Navigation Links
Researchers discover new strategies for antibiotic resistance
Date:8/29/2007

TORRANCE (August 29, 2007) - With infections increasingly resistant to even the most modern antibiotics, researchers at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) report in the September issue of Nature Reviews Microbiology on new clues they have uncovered in immune system molecules that defend against infection.

Drs. Michael R. Yeaman and Nannette Y. Yount present evidence that small proteins in the immune systems of humans and all kingdoms of life share fundamental structural and functional characteristics that enable these molecules to inhibit or kill microbial pathogens even as these pathogens evolve to resist conventional antibiotics.

"These findings reveal that nature uses a recurring molecular strategy to defend against infection," said Dr. Yeaman. "A clearer understanding of this strategy provides new opportunities to develop innovative anti-infective therapies to better prevent or treat life-threatening infections that resist current antibiotics."

Most modern antibiotics work by targeting specific structures or functions in microbial pathogens. If the targets change due to mutation, pathogens can quickly become resistant to the antibiotics. In contrast, immune system molecules have retained the ability to fight infection even as microbes evolve.

"While human ingenuity has thus far created antibiotics that pathogens seem to resist after just a few years, nature has created molecules in our immune systems that retain the ability to defend against infection even after millions of years of evolution," said Dr. Yeaman. "We have a lot to learn from nature."

The September article sheds new light on the molecular basis for the antimicrobial capabilities of these molecules. Drs. Yeaman and Yount report that a structure they discovered in these molecules in 2004 known as the y core allows for "hypermutability," or unusually high rates of mutation or modification at s
'/>"/>

Contact: Laura Mecoy
lmecoy@issuesmanagement.com
310-546-5860
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. NYU researchers simulate molecular biological clock
5. Researchers reveal the infectious impact of salmon farms on wild salmon
6. Researchers identify target for cancer drugs
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Stem cells in bone marrow need to produce hydrogen ... tissue, according to a new study from the Center ... of Dentistry of USC. , Professor Songtao Shi, principal ... sulfide produced by the cells governs the flow of ... cellular signals that results in osteogenesis, or the creation ...
(Date:4/17/2014)... the Amazon help create tinderbox conditions for wildfires ... forest loss during drought years, according to a ... in the Amazon could reach a "tipping point" ... to large-scale loss of trees, making recovery more ... Penn State. , "We documented one of the ...
(Date:4/17/2014)... detected new early-warning signs of the potential loss of ... implications for the diagnosis and treatment of diabetic retinopathy, ... , "We had not expected to see such striking ... Ann Elsner, professor and associate dean in the IU ... "We set out to study the early signs, in ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
... at his 4th annual Nutrition & The Eye conference, April ... of Missouri in St. Louis, says molecular medicine is beginning ... other therapies have been exhausted. "These nutritional molecules have ... , cancer research and some human studies", Dr Richer reported. ...
... your carbon footprint frequently include buying compact florescent light bulbs, ... local produce. But how much difference do these actions make? ... California, Berkeley, suggests that who you are and where you ... largest impact. "Everyone has a unique carbon footprint," says ...
... 14, 2011 Novocure today announced that the ... NovoTTF-100A System (NovoTTF) for the treatment of adult ... tumor recurrence after receiving chemotherapy. The portable, ... patients maintain their normal daily activities. The NovoTTF ...
Cached Biology News:Low-cost molecular medicine should be included in modern eye physicians' tool kit 2When it comes to carbon footprints, location and lifestyle matter 2When it comes to carbon footprints, location and lifestyle matter 3When it comes to carbon footprints, location and lifestyle matter 4FDA approves the NovoTTF-100A system for the treatment of patients with recurrent glioblastoma multiforme (GBM) brain tumors 2
(Date:1/15/2014)... Biotechnology Company, Limited ("TaiGen") today announced that they have ... pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ® ... Turkey and other members of ... for the treatment of bacterial infections including those caused ...
(Date:1/14/2014)... 14, 2014 Histogen, Inc., a regenerative ... cells grown under simulated embryonic conditions, today announced that ... Suneva Medical, Inc. for physician-dispensed aesthetic products containing Histogen’s ... This agreement is an amendment to the existing license ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging ... to serve the wound care market. , Free report ... was restructured with a seasoned management team and Board, ...
(Date:1/14/2014)... MA (PRWEB) January 14, 2014 iLab Solutions, ... Detwiler as the new Director of Product Strategy. In this ... well as iLab sub-teams to guide in the development of ... iLab provides the maximum possible benefit to the scientific community ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... Encorium Group, Inc. (Nasdaq: ENCO ), a full service ... for many of the world,s leading pharmaceutical and biotechnology companies, today ... Nasdaq stating that since it had not, as of the date ... June 30, 2009, it was then no longer in compliance with ...
... , MURRIETA, Calif., Aug. 27 Despite ... of its US operations. Copan Diagnostics, Inc. is undertaking a ... and additional medical device manufacturing operations to its facility in ... molding machinery and filling and packing equipment to expand Copan,s ...
... , , , , ... PPHM ) today announced that it will release its financial results for ... 7:00 a.m. EDT and will host a conference call and webcast to ... , Peregrine,s senior management will discuss financial results for ...
Cached Biology Technology:Encorium Announces Receipt of Letters from Nasdaq Regarding its Second Quarter 2009 Form 10-Q Filing 2Encorium Announces Receipt of Letters from Nasdaq Regarding its Second Quarter 2009 Form 10-Q Filing 3Copan Announces Multimillion Expansion for US Pipet Manufacturing Operations 2Peregrine Pharmaceuticals to Report First Quarter FY 2010 Financial Results 2
WD-repeat protein 4...
... omental preadipocytes are isolated ... healthy donors. There is ... cells. Please inquire for ... also available. Academic discounts ...
11-keto Testosterone EIA Antiserum hormones steroids antisera antiserum eias enzyme immunoassays reagents 11-keto-testosterone...
Chaps Cell Extract Buffer can be used to lyse cells under nondenaturing conditions and is recommendedfor the preparation of cell lysates to be used with our caspase signaling pathway antibodies...
Biology Products: