Navigation Links
Researchers find new culprit in castration-resistant prostate cancer
Date:12/13/2012

it regulates the activity of genes without changing their DNA structure. Previously it was found that EZH2 levels are dramatically increased in late-stage castration resistant prostate cancer, Brown said, but researchers thought the protein was acting primarily to turn off gene activity which is its normal role.

Drugs aimed at blocking EZH2 activity are being tested in other cancers, where they are designed to block the protein's gene-suppressing role. However, they carry a risk of harmful side effects as a result. "But we found that isn't the important function of EZH2 in CRPC," Brown explained. "In these cancers, EZH2 works with the androgen receptor to turn on genes involved with cell growth." As a result, he proposes that inhibitors of EZH2 that avoid targeting its gene-repressor function might be a safe and effective strategy for use in castration-resistant prostate cancers.

Further, said Brown, the EZH2 protein itself is activated by a molecular signaling pathway known as PI3K, or PI3 kinase. Several PI3K inhibitors are in clinical trials at present, and Brown said that a combination of drugs to inhibit both that pathway and the EZH2 protein might be yet another way to attack the resistant prostate cancers.


'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. ASU researchers propose new way to look at the dawn of life
2. New geometries: Researchers create new shapes of artificial microcompartments
3. UGA researchers find algal ancestor is key to how deadly pathogens proliferate
4. Researchers identify new components of the epigenetic code for honey bee development
5. Researchers find new genetic pathway behind neurodevelopmental disorders
6. Researchers investigate impacts of climate change on rare tropical plants
7. Researchers identify proteins that indicate which kidney tumors are most likely to spread
8. Microchoreography: Researchers use synthetic molecule to guide cellular dance
9. Einstein researchers receive 2 Grand Challenges Explorations grants to combat HIV and TB
10. University of Tennessee researchers find fungus has cancer-fighting power
11. UC Davis researchers aid effort to sequence the complex wheat genome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers find new culprit in castration-resistant prostate cancer
(Date:5/8/2015)... SAN JOSE, Calif. , May 8, 2015 ... human interface solutions, today announced that members of the executive ... J.P. Morgan 43rd Annual Technology, Media and Telecom Conference ... Westin Waterfront Hotel in Boston, MA ... Date: May 27, 2015 Time: 2:45pm ET Location: The New ...
(Date:5/6/2015)... May 6, 2015 LifeBEAM, a developer of ... producer, announced today that they will expand their partnership ... first bio-sensing cycling helmet and the first joint project ... new colors in order to give cyclists more style ... addition, LifeBEAM and Lazer announced their plan to release ...
(Date:4/27/2015)... more than four decades, AUVSI,s Unmanned Systems ... event for the unmanned land, sea, and air industries. ... local, national, or trade news organization interested in gathering ... applications of unmanned technologies. The conference will explore the ... and how it will soon impact the lives of ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5
... helped boost green foliage across the world,s arid regions ... CO2 fertilisation, according to CSIRO research., In findings based ... National University (ANU), found that this CO2 fertilisation correlated ... from 1982-2010 across parts of the arid areas studied ...
... one of the major reasons why couples travel abroad ... regulations at home or raise concerns about financial inducement, ... Yet little is known about the women who provide ... their motivation and their compensation. A study performed ...
... study performed in Belgium has shown that low-cost ... feasible and effective, with delivery rates not much ... This proof-of-principle study, say the investigators, suggests that ... that the IVF methodology can be significantly simplified ...
Cached Biology News:Deserts 'greening' from rising CO2 2Egg donation in European clinics: Why do women do it? 2Egg donation in European clinics: Why do women do it? 3IVF for 200 euro per cycle 2IVF for 200 euro per cycle 3
(Date:5/21/2015)... 2015 Patent Offering, The patent’s technology ... or therapeutic imaging within a body lumen (open space). ... having a low cost, single-use disposable illumination and camera ... October 18, 2013 and the patent approval was received ... physician to customize the lighting and magnification of the ...
(Date:5/21/2015)... Ontario (PRWEB) May 21, 2015 ... into an exclusive North American distribution agreement with ... testing system. , With more than 160 years ... products and services for laboratory and production facilities, ... operational excellence and differentiated services to enable science. ...
(Date:5/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/qfxkcq/global_cell ) has ... Market Outlook 2020 " report to their offering. ... regenerative medicine is expected to have huge marketing potential. ... in the growth of deregulated organs. Several therapeutic molecules ... to form new tissue or sometimes organ transplant is ...
(Date:5/20/2015)... NEW YORK , May 20, 2015 /PRNewswire-USNewswire/ ... announced a leadership gift of $100 million from ... help create a new laboratory building that will ... campus extension. The Marie-Josée and Henry R. Kravis ... over the FDR Drive, spanning approximately three city ...
Breaking Biology Technology:IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 2The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 4
... Inc., announced today that the organization has not ... 2010, Paul McDaniel became the interim President and ... operations are continuing and several employees who had ... Lisa P. Sumner, Esq., Poyner Spruill LLPAttorney for ...
... LifeVantage Corporation (OTC Bulletin Board: ... science-based therapy for oxidative stress, announced today that a ... scientific journal PLoS ONE.  The study, conducted by researchers ... underlie the ability of Protandim® to suppress tumors in ...
... Science, the innovative biological products and research services business ... announced the global release of a pioneering range of ... Sigma,s proprietary CompoZr zinc finger nuclease (ZFN) ... to offer innovative tools for drug discovery, compound screening ...
Cached Biology Technology:Chemopreventative Effects of Protandim® Examined Further in New Peer-Reviewed Study 2Chemopreventative Effects of Protandim® Examined Further in New Peer-Reviewed Study 3Chemopreventative Effects of Protandim® Examined Further in New Peer-Reviewed Study 4Chemopreventative Effects of Protandim® Examined Further in New Peer-Reviewed Study 5Sigma® Life Science Enters Genetically Modified Cell Market 2Sigma® Life Science Enters Genetically Modified Cell Market 3Sigma® Life Science Enters Genetically Modified Cell Market 4
Tissue-Stat ( Tissue Adherent for Mounting Formalin-Fixed and Frozen Tissue Sections.)...
This monoclonal antibody specifically recognizes Y. pestiscapsular F1 antigen. It does not cross-react with Y. pseudotuberculosisor Y. enterocolitica....
Clarin Mounting Medium (Permanent environmentally safe mounting medium for general histology & cytology use)...
... Plus is formulated for covering tissue sections and ... soluble OR alcohol insoluble end products. ... as Fast Red or AEC that require an ... such as DAB. No heating is required prior ...
Biology Products: