Navigation Links
Researchers find new hope for treatment of chronic leukemia
Date:8/17/2011

Wednesday, August 17, 2011, Cleveland: While testing a new drug designed to treat chronic leukemia, researchers at Cleveland Clinic discovered new markers that could identify which patients would receive maximum benefit from the treatment.

This information was released in the online edition of Blood, a weekly medical journal published by the American Society of Hematology.

Chronic lymphocytic leukemia (CLL), a cancer of the white blood cells that is incurable with standard treatment, is the most common type of leukemia in the Western Hemisphere. Conventional chemotherapy is effective at controlling CLL for many years, but the disease always relapses. CLL is characterized by an uncontrolled cell growth and division due to a defect in a process called programmed cell death, or apoptosis. A group of proteins called the Bcl-2 family is responsible for this defect.

Alex Almasan, Ph.D., a researcher in the Lerner Research Institute (LRI) of Cleveland Clinic in close collaboration with other researchers in both LRI and the Taussig Cancer Institute of Cleveland Clinic collected blood samples from patients with CLL and tested the ability of a new drug to kill the cancerous cells. The drug, Navitoclax, is already in early stage clinical testing for patients with CLL. Navitoclax appears to be effective for some patients, and until this research study, there had been no clear way to predict who will respond to its effects.

In addition, these studies can be informative to the currently ongoing clinical trials with Navitoclax in other hematologic malignancies or solid tumors.

"Follow-up studies on patients that have been treated with Navitoclax, particularly those that are poor responders, could determine whether the Bcl-2 family genes examined in this study may also be important for development of resistance to this agent," said Almasan.


'/>"/>

Contact: Dan Doron
dorond@ccf.org
216-312-0428
Lerner Research Institute
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers find way to align gold nanorods on a large scale
2. UBC researchers discover key mechanism that regulates shape and growth of plants
3. Researchers discover oldest evidence of nails in modern primates
4. Researchers map pathway of infection for a common, potentially life-threatening respiratory virus
5. Researchers demonstrate green tea is effective in treating genetic disorder and types of tumors
6. Researchers discover freshwater mussel species thought to be extinct
7. NYU Langone researchers identify a signaling pathway as possible target for cancer treatment
8. Toronto researchers first to discover new genetic clue in the development of rheumatoid arthritis
9. Researchers decode workings of mysterious, but critical TB drug
10. Researchers fight cholera with computer forecasting
11. Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... the right amount of death at the right time ... to new research that could help in understanding animal ... , In a paper in the journal Trends ... and European colleagues conclude that the kind of positive ... of individuals, or mortality, depends on the size and ...
(Date:11/4/2014)... about the way our bodies are assembled during early ... they are supposed to become a nerve or a ... correct place and alignment? Researchers at the University of ... a new study, UM researchers describe the signaling systems ... at the head-trunk region. Their discovery may have important ...
(Date:11/4/2014)...   3D scanner ... Fuel3D , a developer of 3D scanning solutions, ... $6.4 million (£4 million). This funding builds on the company,s ... and paves the way for the commercial launch of the ... round was led by Chimera Partners and will be used ...
Breaking Biology News(10 mins):When less is more: Death in moderation boosts population density in nature 2The inside story: How the brain and skull stay together 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3
... into a tumor, seal the exits and detonate a ... cells unscathed. , MIT researchers have designed a nanoparticle ... "nanocell" proved effective and safe, with prolonged survival, against ... mice. , The work will be reported in the ...
... Science Express http://www.sciencexpress.org) on July 28th reveals a striking ... open ocean ?the largest and least known part of ... and fishing over the past 50 years, the authors ... surprising global pattern of open ocean hotspots - areas ...
... how organisms grow and flourish, but studying their complex ... Now, a team of chemists and neurobiologists led by ... M. Schuman at the California Institute of Technology has ... synthesis in specific locations. , The new method, which ...
Cached Biology News:MIT engineers an anti-cancer smart bomb 2Scientists discover global pattern of big fish diversity in open oceans 2Scientists discover global pattern of big fish diversity in open oceans 3Scientists discover global pattern of big fish diversity in open oceans 4Scientists discover global pattern of big fish diversity in open oceans 5Protein synthesis can be controlled by light, opening way for new scientific, medical applications 2Protein synthesis can be controlled by light, opening way for new scientific, medical applications 3
(Date:11/27/2014)... , Nov. 27, 2014 ... the "Global Palmitic Acid Industry Report 2014" ... The Global Palmitic Acid Industry ... the current state of the global palmitic acid industry. ... the industry including definitions, classifications, applications and industry chain ...
(Date:11/27/2014)... England , November 27, 2014 ... online on ScienceDirect   Elsevier , ... products and solutions, is pleased to announce the launch ... . The launch of ... the rapid advances at the forefront of applied sciences ...
(Date:11/27/2014)... BELLINGHAM, Washington, and PITTSFIELD, Massachusetts, USA (PRWEB) November 26, ... pinpoint cancer cells with more accuracy, additive systems to ... improve highway safety by analyzing road conditions are among ... Awards for Photonics Innovation . The awards are sponsored ... photonics , and Photonics Media . , Winners ...
(Date:11/26/2014)... 2014 The report on the Global ... the concerned market for revenue forecasts and market trends. ... of 51.9% from 2013 to 2018. At the projected ... of $1,415.6 million by 2018. , Browse through the ... for information about the market segmentation and in-depth analysis ...
Breaking Biology Technology:Global Palmitic Acid Industry Report 2014 2Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 2Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 3Finalists Named for 2015 Prism Awards for Photonics Innovation 2Finalists Named for 2015 Prism Awards for Photonics Innovation 3Finalists Named for 2015 Prism Awards for Photonics Innovation 4Finalists Named for 2015 Prism Awards for Photonics Innovation 5Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 2Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 3Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 4
... ... ... -- Artemis Health Institute , a leading international hospital located just outside Delhi, is ... hospital recently reported a 10% month on month increase in medical tourist admissions, and now ...
... invented by a Monash University researcher could dramatically ... Monash biomedical engineer Brian Lithgow has developed ... for the mind,. Patterns of electrical activity in ... against distinct response patterns found in depression, schizophrenia ...
... A team of scientists, led by a biomedical engineer at ... the first time that mathematical models created from data ... previously unknown cellular mechanisms. This brings biologists a step closer ... inner workings of the cell as readily as NASA engineers ...
Cached Biology Technology:Artemis Continues to Attract More Medical Tourists from USA 2Artemis Continues to Attract More Medical Tourists from USA 3'ECG for the mind' could diagnose depression in an hour 2Scientists use math modeling to predict unknown biological mechanism of regulation 2
Recombinant Human Erythropoietin (Tissue Culture Grade)...
One-step, microplate or cuvet, colorimetric, detection range 0.78 ug/dL to 65 ug/dL Zn in serum, plasma, urine, saliva etc. Procedure: 10 min....
Human PDGF R beta MAb (Clone # PR7212)...
Recombinant Mouse IL-23, CF...
Biology Products: