Navigation Links
Researchers discover a missing link in signals contributing to neurodegeneration
Date:5/9/2013

In many neurodegenerative diseases the neurons of the brain are over-stimulated and this leads to their destruction. After many failed attempts and much scepticism this process was finally shown last year to be a possible basis for treatment in some patients with stroke. But very few targets for drugs to block this process are known.

In a new highly detailed study, researchers have discovered a previously missing link between over-stimulation and destruction of brain tissue, and shown that this might be a target for future drugs. This research, led by the A. I. Virtanen Institute at the University of Eastern Finland in collaboration with scientists from Lausanne University Hospital, University of Lausanne and the company Xigen Pharma AG, was published in the Journal of Neuroscience.

What is this missing link? We have known for years that over-stimulated neurons produce nitric oxide molecules. Although this can activate a signal for destruction of cells, the small amount of nitric oxide produced cannot alone explain the damage to the brain. The team now show that a protein called NOS1AP links the nitric oxide that is produced to the damage that results. NOS1AP binds an initiator of cell destruction called MKK3 and also moves within the cell to the source of nitric oxide when cells are over-activated. The location of these proteins in cells causes them to convert the over-stimulation signal into a cell destruction response. The team designed a chemical that prevents NOS1AP from binding the source of nitric oxide. This reduces the cell destruction response in cells of the brain and as a result it limits brain lesions in rodents.

This translational research was funded mainly by the Academy of Finland, the European Union and the University of Eastern Finland and used the recently developed high-throughput imaging facilities at the A. I. Virtanen Institute. The researchers hope that continuation of their work could lead to improved
'/>"/>

Contact: Michael Courtney
mjczmjc@gmail.com
358-403-553-663
University of Eastern Finland
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... JOSE, Calif. , March 2, 2015 /PRNewswire/ ... the leading developer of human interface solutions, today ... technology that is designed to enable rapid and ... Natural ID™ module for gaming is a turnkey ... ODMs the ability to quickly integrate fingerprint ID ...
(Date:3/2/2015)... Ala. , March 2, 2015  Businesses ... processing. Data protection company Tharon Rankins Enterprises has ... that provides an ultra-safe way for businesses to ... their financial transactions. Beconux is ... Tharon Rankins Enterprises. Functioning similarly to an ATM ...
(Date:3/2/2015)... March 2, 2015   Neurotechnology , a provider ... the SentiGaze Software Development Kit (SDK). The ... that use off-the-shelf webcams to track eye movements and ... a monitor. Heatmaps can be used for applications such ... online advertising. The SDK can also be used to ...
Breaking Biology News(10 mins):Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3Personal Data Protection Company Launches New Product 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3
... called microRNAs, only 19 to 21 nucleotides in length, ... genes. They do this by specifically binding to and ... for conveying the information from genes to the cellular ... building blocks of the body. Several hundred species of ...
... team of Canadian researchers, lead by Dr. Susan George ... and Mental health (CAMH), discovered a distinct dopamine signalling ... types of dopamine receptors, this novel target may have ... Published in the Proceedings of the National Academy of ...
... study sheds new light on the role of carbon dioxide ... that instead of sinking, carbon dioxide is often consumed by ... dimly lit area 100 to 1,000 meters below the surface. ... it can be stored and prevented from re-entering the atmosphere ...
Cached Biology News:Killing the messenger RNA -- But which one? 2New dopamine brain target discovered 2Ocean's 'twilight zone' may be a key to understanding climate change 2
(Date:3/2/2015)... Shimadzu Scientific Instruments will showcase several ... and marijuana analysis at the Pittcon 2015 conference and ... at the Ernest N. Morial Convention Center in New ... 3121 to discuss laboratory challenges with Shimadzu’s technical experts ... help save time, money and effort in the lab. ...
(Date:3/2/2015)... 02, 2015 In the five years ... has experienced robust growth. The industry, which consists of ... energy resources and other goods, has grown on account ... As a result, IBISWorld forecasts that industry revenue will ... $946.8 million over the five-year period, including an anticipated ...
(Date:3/2/2015)... 02, 2015 Resilinc released ... report which summarizes and analyzes nearly 700 unique ... EventWatch™ 24X7 global event monitoring and alert reporting ... a free trial period of the email service to ... that can negatively impact revenue, market share, customer satisfaction, ...
(Date:3/2/2015)... 2, 2015 Analyzing a puzzling multisystem ... a new syndrome, shedding light on key biological ... important information to help caregivers manage the disorder, ... "This syndrome illuminates a very important ... switch that controls many other genes," said study ...
Breaking Biology Technology:Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 2Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 3Laboratory Testing Services in Canada Industry Market Research Report Now Available from IBISWorld 2Laboratory Testing Services in Canada Industry Market Research Report Now Available from IBISWorld 3Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 2Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 3New Genetic Syndrome Found, Arising from Errors in 'Master Switch' During Early Development 2New Genetic Syndrome Found, Arising from Errors in 'Master Switch' During Early Development 3New Genetic Syndrome Found, Arising from Errors in 'Master Switch' During Early Development 4
... 2011 Optimer Pharmaceuticals, Inc. (NASDAQ: OPTR ) ... of its Board of Directors approved the grant of inducement ... common stock to 7 new employees. (Logo: ... price per share equal to $11.83, the fair market value ...
... the quest to form perfectly smooth single-molecule layers of ... at the U.S. Department of Energy,s Brookhaven National Laboratory ... frozen at a temperature where the bulk material is ... extending from organic solar cells to biosensors, and understanding ...
... March 31, 2011 BioSpace launched the ... sciences companies in The Research Triangle Park and across North ... more than 10 life science employers. Each campaign participant,s logo ... that is promoted online and at industry events or ...
Cached Biology Technology:Optimer Pharmaceuticals Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4) 2Expanding the degrees of surface freezing 2BioSpace Highlights North Carolina's Life Science Regions 2
... secretion of cytoplasmic granules, is a ... of leukocytes (e.g. basophils, neutrophils, eosinophils, ... histamine, these secretory granules contain many ... and many proteases (Hallgren, 2001). Tryptase, ...
... Processing Service enables scientists who do not have ... software to have their biological samples tested for ... as easy as 1-2-3 Chose the ... samples from the S&S antibody menu. Send ...
... This exceptionally sensitive nucleic acid gel stain ... low background in gels, making it ideal for ... standard UV transilluminators. SYBR Green I nucleic ... in capillary electrophoresis, real-time PCR assays and bandshift ...
... cross-linking techniques are defined by the author ... Wong. This valuable hardcover guide includes hundreds ... application references. More than 300 pages detail ... conjugate preparation from selection and design ...
Biology Products: