Navigation Links
Researchers find new culprit in castration-resistant prostate cancer
Date:12/13/2012

it regulates the activity of genes without changing their DNA structure. Previously it was found that EZH2 levels are dramatically increased in late-stage castration resistant prostate cancer, Brown said, but researchers thought the protein was acting primarily to turn off gene activity which is its normal role.

Drugs aimed at blocking EZH2 activity are being tested in other cancers, where they are designed to block the protein's gene-suppressing role. However, they carry a risk of harmful side effects as a result. "But we found that isn't the important function of EZH2 in CRPC," Brown explained. "In these cancers, EZH2 works with the androgen receptor to turn on genes involved with cell growth." As a result, he proposes that inhibitors of EZH2 that avoid targeting its gene-repressor function might be a safe and effective strategy for use in castration-resistant prostate cancers.

Further, said Brown, the EZH2 protein itself is activated by a molecular signaling pathway known as PI3K, or PI3 kinase. Several PI3K inhibitors are in clinical trials at present, and Brown said that a combination of drugs to inhibit both that pathway and the EZH2 protein might be yet another way to attack the resistant prostate cancers.


'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. ASU researchers propose new way to look at the dawn of life
2. New geometries: Researchers create new shapes of artificial microcompartments
3. UGA researchers find algal ancestor is key to how deadly pathogens proliferate
4. Researchers identify new components of the epigenetic code for honey bee development
5. Researchers find new genetic pathway behind neurodevelopmental disorders
6. Researchers investigate impacts of climate change on rare tropical plants
7. Researchers identify proteins that indicate which kidney tumors are most likely to spread
8. Microchoreography: Researchers use synthetic molecule to guide cellular dance
9. Einstein researchers receive 2 Grand Challenges Explorations grants to combat HIV and TB
10. University of Tennessee researchers find fungus has cancer-fighting power
11. UC Davis researchers aid effort to sequence the complex wheat genome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers find new culprit in castration-resistant prostate cancer
(Date:6/23/2015)... BEACH GARDENS, Fla. , June 23, ... multi-factor identity management and authentication solutions, today announced ... Altus strong, multi-factor authentication solution.  The enhancements ... of use of the DigitalPersona Altus platform ... biometric reader compatibility. In today,s ...
(Date:6/17/2015)... GERMANTOWN, Maryland , June 17, 2015 ...   Produktlinie mit DNA-Tests verbessert den Analyseprozess und ... QGEN ; Frankfurt Prime Standard: QIA) hat heute in ... Produktlinie Investigator ® für ... Die neuen Kits zur Erstellung genetischer Fingerabdrücke bieten eine ...
(Date:6/17/2015)... Fla. , June 17, 2015  Crossmatch™, ... today announced that its U.are.U ® 4500 ... Togo,s Eateries, Inc., a ... sandwich chain, to increase security, improve accountability and ... readers enable instant, non-repudiable identity confirmation for employee ...
Breaking Biology News(10 mins):Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3
... the coast of El Salvador late last year directly ... to test results released today by the Wildlife Conservation ... from the Salvadoran government and the US Agency for ... White journeyed to the southern coast of El Salvador ...
... cancer followed by radiation therapy often experience breast ... surgery. Researchers at the McGowan Institute for Regenerative ... University, have developed a polymer-based therapy for breast ... filler after surgery and a clinically effective therapy. ...
... the 21st century, state-of-the-art anti-aging technologies may extend human ... host of social and economic challenges, says biologist Shripad ... these medical advances would have major implications for the ... and Virginia Morrison Professor of Population Studies, will give ...
Cached Biology News:Red Tide causes sea turtle die-off in El Salvador 2Chemotherapy gel may fight breast cancer and reduce breast deformity 2World faces challenge as life expectancies lengthen, scientist says 2World faces challenge as life expectancies lengthen, scientist says 3World faces challenge as life expectancies lengthen, scientist says 4
(Date:6/30/2015)... June 30, 2015  Juniper Pharmaceuticals, Inc. (Nasdaq: ... developing therapeutics that address unmet medical needs in ... Elston will present at the Cantor Fitzgerald ... 8, 2015Time: , 4:45 PM EDTLocation: , Le ... archive): , www.juniperpharma.com, under  ,Investor, or  ...
(Date:6/30/2015)... , ... June 30, 2015 , ... ... Study will provide new insights on mechanics of fecal microbiota transplantation in C. ... to study the microbiome of patients undergoing fecal microbiota transplantation (FMT) as a ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... ... services to the federal government, announced in a paper published this week in ... a potential problem with the diagnostic techniques currently used to detect the Ebola ...
(Date:6/30/2015)... DENVER, CO (PRWEB) , ... June 30, 2015 , ... ... technologies, today announced that it has hired Gem Swartz to head up its account ... as senior account director. Both Gem and Amanda bring senior account management and delivery ...
Breaking Biology Technology:Juniper Pharmaceuticals to Present at Cantor Fitzgerald Inaugural Healthcare Conference on July 8, 2015 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 4Matrix Marketing Group Expands Client Services Team 2
... http://www.obn.org.uk/obn_/menu.php?p=rss&rn=rssfeed&prechk_news=1 ... stories were recognised last night at the OBN ... network, which provides comprehensive support for biotech and ... the Awards at a capacity black tie event ...
... Sept. 13, 2011 Microban recently conducted ... and biofilm growth on High Consistency Rubber (HCR) ... of urinary catheters.  Urinary infections are a costly ... technologies have had limited success in reducing infection ...
... Portugal, Sept. 13, 2011 Metabolic Solutions Development Company, ... sensitizers, MSDC-0160 and MSDC-0602, stimulate progenitor cells ... instead of white fat cells. Brown fat, which diminishes ... The mechanism of action by which MSDC-0160 and MSDC-0602 ...
Cached Biology Technology:OBN's 2011 Annual Awards Dinner Celebrates UK Bioscience Success Stories 2OBN's 2011 Annual Awards Dinner Celebrates UK Bioscience Success Stories 3Microban Medical Silver Antimicrobial Technologies for HCR Silicone Achieve 5 Log Reductions in Bacteria Growth and Prevent Biofilm Formation 2Metabolic Solutions Development Company Presents New Brown Fat Research at the European Association for the Study of Diabetes 2
... Application: The simple three step procedure (PCR, ... be completed in one day. The typical ... than 80%. , Features and Benefits: , ... cloned into any expression vector , High ...
Designed for use with all 96-well SPRI reagent kits. Used with round bottom 96-well microplates, and 96-well thermal cycling plates....
... be used with all 96-well ... stacking of covered plates ... with automated systems ... are available for use with ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,667-7) ... assistance. ID clarifier: barcoded, bulk ...
Biology Products: