at Cincinnati Children's Hospital Medical Center have identified biomarkers of poor outcomes in preterm infants that may help identify new approaches to prevention.

Ardythe Morrow, PhD, a researcher at the Cincinnati Children's Perinatal Institute, has identified a polymorphism a variant in a particular DNA sequence in a gene important to the development of the immune system. She found that this polymorphism raises the risk of bad outcomes in preterm infants, including death; necrotizing enterocolitis, which is the death of intestinal tissue; and gram negative sepsis, an overwhelming infection.

The study is published online in the Journal of Pediatrics.

"The secretor gene (FUT2) controls secretion of a substance known as 'H antigen' in saliva, urine, plasma, and other body fluids. Our data suggest that H antigen may be important to the health of preterm infants," says Dr. Morrow. "Research is continuing to better understand the impact of FUT2 in prematurity and should provide important insights into disease progression and infant vulnerability. We speculate these high risk infants may especially benefit from human milk oligosaccharide, a complex carboyhydrate made by enzymes of the FUT2 gene."

Dr. Morrow and her colleagues collected saliva samples from 410 infants born at or before 32 weeks gestational age. Among these infants, 26 died, 30 had necrotizing enterocolitis and 96 had confirmed sepsis.

Death occurred in 15 percent of 135 infants with low H antigen in their saliva, compared to 2 percent of 248 infants with high levels of H antigen in saliva. Low H antigen was also associated with greater odds of death due to necrotizing enterocolitis and sepsis, as well as higher odds of necrotizing enterocolitis. In addition, no secretion of H antigen predicted gram negative sepsis.

Dr. Morrow and her colleagues at Cincinnati Children's are now analyzing national data and tissue samples for a new study designed to test the role of intestinal colonization in preterm infants in relation to their FUT2 genotype. Other studies are underway to test the role of specific oligosaccharides (complex carbohydrates) in human milk in disease prevention.


'/>"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... , Feb. 2, 2016  BioMEMS ... are primarily focused on medical screening and ... point-of-care parameters. Wearable devices that facilitate and ... freedom of movement are being bolstered through ... human biomedical signal acquisition coupled with wireless ...
(Date:2/2/2016)... , Feb. 2, 2016   Parabon NanoLabs ... the U.S. Army Research Office and the Defense ... and sensitivity of the company,s Snapshot Kinship ... Mission and, more generally, defense-related DNA forensics.  Although ... capabilities (predicting appearance and ancestry from DNA evidence), ...
(Date:2/1/2016)... wallet ( www.wocketwallet.com ) announces the launch of a new video featuring ... Las Vegas , where Joey appeared at the Wocket booth ... , where Joey appeared at the Wocket booth to meet and ... at the Consumer Electronics Show (CES2016) in Las Vegas ... fans. --> --> The video ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... February 08, 2016 , ... Net-Translators, ... today the launch of its revamped and improved website. In an on-going effort ... the redesigned website will better communicate how the company designs and delivers thorough, ...
(Date:2/9/2016)... ... February 09, 2016 , ... The publishing ... Open Access publishing is one of the popular publication models that has received ... journals and 3000+ International Conferences across the globe, OMICS International ...
(Date:2/9/2016)... , February 9, 2016 Web ... paper and protect IP   E-WorkBook 10 ... rolled out in Germany early this ... valuable IP. Users will be able to search for information ... as part of the application, to boost collaboration and productivity. ...
(Date:2/8/2016)... /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") ... clean technology companies in the TSX Venture 50 TM . ... on the TSX Venture Exchange, in each of five major ... & life sciences, diversified industries and technology – based ... on investment, market cap growth, trading volume and analyst coverage. ...
Breaking Biology Technology: