Navigation Links
Researchers develop oral delivery system to treat inflammatory bowel diseases
Date:10/10/2010

ately 600 nanometers for optimal oral delivery.

For their experiments, the researchers used a mouse model of ulcerative colitis -- a debilitating inflammatory bowel disease in which the digestive tract becomes inflamed, causing severe diarrhea and abdominal pain that can lead to life-threatening complications.

The researchers orally administered thioketal nanoparticles loaded with siRNA that inhibits an inflammation-promoting cytokine called tumor necrosis factor - alpha (TNF-α). The nanoparticles traveled directly to the mouse colons where reactive oxygen species were being produced in excess and decreased the cytokine production levels there.

Tissue samples from the colons treated with siRNA delivered by these thioketal nanoparticles exhibited intact epitheliums, well-defined fingerlike "crypt" structures and lower levels of inflammation -- signs that the colon was protected against ulcerative colitis.

"Since ulcerative colitis is restricted to the colon, these results confirm that the siRNA-loaded thioketal nanoparticles remain stable in non-inflamed regions of the gastrointestinal tract while targeting siRNA to inflamed intestinal tissues," explained the paper's lead author Scott Wilson, a graduate student in the Georgia Tech School of Chemical & Biomolecular Engineering.

The paper showed that thioketal nanoparticles have the chemical and physical properties needed to overcome the obstacles of gastrointestinal fluids, intestinal mucosa and cellular barriers to provide therapy to inflamed intestinal tissues, he added.

The researchers are currently working on increasing the degradation rate of the nanoparticles and enhancing their reactivity with reactive oxygen species. The team also plans to conduct a biodistribution study to detail how the nanoparticles travel through the body.

"Polymer toxicity is something we'll have to investigate further, but during this study we discovered that thioketa
'/>"/>

Contact: Abby Vogel Robinson
abby@innovate.gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. In Parkinsons disease, brain cells abandon mitochondria, researchers report
2. MIT researchers develop a better way to see molecules at work in living brain cells
3. Scripps researchers, UCSD chemists to create center devoted to chemistrys influence on climate
4. New fisheries system will save about $20 million, Iowa State University researchers find
5. The world is full of darkness, reflected in the physiology of the human retina, Penn researchers say
6. FSU researchers examine how bacteria become resistant to antibiotics
7. Knome Awards Human Exome Sequencing and Analysis to Biomedical Researchers
8. Researchers study sleep apnea and lack of oxygen
9. Bonn researchers use light to make the heart stumble
10. Researchers engineer adult stem cells that do not age
11. OU researchers selected by Navy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers develop oral delivery system to treat inflammatory bowel diseases
(Date:11/12/2014)... Fla. , Nov. 12, 2014 Crossmatch™, ... today that its U.are.U ® fingerprint readers have ... chain in Central Mexico . The ... 2014 to eliminate payroll issues caused by employees clocking ... installing the U.are.U fingerprint readers, Montparnasse relied on paper ...
(Date:11/7/2014)... 2014  In conjunction with the Glendale ... Community Foundation of the Verdugos has announced the " ... a $250,000 initiative to keep the Verdugo Regional Crime Lab ... six months of existence, the Lab has processed more than ... law enforcement. "Because our number one priority is ...
(Date:11/6/2014)... is an asset for a predator. Except when that predator ... tiger beetle, relative to its size, is the fastest creature ... body lengths per second (at about five miles per hour). ... take the sprinting gold from the tiger beetle, a person ... The tiger beetle has a problem. At peak speeds, everything ...
Breaking Biology News(10 mins):Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2The tiger beetle: Too fast to see 2
... A new research paper by a team of researchers ... (ECI) demonstrates how two cutting-edge technologies can provide a ... for invasive species before they get into our country ... cause ecological and economic damage worldwide, including the loss ...
... This press release is available in French . ... JUVS ) is a new quarterly, electronic-only publication that is now ... Fall of 2013. Developed in partnership with Unmanned Systems Canada (USC-STC) ... is an exciting addition to the NRC Research Press journal ...
... a negative impact on bees, ability to learn following exposure ... researchers found that the pesticides, used in the research at ... the learning circuits in the bee,s brain. They also found ... or completely forgot important associations between floral scent and food ...
Cached Biology News:Notre Dame researchers are using new technologies to combat invasive species 2NRC Research Press adds a new title to collection of scientific and technical journals 2Pesticide combination affects bees' ability to learn 2
(Date:11/21/2014)... Los Angeles, CA (PRWEB) November 21, 2014 ... is it that makes Albert Einstein so instantly recognizable? ... South African-born physicist, mathematician, astronomer and author Hilton Ratcliffe ... that they have nothing at all to do with ... ( Muse Harbor Publishing , November 21, 2014), Ratcliffe ...
(Date:11/21/2014)... DIEGO , Nov. 20, 2014  Cytori Therapeutics (NASDAQ: ... Marc Hedrick , M.D. will present live at VirtualInvestorConferences.com on ... 2014 TIME:    11:15 am PT / 2:15 pm ... URL into your browser,s address bar: http://bit.ly/1B2KGaL ... and receive event updates. This will be ...
(Date:11/18/2014)... pH measurement and control is vital in a ... food and beverage industries. But what exactly is pH, ... sensors work? METTLER TOLEDO has produced a guide to ... these questions and more. , METTLER TOLEDO provides a ... The actual sensor, the pH electrode, is therefore the ...
(Date:11/18/2014)... 2014 2014 Deep Research ... professional and in-depth report on Polytetrahydrofuran (PTMEG) ... including its definition, characterization, application, and industry ... exploration covers the worldwide business investigation, including ... covering macroeconomic environment & financial circumstance examination. ...
Breaking Biology Technology:“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4pH Guide from METTLER TOLEDO Explains Measurement, Theory and Practice of pH Applications 2PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 2PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 3
... that could be used in novel security devices to ... sensors, according to research published tomorrow (8 April) in ... which are based on a fundamental science discovery in ... to instantly detect the presence of particular molecules, for ...
... Bulletin Board: TBIO), a leading global biotechnology company, announces ... Dana-Farber Cancer Institute, Boston, MA with regard to a ... standard PCR technology enriches mutations in samples where normal ... Mike Makrigiorgos who has demonstrated its effectiveness in enriching ...
... Calif., April 7 Voler Systems ( http://www.volersystems.com ) ... Program" which provides full-service consulting from concept and design ... economic conditions are not deterring Voler from investing in ... needs and reducing time-to-market for new medical devices. During ...
Cached Biology Technology:New security and medical sensor devices made possible by metallic nanostructures 2Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations 2Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations 3Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations 4Voler Systems Continues Investments and Expands Services 2
Recorder, 6", 7 Day, 1 Pen, 0 to 100°C, 220V, 50/60 Hz, for 4520, Customer Installed...
... STAR3000 HISTAR detection systems provide linking ... used with species specific primary antibodies ... specimens. Visualisation is accomplished using an ... novel polymer labelling technology. Secondary antibodies ...
Taq DNA Polymerase (T. aquaticus), 250 units. For PCR and other procedures requiring DNA polymerase activity at elevated temperatures. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzyme...
... AmpliTaq DNA Polymerase is ... the PCR process, a testimony to its ... activity profile makes it ideal for PCR ... to guarantee reproducible results. ,, AmpliTaq ...
Biology Products: