Navigation Links
Researchers develop oral delivery system to treat inflammatory bowel diseases
Date:10/10/2010

Researchers at the Georgia Institute of Technology and Emory University have developed a novel approach for delivering small bits of genetic material into the body to improve the treatment of inflammatory bowel diseases. Delivering short strands of RNA into cells has become a popular research area because of its potential therapeutic applications, but how to deliver them into targeted cells in a living organism has been an obstacle.

In the Oct. 10 advance online edition of the journal Nature Materials, researchers describe how they encapsulated short pieces of RNA into engineered particles called thioketal nanoparticles and orally delivered the genetic material directly to the inflamed intestines of animals. The research was sponsored by the National Science Foundation and National Institutes of Health.

"The thioketal nanoparticles we designed are stable in both acids and bases and only break open to release the pieces of RNA in the presence of reactive oxygen species, which are found in and around inflamed tissue in the gastrointestinal tract of individuals with inflammatory bowel diseases," said Niren Murthy, an associate professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.

This work was done in collaboration with Emory University Division of Digestive Diseases professor Shanthi Sitaraman, associate professor Didier Merlin and postdoctoral fellow Guillaume Dalmasso.

The thioketal nanoparticles protect the small interfering RNAs (siRNAs) from the harsh environment of the gastrointestinal tract and target them directly to the inflamed intestinal tissues. This localized approach is necessary because siRNAs can cause major side-effects if injected systemically.

In the paper, the thioketal nanoparticles were formulated from a new polymer -- poly-(1,4-phenyleneacetone dimethylene thioketal) (PPADT) -- and engineered to have a diameter of approxim
'/>"/>

Contact: Abby Vogel Robinson
abby@innovate.gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. In Parkinsons disease, brain cells abandon mitochondria, researchers report
2. MIT researchers develop a better way to see molecules at work in living brain cells
3. Scripps researchers, UCSD chemists to create center devoted to chemistrys influence on climate
4. New fisheries system will save about $20 million, Iowa State University researchers find
5. The world is full of darkness, reflected in the physiology of the human retina, Penn researchers say
6. FSU researchers examine how bacteria become resistant to antibiotics
7. Knome Awards Human Exome Sequencing and Analysis to Biomedical Researchers
8. Researchers study sleep apnea and lack of oxygen
9. Bonn researchers use light to make the heart stumble
10. Researchers engineer adult stem cells that do not age
11. OU researchers selected by Navy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers develop oral delivery system to treat inflammatory bowel diseases
(Date:8/21/2014)... published in the journal Carcinogenesis by researchers ... for the protein adenomatous polyposis coli (APC) in suppressing ... in the U.S. , Lead author Kristi Neufeld, associate ... of the Cancer Biology program at the KU Cancer ... trying to understand the various activities of APC, a ...
(Date:8/21/2014)... in severe abdominal pain, vomiting and systemic inflammation. Every ... with the disease resulting in 1000 deaths. There is ... fluid and nutritional support. , Dr Jason Bruce, ... research, said "The major causes of pancreatitis include bile ... combined with a high fat diet. In fact, the ...
(Date:8/20/2014)... 2014 /CNW/ -  Issue Serious allergic ... become life threatening for some children.    What ... Canadians have food allergies and this number may be increasing, ... are estimated to have food allergies.  The ... and hives to breathing difficulties and loss of consciousness. Symptoms ...
Breaking Biology News(10 mins):Research offers insight into cellular biology of colorectal cancer 2Research offers insight into cellular biology of colorectal cancer 3Insulin offers new hope for the treatment of acute pancreatitis 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... in six will get prostate cancer during his lifetime, making ... a new partnership with Areva Med, UC researchers will investigate ... of prostate cancer tumors. In the study, UC researchers ... efficacy of a new agent targeted against a specific protein ...
... researchers from the Johns Hopkins University School of Medicine ... by European scientific institutions. Andrew P. Feinberg, M.D., ... of the Center for Epigenetics, will receive the honorary ... ceremony in the Stockholm City Hall on May 7. ...
... Researchers in China are reporting that they have found a ... cells -- that have been reprogrammed into a primordial, embryonic-like ... a paper published online last week by the Journal ... the Chinese Academy of Sciences point to a marker they ...
Cached Biology News:UC to test targeted treatment for prostate cancer 22 Hopkins scientists awarded European honorary doctorates 2Chinese scientists discover marker indicating the developmental potential of stem cells 2
(Date:8/21/2014)... New Rochelle, N.Y. (PRWEB) August 21, 2014 ... it is the first private college in the Mid-Hudson ... The College will now begin accepting applications from qualified ... , “We are very pleased to have been ... to support Governor Cuomo’s transformative initiative to stimulate economic ...
(Date:8/21/2014)... Aug. 21, 2014 OTC Markets ... Inc., a biotechnology company, on its approval to ... traded on OTCQX®, the best marketplace for established ... Group. Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... successful execution of its growth strategy and achievement ...
(Date:8/21/2014)... August 21, 2014 Pursuit Solutions ... optimization technology and services for Life Sciences sales ... Pharma’s Use of New Commercial Sales Models” by ... Analytics. , The article examines some innovative models ... are being tested in the pharmaceutical market. Robinson ...
(Date:8/21/2014)... August 21, 2014 SoundConnect ... been recognized as one of the nation’s Fastest ... magazine for the 2nd consecutive year. Inc. magazine ... annual Inc. 500|5000, an exclusive ranking of the ... most comprehensive look at the most important segment ...
Breaking Biology Technology:The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3
... Roche (SWX: ROG.VX; RO.S; OTCQX; RHHBY) today announced that ... accepted for payment all shares validly tendered and not ... shares of common stock of Memory Pharmaceuticals Corp. (Nasdaq: ... cash.As of the expiration of the tender offer, a ...
... Inc.,(Nasdaq: BNVI ) announced today results ... to identify estrogenic drugs that are,safer. The data, ... new regulatory elements can distinguish the estrogenic,pharmacological activity ... prediction of specific tissue effect. , ...
... CHICAGO, Dec. 31 A landmark study published today ... that use of a specially-designed machine to store kidneys ... function when compared to those stored in a traditional ... the LifePort(R) Kidney Transporter monitors the temperature and vascular ...
Cached Biology Technology:Roche Purchases Shares in Tender Offer For Memory Pharmaceuticals Corp. 2Roche Purchases Shares in Tender Offer For Memory Pharmaceuticals Corp. 3Roche Purchases Shares in Tender Offer For Memory Pharmaceuticals Corp. 4Bionovo Publishes Discoveries in Predictable Tissue Selectivity for Selective Estrogen Receptor Modulators Platform 2Bionovo Publishes Discoveries in Predictable Tissue Selectivity for Selective Estrogen Receptor Modulators Platform 3Study Shows Machine Perfusion Significantly Improves Transplant Results 2Study Shows Machine Perfusion Significantly Improves Transplant Results 3
Mouse monoclonal antibody to ANAPC2 - anaphase promoting complex subunit 2...
...
... long and outstanding history in the ... ago we became aware that our ... modified to inject Xenopus oocytes. We ... microdispenser to eliminate any tip movement ...
The Programmable MP-3500P-F Power Supply can be applied for any Microfluidic application....
Biology Products: