Navigation Links
Researchers genetically link Lou Gehrig's disease in humans to dog disease
Date:1/21/2009

COLUMBIA, Mo. An incurable, paralyzing disease in humans is now genetically linked to a similar disease in dogs. Researchers from the University of Missouri and the Broad Institute have found that the genetic mutation responsible for degenerative myelopathy (DM) in dogs is the same mutation that causes amyotrophic lateral sclerosis (ALS), the human disease also known as Lou Gehrig's Disease. As a result of the discovery, which will be published in the Proceedings of the National Academy of Sciences this week, researchers can now use dogs with DM as animal models to help identify therapeutic interventions for curing the human disease, ALS.

"We uncovered the genetic mutation of degenerative myelopathy, which has been unknown for 30 years, and linked it to ALS, a human disease that has no cure," said Joan Coates, a veterinary neurologist and associate professor of veterinary medicine and surgery in the MU College of Veterinary Medicine. "Dogs with DM are likely to provide scientists with a more reliable animal model for ALS. Also, this discovery will pave the way for DNA tests that will aid dog breeders in avoiding DM in the future."

Previously, ALS research has relied heavily on transgenic rodents that expressed the mutant human gene SOD1, which causes ALS. Researchers found that dogs with DM also had mutations in their SOD1 gene. Many rodent models possess very high levels of the SOD1 protein that can produce pathologic processes distinct from those occurring in ALS patients. Since the SOD1 mutation is spontaneous in dogs, the clinical spectrum in dogs may represent more accurately that of human ALS.

"Compared with the rodent models for ALS, dogs with DM are more similar to people in size, structure and complexity of their nervous systems, and duration of the disease," said Gary Johnson, associate professor of veterinary pathobiology in the MU College of Veterinary Medicine. "The results from clinical trials conducted w
'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Texas Medical Center researchers win collaborative grants
2. Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
3. Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
4. JDRF-funded researchers discover proteins regulating human beta cell replication
5. Researchers to use K-States BSL-3 Lab for $1 million study of fungus threatening wheat crops
6. Researchers identify potential new weapon in battle against HIV infection
7. U-M researchers discover new genes that fuse in cancer
8. Researchers first to see reactive oxygen species in vital enzyme
9. Dartmouth researchers find new protein function
10. Burnham researchers discover on switch for cell death signaling mechanism
11. Salk researchers develop novel glioblastoma mouse model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... genetics company, has received from the National Institutes ... a two-year project to support the further development ... genetic discovery. , Specifically, the grant supports ... web-based surveys to improve the company,s ability to ... survey tools to support the collection of a ...
(Date:7/29/2014)... of cell, including sperm, bacteria and algae, propel ... protrusions, about one-hundredth of a millimetre long, function ... Similar, shorter structures called cilia are found on ... roles such as moving liquids over the cell. ... they transport mucus and expel pathogens from our ...
(Date:7/28/2014)... team of researchers led by the University of Arizona ... The genetic information will enhance scientists, and agriculturalists, understanding ... as enable the development of new rice varieties that ... to help solve global hunger challenges. , The paper, ... ) and evidence for independent domestication," was published online ...
Breaking Biology News(10 mins):23andMe scientists receive approximately $1.4 million in funding from National Institutes of Health 223andMe scientists receive approximately $1.4 million in funding from National Institutes of Health 3Microscopic rowing -- without a cox 2Microscopic rowing -- without a cox 3Generating a genome to feed the world: UA-led team sequences African rice 2Generating a genome to feed the world: UA-led team sequences African rice 3Generating a genome to feed the world: UA-led team sequences African rice 4
... UC Irvine microbiologists have learned how a probiotic ... gut bacterial infections caused by Salmonella , paving ... affect millions of people annually. Manuela Raffatellu, assistant ... UC Irvine and the University of Washington identified how ...
... and ingredients are improving the taste, appearance and nutritional ... expected to grow to $6 billion by 2017, according ... Food Technologists (IFT) Annual Meeting & Food Expo in ... celiac disease, an immune disorder triggered by the ingestion ...
... to be a proven strong nutrient-rich food providing essential ... some toxicologists still keep a watchful eye on safety, ... 2013 Institute of Food Technologists (IFT) Annual Meeting & ... evidence shows that health benefits derived from the consumption ...
Cached Biology News:Probiotic bacterium lessens severity of Salmonella infections by hoarding iron 2New technologies and ingredients provide better options for gluten-free eating 2Seafood still considered a good source of nutrients but consumers confused on safety 2
(Date:7/29/2014)... The first product launch from start-up Hurley Research ... What sets Droidles completely apart from other stand alone ... to communicate, share code with each other and evolve ... invention is the system,” said Hurley Research founder Jay ... their own, both physically and on the internet." Remote ...
(Date:7/29/2014)... The prestigious "Discovery or Exploration in ... awarded to Juliana Hillis and Kaylie O’Connell, students at ... “From an Egg, Everything: America’s First IVF Baby". This ... the National History Day program during a week-long final ... in Washington, D.C. , The growing popularity of the ...
(Date:7/29/2014)... CA (PRWEB) July 29, 2014 ... medical devices, and cloud based eClinical technologies, have been ... Device Online. These follow a long line of white ... profile publications including Life Science Leader, Pharmaceutical Online, and ... Clinovo provided a paper by CTO Marc Desgrousilliers, ...
(Date:7/29/2014)... , July 29, 2014 ... System (LBS) zur Erfassung biologischer Daten in ... entwickelt und patentiert. Das LBS nimmt gleichzeitig ... Koronararterie des Patienten und sucht erhöhte biologische ... das Potenzial, die Entdeckung und Entwicklung neuer ...
Breaking Biology Technology:Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 2PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 4
... (Nasdaq: BMRN ) today announced that Jean-Jacques,Bienaime, Chief ... the 3rd Annual Citi Biotech Day in New York ... Interested parties may access a live audio webcast ... BioMarin website, http://www.BMRN.com .,A replay of the call ...
... ANGELES, Sept. 2 Signalife, Inc. (Amex:,SGN) announced ... tomorrow, at,the opening of the market, regarding the ... About Signalife, Signalife, Inc. is a life ... of disease through continuous biomedical signal,monitoring. Signalife uses ...
... Genome,Sciences, Inc. (Nasdaq: HGSI ) announced today ... Annual Healthcare Conference will be webcast,and may be ... http://www.newscom.com/cgi-bin/prnh/20080416/HGSLOGO ), A member of Human ... overview on Thursday, September 4, 2008 at 8:35 ...
Cached Biology Technology:BioMarin to Present at the Citi Biotech Day 2Signalife to Issue Breaking News Regarding Vianale & Vianale Tomorrow 2
... Time-resolved microscopy is the ultimate tool ... subcellular structures. Its applications previously have been ... because microscope optics do not transmit in ... leader in fluorescence spectroscopy, introduces a filter-based ...
... many of the automation concepts from High ... are similar to those for HTS: ... or 48 wells with well volumes of ... number of wells has increased to 96 ...
... ,Kit containing Dermal Fibroblasts (Mouse/BalbC) and media. ... long-term culture, and is guaranteed to provide ... from the date supplied, when used with ... embryonic day 18.5 ,Applications: ,Cultivation: ...
... Sphingobeads are designed for ... and characterize sphingosine binding proteins. ... 1 mL of agarose beads ... bound through the terminus of ...
Biology Products: