Navigation Links
Researchers discover new strategies for antibiotic resistance
Date:8/29/2007

TORRANCE (August 29, 2007) - With infections increasingly resistant to even the most modern antibiotics, researchers at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) report in the September issue of Nature Reviews Microbiology on new clues they have uncovered in immune system molecules that defend against infection.

Drs. Michael R. Yeaman and Nannette Y. Yount present evidence that small proteins in the immune systems of humans and all kingdoms of life share fundamental structural and functional characteristics that enable these molecules to inhibit or kill microbial pathogens even as these pathogens evolve to resist conventional antibiotics.

"These findings reveal that nature uses a recurring molecular strategy to defend against infection," said Dr. Yeaman. "A clearer understanding of this strategy provides new opportunities to develop innovative anti-infective therapies to better prevent or treat life-threatening infections that resist current antibiotics."

Most modern antibiotics work by targeting specific structures or functions in microbial pathogens. If the targets change due to mutation, pathogens can quickly become resistant to the antibiotics. In contrast, immune system molecules have retained the ability to fight infection even as microbes evolve.

"While human ingenuity has thus far created antibiotics that pathogens seem to resist after just a few years, nature has created molecules in our immune systems that retain the ability to defend against infection even after millions of years of evolution," said Dr. Yeaman. "We have a lot to learn from nature."

The September article sheds new light on the molecular basis for the antimicrobial capabilities of these molecules. Drs. Yeaman and Yount report that a structure they discovered in these molecules in 2004 known as the y core allows for "hypermutability," or unusually high rates of mutation or modification at s
'/>"/>

Contact: Laura Mecoy
lmecoy@issuesmanagement.com
310-546-5860
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. NYU researchers simulate molecular biological clock
5. Researchers reveal the infectious impact of salmon farms on wild salmon
6. Researchers identify target for cancer drugs
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... in the creation of the Santa Ana Wildfire Threat ... threat potential of the powerful, hot, dry Santa Ana ... The index was introduced Sept. 17 by the U.S. ... Gas and Electric. , The index includes four classification ... used to help fire agencies and other emergency responders, ...
(Date:9/17/2014)... doctoral student have designed a device based on a ... and dew., The device could provide water in drought-stricken ... Cheng Luo, professor in the Mechanical & Aerospace Engineering ... College of Engineering department, published "Bioinspired Plate-Based Fog Collectors" ... Society) Applied Materials & Interfaces ...
(Date:9/17/2014)... DIEGO, Calif. (Sept. 17, 2014) A rare genetic disorder ... according to a recent joint investigation by researchers at ... San Diego. In addition to suggesting better treatment options ... more clues into the genetic underpinnings of autism., Jacobsen ... the National Institutes of Health. It occurs in a ...
Breaking Biology News(10 mins):UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2Shorebird's beak inspires UT Arlington research on water collection 2A link between Jacobsen syndrome and autism 2
... in the branches of trees hemming the shorelines during ... coastal residents in Indonesia, India, Thailand and Sri Lanka. ... Chandra Giri from the U.S. Geological Survey (USGS) decided ... which make up valuable forest ecosystems called mangroves -- ...
... molecular machines that transport substances, catalyze chemical reactions, pump ... amino acids and the individual amino acid sequence is ... protein can carry out inside the cell are determined ... this so-called tertiary structure presents a great challenge to ...
... of an exotic, infectious virus that has caused three recent ... virus might damage lungs during infection. The findings also suggest ... Not only does the infection from monkeypox virus increase ... of proteins that keep lung tissue intact and lubricated. The ...
Cached Biology News:Root of the matter: A new map shows life-saving forests' scarcity defies past estimates 2Root of the matter: A new map shows life-saving forests' scarcity defies past estimates 3Root of the matter: A new map shows life-saving forests' scarcity defies past estimates 4Root of the matter: A new map shows life-saving forests' scarcity defies past estimates 5Structural genomics accelerates protein structure determination 2Structural genomics accelerates protein structure determination 3Deadly monkeypox virus might cause disease by breaking down lung tissue 2Deadly monkeypox virus might cause disease by breaking down lung tissue 3Deadly monkeypox virus might cause disease by breaking down lung tissue 4
(Date:9/18/2014)... Sept. 18, 2014  Neogen Corporation (Nasdaq: ... a strategic agreement with Merck Animal Health to market ... The Igenity Dairy Heifer Program consists of genomic ... the genetic potential of replacement dairy heifers. The genomic ... born, and is an excellent tool in the decision-making ...
(Date:9/18/2014)... September 18, 2014 OMICS Group ... globe to participate in the ‘Open Access Week’ ... to OMICS Group Pharma Journals from ... of the fastest emerging Sciences, accelerating with a ... services across the globe. The industry is gearing ...
(Date:9/18/2014)... and diabetes prevention, could actually hasten the development of ... in a surprising way: by changing the composition and ... of bacteria residing in our intestines. These findings, the ... today in Nature . Among other things, says ... who led this research together with Prof. Eran Segal ...
(Date:9/18/2014)... California (PRWEB) September 18, 2014 Silicon-valley ... forces with Digitaliza TXT , the latest addition ... to its Clinical Research Organization (CRO) Program, Clinovo further ... “After three days of ClinCapture training, we are now ... TXT CEO Ana Pulido. “We can also rely on ...
Breaking Biology Technology:Merck Animal Health to market Neogen's dairy genomic program 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 2Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 3
... (Nasdaq:,CEPH) today announced that its Analyst Day in New ... be webcast live on the investor relations section of,its ... will review the company,s business,strategy, marketing plan and research ... November 5, 2008 beginning at,approximately 12:30 p.m. EST and ...
... - A ... FREMONT, Calif., Oct. 30 WaferGen Biosystems,Inc. (OTC ... genotyping, cell biology and stem cell research systems,today announced ... a,team of researchers at University of Pittsburgh an approximately ...
... role in the move,to incorporate mobile technology into ... announced it will launch a new program,designed to ... mobile,platform, the Dystonia Medical Research Foundation has partnered ... of mobile technology,to the nonprofit sector., The ...
Cached Biology Technology:Cephalon, Inc. to Webcast Analyst Day 2Cephalon, Inc. to Webcast Analyst Day 3NIH Awards Approximately $3M Grant for Research Involving WaferGen's SmartChip(TM) Real-Time PCR System at the University of Pittsburgh 2NIH Awards Approximately $3M Grant for Research Involving WaferGen's SmartChip(TM) Real-Time PCR System at the University of Pittsburgh 3NIH Awards Approximately $3M Grant for Research Involving WaferGen's SmartChip(TM) Real-Time PCR System at the University of Pittsburgh 4NIH Awards Approximately $3M Grant for Research Involving WaferGen's SmartChip(TM) Real-Time PCR System at the University of Pittsburgh 5NIH Awards Approximately $3M Grant for Research Involving WaferGen's SmartChip(TM) Real-Time PCR System at the University of Pittsburgh 6Nonprofit Puts the Power to Cure Neurological Disease in the Hands of the Masses: Texting Technology Brings Awareness & Supports Research 2Nonprofit Puts the Power to Cure Neurological Disease in the Hands of the Masses: Texting Technology Brings Awareness & Supports Research 3
Apoptosis Detection Systems and Reagents...
...
DAPI: 4', 6-Diamino-2-phenylindole dihydrochloride. Antifade Solution: p-Phenylenediamine and glycerol in PBS solution. 0.4g/mL DAPI suspended in Antifade....
Anti-Mouse Qa.m8, Ascites (Clone 5035-24.1) (mouse IgG3)...
Biology Products: