Navigation Links
Researchers explore new driver of transplant rejection: Platelets
Date:2/17/2009

Platelets, tiny and relatively uncharted tenants of the bloodstream known mostly for their role in blood clotting, turn out to also rally sustained immune system inflammatory responses that play a critical role in organ transplant rejection, according to a new report from Johns Hopkins scientists.

"Platelets potentially hold sway over many aspects of transplant biology," says Craig Morrell, D.V.M., Ph.D., an assistant professor of molecular and comparative pathobiology at the Johns Hopkins University School of Medicine. "Our data, as well as others', show a surprising interplay of platelets and the immune system, so it's time for the transplant world at large to have platelets on its radar."

A self-described "platelet guy" transfixed by the unexplored biology of these circulating bodies, Morrell collaborated with clinicians in the fields of transplant to write a comprehensive review of platelets and transplant biology, published in the January issue of the American Journal of Transplantation.

"It all began with the observation that when transplant tissue is rejected, platelets line up in the interior of blood vessels feeding the tissue," Morrell says. "It turns out they are not just bystanders, but have a role in driving that rejection."

As one of the most abundant cell types in the blood second only to the oxygen-carrying red variety platelets are ubiquitous but relatively unexplored, Morrell says. "It's crazy how many potentially active molecules are jam-packed in these small cells and that we're only just beginning to appreciate their pro-inflammatory qualities."

In fact, mounting evidence from Morrell and others shows that platelets are part of a sustained and general immune response that can trigger or exacerbate organ rejection. Not only do they rush to the scene of a wound and adhere to local blood vessels, preventing fatal bleeding, they also dump out granules that "talk to" immune system white blood
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
2. Researchers isolate protein domain linked to tumor progression
3. CSHL researchers identify gene that helps plant cells keep communication channels open
4. Researchers identify gene linked to aggressive progression of liver cancer
5. Case Western Reserve researchers looking at light-induced toxins in air and water
6. McMaster researchers discover new mode of how diseases evolve
7. Researchers shed new light on connection between brain and loneliness
8. Texas researchers provide emissions data for livestock industry
9. Biodiversity itself begets a species cascade, researchers say
10. NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
11. While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... PALM BEACH GARDENS, Fla. , June 17, ... identity management solutions, today announced that its U.are.U ... by Togo,s Eateries, Inc., ... based fast casual sandwich chain, to increase security, ... (POS). The Crossmatch fingerprint readers enable instant, non-repudiable identity ...
(Date:6/16/2015)... Sweden , June 16, 2015 ... from previously communicated that it will amount to at least ... MSEK. Due to the rapid increase in market growth and ... the previously communicated guidance that revenue for 2015 will exceed ... will amount to approximately 2,200 MSEK. Due to ...
(Date:6/12/2015)... 12, 2015  Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring, announced the ... electronically capture, analyze and identify participants of a ... This system can: , ... and subsequent sign-on process is actually the person ...
Breaking Biology News(10 mins):Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 2
... six years of regular aerial surveys and genetics data collected ... pointing to the central Gulf of Maine as a mating ... recently published online in the journal Endangered Species Research ... ) is one of the most endangered marine mammal species ...
... Glacier retreat areas provide an excellent window into the ... to study how quickly soil biological functions become established ... static in the landscape, but instead evolve with time ... how these factors interact can lead to advancements in ...
... as cold sores has an internal pressure eight times higher than ... DNA into human cells, scientists are reporting in a new study. ... human virus opens the door to new treatments for viral ... the American Chemical Society . Alex Evilevitch and colleagues point ...
Cached Biology News:Are North Atlantic right whales mating in the Gulf of Maine? 2Are North Atlantic right whales mating in the Gulf of Maine? 3University of Alberta scientists get dirty at the Robson Glacier 2
(Date:7/3/2015)... ... 03, 2015 , ... The global failure analysis market is expected to reach ... bioscience market is expected to grow at the highest CAGR of 8.46%; its growth ... the research labs and academic institutions for root cause analysis of failure. The market ...
(Date:7/2/2015)... , ... July 03, 2015 , ... Cuvettes have been used in countless labs for ... to find the cuvette they needed. As expected, this was a daunting and tiring ... wrong part because they were not able to navigate the complex catalog structure. , Now ...
(Date:7/2/2015)... Memphis, TN (PRWEB) , ... July 02, 2015 ... ... in the development and manufacturing of surgical instruments in Orthopedics, announced today the ... orthopedic contract-manufacturing and the world's largest provider of surgical instruments to the Spine ...
(Date:7/1/2015)... BANGALORE, India , July 1, 2015 ... that uses next generation sequencing technology to empower cancer ... Storrer as chief executive officer. In his expanded ... responsible for all strategy, business expansion and worldwide operations ... served as Strand,s chairman and CEO since its founding ...
Breaking Biology Technology:Failure Analysis Market to Grow at 7.52% CAGR to 2020 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 4Failure Analysis Market to Grow at 7.52% CAGR to 2020 5New Cuvette E-Commerce Website Launched by FireflySci 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3
... 2011 Cell Therapeutics, Inc. ("CTI") (Nasdaq and MTA: ... a randomized pivotal trial of pixantrone for the treatment ... the  U.S. Food and Drug Administration,s (the "FDA") Division ... trial, referred to as the PIX-R or PIX 306 ...
... LAFAYETTE, Ind. - Researchers are developing a technology that ... efficient by using a new manufacturing method that employs ... to overcome two major obstacles that hinder widespread adoption ... and increase the efficiency of converting sunlight into an ...
... 9, 2011 Reportlinker.com announces that a ... its catalogue: Diabetic Retinopathy ... to 2017 http://www.reportlinker.com/p0444349/Diabetic-Retinopathy-Therapeutics---Pipeline-Assessment-and-Market-Forecasts-to-2017.html ... Pipeline Assessment and Market Forecasts to 2017 ...
Cached Biology Technology:FDA Provides Guidance for Design of Cell Therapeutics' Pixantrone Pivotal Trial 2FDA Provides Guidance for Design of Cell Therapeutics' Pixantrone Pivotal Trial 3FDA Provides Guidance for Design of Cell Therapeutics' Pixantrone Pivotal Trial 4FDA Provides Guidance for Design of Cell Therapeutics' Pixantrone Pivotal Trial 5Ultrafast laser 'scribing' technique to cut cost, hike efficiency of solar cells 2Reportlinker Adds Diabetic Retinopathy Therapeutics - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Diabetic Retinopathy Therapeutics - Pipeline Assessment and Market Forecasts to 2017 3