Navigation Links
Researchers explore new driver of transplant rejection: Platelets
Date:2/17/2009

Platelets, tiny and relatively uncharted tenants of the bloodstream known mostly for their role in blood clotting, turn out to also rally sustained immune system inflammatory responses that play a critical role in organ transplant rejection, according to a new report from Johns Hopkins scientists.

"Platelets potentially hold sway over many aspects of transplant biology," says Craig Morrell, D.V.M., Ph.D., an assistant professor of molecular and comparative pathobiology at the Johns Hopkins University School of Medicine. "Our data, as well as others', show a surprising interplay of platelets and the immune system, so it's time for the transplant world at large to have platelets on its radar."

A self-described "platelet guy" transfixed by the unexplored biology of these circulating bodies, Morrell collaborated with clinicians in the fields of transplant to write a comprehensive review of platelets and transplant biology, published in the January issue of the American Journal of Transplantation.

"It all began with the observation that when transplant tissue is rejected, platelets line up in the interior of blood vessels feeding the tissue," Morrell says. "It turns out they are not just bystanders, but have a role in driving that rejection."

As one of the most abundant cell types in the blood second only to the oxygen-carrying red variety platelets are ubiquitous but relatively unexplored, Morrell says. "It's crazy how many potentially active molecules are jam-packed in these small cells and that we're only just beginning to appreciate their pro-inflammatory qualities."

In fact, mounting evidence from Morrell and others shows that platelets are part of a sustained and general immune response that can trigger or exacerbate organ rejection. Not only do they rush to the scene of a wound and adhere to local blood vessels, preventing fatal bleeding, they also dump out granules that "talk to" immune system white blood
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
2. Researchers isolate protein domain linked to tumor progression
3. CSHL researchers identify gene that helps plant cells keep communication channels open
4. Researchers identify gene linked to aggressive progression of liver cancer
5. Case Western Reserve researchers looking at light-induced toxins in air and water
6. McMaster researchers discover new mode of how diseases evolve
7. Researchers shed new light on connection between brain and loneliness
8. Texas researchers provide emissions data for livestock industry
9. Biodiversity itself begets a species cascade, researchers say
10. NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
11. While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... A Kansas State University engineer has developed a ... detects improvised explosive devices. The same technique could ... the Steven M. and Kay L. Theede chair ... nuclear engineering, and his research team have created ... or in car trunks. The distance detection method ...
(Date:4/17/2014)... This news release is available in German . ... fails to pay the protection money demanded of him, he ... are seldom required, however, as fear of the consequences is ... is observed in parasitic birds, which lay their eggs in ... egg out, the brood parasites take their revenge by destroying ...
(Date:4/17/2014)... many serious conditions such as heart disease, epilepsy and ... therapies. Unfortunately, there is still much scientists do not ... and unexpected insight into the structure of sodium channels ... - which are responsible for ,fine-tuning, the activity of ... recent edition of the Journal of Biological Chemistry ...
Breaking Biology News(10 mins):Patented research remotely detects nitrogen-rich explosives 2Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Structure of sodium channels different than previously believed 2
... at Rensselaer Polytechnic Institute have developed a new energy ... simple sheet of black paper. The nanoengineered battery ... meeting the trickiest design and energy requirements of tomorrows ... with its ability to function in temperatures up to ...
... with sepsis mount the same immune response, even when ... the first large-scale natural history study of sepsis. The ... researchers in the August 13/27 issue of the Archives ... the immune system responds to infection interpretations on ...
... In some ways, certain tumors resemble bee colonies, says pathologist ... specific role, and just a fraction of the cells serve ... an unspecialized state and seed new tumors. These cells can ... bulk of the tumor. These queens are cancer ...
Cached Biology News:Beyond batteries: Storing power in a sheet of paper 2Beyond batteries: Storing power in a sheet of paper 3Study begins to reveal clues to the cause and progression of sepsis 2Study begins to reveal clues to the cause and progression of sepsis 3Newly created cancer stem cells could aid breast cancer research 2Newly created cancer stem cells could aid breast cancer research 3
(Date:1/15/2014)... , January 15, 2014 A study ... races on the Formula 1 track could help to tackle ... Applied Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) ... healthcare provider Simplyhealth. Telemetry technology, which is inspired ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to ... Science organizations who need document translations. Clients will now ... documents in advance with a selection of nearly 50 life ... a critical factor in clinical and scientific fields, and decrease ...
(Date:1/15/2014)... TAIPEI , Jan. 15, 2014 TaiGen Biotechnology ... an exclusive agreement with R-Pharm, a leading Russian pharmaceutical ... in the Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic for ...
(Date:1/14/2014)... provider of strategic communications services to corporations and organizations preparing for ... United States and Europe , today ... to the firm,s Washington, D.C. office. ... years of service as Associate Commissioner for the Office of External ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2
... CITY, Sept. 1 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: ... global biopharmaceutical company focused on endocrine therapy and oncology, ... Medical Officer, Paul Blake, M.D., will present a corporate ... Global Investment Conference on Wednesday, September 9, 2009 at ...
... ... leader in adult stem cell research and manufacturing, announced today that it has been ... stem cells for human clinical trials. This Drug Manufacturing License recognizes Stemedica as ... Regulations. , ...
... have completed the first thorough, system-level assessment of ... microbes known as Shewanella. Microbes belonging to that ... cleaning up contaminated areas in the environment. ... of Technology, Michigan State University and the Pacific ...
Cached Biology Technology:Stemedica Achieves Major Milestone - Company Receives License to Manufacture Clinical Grade Stem Cells 2Stemedica Achieves Major Milestone - Company Receives License to Manufacture Clinical Grade Stem Cells 3Hidden diversity in key environmental cleanup microbes found by systems biology assessment 2Hidden diversity in key environmental cleanup microbes found by systems biology assessment 3
Human peripheral blood eosinophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Human peripheral blood PBMCs, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Cord blood endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Progenitor Cells...
Human plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Biology Products: