Navigation Links
Researchers find new hope for treatment of chronic leukemia
Date:8/17/2011

Wednesday, August 17, 2011, Cleveland: While testing a new drug designed to treat chronic leukemia, researchers at Cleveland Clinic discovered new markers that could identify which patients would receive maximum benefit from the treatment.

This information was released in the online edition of Blood, a weekly medical journal published by the American Society of Hematology.

Chronic lymphocytic leukemia (CLL), a cancer of the white blood cells that is incurable with standard treatment, is the most common type of leukemia in the Western Hemisphere. Conventional chemotherapy is effective at controlling CLL for many years, but the disease always relapses. CLL is characterized by an uncontrolled cell growth and division due to a defect in a process called programmed cell death, or apoptosis. A group of proteins called the Bcl-2 family is responsible for this defect.

Alex Almasan, Ph.D., a researcher in the Lerner Research Institute (LRI) of Cleveland Clinic in close collaboration with other researchers in both LRI and the Taussig Cancer Institute of Cleveland Clinic collected blood samples from patients with CLL and tested the ability of a new drug to kill the cancerous cells. The drug, Navitoclax, is already in early stage clinical testing for patients with CLL. Navitoclax appears to be effective for some patients, and until this research study, there had been no clear way to predict who will respond to its effects.

In addition, these studies can be informative to the currently ongoing clinical trials with Navitoclax in other hematologic malignancies or solid tumors.

"Follow-up studies on patients that have been treated with Navitoclax, particularly those that are poor responders, could determine whether the Bcl-2 family genes examined in this study may also be important for development of resistance to this agent," said Almasan.


'/>"/>

Contact: Dan Doron
dorond@ccf.org
216-312-0428
Lerner Research Institute
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers find way to align gold nanorods on a large scale
2. UBC researchers discover key mechanism that regulates shape and growth of plants
3. Researchers discover oldest evidence of nails in modern primates
4. Researchers map pathway of infection for a common, potentially life-threatening respiratory virus
5. Researchers demonstrate green tea is effective in treating genetic disorder and types of tumors
6. Researchers discover freshwater mussel species thought to be extinct
7. NYU Langone researchers identify a signaling pathway as possible target for cancer treatment
8. Toronto researchers first to discover new genetic clue in the development of rheumatoid arthritis
9. Researchers decode workings of mysterious, but critical TB drug
10. Researchers fight cholera with computer forecasting
11. Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Advances in stem cell research will provide enormous ... Basically, stem cells could replicate any other cells ... Alzheimer,s disease, repairing damaged spinal cords, treating kidney, ... whole. The potential for profit is staggering. Prof. ... that this field of research still faces myriad ...
(Date:8/1/2014)... August 1, 2014 The Journal of Nutrition ... and Best Great Educational Material (GEM) awards, which were ... (SNEB) annual conference, "Nutrition Education Impact: Local to Global," ... These annual awards recognize the authors of the ... JNEB, as judged by members of the JNEB Journal ...
(Date:8/1/2014)... at The Scripps Research Institute (TSRI) have identified a ... in brown fat cells. , The study, which ... the Proceedings of the National Academy of Sciences ... fat thermogenesis," which is of great interest to medical ... also protect against diabetes. , "This finding offers new ...
Breaking Biology News(10 mins):Scripps Research Institute scientists find new calorie-burning switch in brown fat 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 3
... Washington, D.C. (January 25, 2011) -- In ... displays, touch panels, electronic ink, and solar cells, ... physicists in Iran have created a spintronic device ... being pursued by the semiconductor and electronics industries ...
... theory of natural selection on the realization that genetic ... Some individuals are better adapted to a given environment ... pass on their genes to future generations. But exactly ... poses somewhat of a puzzle to evolutionary biologists. ...
... Duke University bioengineers have developed a new method ... DNA sequences. These novel sequences of recombinant DNA ... types of drugs and bioengineered tissues. Current methods for ... the researchers said, which has hindered the development of ...
Cached Biology News:Armchair nanoribbons made into spintronic device 2Evolution by mistake 2Evolution by mistake 3Evolution by mistake 4New method for rapidly producing protein-polymers 2
(Date:7/31/2014)... , July 31, 2014 Nearly 20,000 ... th Annual Meeting & Clinical Lab Expo in ... meeting featured never-before-seen breakthroughs in diagnostic research and technology ... they need. As of Wednesday, July 30, ... AACC Annual Meeting & Clinical Lab Expo, with more ...
(Date:7/31/2014)... have mapped the sound-processing part of the mouse brain ... and the trees in view. Their imaging technique allows ... within mice, and it enabled the team to watch ... other. The results, which represent a step toward better ... July 31 the journal Neuron . , In ...
(Date:7/31/2014)... Calif. , July 31, 2014 Rogne ... San Francisco Bay Area , has acquired a ... of Oxford,s commercialisation company. The potent anti-inflammatory activity of ... at the University of Oxford,s Sir William ... company, which has raised over $1.5 million in seed ...
(Date:7/31/2014)... , July 31, 2014 Research ... "Global Genomics Market 2014-2018" report to their ... Genomics is the study of the genetic material ... be a strong basis for the discovery and development ... human diseases or health conditions. Genomics is supported by ...
Breaking Biology Technology:Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3New mapping approach lets scientists zoom in and out as the brain processes sound 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... AvidBiotics Corp. announced the issuance of foundational ... massive diversity within precisely targeted sites of protein-encoding ... to as Diversity Generating Retroelements (DGR) and patents ... and in Europe (#1,173,995). UCLA and AvidBiotics ...
... Exchange Symbol: MS , EDMONTON, Nov. 12 /PRNewswire-FirstCall/ - ... operational results for the three and nine months ended ... license and collaboration agreement between BioMS Medical and Eli ... with the effect that all commercial rights to dirucotide ...
... Regado Biosciences, a privately held company leading the ... that David Mazzo, PhD, CEO and President, will be ... Conference at the St. Regis Hotel in New York ... (EST) on Tuesday, November 17 and will include an ...
Cached Biology Technology:AvidBiotics Corp. Granted Key U.S. and European Patents on Unique Protein Modification Platform 2BioMS Medical Announces Third Quarter 2009 Results 2BioMS Medical Announces Third Quarter 2009 Results 3BioMS Medical Announces Third Quarter 2009 Results 4BioMS Medical Announces Third Quarter 2009 Results 5BioMS Medical Announces Third Quarter 2009 Results 6BioMS Medical Announces Third Quarter 2009 Results 7BioMS Medical Announces Third Quarter 2009 Results 8Regado Biosciences to Present at the Lazard Capital Markets 6th Annual Healthcare Conference on November 17, 2009 2
Purified anti-Fanconi anemia D2-Phosphorylated (Ser222)...
A431 cells stimulated with EGF Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
... 'The Gene Construction KitTM allows graphic ... drawing options. It has an award winning ... DNA sequences in addition to providing sophisticated ... GCK was named the "Best Plasmid Mapping ...
... collects data from balances and scales with RS232 ... other program. If you can type the weight ... collection process Simple to use parser extracts ... , Add user information , Collect data at ...
Biology Products: