Navigation Links
Researchers discover new strategies for antibiotic resistance
Date:8/29/2007

TORRANCE (August 29, 2007) - With infections increasingly resistant to even the most modern antibiotics, researchers at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) report in the September issue of Nature Reviews Microbiology on new clues they have uncovered in immune system molecules that defend against infection.

Drs. Michael R. Yeaman and Nannette Y. Yount present evidence that small proteins in the immune systems of humans and all kingdoms of life share fundamental structural and functional characteristics that enable these molecules to inhibit or kill microbial pathogens even as these pathogens evolve to resist conventional antibiotics.

"These findings reveal that nature uses a recurring molecular strategy to defend against infection," said Dr. Yeaman. "A clearer understanding of this strategy provides new opportunities to develop innovative anti-infective therapies to better prevent or treat life-threatening infections that resist current antibiotics."

Most modern antibiotics work by targeting specific structures or functions in microbial pathogens. If the targets change due to mutation, pathogens can quickly become resistant to the antibiotics. In contrast, immune system molecules have retained the ability to fight infection even as microbes evolve.

"While human ingenuity has thus far created antibiotics that pathogens seem to resist after just a few years, nature has created molecules in our immune systems that retain the ability to defend against infection even after millions of years of evolution," said Dr. Yeaman. "We have a lot to learn from nature."

The September article sheds new light on the molecular basis for the antimicrobial capabilities of these molecules. Drs. Yeaman and Yount report that a structure they discovered in these molecules in 2004 known as the y core allows for "hypermutability," or unusually high rates of mutation or modification at s
'/>"/>

Contact: Laura Mecoy
lmecoy@issuesmanagement.com
310-546-5860
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. NYU researchers simulate molecular biological clock
5. Researchers reveal the infectious impact of salmon farms on wild salmon
6. Researchers identify target for cancer drugs
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... Geneticist Fred Alt will be awarded the 44th Rosenstiel ... University for his pioneering research exploring the mechanisms of ... and cancer cells. Alt is the second alumnus to ... the Nobel Prize in 2003. , Alt is the ... Genetics at Harvard Medical School and an investigator at ...
(Date:10/14/2014)... new study published in Cancer Research shows ... and colon cancers—can promote the development of skin cancers ... and survival of sun-damaged skin cells. , Previously considered ... proteins called sirtuins that help regulate genomic stability and ... SIRT6 helps repair DNA damage, which can lead to ...
(Date:10/14/2014)... how to produce enough food to feed the world ... Organization of the United Nations predicts that food production ... feed a growing global population, and plants are one ... Plants—grains, cereals, fruits, vegetables, and more—feed humans directly ... tap into our knowledge of how plants work to ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... clear how salt, a scourge to agriculture, halts the growth ... the Carnegie Institution,s Jos Dinneny and Lina Duan, found that ... that an inner layer of tissue in the branching roots ... a stress hormone, which stops root growth. The study, published ...
... In a speech later today, Minister for Universities and ... research in Industrial Biotechnology and Bioenergy. The funding, from ... create networks and collaborative research between academia and industry ... UK and new ,green collar, jobs. The funding ...
... COLUMBIA, Mo. More than one-third of Americans are ... such as Type 2 diabetes and cardiovascular problems. In ... have suggested ways to improve the health outcomes of ... at the University of Missouri suggests certain exercises that ...
Cached Biology News:Breakthrough: How salt stops plant growth 2£35 million to support research for vital industrial sector 2Women must do more to reap same positive health outcomes as men, MU research suggests 2
(Date:10/22/2014)... (PRWEB) October 21, 2014 The ... the inorganic refrigerants market in Americas with analysis ... TOC of the Americas Inorganic Refrigerants Market report, ... provided. This also provides a glimpse of the ... is supported by various tables and figures. ...
(Date:10/22/2014)... NJ (PRWEB) October 22, 2014 ... and services – has been working with a team ... and New Haven Farms Community Farming Collaborative to provide ... ePRO solution. The study, which started in May, ... program that provides participants weekly exposure to and participation ...
(Date:10/22/2014)... October 22, 2014 According to ... by Service Type (Consulting, Integration, Deployment & Support), ... Deployment Model (Public, Private, Others (Hybrid & Community)) ... defines and segments the Cloud Professional Services Market ... forecasting of revenues. It also identifies the drivers ...
(Date:10/22/2014)... DUBLIN , Oct. 22, 2014 ... "Organic Electronics Market by Material, by Application, Geography ... report to their offering. Organic electronics, ... a branch of material science which deals with small ... as organic because small molecules and polymers are carbon ...
Breaking Biology Technology:The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3
... InterMune, Inc.,(Nasdaq: ITMN ) announced today that it ... 6, 2008 at 4:00 p.m. Eastern time.,A live conference ... 4:30 p.m.,Eastern time that same day., To access ... ID# 71184785. To access the,webcast, please log on to ...
... in U.S. Phase II Study,of Nitazoxanide in Treatment-Naive ... Fla., Oct. 28 Romark Laboratories, a privately,held ... nitazoxanide at the upcoming 59th Annual Meeting of ... (AASLD), also known as The,Liver Meeting(R), and the ...
... Affitech AS, the human,therapeutic antibody company, today ... to the innovative diabody technology originally owned ... vaccine company. Also known as,bi-specific single chain ... attributes make them attractive,candidates for a variety ...
Cached Biology Technology:InterMune to Release Third Quarter 2008 Financial Results on November 6 2Romark Laboratories Announces Presentation of New Nitazoxanide Data at 59th Annual AASLD Meeting and 50th Anniversary IASL Meeting in San Francisco 2Affitech Acquires Pharmexa's Diabody Technology 2
...
Peptide-affinity Purified Polyclonal Antibody to MAML1 / Mastermind Peptide with sequence VLPTCPMAEFALPR, from N Terminus of the protein sequence according to NP_055572....
Mouse monoclonal [5H9] to RAD52 ( Abpromise for all tested applications). entrezGeneID: 5893 SwissProtID: P43351...
... the family of calcium binding proteins such as ... of an alpha and beta chain whereas S100B ... protein is also expressed in the antigen presenting ... and interdigitating reticulum cells in the paracortex of ...
Biology Products: