Navigation Links
Researchers find chink in the armor of viral 'tummy bug'
Date:12/23/2008

Researchers at Griffith University's Institute for Glycomics in collaboration with colleagues at the University of Melbourne have moved a step closer to identifying a broad spectrum treatment for the dreaded 'viral tummy bug' or rotavirus.

These highly-infectious viruses are the leading cause of severe diarrhoea in young children, responsible for thousands of hospitalisations in the developed world, and hundreds of thousands of deaths each year in developing countries.

Institute Executive Director Professor Mark von Itzstein said research findings published in the world-leading Chemical Biology journal Nature Chemical Biology this week demanded a total rethink of how these viruses work.

"Rotaviruses are thought to infect the bodies by sticking to certain types of sugars called sialic acids on the surface of our stomach cells. They then enter cells and reproduce rapidly, causing illness," he said.

"Rotavirus vaccines are still in their infancy, as problems emerged with the first vaccine that was trialled a number of years ago. While other vaccines are now in clinical use, new directions are required in the development of potential drugs to prevent or treat this deadly virus."

He said that to better understand how carbohydrates are involved in rotavirus infection, researchers had focussed on treating mammalian cells with a protein called sialidase which cuts these surface sugars so the virus cannot attach.

Previous to his group's work most scientists believed only some of the many strains of rotavirus infection could be prevented with sialidase treatment while others were apparently immune to its effects.

This led to the conclusion that some viruses depend on sialic acid to infect the body while others were thought to cause infection independent of sialic acid.

"Unsuccessful attempts to reduce rotavirus infection with this treatment led scientists to group rotaviruses into two class
'/>"/>

Contact: Jeannette Langan
j.langan@griffith.edu.au
61-755-528-654
Research Australia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biomedical researchers create artificial human bone marrow in a test tube
2. Princeton researchers discover new type of laser
3. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
4. James Thomson receives 2008 Massry Prize honoring stem cell researchers
5. Researchers push nature beyond its limits to create higher-density biofuels
6. Researchers advance knowledge of little nano-machines in our body
7. No quick or easy technological fix for climate change, researchers say
8. Researchers find natures shut-off switch for cellulose production
9. Researchers compile molecular manual for 100s of inherited diseases
10. Pitt researchers create non-toxic clean-up method for potentially toxic nano materials
11. Researchers identify new anti-tumor gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... HEIGHTS, Ill. (September 30, 2014) People who suffer ... can do to control their asthma besides properly taking ... a new article in the Annals of Allergy, ... American College of Allergy, Asthma and Immunology (ACAAI), asthma ... examining their lifestyle. The woman described in the Annals ...
(Date:9/29/2014)... 2014 -- Plants have a symbiotic relationship with ... extract nutrients and defend against invaders an ... and vegetables. Now, scientist have discovered that plants ... thus ensuring that sprouting plants are colonized from ... Notre Dame, presented their findings today at the ...
(Date:9/29/2014)... should use ventilation when cooking with a gas stove, ... new study showed an association between gas kitchen stove ... "In homes where a gas stove was used without ... than in homes where a gas stove was used ... the College of Public Health and Human Sciences at ...
Breaking Biology News(10 mins):Asthma symptoms kicking up? Check your exposure to air pollution 2Plants prepackage beneficial microbes in their seeds 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... people who have a drink or two might be more ... from a University of Florida research group in the ... people 50 or older in the study metabolized alcohol similar ... tests after having moderate amounts of alcohol and did not ...
... seven new species of bamboo coral discovered on a ... Marine National Monument. Six of these species may represent ... classification a genus represents. A genus is a major ... species and below a family. Scientists expect to identify ...
... into children,s health and well-being will help solve global ... The research project, which is headed by Professor Arne ... Sciences at University of Copenhagen and will focus on ... which is based on regional food products. , Overweight ...
Cached Biology News:After a few drinks, older adults more impaired than they think 2After a few drinks, older adults more impaired than they think 3New deep-sea coral discovered on NOAA-supported mission 2Enhanced quality of 'LIFE' through Nordic food 2
(Date:9/30/2014)... (PRWEB) September 30, 2014 Whitehouse ... been chosen by the Parenteral Drug Association (PDA) ... and 19, 2014) on container closure integrity testing. This ... integrity test methods and philosophies detailed in the recently ... Evaluation. The course will span container closure ...
(Date:9/30/2014)... Pittsburgh PA (PRWEB) September 30, 2014 ... Nurses ( IACRN), a non-profit organization based ... Clinical Research Excellence and Safety (ACRES), a ... of a strategic alliance agreement, setting the stage ... is to enhance clinical research quality and safety ...
(Date:9/29/2014)... diagnostics today, with imaging techniques like MRI (magnetic ... (nuclear magnetic resonance) increasing steeply over the last ... and quality still limit these techniques because of ... hyperpolarization, which involves injecting the patient with substances ... distribution and fate of specific molecules in the ...
(Date:9/29/2014)... VIRGINIA BEACH, Va. , Sept. 29, 2014 ... scientists from the fields of cartilage repair, regeneration, ... as attendees from around the world gathered to ... 2014 LifeNet Health Institute of Regenerative Medicine symposium, ... Future Direction . Topics included Orthopedic Biosurgery, Minced ...
Breaking Biology Technology:Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4IACRN and ACRES to Support Clinical Research Nurses 2IACRN and ACRES to Support Clinical Research Nurses 3A safer approach for diagnostic medical imaging 2A safer approach for diagnostic medical imaging 3World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3
... DCGN ) today announced that it will host a ... Weisel Partners Healthcare,Conference 2008., The presentation will be ... / 6:30,PM British Summer Time on Wednesday, September 3 ... be accessed through the Investors page on,deCODE,s website, ...
... Abaxis, Inc.,(Nasdaq: ABAX ), a medical products ... Don Wood, Vice President,Operations, and Al Santa Ines, ... Annual West Coast Emerging Growth Institutional Investor Forum ... at the Ritz-Carlton Hotel, San,Francisco, CA., About ...
... Pharmaceuticals,Inc. (Nasdaq: ARNA ) announced today that the ... Biotech Industry Conference on September,4, 2008 at 11:00 a.m. ... Hotel in New York City. Jack Lief, Arena,s President,and ... of the,company, including its clinical development and discovery programs., ...
Cached Biology Technology:deCODE genetics to Webcast Presentation at Thomas Weisel Partners Healthcare Conference 2008 2Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference 2Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference 3
... system is ideal for routine binary separations. ... Adept CE 4201 UV-Visible variable wavelength detector. ... by the two highly accurate and precise, ... solvent delivery pumps., Chromatograms may be plotted on ...
... A549 cells were cultured in Ham's F12K medium ... log phase of growth. In order to keep ... fixed in acetone-methanol. The cells are arrayed on ... each wells surface specifically treated to enhance cellular ...
CELLine System cultivation flask (for secreted products)...
... K28/86.2, PDZ Domain GenBank Accession ... GST fusion to residues 77-299 of ... pH 7.4, 0.075M NaCl containing 0.05% ... by immunoblot on rat brain microsomal ...
Biology Products: