Navigation Links
Researchers identify biomarkers of poor outcomes in preemies
Date:1/27/2011

Researchers at Cincinnati Children's Hospital Medical Center have identified biomarkers of poor outcomes in preterm infants that may help identify new approaches to prevention.

Ardythe Morrow, PhD, a researcher at the Cincinnati Children's Perinatal Institute, has identified a polymorphism a variant in a particular DNA sequence in a gene important to the development of the immune system. She found that this polymorphism raises the risk of bad outcomes in preterm infants, including death; necrotizing enterocolitis, which is the death of intestinal tissue; and gram negative sepsis, an overwhelming infection.

The study is published online in the Journal of Pediatrics.

"The secretor gene (FUT2) controls secretion of a substance known as 'H antigen' in saliva, urine, plasma, and other body fluids. Our data suggest that H antigen may be important to the health of preterm infants," says Dr. Morrow. "Research is continuing to better understand the impact of FUT2 in prematurity and should provide important insights into disease progression and infant vulnerability. We speculate these high risk infants may especially benefit from human milk oligosaccharide, a complex carboyhydrate made by enzymes of the FUT2 gene."

Dr. Morrow and her colleagues collected saliva samples from 410 infants born at or before 32 weeks gestational age. Among these infants, 26 died, 30 had necrotizing enterocolitis and 96 had confirmed sepsis.

Death occurred in 15 percent of 135 infants with low H antigen in their saliva, compared to 2 percent of 248 infants with high levels of H antigen in saliva. Low H antigen was also associated with greater odds of death due to necrotizing enterocolitis and sepsis, as well as higher odds of necrotizing enterocolitis. In addition, no secretion of H antigen predicted gram negative sepsis.

Dr. Morrow and her colleagues at Cincinnati Children's are now analyzing national data and tissue sampl
'/>"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... University of Texas Medical Branch at Galveston are ... with radiation for cervical cancer should begin colorectal ... The UTMB researchers, finding a high incidence of ... with radiation, offer new recommendations that the younger ... about eight years after their initial cervical cancer ...
(Date:4/17/2014)... immune system may fight cancers and viral infections. The ... treat illness. , The research, in mice, suggests that ... specialized squads of defenders that patrol only one ... the body. , Scientists at Washington University School of ... skin and uterus each has dedicated immune cells, which ...
(Date:4/17/2014)... feature of The Proceedings of the ... April 29, raises a number of startling questions about ... us take for granted. At the end of the ... globe shifted from hunting animals and gathering fruits and ... so straightforward and yet the more scientists learn, the ...
Breaking Biology News(10 mins):Radiation therapy for cervical cancer increases risk for colorectal cancer 2Some immune cells defend only 1 organ 2Genetic study tackles mystery of slow plant domestications 2Genetic study tackles mystery of slow plant domestications 3Genetic study tackles mystery of slow plant domestications 4
... try to reach for a break in the canopy formed ... avoidance syndrome or SAS. Now, the molecular details of SAS ... Institute for Biological Studies. To step out of ... for the synthesis of the plant growth hormone auxin that ...
... Cold Spring Harbor, NY In the neuromuscular disease ... caused by a single gene mutation leads to serious ... control. Now, in laboratory experiments, researchers at ... induced cells to replenish the protein by activating an ...
... born with silver spoons in their mouths. The same ... world, according to research done in part by the ... squirrels in Kluane, Yukon, revealed that advantageous silver spoon ... between birth and weaning could reflect later on each ...
Cached Biology News:A place in the sun 2A place in the sun 3Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 Two champions ... continued their sponsorship of an annual competition for middle ... and access to, innovative STEM study. The competition presents ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
(Date:1/14/2014)... 2014  3D Communications, a leading provider of strategic communications services to ... events in the United States and ... Cox , JD, is returning to the firm,s Washington, ... 3D after more than two years of service as Associate Commissioner ...
(Date:1/14/2014)... 2014 iLab Solutions, the leader in core ... Director of Product Strategy. In this role, Michelle will work ... to guide in the development of iLab products. Her main ... possible benefit to the scientific community by offering the most ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... third-party plug-in for popular embedded tool suite. , ... ... Quadros Systems, Inc., a leading supplier of configurable and scalable ... module for the RTXC Quadros RTOS is now available for ...
... on Tuesday, July 15 at 4:30 p.m. Eastern -, ... VRML ), a molecular diagnostics company, will host a ... Ueland,M.D., Principal Investigator on the submission and Associate Professor ... the keynote,speaker of the roundtable., Vermillion,s ovarian tumor ...
... 11 Signalife,Inc. (Amex: SGN ) announced ... its previously-announced merger or similar business combination with,Heart ... has been,appointed to proceed with due diligence and ... presently contemplated, a new parent,company will be established ...
Cached Biology Technology:RTXC Kernel Awareness Module from Quadros Systems Now Available for Keil Vision Debugger 2RTXC Kernel Awareness Module from Quadros Systems Now Available for Keil Vision Debugger 3RTXC Kernel Awareness Module from Quadros Systems Now Available for Keil Vision Debugger 4Vermillion to Host Live Roundtable Discussion With Principal Investigator of OVA1(TM) Submission 2Vermillion to Host Live Roundtable Discussion With Principal Investigator of OVA1(TM) Submission 3Signalife Board Approves Merger 2Signalife Board Approves Merger 3
... Activins are polypeptide hormones which belong ... superfamily. The TGF- superfamily is a ... which control many aspects of development, ... Other members incude TGF-s, bone morphogenetic ...
... Activins are polypeptide hormones which ... (TGF-) superfamily. The TGF- superfamily is ... factors which control many aspects of ... (1). Other members incude TGF-s, bone ...
... are polypeptide hormones which belong to ... The TGF- superfamily is a large ... control many aspects of development, reproductive ... members incude TGF-s, bone morphogenetic proteins, ...
... Sterile plating in just seconds , ... ethanol flaming, More uniform spreading and more ... dispenser bottle for spreading 100 plates or single-use ... easiest way to spread cells on multiple plates ...
Biology Products: