Navigation Links
Researchers find chink in the armor of viral 'tummy bug'
Date:12/23/2008

Researchers at Griffith University's Institute for Glycomics in collaboration with colleagues at the University of Melbourne have moved a step closer to identifying a broad spectrum treatment for the dreaded 'viral tummy bug' or rotavirus.

These highly-infectious viruses are the leading cause of severe diarrhoea in young children, responsible for thousands of hospitalisations in the developed world, and hundreds of thousands of deaths each year in developing countries.

Institute Executive Director Professor Mark von Itzstein said research findings published in the world-leading Chemical Biology journal Nature Chemical Biology this week demanded a total rethink of how these viruses work.

"Rotaviruses are thought to infect the bodies by sticking to certain types of sugars called sialic acids on the surface of our stomach cells. They then enter cells and reproduce rapidly, causing illness," he said.

"Rotavirus vaccines are still in their infancy, as problems emerged with the first vaccine that was trialled a number of years ago. While other vaccines are now in clinical use, new directions are required in the development of potential drugs to prevent or treat this deadly virus."

He said that to better understand how carbohydrates are involved in rotavirus infection, researchers had focussed on treating mammalian cells with a protein called sialidase which cuts these surface sugars so the virus cannot attach.

Previous to his group's work most scientists believed only some of the many strains of rotavirus infection could be prevented with sialidase treatment while others were apparently immune to its effects.

This led to the conclusion that some viruses depend on sialic acid to infect the body while others were thought to cause infection independent of sialic acid.

"Unsuccessful attempts to reduce rotavirus infection with this treatment led scientists to group rotaviruses into two class
'/>"/>

Contact: Jeannette Langan
j.langan@griffith.edu.au
61-755-528-654
Research Australia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biomedical researchers create artificial human bone marrow in a test tube
2. Princeton researchers discover new type of laser
3. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
4. James Thomson receives 2008 Massry Prize honoring stem cell researchers
5. Researchers push nature beyond its limits to create higher-density biofuels
6. Researchers advance knowledge of little nano-machines in our body
7. No quick or easy technological fix for climate change, researchers say
8. Researchers find natures shut-off switch for cellulose production
9. Researchers compile molecular manual for 100s of inherited diseases
10. Pitt researchers create non-toxic clean-up method for potentially toxic nano materials
11. Researchers identify new anti-tumor gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... many sobering examples of how wildlife loss leads to ... co-authored by Wildlife Conservation Society (WCS) Health & ... Golden, calls for an interdisciplinary approach to tackle global ... supports about 15% of the world,s people and provides ... poor. It should come as no surprise that today,s ...
(Date:7/24/2014)... SAN DIEGO , July 24, 2014 /PRNewswire-iReach/ -- ... managing data from cardiac devices, has cut emergency room ... the UC San Diego (UCSD) Medical Center, according to ... Journal. The UCSD Emergency Departments are using the suite ... such as pacemakers or defibrillators. "Using Geneva,s ...
(Date:7/24/2014)... use of native animal species for food or commercial ... significant factor in the decline of many species of ... indicates that more than half of the species being ... hornbills., "By surveying not only the meat made available ... inside the forest by hunters and brought to villages ...
Breaking Biology News(10 mins):New study draws links between wildlife loss and social conflicts 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3
... 2009 Two weeks after the rains begin, an elephant family ... up for pregnancy and birth. But when they wandered off their ... that elephants couldn,t eat it, according to a University of Utah ... research which suggests how climate change and human encroachment may ...
... hide from the immune system undermine the virus,s ability to ... 13 issue of the Journal of Experimental Medicine . ... When HIV infects a cell, a complex of human immune ... T cells by displaying bits of the virus on the ...
... two groups of researchers have come to the same conclusion: ... hearing loss. The new gene - called a microRNA - ... of hundreds of other molecules within sensory hair cells of ... genetic understanding of a condition that is common in humans ...
Cached Biology News:Diet secrets of 'the Royals' 2Diet secrets of 'the Royals' 3Diet secrets of 'the Royals' 4Diet secrets of 'the Royals' 5HIV pays a price for invisibility 2New insights into progressive hearing loss 2New insights into progressive hearing loss 3New insights into progressive hearing loss 4
(Date:7/24/2014)... SAN DIEGO , July 24, 2014 /PRNewswire/ ... company, announced today the appointment of Adam ... (COO). Cypher Genomics provides rapid and comprehensive annotation ... discovery and clinical reporting. "Cypher,s technology ... to improve healthcare by enhancing diagnostic accuracy, optimizing ...
(Date:7/23/2014)... 2014 Lyfebulb, the International Pemphigus Pemphigoid ... NASDAQ OMX First North Premier, Stockholm ... a collaboration to increase awareness of unmet needs ... event attended by more than sixty patients, physicians, ... health and wellness company dedicated to serving the ...
(Date:7/23/2014)... have made great strides in saving China,s endangered national ... over 65 giant panda reserves that have been established ... just 1596 pandas remain in the wild. , ... save the panda by improving genetic diversity, avoid inbreeding ... how are these high-profile programs doing so far? , ...
(Date:7/23/2014)... /PRNewswire-iReach/ -- Think Drinks are a neuroscience-backed drink regimen ... They are the first functional focus beverage to give ... alternative to the temporary fix associated with energy drinks. ... 29, 2014, with hopes to raise $50,000 over the ... http://photos.prnewswire.com/prnh/20140723/129697 Think Drinks were ...
Breaking Biology Technology:Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 4Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 5truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2
... path for the conversion of sunlight to electricity ... with Lawrence Berkeley National Laboratory (Berkeley Lab) have ... effect can take place in semiconductor thin-films. This ... voltage limitation that continues to plague conventional solid-state ...
... ... bj-diagnostik, under its brand “DNA-Planet”, introduces a newly structured offer ... considers the exact analysis necessary to solve the genetic kinship relation ... relatedness based on the facts of each individual case. In addition, ...
... 2010) Scientists have discovered the world,s smallest superconductor, ... one nanometer wide. The Ohio University-led study, published Sunday ... Nature Nanotechnology , provides the first evidence that nanoscale ... used for nanoscale electronic devices and energy applications. ...
Cached Biology Technology:New path to solar energy via solid-state photovoltaics 2New path to solar energy via solid-state photovoltaics 3DNA-Planet Launches New Service for Customer-Individual Indirect DNA Paternity Testing and Kinship Analysis 2DNA-Planet Launches New Service for Customer-Individual Indirect DNA Paternity Testing and Kinship Analysis 3DNA-Planet Launches New Service for Customer-Individual Indirect DNA Paternity Testing and Kinship Analysis 4Scientists discover world's smallest superconductor 2
Human VASA Biotinylated Affinity Purified PAb...
Recombinant Mouse Matrilin-4, CF Protein Family: Extracellular Matrix Molecules, Chondrogenesis Markers...
An instrument that delivers an accurate and uniform amount of light energy to cells to photoactivate csiRNA products....
Use the DUALmembrane kit 3 to carry out DUALmembrane interaction analysis and cDNA library screening to characterize interactions between integral membrane proteins and to identify novel interaction ...
Biology Products: